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The map label for this gene is cysJ [H]

Identifier: 194736260

GI number: 194736260

Start: 2995889

End: 2997688

Strand: Reverse

Name: cysJ [H]

Synonym: SeSA_A3102

Alternate gene names: 194736260

Gene position: 2997688-2995889 (Counterclockwise)

Preceding gene: 194737536

Following gene: 194736741

Centisome position: 63.66

GC content: 57.83

Gene sequence:

>1800_bases
ATGACGACACCGGCTCCACTGACTGGGTTGCTTCCGCTTAATCCGGAGCAACTGGCGCGCCTTCAGGCCGCGACAACCGA
CCTTACTCCCGAACAGCTTGCCTGGGTCTCCGGCTATTTTTGGGGCGTACTGAACCCGCGCTCAGGCGCTGTTGCCGTCA
CGCCTGTTCCTGAGCGGAAGATGCTGGGGGTTACGCTTATCTCCGCTTCGCAAACCGGCAATGCGCGTCGTGTGGCGGAA
GCGCTGCGTGATGATCTGCTGGCGGCCAACCTTAATGTGACACTGGTGAACGCCGGCGACTACAAATTCAAACAGATTGC
CAGTGAAAAACTGTTGGTGATAGTGACGTCCACCCAGGGAGAAGGCGAGCCGCCGGAAGAGGCTGTCGCGCTGCATAAAT
TCCTGTTCTCCAAAAAAGCGCCGAAACTGACCGATACCGCGTTTGCCGTATTTAGCCTTGGCGATACATCCTATGAATTC
TTCTGCCAGTCCGGAAAAGATTTCGACAGCAAACTGGCGGAACTGGGCGGTGAACGTCTGCTCGACCGTGTCGATGCTGA
CGTTGAATATCAGGCAGCTGCCAGCGAATGGCGCGCCCGCGTGGTTGATGTTCTGAAGTCCCGCGTACCTGTCGCGGCAC
CTTCGCAATCCGTCGCTACTGGCGCGGTAAACGACATCCACACCAGCCCCTATACCAAAGACGCGCCGCTGACCGCGACC
CTCGCCGTGAATCAGAAAATCACCGGTCGCAACTCGGAAAAAGACGTTCGCCATATTGAGATTGATTTAGGCGACTCCGG
TCTGCGTTACCAGCCGGGCGATGCGCTGGGCGTCTGGTATCAGAACGATCCGGCTCTGGTGAAGGAGCTGGTTGAGTTGC
TGTGGCTGAAGGGCGATGAGCCGGTGACGGTTGATGGTAAAACCCTGCCGCTCGCCGAAGCGCTGGAGTGGCACTTCGAG
CTGACGGTGAATACCGCCAACATTGTTGAGAACTACGCGACCCTGACGCGCAGTGAGTCGCTGTTGCCATTAGTGGGCGA
CAAAGCGCAGCTCCAGCACTACGCCGCGACCACGCCCATTGTTGATATGGTGCGTTTCTCTCCGGCGCAGCTCGACGCTG
AAGCATTAATCGGCCTGCTGCGTCCGCTGACGCCGCGTCTGTACTCCATCGCCTCCGCGCAGGCGGAAGTCGAAAGCGAA
GTACACGTAACCGTCGGCGTCGTGCGCTACGATATTGAAGGCCGCGCCCGCGCGGGTGGTGCTTCCAGCTTCCTCGCCGA
CCGCGTGGAAGAAGAGGGCGAAGTGCGCGTGTTTATTGAACACAACGATAATTTCCGCCTGCCAGCTAACCCGGAAACGC
CGGTGATTATGATTGGCCCAGGTACGGGTATCGCGCCGTTCCGCGCCTTTATGCAGCAACGCGCCGCCGACGGTGCGGAA
GGCAAGAACTGGCTGTTCTTCGGTAACCCGCACTTCACCGAAGACTTCCTTTATCAGGTTGAATGGCAGCGTTACGTGAA
AGAAGGCGTGCTGAACCGGATCGATCTGGCCTGGTCCCGCGATCAAAAAGAAAAAATCTACGTACAAGACAAACTGCGCG
AACAGGGCGCGGAGCTGTGGCGCTGGATCAATGACGGTGCCCACATTTATGTCTGCGGCGACGCCAGGCGTATGGCCGCA
GATGTCGAAAAAGCATTGCTGGAAGTGATTGCTGAATTCGGTGCAATGGACATCGAAGCGGCGGATGAATTTTTAAGTGA
GCTGCGCGTCGAGCGCCGTTATCAGCGAGATGTCTACTAA

Upstream 100 bases:

>100_bases
ATGTACGCTCCTGGGGCGCGATCAGCTTACAGTCTGGGCTACAGCGAACTTGAATGATTTTGTGTATAGATCCGCTTTGC
TTACTGGAACATAACGACGC

Downstream 100 bases:

>100_bases
TGAGCGAAAAACATCCAGGCCCACTGGTGGTCGAAGGTAAACTGTCCGATGCCGAGCGCATGAAGCTGGAAAGCAACTAC
CTGCGCGGTACCATTGCGGA

Product: sulfite reductase subunit alpha

Products: NA

Alternate protein names: SiR-FP [H]

Number of amino acids: Translated: 599; Mature: 598

Protein sequence:

>599_residues
MTTPAPLTGLLPLNPEQLARLQAATTDLTPEQLAWVSGYFWGVLNPRSGAVAVTPVPERKMLGVTLISASQTGNARRVAE
ALRDDLLAANLNVTLVNAGDYKFKQIASEKLLVIVTSTQGEGEPPEEAVALHKFLFSKKAPKLTDTAFAVFSLGDTSYEF
FCQSGKDFDSKLAELGGERLLDRVDADVEYQAAASEWRARVVDVLKSRVPVAAPSQSVATGAVNDIHTSPYTKDAPLTAT
LAVNQKITGRNSEKDVRHIEIDLGDSGLRYQPGDALGVWYQNDPALVKELVELLWLKGDEPVTVDGKTLPLAEALEWHFE
LTVNTANIVENYATLTRSESLLPLVGDKAQLQHYAATTPIVDMVRFSPAQLDAEALIGLLRPLTPRLYSIASAQAEVESE
VHVTVGVVRYDIEGRARAGGASSFLADRVEEEGEVRVFIEHNDNFRLPANPETPVIMIGPGTGIAPFRAFMQQRAADGAE
GKNWLFFGNPHFTEDFLYQVEWQRYVKEGVLNRIDLAWSRDQKEKIYVQDKLREQGAELWRWINDGAHIYVCGDARRMAA
DVEKALLEVIAEFGAMDIEAADEFLSELRVERRYQRDVY

Sequences:

>Translated_599_residues
MTTPAPLTGLLPLNPEQLARLQAATTDLTPEQLAWVSGYFWGVLNPRSGAVAVTPVPERKMLGVTLISASQTGNARRVAE
ALRDDLLAANLNVTLVNAGDYKFKQIASEKLLVIVTSTQGEGEPPEEAVALHKFLFSKKAPKLTDTAFAVFSLGDTSYEF
FCQSGKDFDSKLAELGGERLLDRVDADVEYQAAASEWRARVVDVLKSRVPVAAPSQSVATGAVNDIHTSPYTKDAPLTAT
LAVNQKITGRNSEKDVRHIEIDLGDSGLRYQPGDALGVWYQNDPALVKELVELLWLKGDEPVTVDGKTLPLAEALEWHFE
LTVNTANIVENYATLTRSESLLPLVGDKAQLQHYAATTPIVDMVRFSPAQLDAEALIGLLRPLTPRLYSIASAQAEVESE
VHVTVGVVRYDIEGRARAGGASSFLADRVEEEGEVRVFIEHNDNFRLPANPETPVIMIGPGTGIAPFRAFMQQRAADGAE
GKNWLFFGNPHFTEDFLYQVEWQRYVKEGVLNRIDLAWSRDQKEKIYVQDKLREQGAELWRWINDGAHIYVCGDARRMAA
DVEKALLEVIAEFGAMDIEAADEFLSELRVERRYQRDVY
>Mature_598_residues
TTPAPLTGLLPLNPEQLARLQAATTDLTPEQLAWVSGYFWGVLNPRSGAVAVTPVPERKMLGVTLISASQTGNARRVAEA
LRDDLLAANLNVTLVNAGDYKFKQIASEKLLVIVTSTQGEGEPPEEAVALHKFLFSKKAPKLTDTAFAVFSLGDTSYEFF
CQSGKDFDSKLAELGGERLLDRVDADVEYQAAASEWRARVVDVLKSRVPVAAPSQSVATGAVNDIHTSPYTKDAPLTATL
AVNQKITGRNSEKDVRHIEIDLGDSGLRYQPGDALGVWYQNDPALVKELVELLWLKGDEPVTVDGKTLPLAEALEWHFEL
TVNTANIVENYATLTRSESLLPLVGDKAQLQHYAATTPIVDMVRFSPAQLDAEALIGLLRPLTPRLYSIASAQAEVESEV
HVTVGVVRYDIEGRARAGGASSFLADRVEEEGEVRVFIEHNDNFRLPANPETPVIMIGPGTGIAPFRAFMQQRAADGAEG
KNWLFFGNPHFTEDFLYQVEWQRYVKEGVLNRIDLAWSRDQKEKIYVQDKLREQGAELWRWINDGAHIYVCGDARRMAAD
VEKALLEVIAEFGAMDIEAADEFLSELRVERRYQRDVY

Specific function: Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow f

COG id: COG0369

COG function: function code P; Sulfite reductase, alpha subunit (flavoprotein)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 flavodoxin-like domain [H]

Homologues:

Organism=Homo sapiens, GI127139033, Length=601, Percent_Identity=29.783693843594, Blast_Score=236, Evalue=5e-62,
Organism=Homo sapiens, GI7657393, Length=593, Percent_Identity=29.8482293423271, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI221316709, Length=593, Percent_Identity=29.6795952782462, Blast_Score=218, Evalue=1e-56,
Organism=Homo sapiens, GI221316705, Length=602, Percent_Identity=29.4019933554817, Blast_Score=217, Evalue=3e-56,
Organism=Homo sapiens, GI24041029, Length=597, Percent_Identity=29.8157453936348, Blast_Score=216, Evalue=4e-56,
Organism=Homo sapiens, GI10835173, Length=654, Percent_Identity=29.3577981651376, Blast_Score=201, Evalue=2e-51,
Organism=Homo sapiens, GI221316707, Length=522, Percent_Identity=29.6934865900383, Blast_Score=194, Evalue=1e-49,
Organism=Homo sapiens, GI40254422, Length=655, Percent_Identity=28.0916030534351, Blast_Score=168, Evalue=1e-41,
Organism=Homo sapiens, GI169790956, Length=421, Percent_Identity=28.2660332541568, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI169790958, Length=421, Percent_Identity=28.2660332541568, Blast_Score=154, Evalue=2e-37,
Organism=Escherichia coli, GI1789123, Length=599, Percent_Identity=91.1519198664441, Blast_Score=1117, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17554134, Length=592, Percent_Identity=30.2364864864865, Blast_Score=224, Evalue=7e-59,
Organism=Caenorhabditis elegans, GI17566446, Length=588, Percent_Identity=25.5102040816327, Blast_Score=138, Evalue=9e-33,
Organism=Caenorhabditis elegans, GI17531441, Length=395, Percent_Identity=24.5569620253165, Blast_Score=88, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6321832, Length=641, Percent_Identity=29.0171606864275, Blast_Score=207, Evalue=5e-54,
Organism=Saccharomyces cerevisiae, GI6321143, Length=392, Percent_Identity=31.1224489795918, Blast_Score=159, Evalue=9e-40,
Organism=Saccharomyces cerevisiae, GI6325305, Length=626, Percent_Identity=23.1629392971246, Blast_Score=127, Evalue=5e-30,
Organism=Drosophila melanogaster, GI17137192, Length=600, Percent_Identity=28.8333333333333, Blast_Score=215, Evalue=7e-56,
Organism=Drosophila melanogaster, GI24582192, Length=511, Percent_Identity=30.3326810176125, Blast_Score=198, Evalue=8e-51,
Organism=Drosophila melanogaster, GI78706872, Length=528, Percent_Identity=30.6818181818182, Blast_Score=175, Evalue=9e-44,
Organism=Drosophila melanogaster, GI24583543, Length=528, Percent_Identity=30.6818181818182, Blast_Score=175, Evalue=1e-43,
Organism=Drosophila melanogaster, GI78706876, Length=528, Percent_Identity=30.6818181818182, Blast_Score=175, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24660907, Length=595, Percent_Identity=24.5378151260504, Blast_Score=140, Evalue=3e-33,
Organism=Drosophila melanogaster, GI24660903, Length=595, Percent_Identity=24.5378151260504, Blast_Score=140, Evalue=3e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010199
- InterPro:   IPR003097
- InterPro:   IPR017927
- InterPro:   IPR001094
- InterPro:   IPR008254
- InterPro:   IPR001709
- InterPro:   IPR023173
- InterPro:   IPR001433
- InterPro:   IPR017938 [H]

Pfam domain/function: PF00667 FAD_binding_1; PF00258 Flavodoxin_1; PF00175 NAD_binding_1 [H]

EC number: =1.8.1.2 [H]

Molecular weight: Translated: 66255; Mature: 66123

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: PS50902 FLAVODOXIN_LIKE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTPAPLTGLLPLNPEQLARLQAATTDLTPEQLAWVSGYFWGVLNPRSGAVAVTPVPERK
CCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHEEEEEECCCCCEEEECCCCCCC
MLGVTLISASQTGNARRVAEALRDDLLAANLNVTLVNAGDYKFKQIASEKLLVIVTSTQG
EEEEEEEECCCCCCHHHHHHHHHHHHEEECCCEEEEECCCCHHHHHCCCCEEEEEECCCC
EGEPPEEAVALHKFLFSKKAPKLTDTAFAVFSLGDTSYEFFCQSGKDFDSKLAELGGERL
CCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCEEHHCCCCCCHHHHHHHHCHHHH
LDRVDADVEYQAAASEWRARVVDVLKSRVPVAAPSQSVATGAVNDIHTSPYTKDAPLTAT
HHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEE
LAVNQKITGRNSEKDVRHIEIDLGDSGLRYQPGDALGVWYQNDPALVKELVELLWLKGDE
EEECCEECCCCCCCCCEEEEEEECCCCCEECCCCEEEEEECCCHHHHHHHHHHHHCCCCC
PVTVDGKTLPLAEALEWHFELTVNTANIVENYATLTRSESLLPLVGDKAQLQHYAATTPI
CEEECCCCCCHHHHHEEEEEEEEEHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCH
VDMVRFSPAQLDAEALIGLLRPLTPRLYSIASAQAEVESEVHVTVGVVRYDIEGRARAGG
HHHHHCCCHHCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEEEEEEEEECCCCCCCCC
ASSFLADRVEEEGEVRVFIEHNDNFRLPANPETPVIMIGPGTGIAPFRAFMQQRAADGAE
HHHHHHHHHCCCCCEEEEEEECCCEECCCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCC
GKNWLFFGNPHFTEDFLYQVEWQRYVKEGVLNRIDLAWSRDQKEKIYVQDKLREQGAELW
CCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHEEHHCCCCCCCEEHHHHHHHHHHHHHH
RWINDGAHIYVCGDARRMAADVEKALLEVIAEFGAMDIEAADEFLSELRVERRYQRDVY
HHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TTPAPLTGLLPLNPEQLARLQAATTDLTPEQLAWVSGYFWGVLNPRSGAVAVTPVPERK
CCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHEEEEEECCCCCEEEECCCCCCC
MLGVTLISASQTGNARRVAEALRDDLLAANLNVTLVNAGDYKFKQIASEKLLVIVTSTQG
EEEEEEEECCCCCCHHHHHHHHHHHHEEECCCEEEEECCCCHHHHHCCCCEEEEEECCCC
EGEPPEEAVALHKFLFSKKAPKLTDTAFAVFSLGDTSYEFFCQSGKDFDSKLAELGGERL
CCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCEEHHCCCCCCHHHHHHHHCHHHH
LDRVDADVEYQAAASEWRARVVDVLKSRVPVAAPSQSVATGAVNDIHTSPYTKDAPLTAT
HHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEE
LAVNQKITGRNSEKDVRHIEIDLGDSGLRYQPGDALGVWYQNDPALVKELVELLWLKGDE
EEECCEECCCCCCCCCEEEEEEECCCCCEECCCCEEEEEECCCHHHHHHHHHHHHCCCCC
PVTVDGKTLPLAEALEWHFELTVNTANIVENYATLTRSESLLPLVGDKAQLQHYAATTPI
CEEECCCCCCHHHHHEEEEEEEEEHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCH
VDMVRFSPAQLDAEALIGLLRPLTPRLYSIASAQAEVESEVHVTVGVVRYDIEGRARAGG
HHHHHCCCHHCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEEEEEEEEECCCCCCCCC
ASSFLADRVEEEGEVRVFIEHNDNFRLPANPETPVIMIGPGTGIAPFRAFMQQRAADGAE
HHHHHHHHHCCCCCEEEEEEECCCEECCCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCC
GKNWLFFGNPHFTEDFLYQVEWQRYVKEGVLNRIDLAWSRDQKEKIYVQDKLREQGAELW
CCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHEEHHCCCCCCCEEHHHHHHHHHHHHHH
RWINDGAHIYVCGDARRMAADVEKALLEVIAEFGAMDIEAADEFLSELRVERRYQRDVY
HHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA