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The map label for this gene is gcvT [H]

Identifier: 194735702

GI number: 194735702

Start: 3118123

End: 3119217

Strand: Reverse

Name: gcvT [H]

Synonym: SeSA_A3225

Alternate gene names: 194735702

Gene position: 3119217-3118123 (Counterclockwise)

Preceding gene: 194736217

Following gene: 194736611

Centisome position: 66.24

GC content: 55.16

Gene sequence:

>1095_bases
ATGGCCCAACAGACGCCTTTGTACGAACAACACACGCTATGCGGCGCCCGCATGGTCGATTTTCATGGCTGGATGATGCC
CCTGCATTACGGCTCTCAGCTTGATGAACACCACGCTGTGCGCACCGATGCCGGGATGTTTGATGTATCGCATATGACCA
TTGTCGATCTTCATGGTAGCCGTACACGAGAGTTTCTACGTTATCTGCTGGCAAACGACGTCGCGAAGCTAACGAAGACG
GGTAAAGCCCTCTACTCCGGTATGCTTAACGCATCGGGCGGCGTGATTGATGACCTTATCGTCTACTACTTCACTGAAGA
TTTCTTCCGTCTCGTTGTTAACTCCGCCACCCGCGAAAAAGACCTCTCCTGGATTACCCAACATGCTGAACCTTATGCCA
TCGACATCACCGTTCGTGACGACCTGTCGCTGATTGCGGTACAGGGGCCGAATGCGCAGGAAAAAGCGGCGACTCTGTTT
ACTGACCAACAGCGCCATGCAGTAGAAGGTATGAAGCCGTTCTTCGGCGTACAGGCGGGTGATTTGTTTATCGCCACCAC
CGGTTATACCGGCGAAGCGGGCTATGAAATCGCCATGCCGAATGAAAAAGCGGCGGATTTCTGGCGTGCGCTGGTGGAGG
CGGGCGTGAAGCCGTGCGGTCTTGGCGCGCGCGACACGCTGCGTCTGGAAGCAGGCATGAACCTGTACGGTCAGGAGATG
GATGAAGGTATCTCTCCGCTGGCGGCTAATATGGGATGGACTATCGCCTGGGAACCTGCTGACCGCGACTTTATTGGCCG
TGAGGCGCTGGAGATGCAGCGTGAAAAAGGCCATGAGCAGCTTGTCGGTCTGGTGATGACCGAGAAAGGTGTATTGCGTA
ATGAACTGCCGGTGCGTTTTACCGATGCGCAGGGCAATCAGCAAGAAGGCATTATCACCAGCGGGACGTTTTCCCCAACG
TTGGGCTACAGCATTGCGCTGGCGCGCGTTCCGGCGGGCATCGGCGAGACGGCGATTGTACAAATTCGTAACCGTGAAAT
GCCGGTAAAAGTGACTAAACCTGTTTTTGTGCGTAACGGCAAAGCCGTCGCGTGA

Upstream 100 bases:

>100_bases
GTTTGCGTCGGCGCAGGAAAAAGGGCGTCGATGCCAGGTTTCGTGGCGAAGATTTCCCATGAAAATGGTTGTTAGCCCCC
GCTAATTCAACGAGGAAAAG

Downstream 100 bases:

>100_bases
TTCATCCTTTTTTGGAGATTAATTGATGAGCAACGTACCCGCAGAACTGAAATACAGCAAAGAACACGAATGGCTGCGTA
AAGAAGCGGATGGCACTTAC

Product: glycine cleavage system aminomethyltransferase T

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 364; Mature: 363

Protein sequence:

>364_residues
MAQQTPLYEQHTLCGARMVDFHGWMMPLHYGSQLDEHHAVRTDAGMFDVSHMTIVDLHGSRTREFLRYLLANDVAKLTKT
GKALYSGMLNASGGVIDDLIVYYFTEDFFRLVVNSATREKDLSWITQHAEPYAIDITVRDDLSLIAVQGPNAQEKAATLF
TDQQRHAVEGMKPFFGVQAGDLFIATTGYTGEAGYEIAMPNEKAADFWRALVEAGVKPCGLGARDTLRLEAGMNLYGQEM
DEGISPLAANMGWTIAWEPADRDFIGREALEMQREKGHEQLVGLVMTEKGVLRNELPVRFTDAQGNQQEGIITSGTFSPT
LGYSIALARVPAGIGETAIVQIRNREMPVKVTKPVFVRNGKAVA

Sequences:

>Translated_364_residues
MAQQTPLYEQHTLCGARMVDFHGWMMPLHYGSQLDEHHAVRTDAGMFDVSHMTIVDLHGSRTREFLRYLLANDVAKLTKT
GKALYSGMLNASGGVIDDLIVYYFTEDFFRLVVNSATREKDLSWITQHAEPYAIDITVRDDLSLIAVQGPNAQEKAATLF
TDQQRHAVEGMKPFFGVQAGDLFIATTGYTGEAGYEIAMPNEKAADFWRALVEAGVKPCGLGARDTLRLEAGMNLYGQEM
DEGISPLAANMGWTIAWEPADRDFIGREALEMQREKGHEQLVGLVMTEKGVLRNELPVRFTDAQGNQQEGIITSGTFSPT
LGYSIALARVPAGIGETAIVQIRNREMPVKVTKPVFVRNGKAVA
>Mature_363_residues
AQQTPLYEQHTLCGARMVDFHGWMMPLHYGSQLDEHHAVRTDAGMFDVSHMTIVDLHGSRTREFLRYLLANDVAKLTKTG
KALYSGMLNASGGVIDDLIVYYFTEDFFRLVVNSATREKDLSWITQHAEPYAIDITVRDDLSLIAVQGPNAQEKAATLFT
DQQRHAVEGMKPFFGVQAGDLFIATTGYTGEAGYEIAMPNEKAADFWRALVEAGVKPCGLGARDTLRLEAGMNLYGQEMD
EGISPLAANMGWTIAWEPADRDFIGREALEMQREKGHEQLVGLVMTEKGVLRNELPVRFTDAQGNQQEGIITSGTFSPTL
GYSIALARVPAGIGETAIVQIRNREMPVKVTKPVFVRNGKAVA

