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The map label for this gene is plsC [H]

Identifier: 194736594

GI number: 194736594

Start: 3243109

End: 3243846

Strand: Reverse

Name: plsC [H]

Synonym: SeSA_A3359

Alternate gene names: 194736594

Gene position: 3243846-3243109 (Counterclockwise)

Preceding gene: 194735135

Following gene: 194736171

Centisome position: 68.88

GC content: 50.27

Gene sequence:

>738_bases
ATGCTATATATTTTTCGTCTTATTGTTACCGTTATTTACTCCATTCTGGTCTGTGTTTTCGGTTCTATTTACTGCCTTTT
CAGCCCACGTAACCCAAAACACGTGGCGACGTTTGGACATATGTTCGGTCGTCTGGCCCCGCTGTTTGGCCTGAAAGTGG
AGTGCCGCAAACCCGCCGACGCGGAAAGCTATGGCAATGCTATCTATATCGCTAACCACCAGAATAATTATGATATGGTC
ACGGCGTCGAATATTGTGCAGCCGCCAACGGTGACGGTGGGGAAAAAAAGCCTGCTTTGGATCCCGTTTTTTGGGCAACT
GTACTGGCTGACCGGTAATCTGTTGATTGACCGTAATAACCGCGCCAAAGCGCATAGCACCATTGCGGCAGTGGTTAACC
ATTTTAAAAAGCGCCGTATTTCTATCTGGATGTTCCCTGAAGGTACGCGTAGCCGGGGACGCGGTCTGCTGCCGTTTAAA
ACCGGCGCGTTTCATGCGGCTATCGCGGCTGGTGTGCCGATCATTCCTGTCTGCGTTTCCAACACCTCTAACAAAGTCAA
TCTAAACCGCCTGAACAACGGACTGGTTATTGTGGAAATGCTGCCGCCAGTCGACGTCAGCGAATATGGTAAAGATCAGG
TTCGCGAGCTGGCGGCCCACTGCCGTGCGTTAATGGAGCAAAAAATCGCGGAACTTGATAAAGAGGTTGCGGAACGTGAA
GCGACCGGTAAGGTTTAA

Upstream 100 bases:

>100_bases
CGATTAACAATACGTTTTTCCAGAGAGCCACACTTACCAAAATCCTAACCTGAATTTCAGTGACGTAGAATGCCGGGCTC
TTAGGCCTTCAGAGGTTGTT

Downstream 100 bases:

>100_bases
GCAGCCTTACTCTGTTATTGTAGAAATCATTTTTTCAGGCACAACTCTTTAGCCTGTTTTACATGGAGCTTATATGTCAT
TCAGTCGGCGTCAGTTTCTT

Product: 1-acyl-sn-glycerol-3-phosphate acyltransferase

Products: NA

Alternate protein names: 1-AGP acyltransferase; 1-AGPAT; Lysophosphatidic acid acyltransferase; LPAAT; Phosphatidic acid synthase; PA synthase [H]

Number of amino acids: Translated: 245; Mature: 245

Protein sequence:

>245_residues
MLYIFRLIVTVIYSILVCVFGSIYCLFSPRNPKHVATFGHMFGRLAPLFGLKVECRKPADAESYGNAIYIANHQNNYDMV
TASNIVQPPTVTVGKKSLLWIPFFGQLYWLTGNLLIDRNNRAKAHSTIAAVVNHFKKRRISIWMFPEGTRSRGRGLLPFK
TGAFHAAIAAGVPIIPVCVSNTSNKVNLNRLNNGLVIVEMLPPVDVSEYGKDQVRELAAHCRALMEQKIAELDKEVAERE
ATGKV

Sequences:

>Translated_245_residues
MLYIFRLIVTVIYSILVCVFGSIYCLFSPRNPKHVATFGHMFGRLAPLFGLKVECRKPADAESYGNAIYIANHQNNYDMV
TASNIVQPPTVTVGKKSLLWIPFFGQLYWLTGNLLIDRNNRAKAHSTIAAVVNHFKKRRISIWMFPEGTRSRGRGLLPFK
TGAFHAAIAAGVPIIPVCVSNTSNKVNLNRLNNGLVIVEMLPPVDVSEYGKDQVRELAAHCRALMEQKIAELDKEVAERE
ATGKV
>Mature_245_residues
MLYIFRLIVTVIYSILVCVFGSIYCLFSPRNPKHVATFGHMFGRLAPLFGLKVECRKPADAESYGNAIYIANHQNNYDMV
TASNIVQPPTVTVGKKSLLWIPFFGQLYWLTGNLLIDRNNRAKAHSTIAAVVNHFKKRRISIWMFPEGTRSRGRGLLPFK
TGAFHAAIAAGVPIIPVCVSNTSNKVNLNRLNNGLVIVEMLPPVDVSEYGKDQVRELAAHCRALMEQKIAELDKEVAERE
ATGKV

