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The map label for this gene is tyrP [H]

Identifier: 194737475

GI number: 194737475

Start: 2008191

End: 2009459

Strand: Direct

Name: tyrP [H]

Synonym: SeSA_A2092

Alternate gene names: 194737475

Gene position: 2008191-2009459 (Clockwise)

Preceding gene: 194734185

Following gene: 194734310

Centisome position: 42.65

GC content: 55.48

Gene sequence:

>1269_bases
ATGCCTTACCCTGCGCCGCGGATATCACCGTTCTTTGTTACCGGGGTAGTAGAAAGCGTGAAAAACAGAACTCTGGGCAG
TATTTTTATCGTGGCAGGCACCACTATCGGCGCCGGGATGCTGGCAATGCCGCTGGCAGCGGCTGGCGTTGGTTTCAGCG
TCACGCTGGGATTGTTGATTGGCCTGTGGGCGCTGATGTGTTATACCGCGCTACTATTACTGGAGGTATATCAACACGTT
CCGGCAGATACCGGGCTGGGCTCGTTGGCAAAACGCTATCTTGGACGTTACGGACAGTGGCTTACGGGATTCAGTATGAT
GTTCTTACTGTATGCGCTCACCGCCGCCTACATTTCCGGAGCCGGAGAATTACTGGCATCCAGTATTAATAACTGGCTTG
GCGCCACGCTCTCGCCCGCTGCCGGGGTGCTGCTGTTCACCTTTGTTGCCGGTGGGGTGGTGTGTGTGGGCACCTCGCTG
GTCGACCTTTTTAACCGCTTCCTGTTTAGCGCAAAGATCATTTTTCTGGTCATCATGCTTGCGTTGCTCACGCCACATAT
TCATAAAGTAAATCTTCTTACGCTTCCTTTACAGCAGGGGCTGGCGTTATCCGCCATACCGGTCATTTTCACCTCGTTTG
GTTTTCACGGAAGCGTACCGAGTATTGTGAGTTATATGAACGGCAACATTCGCCGGCTGCGTTGGGTCTTTATGACGGGT
AGTGCCATTCCGTTAGTGGCCTATATTTTTTGGCAGCTCGCCACGCTGGGAAGTATCGACTCGCCGACATTCAGAGGGCT
ACTGGCCAGCCATGCCGGGTTAAATGGCCTGCTGCAGGCACTCAGAGAAGTGGTCGCTTCGCCACATGTCGAACTGGCGG
TCCACCTGTTCGCCGATCTGGCGCTGGCGACCTCTTTTCTGGGCGTAGCGCTAGGATTATTTGATTACCTGGCCGATCTA
TTCCAGCGCCGCAGTACGGTGTCCGGACGTCTGCAAACCGGGCTGATTACCTTTCTGCCGCCGCTGGCGTTTGCGCTTTT
CTACCCACGTGGATTTGTGATGGCATTAGGCTATGCCGGCGTAGCGCTGGCAGTGCTGGCACTGCTCATCCCTGCCATGC
TGGTCTGGCAATGCCGTAAACAGAGCCCTCAGGCGGGATATCGTGTGGCAGGCGGCACGCCAGCGCTGGTGCTGGTGTTT
ATCTGCGGCATTGTCGTGATTGGCGTCCAGTTTTCGATCGCACTGGGGTTCCTGCCCGATCCAGGTTAA

Upstream 100 bases:

>100_bases
GCGGCGGTTGTCCGCGTCTCTTCCCATATTCGCTTTTATGCCCGGAACTGTAAATTTTACAGTACACCCATTGTAACGAC
CATTTGACGAAAATAGCGTA

Downstream 100 bases:

>100_bases
TGCCAGGCAAAGATTACCGGGCCCGGACGCCGTCCAGGCTCGATAATCATCACGCTATGGCCGTTTACGAGCCATTAATG
CAGGCAGCACTGCTTAAATT

Product: tyrosine-specific transport protein

Products: Proton [Cytoplasm]; L-tyrosine [Cytoplasm] [C]

Alternate protein names: Tyrosine permease [H]

Number of amino acids: Translated: 422; Mature: 421

Protein sequence:

>422_residues
MPYPAPRISPFFVTGVVESVKNRTLGSIFIVAGTTIGAGMLAMPLAAAGVGFSVTLGLLIGLWALMCYTALLLLEVYQHV
PADTGLGSLAKRYLGRYGQWLTGFSMMFLLYALTAAYISGAGELLASSINNWLGATLSPAAGVLLFTFVAGGVVCVGTSL
VDLFNRFLFSAKIIFLVIMLALLTPHIHKVNLLTLPLQQGLALSAIPVIFTSFGFHGSVPSIVSYMNGNIRRLRWVFMTG
SAIPLVAYIFWQLATLGSIDSPTFRGLLASHAGLNGLLQALREVVASPHVELAVHLFADLALATSFLGVALGLFDYLADL
FQRRSTVSGRLQTGLITFLPPLAFALFYPRGFVMALGYAGVALAVLALLIPAMLVWQCRKQSPQAGYRVAGGTPALVLVF
ICGIVVIGVQFSIALGFLPDPG

Sequences:

>Translated_422_residues
MPYPAPRISPFFVTGVVESVKNRTLGSIFIVAGTTIGAGMLAMPLAAAGVGFSVTLGLLIGLWALMCYTALLLLEVYQHV
PADTGLGSLAKRYLGRYGQWLTGFSMMFLLYALTAAYISGAGELLASSINNWLGATLSPAAGVLLFTFVAGGVVCVGTSL
VDLFNRFLFSAKIIFLVIMLALLTPHIHKVNLLTLPLQQGLALSAIPVIFTSFGFHGSVPSIVSYMNGNIRRLRWVFMTG
SAIPLVAYIFWQLATLGSIDSPTFRGLLASHAGLNGLLQALREVVASPHVELAVHLFADLALATSFLGVALGLFDYLADL
FQRRSTVSGRLQTGLITFLPPLAFALFYPRGFVMALGYAGVALAVLALLIPAMLVWQCRKQSPQAGYRVAGGTPALVLVF
ICGIVVIGVQFSIALGFLPDPG
>Mature_421_residues
PYPAPRISPFFVTGVVESVKNRTLGSIFIVAGTTIGAGMLAMPLAAAGVGFSVTLGLLIGLWALMCYTALLLLEVYQHVP
ADTGLGSLAKRYLGRYGQWLTGFSMMFLLYALTAAYISGAGELLASSINNWLGATLSPAAGVLLFTFVAGGVVCVGTSLV
DLFNRFLFSAKIIFLVIMLALLTPHIHKVNLLTLPLQQGLALSAIPVIFTSFGFHGSVPSIVSYMNGNIRRLRWVFMTGS
AIPLVAYIFWQLATLGSIDSPTFRGLLASHAGLNGLLQALREVVASPHVELAVHLFADLALATSFLGVALGLFDYLADLF
QRRSTVSGRLQTGLITFLPPLAFALFYPRGFVMALGYAGVALAVLALLIPAMLVWQCRKQSPQAGYRVAGGTPALVLVFI
CGIVVIGVQFSIALGFLPDPG

Specific function: Involved in transporting tyrosine across the cytoplasmic membrane [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788218, Length=403, Percent_Identity=88.5856079404466, Blast_Score=693, Evalue=0.0,
Organism=Escherichia coli, GI1790145, Length=412, Percent_Identity=33.0097087378641, Blast_Score=199, Evalue=3e-52,
Organism=Escherichia coli, GI1789552, Length=369, Percent_Identity=33.0623306233062, Blast_Score=195, Evalue=4e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002091
- InterPro:   IPR013061
- InterPro:   IPR013059
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 44819; Mature: 44688

Theoretical pI: Translated: 9.73; Mature: 9.73

Prosite motif: PS00594 AROMATIC_AA_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPYPAPRISPFFVTGVVESVKNRTLGSIFIVAGTTIGAGMLAMPLAAAGVGFSVTLGLLI
CCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHCCHHHHHHHHHH
GLWALMCYTALLLLEVYQHVPADTGLGSLAKRYLGRYGQWLTGFSMMFLLYALTAAYISG
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGELLASSINNWLGATLSPAAGVLLFTFVAGGVVCVGTSLVDLFNRFLFSAKIIFLVIML
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALLTPHIHKVNLLTLPLQQGLALSAIPVIFTSFGFHGSVPSIVSYMNGNIRRLRWVFMTG
HHHCCCCCEEEEEEECHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCCEEEEEEEECC
SAIPLVAYIFWQLATLGSIDSPTFRGLLASHAGLNGLLQALREVVASPHVELAVHLFADL
CHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHH
ALATSFLGVALGLFDYLADLFQRRSTVSGRLQTGLITFLPPLAFALFYPRGFVMALGYAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
VALAVLALLIPAMLVWQCRKQSPQAGYRVAGGTPALVLVFICGIVVIGVQFSIALGFLPD
HHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
PG
CC
>Mature Secondary Structure 
PYPAPRISPFFVTGVVESVKNRTLGSIFIVAGTTIGAGMLAMPLAAAGVGFSVTLGLLI
CCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHCCHHHHHHHHHH
GLWALMCYTALLLLEVYQHVPADTGLGSLAKRYLGRYGQWLTGFSMMFLLYALTAAYISG
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGELLASSINNWLGATLSPAAGVLLFTFVAGGVVCVGTSLVDLFNRFLFSAKIIFLVIML
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALLTPHIHKVNLLTLPLQQGLALSAIPVIFTSFGFHGSVPSIVSYMNGNIRRLRWVFMTG
HHHCCCCCEEEEEEECHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCCEEEEEEEECC
SAIPLVAYIFWQLATLGSIDSPTFRGLLASHAGLNGLLQALREVVASPHVELAVHLFADL
CHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHH
ALATSFLGVALGLFDYLADLFQRRSTVSGRLQTGLITFLPPLAFALFYPRGFVMALGYAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
VALAVLALLIPAMLVWQCRKQSPQAGYRVAGGTPALVLVFICGIVVIGVQFSIALGFLPD
HHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
PG
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-tyrosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3049553; 9097040; 9278503 [H]