Click here to switch to the map view.

The map label for this gene is ompC [H]

Identifier: 194734756

GI number: 194734756

Start: 1573874

End: 1574992

Strand: Direct

Name: ompC [H]

Synonym: SeSA_A1634

Alternate gene names: 194734756

Gene position: 1573874-1574992 (Clockwise)

Preceding gene: 194736726

Following gene: 194737677

Centisome position: 33.42

GC content: 45.93

Gene sequence:

>1119_bases
ATGAAAAAAGTAGTGGTGTTATCTGCGGTAGCCGCAGCCGTAATGATGGCTGGAGCCGCCAACGCAGCAGAAATCTATAA
CAAGGATGGCAATAAACTGGATTTGTATGGCAAGGTCGACGGCCTGCATTATTTTTCCAGTAATCATAGTACGGATGGCG
ATCAATCTTATATCCGTATGGGTATTAAAGGCGAAACTCAAATTACCGATCAACTAACCGGTTTTGGACAGTGGGAGTAT
CAGGTCAACGCCAATCGTCCGGAAGATGGTGACTCCAGCGGTTCCCCGCAAAGCTGGACGCGTCTCGGTTTTGCTGGTTT
GGCATTTGCCGATATGGGGTCTGTTGATTATGGTCGTAACTATGGCGTGTTATACGACATTGGTTCATGGACTGACGTAC
TGCCTGAATTTGGTAATGATTCGTATGAAGCTTCCGATAATTTTATGACCGGACGTGCGAATGGCGTTCTGACTTATCGT
AATAATGATTTCTTTGGTCTGGTTGATGGTCTGAATATTGCGTTGCAGTATCAGGGTAAAAATGACGGCCTGTCGAAAGA
AGGCGATCCTTTAAGTAATAATGCCAGAAAAAGTATCGCGTACCAGAATGGCGATGGTTTCGGGGCATCAGCGACATATG
ATTTGGGCATGGGGGTGAGCCTGGGGGCAGCCTATACCAGTTCCAAACGCACGCTTGATCAGATGACGCAAGATAAATAC
GACAATGGTGACCGCGCTGAAGCCTGGACTGGCGGCGTGAAGTATGATGCCAATAATATTTACCTGGCGGCAAACTATAC
CCGTACTTATGATATGACCTATATGGGCGATACATTGGGCGGCTTTGCACATAAAACCGATAACTGGGAAATGGTAGGGC
AATATCAATTTGATAATGGCTTACGCCCATCACTGGCGTTCCTGCAATCCAGAGCCAATGATGTTGATGGACTGGGTTCG
TTCGACCTTGTGAAATATATTGATGTGGGTTCCTACTACTACTTCAATAAAAATATGTCCGCGTATGTTGACTACAAAAT
CAATCTGCTAAAAGATGGCAACCCATCGAATCCTAATACAGACAACACCGTGGCGCTCGGCTTAGTCTACGAGTTTTGA

Upstream 100 bases:

>100_bases
TGAAACTTAACGTACGGTAATTGTTAGTGATATTGTCCTGGACAGTTCCGCGAGCAGGTTTTGCGGAAAGTCCAAAAATA
AGACAAATAAGGCATATAAA

Downstream 100 bases:

>100_bases
TAAAACTTGCTGATTAAGACAGTTTAGGGATACCCTCCTTTTCCCAAAACTGTGTCACTGCTTAACCTTTATTATTGTTA
ATTTATTCTTTTATTATTTC

Product: outer membrane protein N

Products: NA

Alternate protein names: Porin ompC; Porin ompk36 [H]

Number of amino acids: Translated: 372; Mature: 372

Protein sequence:

>372_residues
MKKVVVLSAVAAAVMMAGAANAAEIYNKDGNKLDLYGKVDGLHYFSSNHSTDGDQSYIRMGIKGETQITDQLTGFGQWEY
QVNANRPEDGDSSGSPQSWTRLGFAGLAFADMGSVDYGRNYGVLYDIGSWTDVLPEFGNDSYEASDNFMTGRANGVLTYR
NNDFFGLVDGLNIALQYQGKNDGLSKEGDPLSNNARKSIAYQNGDGFGASATYDLGMGVSLGAAYTSSKRTLDQMTQDKY
DNGDRAEAWTGGVKYDANNIYLAANYTRTYDMTYMGDTLGGFAHKTDNWEMVGQYQFDNGLRPSLAFLQSRANDVDGLGS
FDLVKYIDVGSYYYFNKNMSAYVDYKINLLKDGNPSNPNTDNTVALGLVYEF

Sequences:

>Translated_372_residues
MKKVVVLSAVAAAVMMAGAANAAEIYNKDGNKLDLYGKVDGLHYFSSNHSTDGDQSYIRMGIKGETQITDQLTGFGQWEY
QVNANRPEDGDSSGSPQSWTRLGFAGLAFADMGSVDYGRNYGVLYDIGSWTDVLPEFGNDSYEASDNFMTGRANGVLTYR
NNDFFGLVDGLNIALQYQGKNDGLSKEGDPLSNNARKSIAYQNGDGFGASATYDLGMGVSLGAAYTSSKRTLDQMTQDKY
DNGDRAEAWTGGVKYDANNIYLAANYTRTYDMTYMGDTLGGFAHKTDNWEMVGQYQFDNGLRPSLAFLQSRANDVDGLGS
FDLVKYIDVGSYYYFNKNMSAYVDYKINLLKDGNPSNPNTDNTVALGLVYEF
>Mature_372_residues
MKKVVVLSAVAAAVMMAGAANAAEIYNKDGNKLDLYGKVDGLHYFSSNHSTDGDQSYIRMGIKGETQITDQLTGFGQWEY
QVNANRPEDGDSSGSPQSWTRLGFAGLAFADMGSVDYGRNYGVLYDIGSWTDVLPEFGNDSYEASDNFMTGRANGVLTYR
NNDFFGLVDGLNIALQYQGKNDGLSKEGDPLSNNARKSIAYQNGDGFGASATYDLGMGVSLGAAYTSSKRTLDQMTQDKY
DNGDRAEAWTGGVKYDANNIYLAANYTRTYDMTYMGDTLGGFAHKTDNWEMVGQYQFDNGLRPSLAFLQSRANDVDGLGS
FDLVKYIDVGSYYYFNKNMSAYVDYKINLLKDGNPSNPNTDNTVALGLVYEF

Specific function: Forms passive diffusion pores which allow small molecular weight hydrophilic materials across the outer membrane. In K.pneumoniae it has been shown to bind the C1Q component and activate the classical pathway of the complement system [H]

COG id: COG3203

COG function: function code M; Outer membrane protein (porin)

Gene ontology:

Cell location: Cell outer membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Gram-negative porin family [H]

Homologues:

Organism=Escherichia coli, GI1788544, Length=376, Percent_Identity=62.5, Blast_Score=433, Evalue=1e-123,
Organism=Escherichia coli, GI1787641, Length=362, Percent_Identity=62.1546961325967, Blast_Score=422, Evalue=1e-119,
Organism=Escherichia coli, GI1786436, Length=373, Percent_Identity=55.4959785522788, Blast_Score=394, Evalue=1e-111,
Organism=Escherichia coli, GI1787160, Length=380, Percent_Identity=51.8421052631579, Blast_Score=350, Evalue=6e-98,

Paralogues:

None

Copy number: 6020 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 19068 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001897
- InterPro:   IPR013793
- InterPro:   IPR001702 [H]

Pfam domain/function: PF00267 Porin_1 [H]

EC number: NA

Molecular weight: Translated: 40776; Mature: 40776

Theoretical pI: Translated: 4.31; Mature: 4.31

Prosite motif: PS00576 GRAM_NEG_PORIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKVVVLSAVAAAVMMAGAANAAEIYNKDGNKLDLYGKVDGLHYFSSNHSTDGDQSYIRM
CCEEEEHHHHHHHHHHHCCCCHHHHHCCCCCEEEEEEEECCEEEECCCCCCCCCCEEEEE
GIKGETQITDQLTGFGQWEYQVNANRPEDGDSSGSPQSWTRLGFAGLAFADMGSVDYGRN
CCCCCCEEHHHHCCCEEEEEEECCCCCCCCCCCCCCCHHHHHCHHHEEEECCCCCCCCCC
YGVLYDIGSWTDVLPEFGNDSYEASDNFMTGRANGVLTYRNNDFFGLVDGLNIALQYQGK
CEEEEECCCHHHHHHHHCCCCCCCCCCEEECCCCEEEEEECCCEEEEEECCEEEEEECCC
NDGLSKEGDPLSNNARKSIAYQNGDGFGASATYDLGMGVSLGAAYTSSKRTLDQMTQDKY
CCCCCCCCCCCCCCCHHEEEEECCCCCCCCEEEECCCCEEECCEECCCHHHHHHHHHHCC
DNGDRAEAWTGGVKYDANNIYLAANYTRTYDMTYMGDTLGGFAHKTDNWEMVGQYQFDNG
CCCCCCCEECCCEEECCCEEEEEEECEEEEEEEECCCCCCCCCCCCCCEEEEEEEECCCC
LRPSLAFLQSRANDVDGLGSFDLVKYIDVGSYYYFNKNMSAYVDYKINLLKDGNPSNPNT
CCHHHHHHHHCCCCCCCCCCCCEEEEEECCEEEEECCCCEEEEEEEEEEEECCCCCCCCC
DNTVALGLVYEF
CCEEEEEEEEEC
>Mature Secondary Structure
MKKVVVLSAVAAAVMMAGAANAAEIYNKDGNKLDLYGKVDGLHYFSSNHSTDGDQSYIRM
CCEEEEHHHHHHHHHHHCCCCHHHHHCCCCCEEEEEEEECCEEEECCCCCCCCCCEEEEE
GIKGETQITDQLTGFGQWEYQVNANRPEDGDSSGSPQSWTRLGFAGLAFADMGSVDYGRN
CCCCCCEEHHHHCCCEEEEEEECCCCCCCCCCCCCCCHHHHHCHHHEEEECCCCCCCCCC
YGVLYDIGSWTDVLPEFGNDSYEASDNFMTGRANGVLTYRNNDFFGLVDGLNIALQYQGK
CEEEEECCCHHHHHHHHCCCCCCCCCCEEECCCCEEEEEECCCEEEEEECCEEEEEECCC
NDGLSKEGDPLSNNARKSIAYQNGDGFGASATYDLGMGVSLGAAYTSSKRTLDQMTQDKY
CCCCCCCCCCCCCCCHHEEEEECCCCCCCCEEEECCCCEEECCEECCCHHHHHHHHHHCC
DNGDRAEAWTGGVKYDANNIYLAANYTRTYDMTYMGDTLGGFAHKTDNWEMVGQYQFDNG
CCCCCCCEECCCEEECCCEEEEEEECEEEEEEEECCCCCCCCCCCCCCEEEEEEEECCCC
LRPSLAFLQSRANDVDGLGSFDLVKYIDVGSYYYFNKNMSAYVDYKINLLKDGNPSNPNT
CCHHHHHHHHCCCCCCCCCCCCEEEEEECCEEEEECCCCEEEEEEEEEEEECCCCCCCCC
DNTVALGLVYEF
CCEEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7868262; 10196126 [H]