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The map label for this gene is rnb [H]

Identifier: 194737209

GI number: 194737209

Start: 1771732

End: 1773666

Strand: Direct

Name: rnb [H]

Synonym: SeSA_A1830

Alternate gene names: 194737209

Gene position: 1771732-1773666 (Clockwise)

Preceding gene: 194737974

Following gene: 194734043

Centisome position: 37.62

GC content: 55.87

Gene sequence:

>1935_bases
ATGTTTCAGGACAACCCGCTGCTAGCGCAGCTTAAACAGCAACTGCATTCCCAGACGCCGCGCGCTGAAGGGGTCGTAAA
AGCCACGGAAAAAGGCTTTGGCTTCCTTGAGGTTGACGCGCAAAAAAGCTATTTCATTCCTCCGCCGCAGATGAAAAAAG
TGATGCATGGCGATCGTATCGTCGCGGTCATCCACACGGAAAAAGAACGGGAGTCTGCCGAGCCGGAAGAACTGATCGAA
CCGTTCCTGACGCGCTTTGTGGGAAAAGTTCAGGGTAAAAATGACCGCCTGTCCATCGTGCCGGATCATCCGTTGCTGAA
AGACGCGATTCCCTGCCGCGCCGCGCGCGGCGTTCAGCATGAGTTCAAAGAAGGTGACTGGGCGGTTGCCGAAATGCGCC
GCCATCCGCTTAAAGGCGACCGTTCGTTTTACGCCGATTTAACGCAGTACATCACCTTTGCCGACGATCACTTTGTTCCC
TGGTGGGTTACGCTTGCCCGCCACAACCTGGAAAAAGAAGCGCCGAACGGCGTAGCGACGGAGATGCTGGACGAAGGGCT
GGAGCGCCAGGATCTTACCGCGCTGAATTTCGTCACTATCGATAGCGCCAGCACTGAAGATATGGATGACGCGCTTTATG
CTGAGGAATTAGCGGACGGCAGACTCCAGCTTACGGTGGCTATCGCCGATCCTACCGCCTGGATTGCCGAAGGCAGTAAG
CTGGATAACGCCGCGAAAATTCGCGCCTTCACCAACTACCTGCCGGGCTTCAATATTCCTATGCTGCCGCGTGAGCTGTC
TGACGATCTGTGCTCGCTGCGCGCCAACGAAGTGCGTCCGGCGCTCGCCTGTCGCATGATAATCGCCGCAGACGGCACCA
TTGACGATGATATCGCCTTTTTTGCGGCCACGATCGAATCGAAGGCCAAGCTGGCGTACGACAATGTCTCCGACTGGCTG
GAAAATAACGGCACCTGGCAGCCGGATAACGAAGGCATTGCCCAGCAGATTCGTCTGTTGCACCGTATTTGTCTAAGCCG
CAGTGAGTGGCGTCATCATCATGCGTTAGTCTTTAAAGACCGCCCGGATTACCGCTTTGTGCTTGGCGAAAAAGGCGAAG
TACTGGATATTGTGGCGGAACCGCGCCGTATCGCTAACCGTATCGTAGAAGAGTCGATGATCGCCGCTAACCTTTGCGCC
GCGCGCGTACTGCGCGATAAGCTCGGTTTCGGTATTTACAACGTACATACGGGCTTCGATCCCGCGAATGCCGACGCGCT
GGCCGCACTGCTGAAAACGCATGGTCTTCATGTCGATGCCGAAGAGGTGCTGACGCTGGAAGGCTTCTGTAAACTGCGTC
GCGAACTGGATGCGCAGCCCTCCGGTTTCCTTGACAGCCGCATTCGTCGCTTCCAGTCTTTTGCGGAAATCAGCACCGAG
CCGGGGCCGCATTTCGGTCTTGGTCTTGAGGCTTACGCCACCTGGACCTCTCCCATCCGTAAGTATGGCGATATGATTAA
CCATCGCCTGCTGAAAGCGGTCATCAAGGGGGAGGCTATTGCGCGTCCGCAGGAAGATATCACCCAGCAAATGGCGGAAC
GCCGTCGCCTGAACCGTATGGCGGAGCGCGATGTCGGCGACTGGTTATATGCACGCTTCCTTAACGATAAGGCGGGGACA
AATACCCGTTTCGCGGCAGAAATTATTGACGTCAGCCGCGGTGGTATGCGTGTGCGACTGGTCGATAACGGCGCTATCGC
CTTTATCCCTGCCCCGTTCCTGCACGCCGTTCGCGATGAACTGGTATGCAGCCAGGAAAACGGTACGGTACAGATTAAAG
GTGAGACGGTTTATAAAGTGACGGATGTCATTGATGTCACTATTGCGGAAGTTCGCATGGAAACCCGCAGCATTATTGCC
CGACCGGCAGCGTAA

Upstream 100 bases:

>100_bases
GAAACCTATTAACTCATCCATTACAGAAAGAGCGCTTGCTGCGCCAGGCAGAATCGCGTAAAACTGTCAGCCGCTCTTTT
GGCTACGAAAATAGACGAAT

Downstream 100 bases:

>100_bases
CCACGCTTAGCTCGCTCAACGGCCTTTGCTGAGAAGGCAAAGGCCGTTTCTTTTCTTCTTCTCCCTTCCGTCATGCTCTG
CGTTTAATCTTATTCAAGCG

Product: exoribonuclease II

Products: NA

Alternate protein names: Exoribonuclease II; RNase II; Ribonuclease II [H]

Number of amino acids: Translated: 644; Mature: 644

Protein sequence:

>644_residues
MFQDNPLLAQLKQQLHSQTPRAEGVVKATEKGFGFLEVDAQKSYFIPPPQMKKVMHGDRIVAVIHTEKERESAEPEELIE
PFLTRFVGKVQGKNDRLSIVPDHPLLKDAIPCRAARGVQHEFKEGDWAVAEMRRHPLKGDRSFYADLTQYITFADDHFVP
WWVTLARHNLEKEAPNGVATEMLDEGLERQDLTALNFVTIDSASTEDMDDALYAEELADGRLQLTVAIADPTAWIAEGSK
LDNAAKIRAFTNYLPGFNIPMLPRELSDDLCSLRANEVRPALACRMIIAADGTIDDDIAFFAATIESKAKLAYDNVSDWL
ENNGTWQPDNEGIAQQIRLLHRICLSRSEWRHHHALVFKDRPDYRFVLGEKGEVLDIVAEPRRIANRIVEESMIAANLCA
ARVLRDKLGFGIYNVHTGFDPANADALAALLKTHGLHVDAEEVLTLEGFCKLRRELDAQPSGFLDSRIRRFQSFAEISTE
PGPHFGLGLEAYATWTSPIRKYGDMINHRLLKAVIKGEAIARPQEDITQQMAERRRLNRMAERDVGDWLYARFLNDKAGT
NTRFAAEIIDVSRGGMRVRLVDNGAIAFIPAPFLHAVRDELVCSQENGTVQIKGETVYKVTDVIDVTIAEVRMETRSIIA
RPAA

Sequences:

>Translated_644_residues
MFQDNPLLAQLKQQLHSQTPRAEGVVKATEKGFGFLEVDAQKSYFIPPPQMKKVMHGDRIVAVIHTEKERESAEPEELIE
PFLTRFVGKVQGKNDRLSIVPDHPLLKDAIPCRAARGVQHEFKEGDWAVAEMRRHPLKGDRSFYADLTQYITFADDHFVP
WWVTLARHNLEKEAPNGVATEMLDEGLERQDLTALNFVTIDSASTEDMDDALYAEELADGRLQLTVAIADPTAWIAEGSK
LDNAAKIRAFTNYLPGFNIPMLPRELSDDLCSLRANEVRPALACRMIIAADGTIDDDIAFFAATIESKAKLAYDNVSDWL
ENNGTWQPDNEGIAQQIRLLHRICLSRSEWRHHHALVFKDRPDYRFVLGEKGEVLDIVAEPRRIANRIVEESMIAANLCA
ARVLRDKLGFGIYNVHTGFDPANADALAALLKTHGLHVDAEEVLTLEGFCKLRRELDAQPSGFLDSRIRRFQSFAEISTE
PGPHFGLGLEAYATWTSPIRKYGDMINHRLLKAVIKGEAIARPQEDITQQMAERRRLNRMAERDVGDWLYARFLNDKAGT
NTRFAAEIIDVSRGGMRVRLVDNGAIAFIPAPFLHAVRDELVCSQENGTVQIKGETVYKVTDVIDVTIAEVRMETRSIIA
RPAA
>Mature_644_residues
MFQDNPLLAQLKQQLHSQTPRAEGVVKATEKGFGFLEVDAQKSYFIPPPQMKKVMHGDRIVAVIHTEKERESAEPEELIE
PFLTRFVGKVQGKNDRLSIVPDHPLLKDAIPCRAARGVQHEFKEGDWAVAEMRRHPLKGDRSFYADLTQYITFADDHFVP
WWVTLARHNLEKEAPNGVATEMLDEGLERQDLTALNFVTIDSASTEDMDDALYAEELADGRLQLTVAIADPTAWIAEGSK
LDNAAKIRAFTNYLPGFNIPMLPRELSDDLCSLRANEVRPALACRMIIAADGTIDDDIAFFAATIESKAKLAYDNVSDWL
ENNGTWQPDNEGIAQQIRLLHRICLSRSEWRHHHALVFKDRPDYRFVLGEKGEVLDIVAEPRRIANRIVEESMIAANLCA
ARVLRDKLGFGIYNVHTGFDPANADALAALLKTHGLHVDAEEVLTLEGFCKLRRELDAQPSGFLDSRIRRFQSFAEISTE
PGPHFGLGLEAYATWTSPIRKYGDMINHRLLKAVIKGEAIARPQEDITQQMAERRRLNRMAERDVGDWLYARFLNDKAGT
NTRFAAEIIDVSRGGMRVRLVDNGAIAFIPAPFLHAVRDELVCSQENGTVQIKGETVYKVTDVIDVTIAEVRMETRSIIA
RPAA

Specific function: Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction [H]

COG id: COG4776

COG function: function code K; Exoribonuclease II

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI190014623, Length=487, Percent_Identity=24.8459958932238, Blast_Score=121, Evalue=2e-27,
Organism=Homo sapiens, GI190014625, Length=457, Percent_Identity=25.164113785558, Blast_Score=121, Evalue=2e-27,
Organism=Homo sapiens, GI134288890, Length=409, Percent_Identity=27.8728606356968, Blast_Score=106, Evalue=7e-23,
Organism=Homo sapiens, GI219521928, Length=454, Percent_Identity=24.6696035242291, Blast_Score=93, Evalue=9e-19,
Organism=Homo sapiens, GI19115966, Length=454, Percent_Identity=24.6696035242291, Blast_Score=92, Evalue=1e-18,
Organism=Escherichia coli, GI1787542, Length=644, Percent_Identity=90.8385093167702, Blast_Score=1206, Evalue=0.0,
Organism=Escherichia coli, GI87082383, Length=654, Percent_Identity=25.9938837920489, Blast_Score=174, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17553506, Length=409, Percent_Identity=27.3838630806846, Blast_Score=119, Evalue=7e-27,
Organism=Caenorhabditis elegans, GI212645896, Length=469, Percent_Identity=26.0127931769723, Blast_Score=114, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6324552, Length=421, Percent_Identity=23.0403800475059, Blast_Score=99, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24654592, Length=435, Percent_Identity=28.5057471264368, Blast_Score=126, Evalue=4e-29,
Organism=Drosophila melanogaster, GI19922976, Length=435, Percent_Identity=28.5057471264368, Blast_Score=126, Evalue=5e-29,
Organism=Drosophila melanogaster, GI24654597, Length=435, Percent_Identity=28.5057471264368, Blast_Score=126, Evalue=5e-29,
Organism=Drosophila melanogaster, GI24649634, Length=374, Percent_Identity=28.6096256684492, Blast_Score=125, Evalue=7e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011129
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011804 [H]

Pfam domain/function: PF08206 OB_RNB; PF00773 RNB; PF00575 S1 [H]

EC number: =3.1.13.1 [H]

Molecular weight: Translated: 72410; Mature: 72410

Theoretical pI: Translated: 5.55; Mature: 5.55

Prosite motif: PS01175 RIBONUCLEASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQDNPLLAQLKQQLHSQTPRAEGVVKATEKGFGFLEVDAQKSYFIPPPQMKKVMHGDRI
CCCCCHHHHHHHHHHHHCCCCCCCCCEECCCCCEEEEECCCCCCCCCCHHHHHHHCCCEE
VAVIHTEKERESAEPEELIEPFLTRFVGKVQGKNDRLSIVPDHPLLKDAIPCRAARGVQH
EEEEECCHHHCCCCHHHHHHHHHHHHHHHHCCCCCCEEECCCCCHHHHCCCHHHHHCCHH
EFKEGDWAVAEMRRHPLKGDRSFYADLTQYITFADDHFVPWWVTLARHNLEKEAPNGVAT
HHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHCCCCCHHH
EMLDEGLERQDLTALNFVTIDSASTEDMDDALYAEELADGRLQLTVAIADPTAWIAEGSK
HHHHCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCEEEEEEEEECCCHHHHCCCC
LDNAAKIRAFTNYLPGFNIPMLPRELSDDLCSLRANEVRPALACRMIIAADGTIDDDIAF
CCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHEEEEEECCCCCHHHHH
FAATIESKAKLAYDNVSDWLENNGTWQPDNEGIAQQIRLLHRICLSRSEWRHHHALVFKD
HHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCHHHCCCCEEEEEEC
RPDYRFVLGEKGEVLDIVAEPRRIANRIVEESMIAANLCAARVLRDKLGFGIYNVHTGFD
CCCEEEEECCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCC
PANADALAALLKTHGLHVDAEEVLTLEGFCKLRRELDAQPSGFLDSRIRRFQSFAEISTE
CCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCC
PGPHFGLGLEAYATWTSPIRKYGDMINHRLLKAVIKGEAIARPQEDITQQMAERRRLNRM
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
AERDVGDWLYARFLNDKAGTNTRFAAEIIDVSRGGMRVRLVDNGAIAFIPAPFLHAVRDE
HHHCHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEEEEEECCCEEEECHHHHHHHHHH
LVCSQENGTVQIKGETVYKVTDVIDVTIAEVRMETRSIIARPAA
HHEECCCCEEEEECCEEEEEHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MFQDNPLLAQLKQQLHSQTPRAEGVVKATEKGFGFLEVDAQKSYFIPPPQMKKVMHGDRI
CCCCCHHHHHHHHHHHHCCCCCCCCCEECCCCCEEEEECCCCCCCCCCHHHHHHHCCCEE
VAVIHTEKERESAEPEELIEPFLTRFVGKVQGKNDRLSIVPDHPLLKDAIPCRAARGVQH
EEEEECCHHHCCCCHHHHHHHHHHHHHHHHCCCCCCEEECCCCCHHHHCCCHHHHHCCHH
EFKEGDWAVAEMRRHPLKGDRSFYADLTQYITFADDHFVPWWVTLARHNLEKEAPNGVAT
HHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHCCCCCHHH
EMLDEGLERQDLTALNFVTIDSASTEDMDDALYAEELADGRLQLTVAIADPTAWIAEGSK
HHHHCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCEEEEEEEEECCCHHHHCCCC
LDNAAKIRAFTNYLPGFNIPMLPRELSDDLCSLRANEVRPALACRMIIAADGTIDDDIAF
CCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHEEEEEECCCCCHHHHH
FAATIESKAKLAYDNVSDWLENNGTWQPDNEGIAQQIRLLHRICLSRSEWRHHHALVFKD
HHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCHHHCCCCEEEEEEC
RPDYRFVLGEKGEVLDIVAEPRRIANRIVEESMIAANLCAARVLRDKLGFGIYNVHTGFD
CCCEEEEECCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCC
PANADALAALLKTHGLHVDAEEVLTLEGFCKLRRELDAQPSGFLDSRIRRFQSFAEISTE
CCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCC
PGPHFGLGLEAYATWTSPIRKYGDMINHRLLKAVIKGEAIARPQEDITQQMAERRRLNRM
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
AERDVGDWLYARFLNDKAGTNTRFAAEIIDVSRGGMRVRLVDNGAIAFIPAPFLHAVRDE
HHHCHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEEEEEECCCEEEECHHHHHHHHHH
LVCSQENGTVQIKGETVYKVTDVIDVTIAEVRMETRSIIARPAA
HHEECCCCEEEEECCEEEEEHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA