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The map label for this gene is mug

Identifier: 194734340

GI number: 194734340

Start: 3285897

End: 3286403

Strand: Reverse

Name: mug

Synonym: SeSA_A3402

Alternate gene names: 194734340

Gene position: 3286403-3285897 (Counterclockwise)

Preceding gene: 194737378

Following gene: 194735240

Centisome position: 69.79

GC content: 52.86

Gene sequence:

>507_bases
ATGGTTAAGGACATACTGGCGCCAGGGCTACGGGTGGTTTTTTGCGGCATCAATCCGGGACTCTCCTCGGCGAATACCGG
CTTTCCGTTTGCGCATCCCGCGAATCGTTTTTGGAAAGTTATTCATTTGGCCGGTTTCACCGATCGACAGTTGAAACCGG
AAGAGGCGGAAAAATTACTGGATTTTCGCTGCGGGGTAACGAAACTCGTCGACCGACCGACAGTACAAGCGACTGAGGTG
AAGTTGCATGAATTACGTAGCGGCGGACGCAACCTGATTGAAAAAATAGAGGACTACCAGCCCGCAGCGCTGGCGGTGCT
TGGTAAACAGGCTTTTGAACAGGGATTCAGCCAGCGCGGTATCGCCTGGGGTAAACAAAAGATCGCCATTGGCGCGACGA
TGGTGTGGGTGTTGCCGAATCCCAGCGGCTTAAACCGAATTAAAACGGAAAAACTGGTCGAGGCCTATCGCGAACTGGAT
CAAGCGCTCATTATGCGTGGGCTATAG

Upstream 100 bases:

>100_bases
TACGCTGTAATCCAGCCGTAACCGTGCGGGTGCTGTTTTTATAAACAATGTGTTTTCAACCCGTTATACTTAAAGTACGT
TGTATTGCTCAGGAGTAATA

Downstream 100 bases:

>100_bases
CAATGGGGAATGAGGGCGCGAATACTCGCGCTGTGTAGAGATTCTGCAGGCCAAATAGGGCGCTCGCGCATGACCTGATA
AAAAAACGCCGCCTTGCGGC

Product: G/U mismatch-specific DNA glycosylase

Products: NA

Alternate protein names: Double-strand-specific uracil glycosylase; Mismatch-specific uracil DNA-glycosylase; MUG

Number of amino acids: Translated: 168; Mature: 168

Protein sequence:

>168_residues
MVKDILAPGLRVVFCGINPGLSSANTGFPFAHPANRFWKVIHLAGFTDRQLKPEEAEKLLDFRCGVTKLVDRPTVQATEV
KLHELRSGGRNLIEKIEDYQPAALAVLGKQAFEQGFSQRGIAWGKQKIAIGATMVWVLPNPSGLNRIKTEKLVEAYRELD
QALIMRGL

Sequences:

>Translated_168_residues
MVKDILAPGLRVVFCGINPGLSSANTGFPFAHPANRFWKVIHLAGFTDRQLKPEEAEKLLDFRCGVTKLVDRPTVQATEV
KLHELRSGGRNLIEKIEDYQPAALAVLGKQAFEQGFSQRGIAWGKQKIAIGATMVWVLPNPSGLNRIKTEKLVEAYRELD
QALIMRGL
>Mature_168_residues
MVKDILAPGLRVVFCGINPGLSSANTGFPFAHPANRFWKVIHLAGFTDRQLKPEEAEKLLDFRCGVTKLVDRPTVQATEV
KLHELRSGGRNLIEKIEDYQPAALAVLGKQAFEQGFSQRGIAWGKQKIAIGATMVWVLPNPSGLNRIKTEKLVEAYRELD
QALIMRGL

Specific function: Excises ethenocytosine and uracil, which can arise by alkylation or deamination of cytosine, respectively, from the corresponding mispairs with guanine in ds-DNA. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone o

COG id: COG3663

COG function: function code L; G:T/U mismatch-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TDG/mug DNA glycosylase family

Homologues:

Organism=Homo sapiens, GI59853162, Length=149, Percent_Identity=32.8859060402685, Blast_Score=80, Evalue=1e-15,
Organism=Escherichia coli, GI1789449, Length=167, Percent_Identity=80.8383233532934, Blast_Score=291, Evalue=1e-80,
Organism=Drosophila melanogaster, GI21356805, Length=144, Percent_Identity=34.0277777777778, Blast_Score=96, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUG_SALA4 (B5F6A8)

Other databases:

- EMBL:   CP001138
- RefSeq:   YP_002148142.1
- ProteinModelPortal:   B5F6A8
- SMR:   B5F6A8
- PRIDE:   B5F6A8
- GeneID:   6796053
- GenomeReviews:   CP001138_GR
- KEGG:   sea:SeAg_B3398
- HOGENOM:   HBG424886
- OMA:   FARPGNR
- ProtClustDB:   PRK10201
- GO:   GO:0005737
- HAMAP:   MF_01956
- InterPro:   IPR015637
- InterPro:   IPR005122
- Gene3D:   G3DSA:3.40.470.10
- PANTHER:   PTHR12159

Pfam domain/function: PF03167 UDG; SSF52141 UDNA_glycsylseSF

EC number: =3.2.2.28

Molecular weight: Translated: 18650; Mature: 18650

Theoretical pI: Translated: 10.11; Mature: 10.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKDILAPGLRVVFCGINPGLSSANTGFPFAHPANRFWKVIHLAGFTDRQLKPEEAEKLL
CCCHHHCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHH
DFRCGVTKLVDRPTVQATEVKLHELRSGGRNLIEKIEDYQPAALAVLGKQAFEQGFSQRG
HHHCCHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCC
IAWGKQKIAIGATMVWVLPNPSGLNRIKTEKLVEAYRELDQALIMRGL
CCCCCCEEEECEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MVKDILAPGLRVVFCGINPGLSSANTGFPFAHPANRFWKVIHLAGFTDRQLKPEEAEKLL
CCCHHHCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHH
DFRCGVTKLVDRPTVQATEVKLHELRSGGRNLIEKIEDYQPAALAVLGKQAFEQGFSQRG
HHHCCHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCC
IAWGKQKIAIGATMVWVLPNPSGLNRIKTEKLVEAYRELDQALIMRGL
CCCCCCEEEECEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA