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The map label for this gene is lolE [H]

Identifier: 194734795

GI number: 194734795

Start: 1269217

End: 1270461

Strand: Direct

Name: lolE [H]

Synonym: SeSA_A1296

Alternate gene names: 194734795

Gene position: 1269217-1270461 (Clockwise)

Preceding gene: 194735840

Following gene: 194736567

Centisome position: 26.95

GC content: 53.57

Gene sequence:

>1245_bases
ATGGCGTCGCCTTTATCATTATTAATTGGGTTGCGCTTCAGCCGTGGGCGGCGGCGCGGCGGTATGGTTTCGCTCATTTC
CGTCATTTCTACCATCGGTATCGCGCTGGGCGTGGCGGTATTGATTGTCGGTTTAAGCGCGATGAACGGTTTCGAACGCG
AGTTGAACAACCGTATTCTGGCGGTGGTTCCACACGGGGAGATTGAAGCGGTCAATCAGCCGTGGACTAACTGGCGTGAA
GCGCTGGCAAAAGTGCAGAAGGTGCCGGGCATTGCCGCCGCCGCGCCGTATATCAATTTTACCGGCCTGGTAGAGAGCGG
GGCGAATTTGCGCGCCATTCAGGTTAAAGGCGTCGACCCTAAGCAAGAGCAGCAGCTTAGCGCGTTACCGTCATTTGTGC
AAAATCACGCCTGGGATCATTTCAAAGCGGGCGAACAGCAGATCATTATCGGCAAAGGTGTCGCCGATGCGCTGAACGTG
AAACAGGGCGACTGGGTGTCCATCATGATCCCCAATGCGAATGCCGACCATAAGCTGCTCCAGCCCAAACGCGTGCGTTT
GCATGTCATCGGGATTCTGCAACTGAGCGGCCAGCTCGATCACAGCTTCGCCATGATCCCGCTTGAGGATGCGCAGCAGT
ATCTGGATATGGGGTCCAGCGTTTCCGGTATCGCGCTTAAAGTCCATGACGTGTTTAATGCGAACAAACTGGTGCGTGAC
GCGGGTGAGGTGACTAACAGCTATGTCTACATTAAGAGCTGGATCGGCACCTACGGCTATATGTATCGCGATATCCAGAT
GATTCGCGCCATTATGTATCTGGCGATGATTCTGGTGATCGGCGTGGCCTGTTTTAATATCGTTTCCACCTTAGTGATGG
CGGTAAAAGACAAAAGCGGCGACATTGCGGTATTAAGAACGCTGGGGGCGAAAGATGGTTTGATTCGTGCCATTTTCGTC
TGGTACGGACTACTGGCGGGCTTGCTGGGCAGTTTGATTGGCGTGGCGATCGGCGTTGTTGTTTCGCTTCAGCTTACCGC
CATTATTAATGGGATTGAAAAGGCGATCGGGCATCAGTTTTTGTCCGGCGATATCTATTTTATCGACTTCCTGCCATCCG
AATTACATTGGCTGGACGTTGTTTACGTACTGGTCACGGCGTTGTTGTTAAGCTTACTGGCGAGCTGGTATCCGGCGCGG
CGGGCGAGCAACATTGACCCTGCGCGAGTATTGAGCGGCCAGTAA

Upstream 100 bases:

>100_bases
TGGTGACTCACGATTTGCAACTGGCGAAACGTATGAGCCGCCAGCTTGAGATGCGCGATGGTCGCCTGACGGCGGAACTG
AGCCTGATGGGGGCTGAGTA

Downstream 100 bases:

>100_bases
TCGCGGAATATAAAAACAAGGAGCGGTGATGTATTACGGGTTTGACATTGGCGGAACAAAGATTGCGTTAGGCGTATTTG
ACTCAACGCGGCGGCTGCAG

Product: outer membrane-specific lipoprotein transporter subunit LolE

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 414; Mature: 413

Protein sequence:

>414_residues
MASPLSLLIGLRFSRGRRRGGMVSLISVISTIGIALGVAVLIVGLSAMNGFERELNNRILAVVPHGEIEAVNQPWTNWRE
ALAKVQKVPGIAAAAPYINFTGLVESGANLRAIQVKGVDPKQEQQLSALPSFVQNHAWDHFKAGEQQIIIGKGVADALNV
KQGDWVSIMIPNANADHKLLQPKRVRLHVIGILQLSGQLDHSFAMIPLEDAQQYLDMGSSVSGIALKVHDVFNANKLVRD
AGEVTNSYVYIKSWIGTYGYMYRDIQMIRAIMYLAMILVIGVACFNIVSTLVMAVKDKSGDIAVLRTLGAKDGLIRAIFV
WYGLLAGLLGSLIGVAIGVVVSLQLTAIINGIEKAIGHQFLSGDIYFIDFLPSELHWLDVVYVLVTALLLSLLASWYPAR
RASNIDPARVLSGQ

Sequences:

>Translated_414_residues
MASPLSLLIGLRFSRGRRRGGMVSLISVISTIGIALGVAVLIVGLSAMNGFERELNNRILAVVPHGEIEAVNQPWTNWRE
ALAKVQKVPGIAAAAPYINFTGLVESGANLRAIQVKGVDPKQEQQLSALPSFVQNHAWDHFKAGEQQIIIGKGVADALNV
KQGDWVSIMIPNANADHKLLQPKRVRLHVIGILQLSGQLDHSFAMIPLEDAQQYLDMGSSVSGIALKVHDVFNANKLVRD
AGEVTNSYVYIKSWIGTYGYMYRDIQMIRAIMYLAMILVIGVACFNIVSTLVMAVKDKSGDIAVLRTLGAKDGLIRAIFV
WYGLLAGLLGSLIGVAIGVVVSLQLTAIINGIEKAIGHQFLSGDIYFIDFLPSELHWLDVVYVLVTALLLSLLASWYPAR
RASNIDPARVLSGQ
>Mature_413_residues
ASPLSLLIGLRFSRGRRRGGMVSLISVISTIGIALGVAVLIVGLSAMNGFERELNNRILAVVPHGEIEAVNQPWTNWREA
LAKVQKVPGIAAAAPYINFTGLVESGANLRAIQVKGVDPKQEQQLSALPSFVQNHAWDHFKAGEQQIIIGKGVADALNVK
QGDWVSIMIPNANADHKLLQPKRVRLHVIGILQLSGQLDHSFAMIPLEDAQQYLDMGSSVSGIALKVHDVFNANKLVRDA
GEVTNSYVYIKSWIGTYGYMYRDIQMIRAIMYLAMILVIGVACFNIVSTLVMAVKDKSGDIAVLRTLGAKDGLIRAIFVW
YGLLAGLLGSLIGVAIGVVVSLQLTAIINGIEKAIGHQFLSGDIYFIDFLPSELHWLDVVYVLVTALLLSLLASWYPARR
ASNIDPARVLSGQ

Specific function: Part of an ATP-dependent transport system lolCDE responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprote

COG id: COG4591

COG function: function code M; ABC-type transport system, involved in lipoprotein release, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787362, Length=414, Percent_Identity=92.512077294686, Blast_Score=721, Evalue=0.0,
Organism=Escherichia coli, GI1787360, Length=420, Percent_Identity=28.5714285714286, Blast_Score=145, Evalue=5e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003838
- InterPro:   IPR011925
- InterPro:   IPR011926 [H]

Pfam domain/function: PF02687 FtsX [H]

EC number: NA

Molecular weight: Translated: 44982; Mature: 44851

Theoretical pI: Translated: 9.50; Mature: 9.50

Prosite motif: PS00027 HOMEOBOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASPLSLLIGLRFSRGRRRGGMVSLISVISTIGIALGVAVLIVGLSAMNGFERELNNRIL
CCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCEE
AVVPHGEIEAVNQPWTNWREALAKVQKVPGIAAAAPYINFTGLVESGANLRAIQVKGVDP
EEECCCCCEECCCCHHHHHHHHHHHHHCCCCCHHCCCCEEHHHHCCCCCEEEEEEECCCC
KQEQQLSALPSFVQNHAWDHFKAGEQQIIIGKGVADALNVKQGDWVSIMIPNANADHKLL
HHHHHHHHHHHHHHHCCCCHHCCCCCEEEEECCCHHHCCCCCCCEEEEEECCCCCCCCCC
QPKRVRLHVIGILQLSGQLDHSFAMIPLEDAQQYLDMGSSVSGIALKVHDVFNANKLVRD
CCCCEEEEEEEEEEECCCCCCCEEEEEHHHHHHHHHCCCCCCCEEEEEEHHHCHHHHHHH
AGEVTNSYVYIKSWIGTYGYMYRDIQMIRAIMYLAMILVIGVACFNIVSTLVMAVKDKSG
HHHHHCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DIAVLRTLGAKDGLIRAIFVWYGLLAGLLGSLIGVAIGVVVSLQLTAIINGIEKAIGHQF
CEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSGDIYFIDFLPSELHWLDVVYVLVTALLLSLLASWYPARRASNIDPARVLSGQ
HCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCHHHHCCCC
>Mature Secondary Structure 
ASPLSLLIGLRFSRGRRRGGMVSLISVISTIGIALGVAVLIVGLSAMNGFERELNNRIL
CCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCEE
AVVPHGEIEAVNQPWTNWREALAKVQKVPGIAAAAPYINFTGLVESGANLRAIQVKGVDP
EEECCCCCEECCCCHHHHHHHHHHHHHCCCCCHHCCCCEEHHHHCCCCCEEEEEEECCCC
KQEQQLSALPSFVQNHAWDHFKAGEQQIIIGKGVADALNVKQGDWVSIMIPNANADHKLL
HHHHHHHHHHHHHHHCCCCHHCCCCCEEEEECCCHHHCCCCCCCEEEEEECCCCCCCCCC
QPKRVRLHVIGILQLSGQLDHSFAMIPLEDAQQYLDMGSSVSGIALKVHDVFNANKLVRD
CCCCEEEEEEEEEEECCCCCCCEEEEEHHHHHHHHHCCCCCCCEEEEEEHHHCHHHHHHH
AGEVTNSYVYIKSWIGTYGYMYRDIQMIRAIMYLAMILVIGVACFNIVSTLVMAVKDKSG
HHHHHCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DIAVLRTLGAKDGLIRAIFVWYGLLAGLLGSLIGVAIGVVVSLQLTAIINGIEKAIGHQF
CEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSGDIYFIDFLPSELHWLDVVYVLVTALLLSLLASWYPARRASNIDPARVLSGQ
HCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503; 10783239 [H]