Specific function: Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the 2 position. This enzyme can utilize either acyl-CoA or acyl-ACP as the fatty acyl donor [H]

COG id: COG0204

COG function: function code I; 1-acyl-sn-glycerol-3-phosphate acyltransferase

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI5453718, Length=235, Percent_Identity=28.5106382978723, Blast_Score=114, Evalue=9e-26,
Organism=Homo sapiens, GI15100175, Length=235, Percent_Identity=28.5106382978723, Blast_Score=114, Evalue=9e-26,
Organism=Homo sapiens, GI6041665, Length=231, Percent_Identity=27.7056277056277, Blast_Score=105, Evalue=3e-23,
Organism=Escherichia coli, GI1789395, Length=245, Percent_Identity=94.6938775510204, Blast_Score=491, Evalue=1e-140,
Organism=Caenorhabditis elegans, GI17564032, Length=183, Percent_Identity=33.879781420765, Blast_Score=119, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17568319, Length=214, Percent_Identity=33.1775700934579, Blast_Score=107, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6320151, Length=179, Percent_Identity=37.9888268156425, Blast_Score=121, Evalue=9e-29,
Organism=Drosophila melanogaster, GI24641614, Length=214, Percent_Identity=35.0467289719626, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24641612, Length=214, Percent_Identity=35.0467289719626, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI281364648, Length=236, Percent_Identity=28.3898305084746, Blast_Score=116, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24582856, Length=236, Percent_Identity=28.3898305084746, Blast_Score=116, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24582854, Length=236, Percent_Identity=28.3898305084746, Blast_Score=116, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002123
- InterPro:   IPR004552 [H]

Pfam domain/function: PF01553 Acyltransferase [H]

EC number: =2.3.1.51 [H]

Molecular weight: Translated: 27328; Mature: 27328

Theoretical pI: Translated: 10.08; Mature: 10.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLYIFRLIVTVIYSILVCVFGSIYCLFSPRNPKHVATFGHMFGRLAPLFGLKVECRKPAD
CCHHHHHHHHHHHHHHHHHHHCEEEEECCCCCCHHHHHHHHHHHHHHHHCCEEECCCCCC
AESYGNAIYIANHQNNYDMVTASNIVQPPTVTVGKKSLLWIPFFGQLYWLTGNLLIDRNN
HHHHCCEEEEEECCCCCCEEEECCCCCCCCEEECCCEEEEEEHHCEEEEEECEEEEECCC
RAKAHSTIAAVVNHFKKRRISIWMFPEGTRSRGRGLLPFKTGAFHAAIAAGVPIIPVCVS
CCHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHCCCCEEEEEEC
NTSNKVNLNRLNNGLVIVEMLPPVDVSEYGKDQVRELAAHCRALMEQKIAELDKEVAERE
CCCCEEEEEECCCCEEEEEECCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATGKV
CCCCC
>Mature Secondary Structure
MLYIFRLIVTVIYSILVCVFGSIYCLFSPRNPKHVATFGHMFGRLAPLFGLKVECRKPAD
CCHHHHHHHHHHHHHHHHHHHCEEEEECCCCCCHHHHHHHHHHHHHHHHCCEEECCCCCC
AESYGNAIYIANHQNNYDMVTASNIVQPPTVTVGKKSLLWIPFFGQLYWLTGNLLIDRNN
HHHHCCEEEEEECCCCCCEEEECCCCCCCCEEECCCEEEEEEHHCEEEEEECEEEEECCC
RAKAHSTIAAVVNHFKKRRISIWMFPEGTRSRGRGLLPFKTGAFHAAIAAGVPIIPVCVS
CCHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHCCCCEEEEEEC
NTSNKVNLNRLNNGLVIVEMLPPVDVSEYGKDQVRELAAHCRALMEQKIAELDKEVAERE
CCCCEEEEEECCCCEEEEEECCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATGKV
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1557036; 9278503 [H]