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The map label for this gene is rnd [H]

Identifier: 194734944

GI number: 194734944

Start: 1892030

End: 1893157

Strand: Reverse

Name: rnd [H]

Synonym: SeSA_A1959

Alternate gene names: 194734944

Gene position: 1893157-1892030 (Counterclockwise)

Preceding gene: 194735459

Following gene: 194736904

Centisome position: 40.2

GC content: 55.85

Gene sequence:

>1128_bases
TTGAATTACCAAATGATTGAAACGGACGATGCGCTGGCGAGCCTGTGTGAGGCTGTCCGCGCATGTCCGGCTATTGCTTT
AGATACGGAATTTGTCCGTACCCGCACCTATTACCCGCAGTTAGGATTGATCCAGTTATTTGACGGGGCAAATGTCGCCC
TGATCGATCCGCTCGGCATCAGCGACTGGTCGCCGTTAAAAGCGGTGTTGCGCGATACGGGAATCACCAAATTTCTGCAC
GCGGGTAGCGAAGATCTGGAAGTATTTCTGAATGCGTTTGGCGAACTGCCGGAACCCCTGATTGATACGCAAATCCTGGC
GGCGTTTTGCGGGCGCCCGCTGTCGTGGGGGTTTGCGGCGATGGTAGAAGAGTATACGGGCGTGGCGCTGGATAAAAGCG
AGTCTCGTACCGACTGGCTAGCCCGGCCTTTAAGCGAACGTCAGTGTGAATACGCGGCGGCGGATGTCTGGTATCTGTTA
CCGATCGCCAAAAAGCTGATGATTGAAACTGAAGCCGCAGGATGGCTGCCTGCCGCGCTTGATGAATGCCGATTGATGCA
GCAGCGTCGTCAGGAGATTCAGGCGCCGGAAGAGGCATGGCGGGATATCACTAATGCCTGGCAACTGCGTACCCGCCAGT
TAGCCTGTCTGCAACTTTTAGCTGACTGGCGGCTGCGTAAGGCGCGTGAGCGCGATATGGCGGTGAACTTTGTTGTGCGT
GAAGAAAACCTGTGGGCGGTCGCGCGTTATATGCCGGGCAGTCTCGGTGAGCTGGATAGCCTGGGGCTTTCCGGCAGCGA
GATTCGTTTTCACGGCAAGACGTTGATATCGCTGGTGGCGAAAGCACAGGCGTTACCGGAAGAGGCATTGCCGGAGCCCC
TGTTGAATCTGATGGACATGCCGGGCTATCGCAAAGCGTTTAAGGCCATCAAAGCGCTGGTGGCGGAGGTGAGCGCGTCG
CATCACGTCAGCGGCGAGCTACTGGCATCGCGTCGGCAGATTAATCAGTTGCTTAACTGGCACTGGAAATTAAAACCGCA
AAATGGGCAACCGGAATTGATTTCCGGCTGGCGCGCCGAACTGATGGCGGAGAAGTTAACTCTTCTGTTGCAGGAGTATC
CGCGTTAA

Upstream 100 bases:

>100_bases
CCGTGGCAAAGTAGACAATAAAGCCTGAGCGTTAAGTCAGCTAACGAGAGACGCCGGTTAAGCCGGCGTTTTTTTTGGCG
CGAACCAAAGAGAACACGAT

Downstream 100 bases:

>100_bases
CGACGGTAATTGCCGGGAAAACGGCCAGTGAAATAAATGTCCGTATTCGGAATAATGTAAAAAAATAAAAAAGGCAGATT
CTTCTGCCTTTTTTAATCCA

Product: ribonuclease D

Products: NA

Alternate protein names: RNase D [H]

Number of amino acids: Translated: 375; Mature: 375

Protein sequence:

>375_residues
MNYQMIETDDALASLCEAVRACPAIALDTEFVRTRTYYPQLGLIQLFDGANVALIDPLGISDWSPLKAVLRDTGITKFLH
AGSEDLEVFLNAFGELPEPLIDTQILAAFCGRPLSWGFAAMVEEYTGVALDKSESRTDWLARPLSERQCEYAAADVWYLL
PIAKKLMIETEAAGWLPAALDECRLMQQRRQEIQAPEEAWRDITNAWQLRTRQLACLQLLADWRLRKARERDMAVNFVVR
EENLWAVARYMPGSLGELDSLGLSGSEIRFHGKTLISLVAKAQALPEEALPEPLLNLMDMPGYRKAFKAIKALVAEVSAS
HHVSGELLASRRQINQLLNWHWKLKPQNGQPELISGWRAELMAEKLTLLLQEYPR

Sequences:

>Translated_375_residues
MNYQMIETDDALASLCEAVRACPAIALDTEFVRTRTYYPQLGLIQLFDGANVALIDPLGISDWSPLKAVLRDTGITKFLH
AGSEDLEVFLNAFGELPEPLIDTQILAAFCGRPLSWGFAAMVEEYTGVALDKSESRTDWLARPLSERQCEYAAADVWYLL
PIAKKLMIETEAAGWLPAALDECRLMQQRRQEIQAPEEAWRDITNAWQLRTRQLACLQLLADWRLRKARERDMAVNFVVR
EENLWAVARYMPGSLGELDSLGLSGSEIRFHGKTLISLVAKAQALPEEALPEPLLNLMDMPGYRKAFKAIKALVAEVSAS
HHVSGELLASRRQINQLLNWHWKLKPQNGQPELISGWRAELMAEKLTLLLQEYPR
>Mature_375_residues
MNYQMIETDDALASLCEAVRACPAIALDTEFVRTRTYYPQLGLIQLFDGANVALIDPLGISDWSPLKAVLRDTGITKFLH
AGSEDLEVFLNAFGELPEPLIDTQILAAFCGRPLSWGFAAMVEEYTGVALDKSESRTDWLARPLSERQCEYAAADVWYLL
PIAKKLMIETEAAGWLPAALDECRLMQQRRQEIQAPEEAWRDITNAWQLRTRQLACLQLLADWRLRKARERDMAVNFVVR
EENLWAVARYMPGSLGELDSLGLSGSEIRFHGKTLISLVAKAQALPEEALPEPLLNLMDMPGYRKAFKAIKALVAEVSAS
HHVSGELLASRRQINQLLNWHWKLKPQNGQPELISGWRAELMAEKLTLLLQEYPR

Specific function: Cleaves multimeric tRNA precursor at the spacer region. Contribute to the 3' maturation of several stable RNAs [H]

COG id: COG0349

COG function: function code J; Ribonuclease D

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI4505917, Length=263, Percent_Identity=27.3764258555133, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI50301240, Length=263, Percent_Identity=27.3764258555133, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1788105, Length=375, Percent_Identity=86.6666666666667, Blast_Score=683, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17531757, Length=259, Percent_Identity=25.0965250965251, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6324574, Length=309, Percent_Identity=25.8899676375405, Blast_Score=77, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002562
- InterPro:   IPR002121
- InterPro:   IPR010997
- InterPro:   IPR006292
- InterPro:   IPR012337 [H]

Pfam domain/function: PF01612 3_5_exonuc; PF00570 HRDC [H]

EC number: =3.1.13.5 [H]

Molecular weight: Translated: 42344; Mature: 42344

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYQMIETDDALASLCEAVRACPAIALDTEFVRTRTYYPQLGLIQLFDGANVALIDPLGI
CCCCEECCHHHHHHHHHHHHHCCCHHCCHHHHHHHCCCCCCCEEEEECCCCEEEECCCCC
SDWSPLKAVLRDTGITKFLHAGSEDLEVFLNAFGELPEPLIDTQILAAFCGRPLSWGFAA
CCCHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHH
MVEEYTGVALDKSESRTDWLARPLSERQCEYAAADVWYLLPIAKKLMIETEAAGWLPAAL
HHHHHHCCEECCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
DECRLMQQRRQEIQAPEEAWRDITNAWQLRTRQLACLQLLADWRLRKARERDMAVNFVVR
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEE
EENLWAVARYMPGSLGELDSLGLSGSEIRFHGKTLISLVAKAQALPEEALPEPLLNLMDM
CCCHHHHHHHCCCCCCCHHHCCCCCCCEEEHHHHHHHHHHHHHHCCHHCCCHHHHHHHCC
PGYRKAFKAIKALVAEVSASHHVSGELLASRRQINQLLNWHWKLKPQNGQPELISGWRAE
CCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCEEEECCCCCCCHHHHHHHHH
LMAEKLTLLLQEYPR
HHHHHHHHHHHHCCC
>Mature Secondary Structure
MNYQMIETDDALASLCEAVRACPAIALDTEFVRTRTYYPQLGLIQLFDGANVALIDPLGI
CCCCEECCHHHHHHHHHHHHHCCCHHCCHHHHHHHCCCCCCCEEEEECCCCEEEECCCCC
SDWSPLKAVLRDTGITKFLHAGSEDLEVFLNAFGELPEPLIDTQILAAFCGRPLSWGFAA
CCCHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHH
MVEEYTGVALDKSESRTDWLARPLSERQCEYAAADVWYLLPIAKKLMIETEAAGWLPAAL
HHHHHHCCEECCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
DECRLMQQRRQEIQAPEEAWRDITNAWQLRTRQLACLQLLADWRLRKARERDMAVNFVVR
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEE
EENLWAVARYMPGSLGELDSLGLSGSEIRFHGKTLISLVAKAQALPEEALPEPLLNLMDM
CCCHHHHHHHCCCCCCCHHHCCCCCCCEEEHHHHHHHHHHHHHHCCHHCCCHHHHHHHCC
PGYRKAFKAIKALVAEVSASHHVSGELLASRRQINQLLNWHWKLKPQNGQPELISGWRAE
CCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCEEEECCCCCCCHHHHHHHHH
LMAEKLTLLLQEYPR
HHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3041371; 9097040; 9278503; 8107670 [H]