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The map label for this gene is patB [H]

Identifier: 194736773

GI number: 194736773

Start: 1603290

End: 1604492

Strand: Direct

Name: patB [H]

Synonym: SeSA_A1669

Alternate gene names: 194736773

Gene position: 1603290-1604492 (Clockwise)

Preceding gene: 194737574

Following gene: 194738053

Centisome position: 34.05

GC content: 51.45

Gene sequence:

>1203_bases
ATGGATTTTAACCAGATTATCAATCGCAACAATACTGGTTCGGTAAAGTGGGATTTTATTGAGCGTCACTTTGGCGACGG
CGCTGGAAAACTGCTGCCGATGTGGGTTTCTGATTTCGATTTTGCCTGCCCGCCTGAGGTTCAGGCGGCATTGCATCAGC
GAATCGAGCACGGCGTATTTGGCTATAGCGAACGCGATGAGGCCTATTTTAACGCCCTGCTTCACTGGTTTTCATCACGC
CACCAGCTCACGTTAAAACAAGAATGGGTATGCAGCGTGGAAGGCGTCGTACCAGGGTTGGCGCTCTTAGTGCAAATGTT
GACGCATCCAGGCGACGGCGTAGTGGTACAGGGGCCATACTATGGCTCCTTCGCCAAAATAATCACGCTTAATGGTAGAA
AACTGCTGGAGAATCCCCTTAGCGAGTCGCCGGACGATGGCTACCAGATGGATTTTTGCCAACTGGAAAGGCTGTTTCGC
CATGAGCGCCCTCCGCTGATGATTTTGTGTAATCCACATAATCCAACCGGGCGTTGCTGGTCGGCCAACGAGCTGGAGCA
ACTGCTTTTATTATGTGAAGCTTATGATGTCACTCTCATCTCGGATGAAATATGGGCCGATCTATTGCTGCCCGGCGAAA
CCTTTACCTCGGTACTGCATTTAGGGGAGCGCTGGCATAAACGGGTCATCTCCGCCACTGCGGCCAGCAAAACATTTGGC
TTATCGTCGTTGCGAATTTCTAATTTTCTCATTCCCGATCCTACGCTTCGCCAGCGTTTTCTGTCTCGTCTGGACGCTCA
TGGGCTGGACGTCTTTAACGCCCTCTCCGTTCAGGCGGCGACTACCGCATGGAATGAAAGCAGACAGTGGCTGGATTCGC
TACTGGATTACCTGGCGGAAAACCGCCGCTGGTTTGTTGAACAAGCGACAGAGCACCTTCCCTGGGCAAGAATTGTCCCG
GCGCAGGGAACCTATTTATTATGGATGGATTGTAAAAAGCTGGGACTGGATGACGAACAGCTAAAATGGGTAATGGCGGA
TGTCGCGGGTATTGCTCCTTCAATGGGCAGCGGCTTTGGCCCGGCGGGCAGCGGATTTATCCGTTTAAATCTGGGATGTC
CACGTACCTACCTTGAAATGGCAATAGACGGCCTGAAGCGAATATCGGTGAAGACAATTAAAGGAATACCAACAGGCGGA
TGA

Upstream 100 bases:

>100_bases
CGCATTAATTTATGGTTTTAGCGGAATTGGTATTGCCAGAACTGCCTCCGCTTCAGAAAAGTCGCCGCAAGCGTCAGTGA
CGAAATAATAAGGAAACAAG

Downstream 100 bases:

>100_bases
ATTTTTCGGGCGATAAACTGACAACGGTGTTATTTCTGCGGCATGATATCGCCTGAGCGCCAGTAAAAAAACCGGCCATC
AAGGCCGGTTGGGTCCGGAG

Product: aminotransferase class I and II

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MDFNQIINRNNTGSVKWDFIERHFGDGAGKLLPMWVSDFDFACPPEVQAALHQRIEHGVFGYSERDEAYFNALLHWFSSR
HQLTLKQEWVCSVEGVVPGLALLVQMLTHPGDGVVVQGPYYGSFAKIITLNGRKLLENPLSESPDDGYQMDFCQLERLFR
HERPPLMILCNPHNPTGRCWSANELEQLLLLCEAYDVTLISDEIWADLLLPGETFTSVLHLGERWHKRVISATAASKTFG
LSSLRISNFLIPDPTLRQRFLSRLDAHGLDVFNALSVQAATTAWNESRQWLDSLLDYLAENRRWFVEQATEHLPWARIVP
AQGTYLLWMDCKKLGLDDEQLKWVMADVAGIAPSMGSGFGPAGSGFIRLNLGCPRTYLEMAIDGLKRISVKTIKGIPTGG

Sequences:

>Translated_400_residues
MDFNQIINRNNTGSVKWDFIERHFGDGAGKLLPMWVSDFDFACPPEVQAALHQRIEHGVFGYSERDEAYFNALLHWFSSR
HQLTLKQEWVCSVEGVVPGLALLVQMLTHPGDGVVVQGPYYGSFAKIITLNGRKLLENPLSESPDDGYQMDFCQLERLFR
HERPPLMILCNPHNPTGRCWSANELEQLLLLCEAYDVTLISDEIWADLLLPGETFTSVLHLGERWHKRVISATAASKTFG
LSSLRISNFLIPDPTLRQRFLSRLDAHGLDVFNALSVQAATTAWNESRQWLDSLLDYLAENRRWFVEQATEHLPWARIVP
AQGTYLLWMDCKKLGLDDEQLKWVMADVAGIAPSMGSGFGPAGSGFIRLNLGCPRTYLEMAIDGLKRISVKTIKGIPTGG
>Mature_400_residues
MDFNQIINRNNTGSVKWDFIERHFGDGAGKLLPMWVSDFDFACPPEVQAALHQRIEHGVFGYSERDEAYFNALLHWFSSR
HQLTLKQEWVCSVEGVVPGLALLVQMLTHPGDGVVVQGPYYGSFAKIITLNGRKLLENPLSESPDDGYQMDFCQLERLFR
HERPPLMILCNPHNPTGRCWSANELEQLLLLCEAYDVTLISDEIWADLLLPGETFTSVLHLGERWHKRVISATAASKTFG
LSSLRISNFLIPDPTLRQRFLSRLDAHGLDVFNALSVQAATTAWNESRQWLDSLLDYLAENRRWFVEQATEHLPWARIVP
AQGTYLLWMDCKKLGLDDEQLKWVMADVAGIAPSMGSGFGPAGSGFIRLNLGCPRTYLEMAIDGLKRISVKTIKGIPTGG

Specific function: Catalyzes the transformation of cystathionine to homocysteine. Also exhibits cysteine desulfhydrase activity in vitro, producing sulfide from cysteine [H]

COG id: COG1168

COG function: function code E; Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI56713256, Length=174, Percent_Identity=27.0114942528736, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI56713254, Length=174, Percent_Identity=27.0114942528736, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI95147551, Length=195, Percent_Identity=25.1282051282051, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI169881279, Length=195, Percent_Identity=25.1282051282051, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1787909, Length=387, Percent_Identity=33.0749354005168, Blast_Score=223, Evalue=2e-59,
Organism=Escherichia coli, GI1788722, Length=357, Percent_Identity=25.7703081232493, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1786816, Length=308, Percent_Identity=24.025974025974, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322401, Length=184, Percent_Identity=26.0869565217391, Blast_Score=74, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 45060; Mature: 45060

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFNQIINRNNTGSVKWDFIERHFGDGAGKLLPMWVSDFDFACPPEVQAALHQRIEHGVF
CCHHHHHCCCCCCCEEEHHHHHHCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCC
GYSERDEAYFNALLHWFSSRHQLTLKQEWVCSVEGVVPGLALLVQMLTHPGDGVVVQGPY
CCCCCHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCC
YGSFAKIITLNGRKLLENPLSESPDDGYQMDFCQLERLFRHERPPLMILCNPHNPTGRCW
CCCEEEEEEECCHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCC
SANELEQLLLLCEAYDVTLISDEIWADLLLPGETFTSVLHLGERWHKRVISATAASKTFG
CHHHHHHHHHHHHHCCEEEECHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LSSLRISNFLIPDPTLRQRFLSRLDAHGLDVFNALSVQAATTAWNESRQWLDSLLDYLAE
CCHHHHCCEECCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NRRWFVEQATEHLPWARIVPAQGTYLLWMDCKKLGLDDEQLKWVMADVAGIAPSMGSGFG
CCEEHHHHHHHHCCCEEEECCCCCEEEEEEHHHCCCCHHHHHHHHHHHHHCCCCCCCCCC
PAGSGFIRLNLGCPRTYLEMAIDGLKRISVKTIKGIPTGG
CCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MDFNQIINRNNTGSVKWDFIERHFGDGAGKLLPMWVSDFDFACPPEVQAALHQRIEHGVF
CCHHHHHCCCCCCCEEEHHHHHHCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCC
GYSERDEAYFNALLHWFSSRHQLTLKQEWVCSVEGVVPGLALLVQMLTHPGDGVVVQGPY
CCCCCHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCC
YGSFAKIITLNGRKLLENPLSESPDDGYQMDFCQLERLFRHERPPLMILCNPHNPTGRCW
CCCEEEEEEECCHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCC
SANELEQLLLLCEAYDVTLISDEIWADLLLPGETFTSVLHLGERWHKRVISATAASKTFG
CHHHHHHHHHHHHHCCEEEECHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LSSLRISNFLIPDPTLRQRFLSRLDAHGLDVFNALSVQAATTAWNESRQWLDSLLDYLAE
CCHHHHCCEECCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NRRWFVEQATEHLPWARIVPAQGTYLLWMDCKKLGLDDEQLKWVMADVAGIAPSMGSGFG
CCEEHHHHHHHHCCCEEEECCCCCEEEEEEHHHCCCCHHHHHHHHHHHHHCCCCCCCCCC
PAGSGFIRLNLGCPRTYLEMAIDGLKRISVKTIKGIPTGG
CCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8497199; 9274030; 9384377 [H]