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The map label for this gene is fruR [H]

Identifier: 194734558

GI number: 194734558

Start: 138228

End: 139232

Strand: Direct

Name: fruR [H]

Synonym: SeSA_A0134

Alternate gene names: 194734558

Gene position: 138228-139232 (Clockwise)

Preceding gene: 194734361

Following gene: 194734682

Centisome position: 2.94

GC content: 56.52

Gene sequence:

>1005_bases
GTGAAACTGGATGAAATCGCTCGGCTGGCCGGTGTCTCGCGCACAACTGCAAGCTACGTTATAAACGGTAAAGCAAAGCA
ATACCGCGTGAGCGACAAAACCGTAGAAAAAGTCATGGCGGTAGTGCGTGAGCACAATTACCATCCTAACGCTGTGGCTG
CCGGGCTGCGTGCTGGACGCACACGTTCCATTGGTCTGGTGATCCCGGACCTTGAAAACACGAGCTACACCCGTATCGCA
AACTATCTTGAGCGCCAGGCACGCCAGCGTGGCTACCAACTGCTGATCGCCTGTTCTGAAGATCAGCCGGATAACGAAAT
GCGCTGCATTGAGCACCTTTTGCAACGCCAGGTGGATGCAATCATTGTTTCAACTTCGTTACCGCCGGAGCATCCCTTCT
ATCAGCGCTGGGCCAACGATCCGTTCCCCATCGTCGCGCTCGACCGCGCGCTGGATCGCGAACATTTCACCAGCGTGGTC
GGCGCCGATCAGGATGATGCCGAGATGTTGGCGGAAGAGCTGCGTAAATTCCCGGCGGAAACGGTGCTTTATTTGGGCGC
GCTGCCGGAGTTGTCCGTCAGTTTCCTGCGCGAGCAGGGGTTCCGCACCGCATGGAAAGACGATCCGCGGGAGGTGAATT
TCTTATATGCCAACAGCTATGAGCGCGAAGCCGCCGCGCAGTTGTTTGAGAAATGGCTAGAAACGCATCCTATGCCGCAG
GCGCTCTTTACGACATCGTTCGCGCTATTACAGGGCGTGATGGACGTTACGCTGCGGCGCGATGGAAAACTGCCCTCGGA
TTTAGCGATTGCGACCTTCGGCGATCATGAGCTGCTGGATTTTCTGCAATGCCCGGTACTGGCGGTGGCGCAGCGTCATC
GTGATGTCGCGGAACGCGTGCTGGAGATTGTGCTGGCAAGTCTTGATGAACCGCGTAAACCGAAACCCGGCTTAACGCGT
ATTCGGCGAAACCTGTATCGTCGCGGCATTCTGAGCCGTAGCTAA

Upstream 100 bases:

>100_bases
AAGCGGTTGCCGGAGTGATCAAACTGCGCTTAGATGTTAACGATTTTAACCCATGCCGACATAAAGGTTATGGTTTGTAC
AATTTACACAAGGGGCAATT

Downstream 100 bases:

>100_bases
AGGACCGGCGGTAAAAAGACTCTCTCTTCTGCCGCCGTCAAACAAATGCGTATCAGTAAAAATATCCCTCAAATAATTAA
GATTATTCCTTAAAATTATC

Product: DNA-binding transcriptional regulator FruR

Products: NA

Alternate protein names: Catabolite repressor/activator [H]

Number of amino acids: Translated: 334; Mature: 334

Protein sequence:

>334_residues
MKLDEIARLAGVSRTTASYVINGKAKQYRVSDKTVEKVMAVVREHNYHPNAVAAGLRAGRTRSIGLVIPDLENTSYTRIA
NYLERQARQRGYQLLIACSEDQPDNEMRCIEHLLQRQVDAIIVSTSLPPEHPFYQRWANDPFPIVALDRALDREHFTSVV
GADQDDAEMLAEELRKFPAETVLYLGALPELSVSFLREQGFRTAWKDDPREVNFLYANSYEREAAAQLFEKWLETHPMPQ
ALFTTSFALLQGVMDVTLRRDGKLPSDLAIATFGDHELLDFLQCPVLAVAQRHRDVAERVLEIVLASLDEPRKPKPGLTR
IRRNLYRRGILSRS

Sequences:

>Translated_334_residues
MKLDEIARLAGVSRTTASYVINGKAKQYRVSDKTVEKVMAVVREHNYHPNAVAAGLRAGRTRSIGLVIPDLENTSYTRIA
NYLERQARQRGYQLLIACSEDQPDNEMRCIEHLLQRQVDAIIVSTSLPPEHPFYQRWANDPFPIVALDRALDREHFTSVV
GADQDDAEMLAEELRKFPAETVLYLGALPELSVSFLREQGFRTAWKDDPREVNFLYANSYEREAAAQLFEKWLETHPMPQ
ALFTTSFALLQGVMDVTLRRDGKLPSDLAIATFGDHELLDFLQCPVLAVAQRHRDVAERVLEIVLASLDEPRKPKPGLTR
IRRNLYRRGILSRS
>Mature_334_residues
MKLDEIARLAGVSRTTASYVINGKAKQYRVSDKTVEKVMAVVREHNYHPNAVAAGLRAGRTRSIGLVIPDLENTSYTRIA
NYLERQARQRGYQLLIACSEDQPDNEMRCIEHLLQRQVDAIIVSTSLPPEHPFYQRWANDPFPIVALDRALDREHFTSVV
GADQDDAEMLAEELRKFPAETVLYLGALPELSVSFLREQGFRTAWKDDPREVNFLYANSYEREAAAQLFEKWLETHPMPQ
ALFTTSFALLQGVMDVTLRRDGKLPSDLAIATFGDHELLDFLQCPVLAVAQRHRDVAERVLEIVLASLDEPRKPKPGLTR
IRRNLYRRGILSRS

Specific function: Represses some operons but activates others. It is implicated in the regulation of a large number of operons encoding enzymes which comprise central pathways of carbon metabolism. Binds D-fructose as an inducer [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786268, Length=334, Percent_Identity=98.8023952095808, Blast_Score=681, Evalue=0.0,
Organism=Escherichia coli, GI1790194, Length=323, Percent_Identity=28.1733746130031, Blast_Score=114, Evalue=8e-27,
Organism=Escherichia coli, GI1787580, Length=289, Percent_Identity=23.1833910034602, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1787948, Length=308, Percent_Identity=22.4025974025974, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790369, Length=312, Percent_Identity=23.0769230769231, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1790715, Length=289, Percent_Identity=25.9515570934256, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1789068, Length=304, Percent_Identity=25, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI48994940, Length=335, Percent_Identity=24.4776119402985, Blast_Score=64, Evalue=9e-12,
Organism=Escherichia coli, GI1789202, Length=128, Percent_Identity=32.03125, Blast_Score=64, Evalue=9e-12,
Organism=Escherichia coli, GI1788474, Length=207, Percent_Identity=26.5700483091787, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012781
- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 38042; Mature: 38042

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLDEIARLAGVSRTTASYVINGKAKQYRVSDKTVEKVMAVVREHNYHPNAVAAGLRAGR
CCHHHHHHHHCCCHHHHHHEECCCCHHEECCHHHHHHHHHHHHHCCCCCHHHHHHHHCCC
TRSIGLVIPDLENTSYTRIANYLERQARQRGYQLLIACSEDQPDNEMRCIEHLLQRQVDA
CCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHE
IIVSTSLPPEHPFYQRWANDPFPIVALDRALDREHFTSVVGADQDDAEMLAEELRKFPAE
EEEECCCCCCCCHHHHHCCCCCCEEHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHH
TVLYLGALPELSVSFLREQGFRTAWKDDPREVNFLYANSYEREAAAQLFEKWLETHPMPQ
HHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCH
ALFTTSFALLQGVMDVTLRRDGKLPSDLAIATFGDHELLDFLQCPVLAVAQRHRDVAERV
HHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
LEIVLASLDEPRKPKPGLTRIRRNLYRRGILSRS
HHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKLDEIARLAGVSRTTASYVINGKAKQYRVSDKTVEKVMAVVREHNYHPNAVAAGLRAGR
CCHHHHHHHHCCCHHHHHHEECCCCHHEECCHHHHHHHHHHHHHCCCCCHHHHHHHHCCC
TRSIGLVIPDLENTSYTRIANYLERQARQRGYQLLIACSEDQPDNEMRCIEHLLQRQVDA
CCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHE
IIVSTSLPPEHPFYQRWANDPFPIVALDRALDREHFTSVVGADQDDAEMLAEELRKFPAE
EEEECCCCCCCCHHHHHCCCCCCEEHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHH
TVLYLGALPELSVSFLREQGFRTAWKDDPREVNFLYANSYEREAAAQLFEKWLETHPMPQ
HHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCH
ALFTTSFALLQGVMDVTLRRDGKLPSDLAIATFGDHELLDFLQCPVLAVAQRHRDVAERV
HHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
LEIVLASLDEPRKPKPGLTRIRRNLYRRGILSRS
HHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]