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The map label for this gene is lysP [H]

Identifier: 194735104

GI number: 194735104

Start: 2319354

End: 2320823

Strand: Reverse

Name: lysP [H]

Synonym: SeSA_A2439

Alternate gene names: 194735104

Gene position: 2320823-2319354 (Counterclockwise)

Preceding gene: 194735526

Following gene: 194735726

Centisome position: 49.28

GC content: 53.4

Gene sequence:

>1470_bases
ATGGGTTCCAAAACTAAAACCACAGAAGCGCCCGCGCTACGTCGCGAATTAAAGGCGCGTCACCTGACGATGATTGCCAT
TGGCGGCTCCATCGGGACAGGTCTTTTCGTTGCATCTGGTGCGACAATTTCTCAGGCGGGGCCAGGCGGCGCGCTGTTTT
CTTATATTCTGATTGGTTTGATGGTCTACTTCCTGATGACCAGTCTTGGCGAGCTGGCGGCCTATATGCCGGTATCTGGC
TCGTTTGCGACATATGGTCAGAACTATGTGGAAGAAGGCTTTGGTTTCGCGCTGGGCTGGAACTACTGGTACAACTGGGC
GGTGACTATCGCTGTTGACCTAGTTGCCGCACAATTGGTGATGGGCTGGTGGTTCCCGGATACGCCGGGCTGGATCTGGA
GCGCGCTATTCCTCTGCGTCATTTTCTTGCTGAACTACATTTCCGTACGCGGTTTTGGCGAGGCGGAGTACTGGTTCTCG
TTAATTAAAGTCGCGACCGTTATTATCTTCATCATCGTTGGCGTAGCGATGATTATCGGCATCTTTAAAGGTGTCGAGCC
GGTCGGCTGGAGCAACTGGACGACGGGCGATGCGCCTTTTGCTGGCGGTTTTGCGGCAATGATTGGCGTCGCGATGATCG
TGGGCTTCTCTTTCCAGGGAACTGAGCTGATTGGTATTGCCGCCGGGGAATCTGAAAACCCGGAGAAGAATATTCCGCGC
GCGGTGCGTCAGGTGTTCTGGCGTATTCTGCTGTTTTATGTTTTCGCGATTTTGATTATCAGCCTGATCATTCCTTATAC
CGATCCAAACCTGCTGCGTAACGACGTCAAAGACATTAGCGTCAGTCCGTTTACCTTAGTGTTCCAGCATGCGGGCTTGT
TGTCTGCGGCGGCGATAATGAATGCGGTTATCCTGACGGCGGTACTGTCTGCGGGCAACTCCGGAATGTATGCCTCGACC
CGTATGCTCTACACCCTGGCCTGTGACGGTAAGGCCCCGCGTATTTTTGCGAAATTGTCCCGCGGCGGCGTACCGCGCAA
TGCGCTTTATGCCACCACCGTGATTGCCGGTCTTTGCTTTTTGACCTCAATGTTCGGCAACCAGACGGTCTATCTGTGGC
TGTTGAACACCTCCGGTATGACGGGCTTCATCGCCTGGCTGGGGATTGCCATTAGCCATTATCGCTTCCGTCGCGGTTAC
GTGATACAAGGGTATGATGTGAATGATTTGCCGTACCGTTCCGGGTTCTTCCCGCTGGGGCCGATTTTCGCCTTTGTACT
GTGCCTGATTATTACGTTGGGGCAGAACTATGAAGCGTTCCTGAAAGATACCATCGACTGGGGCGGCGTCGCGGCGACCT
ATATCGGTATTCCGCTGTTCCTGCTTATCTGGTTCGGCTACAAGCTGATAAAAGGCACGCATTTCGTGCGCTATAGCGAA
ATGCACTTCCCGGAACGCGTTAAAAAGTAA

Upstream 100 bases:

>100_bases
CCGGTCATGAAGGTCTCTTATAACCGCGCATTTGTGTCGGAAGGATAGTATTTCGTCTGTTACAATCGCGCCTCATTTTT
TGGATGGATAGCATTTTCAC

Downstream 100 bases:

>100_bases
CGCGGTATTCTCGTCATGGCCGGATAAGGCTTTATACCGCTATCCGGCACTGACTGCCTGAACCTGACCCTTCTAACCCT
CTCATTCGAGAGGGTTTTTT

Product: lysine transporter

Products: Proton [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 489; Mature: 488

Protein sequence:

>489_residues
MGSKTKTTEAPALRRELKARHLTMIAIGGSIGTGLFVASGATISQAGPGGALFSYILIGLMVYFLMTSLGELAAYMPVSG
SFATYGQNYVEEGFGFALGWNYWYNWAVTIAVDLVAAQLVMGWWFPDTPGWIWSALFLCVIFLLNYISVRGFGEAEYWFS
LIKVATVIIFIIVGVAMIIGIFKGVEPVGWSNWTTGDAPFAGGFAAMIGVAMIVGFSFQGTELIGIAAGESENPEKNIPR
AVRQVFWRILLFYVFAILIISLIIPYTDPNLLRNDVKDISVSPFTLVFQHAGLLSAAAIMNAVILTAVLSAGNSGMYAST
RMLYTLACDGKAPRIFAKLSRGGVPRNALYATTVIAGLCFLTSMFGNQTVYLWLLNTSGMTGFIAWLGIAISHYRFRRGY
VIQGYDVNDLPYRSGFFPLGPIFAFVLCLIITLGQNYEAFLKDTIDWGGVAATYIGIPLFLLIWFGYKLIKGTHFVRYSE
MHFPERVKK

Sequences:

>Translated_489_residues
MGSKTKTTEAPALRRELKARHLTMIAIGGSIGTGLFVASGATISQAGPGGALFSYILIGLMVYFLMTSLGELAAYMPVSG
SFATYGQNYVEEGFGFALGWNYWYNWAVTIAVDLVAAQLVMGWWFPDTPGWIWSALFLCVIFLLNYISVRGFGEAEYWFS
LIKVATVIIFIIVGVAMIIGIFKGVEPVGWSNWTTGDAPFAGGFAAMIGVAMIVGFSFQGTELIGIAAGESENPEKNIPR
AVRQVFWRILLFYVFAILIISLIIPYTDPNLLRNDVKDISVSPFTLVFQHAGLLSAAAIMNAVILTAVLSAGNSGMYAST
RMLYTLACDGKAPRIFAKLSRGGVPRNALYATTVIAGLCFLTSMFGNQTVYLWLLNTSGMTGFIAWLGIAISHYRFRRGY
VIQGYDVNDLPYRSGFFPLGPIFAFVLCLIITLGQNYEAFLKDTIDWGGVAATYIGIPLFLLIWFGYKLIKGTHFVRYSE
MHFPERVKK
>Mature_488_residues
GSKTKTTEAPALRRELKARHLTMIAIGGSIGTGLFVASGATISQAGPGGALFSYILIGLMVYFLMTSLGELAAYMPVSGS
FATYGQNYVEEGFGFALGWNYWYNWAVTIAVDLVAAQLVMGWWFPDTPGWIWSALFLCVIFLLNYISVRGFGEAEYWFSL
IKVATVIIFIIVGVAMIIGIFKGVEPVGWSNWTTGDAPFAGGFAAMIGVAMIVGFSFQGTELIGIAAGESENPEKNIPRA
VRQVFWRILLFYVFAILIISLIIPYTDPNLLRNDVKDISVSPFTLVFQHAGLLSAAAIMNAVILTAVLSAGNSGMYASTR
MLYTLACDGKAPRIFAKLSRGGVPRNALYATTVIAGLCFLTSMFGNQTVYLWLLNTSGMTGFIAWLGIAISHYRFRRGYV
IQGYDVNDLPYRSGFFPLGPIFAFVLCLIITLGQNYEAFLKDTIDWGGVAATYIGIPLFLLIWFGYKLIKGTHFVRYSEM
HFPERVKK

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of lysine [H]

COG id: COG0833

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=365, Percent_Identity=23.5616438356164, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI1788480, Length=489, Percent_Identity=94.2740286298569, Blast_Score=934, Evalue=0.0,
Organism=Escherichia coli, GI87081708, Length=485, Percent_Identity=38.5567010309278, Blast_Score=326, Evalue=2e-90,
Organism=Escherichia coli, GI48994972, Length=435, Percent_Identity=38.8505747126437, Blast_Score=281, Evalue=6e-77,
Organism=Escherichia coli, GI1786789, Length=418, Percent_Identity=37.5598086124402, Blast_Score=267, Evalue=1e-72,
Organism=Escherichia coli, GI1786302, Length=408, Percent_Identity=35.7843137254902, Blast_Score=256, Evalue=3e-69,
Organism=Escherichia coli, GI1790653, Length=402, Percent_Identity=36.0696517412935, Blast_Score=241, Evalue=8e-65,
Organism=Escherichia coli, GI1789017, Length=409, Percent_Identity=34.2298288508557, Blast_Score=239, Evalue=3e-64,
Organism=Escherichia coli, GI1786602, Length=403, Percent_Identity=38.2133995037221, Blast_Score=230, Evalue=1e-61,
Organism=Escherichia coli, GI87081915, Length=473, Percent_Identity=31.9238900634249, Blast_Score=224, Evalue=1e-59,
Organism=Escherichia coli, GI87081869, Length=395, Percent_Identity=23.7974683544304, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI87082250, Length=234, Percent_Identity=28.6324786324786, Blast_Score=66, Evalue=6e-12,
Organism=Escherichia coli, GI87082023, Length=335, Percent_Identity=24.1791044776119, Blast_Score=65, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6320772, Length=476, Percent_Identity=37.6050420168067, Blast_Score=323, Evalue=3e-89,
Organism=Saccharomyces cerevisiae, GI6324990, Length=488, Percent_Identity=35.2459016393443, Blast_Score=312, Evalue=1e-85,
Organism=Saccharomyces cerevisiae, GI6324061, Length=478, Percent_Identity=34.9372384937238, Blast_Score=301, Evalue=1e-82,
Organism=Saccharomyces cerevisiae, GI6324059, Length=476, Percent_Identity=35.9243697478992, Blast_Score=291, Evalue=2e-79,
Organism=Saccharomyces cerevisiae, GI6322892, Length=475, Percent_Identity=36.6315789473684, Blast_Score=288, Evalue=1e-78,
Organism=Saccharomyces cerevisiae, GI6324924, Length=484, Percent_Identity=33.8842975206612, Blast_Score=277, Evalue=2e-75,
Organism=Saccharomyces cerevisiae, GI6321629, Length=492, Percent_Identity=30.6910569105691, Blast_Score=261, Evalue=2e-70,
Organism=Saccharomyces cerevisiae, GI6324553, Length=429, Percent_Identity=35.6643356643357, Blast_Score=260, Evalue=4e-70,
Organism=Saccharomyces cerevisiae, GI6319824, Length=470, Percent_Identity=29.1489361702128, Blast_Score=239, Evalue=9e-64,
Organism=Saccharomyces cerevisiae, GI6321053, Length=479, Percent_Identity=29.0187891440501, Blast_Score=229, Evalue=7e-61,
Organism=Saccharomyces cerevisiae, GI6322967, Length=468, Percent_Identity=30.982905982906, Blast_Score=229, Evalue=8e-61,
Organism=Saccharomyces cerevisiae, GI6320717, Length=480, Percent_Identity=27.7083333333333, Blast_Score=228, Evalue=1e-60,
Organism=Saccharomyces cerevisiae, GI6319542, Length=470, Percent_Identity=27.4468085106383, Blast_Score=218, Evalue=2e-57,
Organism=Saccharomyces cerevisiae, GI6319543, Length=475, Percent_Identity=29.2631578947368, Blast_Score=218, Evalue=2e-57,
Organism=Saccharomyces cerevisiae, GI6320251, Length=469, Percent_Identity=26.4392324093817, Blast_Score=214, Evalue=2e-56,
Organism=Saccharomyces cerevisiae, GI6324981, Length=491, Percent_Identity=31.5682281059063, Blast_Score=214, Evalue=3e-56,
Organism=Saccharomyces cerevisiae, GI6319608, Length=496, Percent_Identity=27.6209677419355, Blast_Score=205, Evalue=2e-53,
Organism=Saccharomyces cerevisiae, GI6320364, Length=554, Percent_Identity=25.812274368231, Blast_Score=177, Evalue=3e-45,
Organism=Drosophila melanogaster, GI221512776, Length=350, Percent_Identity=24, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24666159, Length=350, Percent_Identity=24, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 53685; Mature: 53553

Theoretical pI: Translated: 9.05; Mature: 9.05

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSKTKTTEAPALRRELKARHLTMIAIGGSIGTGLFVASGATISQAGPGGALFSYILIGL
CCCCCCCCCCHHHHHHHHHHHEEEEEECCCCCCCEEEECCCEECCCCCCHHHHHHHHHHH
MVYFLMTSLGELAAYMPVSGSFATYGQNYVEEGFGFALGWNYWYNWAVTIAVDLVAAQLV
HHHHHHHHHHHHHHHCCCCCCHHHHCHHHHHHCCCEEEECHHHHHHHHHHHHHHHHHHHH
MGWWFPDTPGWIWSALFLCVIFLLNYISVRGFGEAEYWFSLIKVATVIIFIIVGVAMIIG
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
IFKGVEPVGWSNWTTGDAPFAGGFAAMIGVAMIVGFSFQGTELIGIAAGESENPEKNIPR
HHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHH
AVRQVFWRILLFYVFAILIISLIIPYTDPNLLRNDVKDISVSPFTLVFQHAGLLSAAAIM
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
NAVILTAVLSAGNSGMYASTRMLYTLACDGKAPRIFAKLSRGGVPRNALYATTVIAGLCF
HHHHHHHHHHCCCCCCEEHHEEEEEEEECCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHH
LTSMFGNQTVYLWLLNTSGMTGFIAWLGIAISHYRFRRGYVIQGYDVNDLPYRSGFFPLG
HHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCHH
PIFAFVLCLIITLGQNYEAFLKDTIDWGGVAATYIGIPLFLLIWFGYKLIKGTHFVRYSE
HHHHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECC
MHFPERVKK
CCCHHHHCC
>Mature Secondary Structure 
GSKTKTTEAPALRRELKARHLTMIAIGGSIGTGLFVASGATISQAGPGGALFSYILIGL
CCCCCCCCCHHHHHHHHHHHEEEEEECCCCCCCEEEECCCEECCCCCCHHHHHHHHHHH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CCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-lysine [Periplasm] = Proton [Cytoplasm] + L-lysine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1315732; 9278503; 7551055 [H]