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The map label for this gene is hns [H]

Identifier: 194734348

GI number: 194734348

Start: 1824669

End: 1825082

Strand: Direct

Name: hns [H]

Synonym: SeSA_A1884

Alternate gene names: 194734348

Gene position: 1824669-1825082 (Clockwise)

Preceding gene: 194737781

Following gene: 194737073

Centisome position: 38.75

GC content: 46.14

Gene sequence:

>414_bases
ATGAGCGAAGCACTTAAAATTCTGAACAACATCCGTACTCTTCGTGCGCAGGCAAGAGAATGTACTCTGGAAACGCTTGA
AGAAATGCTGGAAAAATTAGAAGTTGTCGTTAATGAGCGTCGTGAAGAAGAAAGCGCTGCTGCTGCTGAAGTGGAAGAAC
GCACTCGTAAGCTGCAACAGTACCGTGAAATGTTAATTGCCGACGGCATTGACCCGAATGAACTGCTGAATAGCATGGCT
GCCGCTAAATCCGGCACCAAAGCTAAACGCGCAGCTCGTCCGGCTAAATATAGCTATGTTGACGAAAACGGTGAAACTAA
AACCTGGACTGGCCAGGGTCGTACACCGGCTGTAATCAAAAAAGCAATGGAAGAACAAGGTAAGCAACTGGAAGATTTCC
TGATCAAGGAATAA

Upstream 100 bases:

>100_bases
TAATTTTGAATTCCTTACATTCCTGGCTATTGCACAACTGAATTTATCGCTCTATTATTAGCTCAACAAACCACCCCAAT
ATAAGTTTGAGATTACTACA

Downstream 100 bases:

>100_bases
TTTACTTCCTGGATGCTTAAAATCCCGCCACTGGCGGGATTTTTTTTGCCTGAGTTCTCCGCTGACGACCCCGGGCATAA
AAAAAGCGCCGGATTTACCA

Product: global DNA-binding transcriptional dual regulator H-NS

Products: NA

Alternate protein names: Histone-like protein HLP-II; Protein B1; Protein H1 [H]

Number of amino acids: Translated: 137; Mature: 136

Protein sequence:

>137_residues
MSEALKILNNIRTLRAQARECTLETLEEMLEKLEVVVNERREEESAAAAEVEERTRKLQQYREMLIADGIDPNELLNSMA
AAKSGTKAKRAARPAKYSYVDENGETKTWTGQGRTPAVIKKAMEEQGKQLEDFLIKE

Sequences:

>Translated_137_residues
MSEALKILNNIRTLRAQARECTLETLEEMLEKLEVVVNERREEESAAAAEVEERTRKLQQYREMLIADGIDPNELLNSMA
AAKSGTKAKRAARPAKYSYVDENGETKTWTGQGRTPAVIKKAMEEQGKQLEDFLIKE
>Mature_136_residues
SEALKILNNIRTLRAQARECTLETLEEMLEKLEVVVNERREEESAAAAEVEERTRKLQQYREMLIADGIDPNELLNSMAA
AKSGTKAKRAARPAKYSYVDENGETKTWTGQGRTPAVIKKAMEEQGKQLEDFLIKE

Specific function: H-NS binds tightly to ds-DNA, increases its thermal stability and inhibits transcription. It also binds to ss-DNA and RNA but with a much lower affinity. H-NS has possible histone-like function. May be a global transcriptional regulator through its abilit

COG id: COG2916

COG function: function code R; DNA-binding protein H-NS

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone-like protein H-NS family [H]

Homologues:

Organism=Escherichia coli, GI1787489, Length=137, Percent_Identity=94.8905109489051, Blast_Score=232, Evalue=9e-63,
Organism=Escherichia coli, GI1789023, Length=135, Percent_Identity=57.037037037037, Blast_Score=134, Evalue=2e-33,

Paralogues:

None

Copy number: 820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1780 Molecules/Cell In: Early Stationary Phase, Rich Media (Based on E. coli). 1020 Molecules/Cell In: Early Stationary Phase, Rich Media (Based on E. coli). 4632 Molecules/Cell In: Gr

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001801 [H]

Pfam domain/function: PF00816 Histone_HNS [H]

EC number: NA

Molecular weight: Translated: 15543; Mature: 15412

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEALKILNNIRTLRAQARECTLETLEEMLEKLEVVVNERREEESAAAAEVEERTRKLQQ
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YREMLIADGIDPNELLNSMAAAKSGTKAKRAARPAKYSYVDENGETKTWTGQGRTPAVIK
HHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHH
KAMEEQGKQLEDFLIKE
HHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SEALKILNNIRTLRAQARECTLETLEEMLEKLEVVVNERREEESAAAAEVEERTRKLQQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YREMLIADGIDPNELLNSMAAAKSGTKAKRAARPAKYSYVDENGETKTWTGQGRTPAVIK
HHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHH
KAMEEQGKQLEDFLIKE
HHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]