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=370, Percent_Identity=32.4324324324324, Blast_Score=164, Evalue=9e-41,
Organism=Homo sapiens, GI257796258, Length=342, Percent_Identity=33.0409356725146, Blast_Score=159, Evalue=5e-39,
Organism=Homo sapiens, GI257796254, Length=368, Percent_Identity=29.3478260869565, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI257796256, Length=313, Percent_Identity=30.9904153354633, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI24797151, Length=360, Percent_Identity=26.3888888888889, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI197927446, Length=297, Percent_Identity=28.2828282828283, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI21361378, Length=297, Percent_Identity=28.2828282828283, Blast_Score=86, Evalue=5e-17,
Organism=Escherichia coli, GI1789272, Length=364, Percent_Identity=94.7802197802198, Blast_Score=719, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17560118, Length=374, Percent_Identity=34.7593582887701, Blast_Score=162, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI71994045, Length=339, Percent_Identity=23.0088495575221, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71994052, Length=339, Percent_Identity=23.0088495575221, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320222, Length=378, Percent_Identity=34.6560846560847, Blast_Score=183, Evalue=4e-47,
Organism=Drosophila melanogaster, GI20129441, Length=376, Percent_Identity=32.1808510638298, Blast_Score=163, Evalue=2e-40,
Organism=Drosophila melanogaster, GI28571104, Length=262, Percent_Identity=28.2442748091603, Blast_Score=95, Evalue=8e-20,
Organism=Drosophila melanogaster, GI20130091, Length=364, Percent_Identity=24.7252747252747, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 40217; Mature: 40086

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQQTPLYEQHTLCGARMVDFHGWMMPLHYGSQLDEHHAVRTDAGMFDVSHMTIVDLHGS
CCCCCCCHHHHHHHCCEEEECCCEEEEECCCCCCCHHHCEECCCCEEEECCEEEEEECCH
RTREFLRYLLANDVAKLTKTGKALYSGMLNASGGVIDDLIVYYFTEDFFRLVVNSATREK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHH
DLSWITQHAEPYAIDITVRDDLSLIAVQGPNAQEKAATLFTDQQRHAVEGMKPFFGVQAG
HHHHHHHCCCCEEEEEEEECCCEEEEEECCCCHHHHHHHHCCCHHHHHHCCCHHHCCCCC
DLFIATTGYTGEAGYEIAMPNEKAADFWRALVEAGVKPCGLGARDTLRLEAGMNLYGQEM
CEEEEECCCCCCCCEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCHHHHHH
DEGISPLAANMGWTIAWEPADRDFIGREALEMQREKGHEQLVGLVMTEKGVLRNELPVRF
HCCCCHHHHCCCCEEEECCCCCCHHHHHHHHHHHHCCHHHHEEEHEECCCCHHCCCCEEE
TDAQGNQQEGIITSGTFSPTLGYSIALARVPAGIGETAIVQIRNREMPVKVTKPVFVRNG
ECCCCCCCCCEEECCCCCCCCCCEEEEECCCCCCCCEEEEEEECCCCCEEECCCEEEECC
KAVA
CCCC
>Mature Secondary Structure 
AQQTPLYEQHTLCGARMVDFHGWMMPLHYGSQLDEHHAVRTDAGMFDVSHMTIVDLHGS
CCCCCCHHHHHHHCCEEEECCCEEEEECCCCCCCHHHCEECCCCEEEECCEEEEEECCH
RTREFLRYLLANDVAKLTKTGKALYSGMLNASGGVIDDLIVYYFTEDFFRLVVNSATREK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHH
DLSWITQHAEPYAIDITVRDDLSLIAVQGPNAQEKAATLFTDQQRHAVEGMKPFFGVQAG
HHHHHHHCCCCEEEEEEEECCCEEEEEECCCCHHHHHHHHCCCHHHHHHCCCHHHCCCCC
DLFIATTGYTGEAGYEIAMPNEKAADFWRALVEAGVKPCGLGARDTLRLEAGMNLYGQEM
CEEEEECCCCCCCCEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCHHHHHH
DEGISPLAANMGWTIAWEPADRDFIGREALEMQREKGHEQLVGLVMTEKGVLRNELPVRF
HCCCCHHHHCCCCEEEECCCCCCHHHHHHHHHHHHCCHHHHEEEHEECCCCHHCCCCEEE
TDAQGNQQEGIITSGTFSPTLGYSIALARVPAGIGETAIVQIRNREMPVKVTKPVFVRNG
ECCCCCCCCCEEECCCCCCCCCCEEEEECCCCCCCCEEEEEEECCCCCEEECCCEEEECC
KAVA
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA