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The map label for this gene is aas [H]

Identifier: 194736096

GI number: 194736096

Start: 3072148

End: 3074307

Strand: Reverse

Name: aas [H]

Synonym: SeSA_A3175

Alternate gene names: 194736096

Gene position: 3074307-3072148 (Counterclockwise)

Preceding gene: 194735617

Following gene: 194734249

Centisome position: 65.28

GC content: 54.77

Gene sequence:

>2160_bases
ATGCTGTTTGGATTTTTCCGTAACCTGTTTCGCGTGCTTTATCGTGTGCGCGTCACTGGCGATGTCCGGGCGCTACAGGG
GAACCGGGTCTTAATTACCCCCAATCACGTTTCATTTATCGATGGTATGCTACTGGCGCTGTTTTTGCCGGTACGGCCTG
TCTTTGCGGTATATACCTCCATCAGCCAGCAATGGTATATGCGCTGGTTAACGCCGCTGATCGATTTTGTGCCGCTCGAT
CCCACTAAACCCATGTCCATTAAACACCTGGTGCGTCTGGTGGAGCAGGGGCGTCCAGTGGTGATTTTCCCGGAAGGGCG
GATTTCCGTGACCGGCTCGCTGATGAAAATTTATGACGGCGCAGGCTTTGTGGCGGCAAAATCGGGCGCAACCGTCATTC
CGCTCCGTATTGACGGCGCGGAGCTTACGCCTTTCAGTCGCCTTAAAGGTCTGGTTAAACGGCGCTTATTCCCCCGCATT
CAGCTTCATATTTTACCGCCGACGCAAATACCGATGCCGGAAGCGCCGCGCGCGCGCGACAGACGTAAGATAGCGGGTGA
GATGCTGCACCAGATCATGATGGAAGCGCGTATGGCGGTGCGCCCGCGCGAGACGTTATACGAATCGTTGCTGGCGGCGC
AATATCGTTACGGCGCAGGTAAAAACTGTATTGAGGACATTAACTTTACGCCGGATACGTATCGTAAGTTACTGACCAAG
AAGCTTTTTGTTGGCCGGATTCTGGAAAAGTACAGCGTTGAGGGCGAGAAAATCGGTTTAATGCTGCCGAATGCCGCCAT
CAGCGCGGCGGTGATTTTCGGCGCGGTTTCTCGTCGCCGCATTCCGGCCATGATGAACTACACAGCGGGGGTAAAAGGGC
TGACCAGCGCGATTACCGCGGCGGAAATTAAAACGATTTTTACCTCCCGCCAGTTCCTCGATAAAGGTAAATTATGGCAC
CTGCCGGAACAGCTAACGCAGGTTCGCTGGGTTTACCTGGAAGATTTAAAAGCGGACGTCACACCCGCCGACAAGCTGTG
GATTTTTGCCCACCTCCTGGCGCCGCGACTGGCACAGGTAAAACAGCAGCCGGAAGACGCGGCGATCATTCTTTTTACCT
CCGGCTCGGAAGGGCACCCGAAAGGGGTGGTGCACAGCCATAAAAGCATTCTGGCGAACGTCGAGCAGATAAAAACGATT
GCGGATTTCACCGCCAATGACCGTTTTATGTCGGCGCTGCCGCTCTTTCACTCGTTCGGTTTGACGGTGGGCCTGTTTAC
GCCGTTGTTGACCGGCGCGGAAGTGTTTCTTTATCCAAGTCCGCTGCACTACCGCATTGTGCCGGAACTGGTCTATGACC
GTAACTGTACCGTGTTGTTTGGTACGTCAACCTTCCTCGGCAACTATGCGCGCTTTGCCAATCCGTATGATTTTTATCGC
CTGCGCTATGTGGTGGCCGGTGCGGAAAAACTTCAGGAGAGCACCAAACAACTGTGGCAGGATAAATTCGGTCTGCGCAT
TCTTGAGGGCTACGGGGTAACGGAATGCGCGCCAGTAGTCTCGATTAACGTGCCGATGGCGGCTAAGCCGGGCACTGTTG
GCCGCATTCTGCCTGGCATGGACGCGCGTCTGCTGGCGGTGCCCGGTATTGAAAACGGCGGTCGGCTACAGCTGAAAGGG
CCGAATATCATGAATGGCTATCTGCGCGTGGAAAAACCGGGCGTGCTGGAGGTGCCGTCAGCGGAAAACGCCAGAGGCGA
AACCGAGCGCGGGTGGTACGACACGGGCGATATTGTACGCTTCGATGAAAATGGTTTTGTGCAGATTCAGGGGCGCGCGA
AACGCTTTGCGAAAATTGCTGGCGAAATGGTCTCGCTGGAGATGGTCGAGCAACTGGCGCTTGGCGTTTCGGCGGACAAA
ATGCACGCTACCGCCATTAAAAGCGATGCCAGCAAAGGTGAAGCGCTGGTACTGTTTACGACTGACAGCGAACTCACCCG
AGAAAAGTTACAGCACTATGCCCGTGAACACGGTATTCCGGAACTTGCCGTCCCGCGTGATATTCGTTATCTGAAACAGC
TTCCCTTGCTTGGCAGCGGGAAACCCGATTTTGTGACGCTGAAAAGTTGGGTGGATGCGCCGGAACAACATCATGAGTGA

Upstream 100 bases:

>100_bases
GGTTTTTTTTCGAACCTATTTTGCTATCGCTCCTGTTACGCAACTCGTGTAATCTGCCACAATTCATGTTTTAGCGAATT
GTCGGCCAAAGGGAGTTGAA

Downstream 100 bases:

>100_bases
GTCAGTACGTACTAACACTTCCATCTGGTCGAAAGGGATGCTGTCGGTGATTGTCGCGCAGTTTCTCTCGGCTTTTGGCG
ATAATGCGCTGCTGTTCGCG

Product: bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase

Products: NA

Alternate protein names: 2-acylglycerophosphoethanolamine acyltransferase; 2-acyl-GPE acyltransferase; Acyl-[acyl-carrier-protein]--phospholipid O-acyltransferase; Acyl-[acyl-carrier-protein] synthetase; Acyl-ACP synthetase; Long-chain-fatty-acid--[acyl-carrier-protein] ligase [H]

Number of amino acids: Translated: 719; Mature: 719

Protein sequence:

>719_residues
MLFGFFRNLFRVLYRVRVTGDVRALQGNRVLITPNHVSFIDGMLLALFLPVRPVFAVYTSISQQWYMRWLTPLIDFVPLD
PTKPMSIKHLVRLVEQGRPVVIFPEGRISVTGSLMKIYDGAGFVAAKSGATVIPLRIDGAELTPFSRLKGLVKRRLFPRI
QLHILPPTQIPMPEAPRARDRRKIAGEMLHQIMMEARMAVRPRETLYESLLAAQYRYGAGKNCIEDINFTPDTYRKLLTK
KLFVGRILEKYSVEGEKIGLMLPNAAISAAVIFGAVSRRRIPAMMNYTAGVKGLTSAITAAEIKTIFTSRQFLDKGKLWH
LPEQLTQVRWVYLEDLKADVTPADKLWIFAHLLAPRLAQVKQQPEDAAIILFTSGSEGHPKGVVHSHKSILANVEQIKTI
ADFTANDRFMSALPLFHSFGLTVGLFTPLLTGAEVFLYPSPLHYRIVPELVYDRNCTVLFGTSTFLGNYARFANPYDFYR
LRYVVAGAEKLQESTKQLWQDKFGLRILEGYGVTECAPVVSINVPMAAKPGTVGRILPGMDARLLAVPGIENGGRLQLKG
PNIMNGYLRVEKPGVLEVPSAENARGETERGWYDTGDIVRFDENGFVQIQGRAKRFAKIAGEMVSLEMVEQLALGVSADK
MHATAIKSDASKGEALVLFTTDSELTREKLQHYAREHGIPELAVPRDIRYLKQLPLLGSGKPDFVTLKSWVDAPEQHHE

Sequences:

>Translated_719_residues
MLFGFFRNLFRVLYRVRVTGDVRALQGNRVLITPNHVSFIDGMLLALFLPVRPVFAVYTSISQQWYMRWLTPLIDFVPLD
PTKPMSIKHLVRLVEQGRPVVIFPEGRISVTGSLMKIYDGAGFVAAKSGATVIPLRIDGAELTPFSRLKGLVKRRLFPRI
QLHILPPTQIPMPEAPRARDRRKIAGEMLHQIMMEARMAVRPRETLYESLLAAQYRYGAGKNCIEDINFTPDTYRKLLTK
KLFVGRILEKYSVEGEKIGLMLPNAAISAAVIFGAVSRRRIPAMMNYTAGVKGLTSAITAAEIKTIFTSRQFLDKGKLWH
LPEQLTQVRWVYLEDLKADVTPADKLWIFAHLLAPRLAQVKQQPEDAAIILFTSGSEGHPKGVVHSHKSILANVEQIKTI
ADFTANDRFMSALPLFHSFGLTVGLFTPLLTGAEVFLYPSPLHYRIVPELVYDRNCTVLFGTSTFLGNYARFANPYDFYR
LRYVVAGAEKLQESTKQLWQDKFGLRILEGYGVTECAPVVSINVPMAAKPGTVGRILPGMDARLLAVPGIENGGRLQLKG
PNIMNGYLRVEKPGVLEVPSAENARGETERGWYDTGDIVRFDENGFVQIQGRAKRFAKIAGEMVSLEMVEQLALGVSADK
MHATAIKSDASKGEALVLFTTDSELTREKLQHYAREHGIPELAVPRDIRYLKQLPLLGSGKPDFVTLKSWVDAPEQHHE
>Mature_719_residues
MLFGFFRNLFRVLYRVRVTGDVRALQGNRVLITPNHVSFIDGMLLALFLPVRPVFAVYTSISQQWYMRWLTPLIDFVPLD
PTKPMSIKHLVRLVEQGRPVVIFPEGRISVTGSLMKIYDGAGFVAAKSGATVIPLRIDGAELTPFSRLKGLVKRRLFPRI
QLHILPPTQIPMPEAPRARDRRKIAGEMLHQIMMEARMAVRPRETLYESLLAAQYRYGAGKNCIEDINFTPDTYRKLLTK
KLFVGRILEKYSVEGEKIGLMLPNAAISAAVIFGAVSRRRIPAMMNYTAGVKGLTSAITAAEIKTIFTSRQFLDKGKLWH
LPEQLTQVRWVYLEDLKADVTPADKLWIFAHLLAPRLAQVKQQPEDAAIILFTSGSEGHPKGVVHSHKSILANVEQIKTI
ADFTANDRFMSALPLFHSFGLTVGLFTPLLTGAEVFLYPSPLHYRIVPELVYDRNCTVLFGTSTFLGNYARFANPYDFYR
LRYVVAGAEKLQESTKQLWQDKFGLRILEGYGVTECAPVVSINVPMAAKPGTVGRILPGMDARLLAVPGIENGGRLQLKG
PNIMNGYLRVEKPGVLEVPSAENARGETERGWYDTGDIVRFDENGFVQIQGRAKRFAKIAGEMVSLEMVEQLALGVSADK
MHATAIKSDASKGEALVLFTTDSELTREKLQHYAREHGIPELAVPRDIRYLKQLPLLGSGKPDFVTLKSWVDAPEQHHE

Specific function: Plays a role in lysophospholipid acylation. Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-

COG id: COG0318

COG function: function code IQ; Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the ATP- dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI187761345, Length=386, Percent_Identity=27.720207253886, Blast_Score=103, Evalue=6e-22,
Organism=Homo sapiens, GI187761343, Length=386, Percent_Identity=27.720207253886, Blast_Score=103, Evalue=6e-22,
Organism=Homo sapiens, GI40807491, Length=411, Percent_Identity=25.5474452554745, Blast_Score=101, Evalue=3e-21,
Organism=Homo sapiens, GI156151445, Length=355, Percent_Identity=26.4788732394366, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI42544132, Length=365, Percent_Identity=25.7534246575342, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI58082049, Length=366, Percent_Identity=24.5901639344262, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1789201, Length=719, Percent_Identity=91.5159944367177, Blast_Score=1368, Evalue=0.0,
Organism=Escherichia coli, GI1788107, Length=509, Percent_Identity=26.9155206286837, Blast_Score=134, Evalue=2e-32,
Organism=Escherichia coli, GI145693145, Length=358, Percent_Identity=29.8882681564246, Blast_Score=131, Evalue=2e-31,
Organism=Escherichia coli, GI1786810, Length=359, Percent_Identity=23.1197771587744, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1786801, Length=317, Percent_Identity=27.1293375394322, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17558820, Length=345, Percent_Identity=28.4057971014493, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI32563687, Length=340, Percent_Identity=27.9411764705882, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI71994703, Length=442, Percent_Identity=26.2443438914027, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71994690, Length=442, Percent_Identity=26.2443438914027, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71994694, Length=442, Percent_Identity=26.2443438914027, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17510401, Length=333, Percent_Identity=25.5255255255255, Blast_Score=89, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17560308, Length=399, Percent_Identity=24.3107769423559, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17531443, Length=399, Percent_Identity=24.3107769423559, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17541856, Length=407, Percent_Identity=25.5528255528256, Blast_Score=81, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17559526, Length=364, Percent_Identity=22.8021978021978, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71985884, Length=278, Percent_Identity=24.1007194244604, Blast_Score=70, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6319699, Length=361, Percent_Identity=26.0387811634349, Blast_Score=98, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6320852, Length=160, Percent_Identity=26.25, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21355181, Length=479, Percent_Identity=24.0083507306889, Blast_Score=101, Evalue=2e-21,
Organism=Drosophila melanogaster, GI18859661, Length=318, Percent_Identity=26.1006289308176, Blast_Score=86, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24581924, Length=361, Percent_Identity=24.3767313019391, Blast_Score=76, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24648260, Length=402, Percent_Identity=24.8756218905473, Blast_Score=74, Evalue=4e-13,
Organism=Drosophila melanogaster, GI19922652, Length=316, Percent_Identity=25, Blast_Score=74, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002123
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF01553 Acyltransferase; PF00501 AMP-binding [H]

EC number: =2.3.1.40; =6.2.1.20 [H]

Molecular weight: Translated: 80521; Mature: 80521

Theoretical pI: Translated: 10.02; Mature: 10.02

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLFGFFRNLFRVLYRVRVTGDVRALQGNRVLITPNHVSFIDGMLLALFLPVRPVFAVYTS
CCHHHHHHHHHHHHHHHCCCCEEEECCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
ISQQWYMRWLTPLIDFVPLDPTKPMSIKHLVRLVEQGRPVVIFPEGRISVTGSLMKIYDG
HHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCEEEECCCCEEECCCEEEEECC
AGFVAAKSGATVIPLRIDGAELTPFSRLKGLVKRRLFPRIQLHILPPTQIPMPEAPRARD
CCEEEECCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCHHH
RRKIAGEMLHQIMMEARMAVRPRETLYESLLAAQYRYGAGKNCIEDINFTPDTYRKLLTK
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHCCCCCHHHHHHHHHH
KLFVGRILEKYSVEGEKIGLMLPNAAISAAVIFGAVSRRRIPAMMNYTAGVKGLTSAITA
HHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHH
AEIKTIFTSRQFLDKGKLWHLPEQLTQVRWVYLEDLKADVTPADKLWIFAHLLAPRLAQV
HHHHHHHHHHHHHHCCCEECCHHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHH
KQQPEDAAIILFTSGSEGHPKGVVHSHKSILANVEQIKTIADFTANDRFMSALPLFHSFG
HCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHC
LTVGLFTPLLTGAEVFLYPSPLHYRIVPELVYDRNCTVLFGTSTFLGNYARFANPYDFYR
HHHHHHHHHHCCCEEEEECCCCCEEEEHHHHCCCCCEEEEECHHHHHCHHHHCCCHHHHH
LRYVVAGAEKLQESTKQLWQDKFGLRILEGYGVTECAPVVSINVPMAAKPGTVGRILPGM
HHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCEEEECCCCCCCCCCCCCCCCCC
DARLLAVPGIENGGRLQLKGPNIMNGYLRVEKPGVLEVPSAENARGETERGWYDTGDIVR
CCEEEEECCCCCCCEEEECCCCEEECEEEECCCCEEECCCCCCCCCCCCCCCCCCCCEEE
FDENGFVQIQGRAKRFAKIAGEMVSLEMVEQLALGVSADKMHATAIKSDASKGEALVLFT
ECCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCEEEEEE
TDSELTREKLQHYAREHGIPELAVPRDIRYLKQLPLLGSGKPDFVTLKSWVDAPEQHHE
CCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCEEEHHHHHCCCHHCCC
>Mature Secondary Structure
MLFGFFRNLFRVLYRVRVTGDVRALQGNRVLITPNHVSFIDGMLLALFLPVRPVFAVYTS
CCHHHHHHHHHHHHHHHCCCCEEEECCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
ISQQWYMRWLTPLIDFVPLDPTKPMSIKHLVRLVEQGRPVVIFPEGRISVTGSLMKIYDG
HHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCEEEECCCCEEECCCEEEEECC
AGFVAAKSGATVIPLRIDGAELTPFSRLKGLVKRRLFPRIQLHILPPTQIPMPEAPRARD
CCEEEECCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCHHH
RRKIAGEMLHQIMMEARMAVRPRETLYESLLAAQYRYGAGKNCIEDINFTPDTYRKLLTK
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHCCCCCHHHHHHHHHH
KLFVGRILEKYSVEGEKIGLMLPNAAISAAVIFGAVSRRRIPAMMNYTAGVKGLTSAITA
HHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHH
AEIKTIFTSRQFLDKGKLWHLPEQLTQVRWVYLEDLKADVTPADKLWIFAHLLAPRLAQV
HHHHHHHHHHHHHHCCCEECCHHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHH
KQQPEDAAIILFTSGSEGHPKGVVHSHKSILANVEQIKTIADFTANDRFMSALPLFHSFG
HCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHC
LTVGLFTPLLTGAEVFLYPSPLHYRIVPELVYDRNCTVLFGTSTFLGNYARFANPYDFYR
HHHHHHHHHHCCCEEEEECCCCCEEEEHHHHCCCCCEEEEECHHHHHCHHHHCCCHHHHH
LRYVVAGAEKLQESTKQLWQDKFGLRILEGYGVTECAPVVSINVPMAAKPGTVGRILPGM
HHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCEEEECCCCCCCCCCCCCCCCCC
DARLLAVPGIENGGRLQLKGPNIMNGYLRVEKPGVLEVPSAENARGETERGWYDTGDIVR
CCEEEEECCCCCCCEEEECCCCEEECEEEECCCCEEECCCCCCCCCCCCCCCCCCCCEEE
FDENGFVQIQGRAKRFAKIAGEMVSLEMVEQLALGVSADKMHATAIKSDASKGEALVLFT
ECCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCEEEEEE
TDSELTREKLQHYAREHGIPELAVPRDIRYLKQLPLLGSGKPDFVTLKSWVDAPEQHHE
CCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCEEEHHHHHCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA