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The map label for this gene is tdcB [H]

Identifier: 194734134

GI number: 194734134

Start: 3318921

End: 3319910

Strand: Reverse

Name: tdcB [H]

Synonym: SeSA_A3435

Alternate gene names: 194734134

Gene position: 3319910-3318921 (Counterclockwise)

Preceding gene: 194734605

Following gene: 194735734

Centisome position: 70.5

GC content: 46.87

Gene sequence:

>990_bases
ATGCACATTACATACGATCTCCCGGTTGCAATTGAAGATATCCTCGAAGCGAAAAAAAGACTGGCGGGGAAGATATATAA
AACGGGAATGCCTCGCTCTAACTATTTTAGTGAACGTTGCAAAGGCGAAATATTTCTCAAGTTTGAAAATATGCAGCGTA
CGGGTTCATTTAAAATTCGTGGCGCTTTTAACAAACTTAGCTCGTTAACGGAGGCGGAAAAACGTAAAGGCGTCGTGGCC
TGTTCCGCAGGTAATCATGCACAGGGCGTTTCTCTTTCTTGCGCAATGCTGGGTATTGACGGCAAAGTCGTGATGCCGAA
GGGCGCGCCAAAGTCAAAAGTGGCGGCCACCTGTGATTATTCGGCGGAAGTGGTGCTCCACGGTGACAACTTCAATGACA
CCATTGCTAAGGTGAGTGAAATTGTCGAAACCGAAGGCCGCATTTTTATTCCGCCTTACGACGATCCAAAAGTCATCGCC
GGACAGGGCACTATTGGTCTGGAAATTATGGAAGATCTGTACGATGTCGATAATGTCATCGTGCCTATTGGCGGCGGCGG
TTTAATTGCAGGTATTGCCATTGCGATTAAATCGATTAACCCGACCATTAAAGTCATCGGCGTACAGGCCGAAAATGTTC
ACGGTATGGCGGCGTCTTATTACGCTGGCGAAATAACCACGCACCGAACGACCGGCACCCTGGCGGATGGTTGTGATGTC
TCCCGCCCGGGCAATTTAACCTATGAAATTGTTCGTGAATTAGTCGATGACATTGTTCTGGTTAGCGAAGATGAAATTCG
TAACAGCATGATCGCTTTAATTCAGCGCAATAAGGTTATTACTGAAGGCGCTGGCGCTCTGGCCTGCGCCGCACTATTAA
GCGGGAAATTAGATAGCCATATTCAGAACAGAAAAACGGTCAGTATTATTTCTGGCGGCAATATCGATCTTTCTCGGGTA
TCACAAATTACGGGTTTAGTTGACGCTTAA

Upstream 100 bases:

>100_bases
TGATATGGAATAAACATATTTAGCGAAATTGACGCCACCTGTTTCTTTTGAACAGTGGGCAACGGTAACTTATTTTTAAT
ACCCAGGTTAAGAGGTTATA

Downstream 100 bases:

>100_bases
TCTTTTCGTGAGGATAGGATATGAGTACTACTGATAGCATTGTATCCAGCCAGGCAAAACAGTCGTCATGGCGTAAATCG
GACACGACGTGGACGCTGGG

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 329; Mature: 329

Protein sequence:

>329_residues
MHITYDLPVAIEDILEAKKRLAGKIYKTGMPRSNYFSERCKGEIFLKFENMQRTGSFKIRGAFNKLSSLTEAEKRKGVVA
CSAGNHAQGVSLSCAMLGIDGKVVMPKGAPKSKVAATCDYSAEVVLHGDNFNDTIAKVSEIVETEGRIFIPPYDDPKVIA
GQGTIGLEIMEDLYDVDNVIVPIGGGGLIAGIAIAIKSINPTIKVIGVQAENVHGMAASYYAGEITTHRTTGTLADGCDV
SRPGNLTYEIVRELVDDIVLVSEDEIRNSMIALIQRNKVITEGAGALACAALLSGKLDSHIQNRKTVSIISGGNIDLSRV
SQITGLVDA

Sequences:

>Translated_329_residues
MHITYDLPVAIEDILEAKKRLAGKIYKTGMPRSNYFSERCKGEIFLKFENMQRTGSFKIRGAFNKLSSLTEAEKRKGVVA
CSAGNHAQGVSLSCAMLGIDGKVVMPKGAPKSKVAATCDYSAEVVLHGDNFNDTIAKVSEIVETEGRIFIPPYDDPKVIA
GQGTIGLEIMEDLYDVDNVIVPIGGGGLIAGIAIAIKSINPTIKVIGVQAENVHGMAASYYAGEITTHRTTGTLADGCDV
SRPGNLTYEIVRELVDDIVLVSEDEIRNSMIALIQRNKVITEGAGALACAALLSGKLDSHIQNRKTVSIISGGNIDLSRV
SQITGLVDA
>Mature_329_residues
MHITYDLPVAIEDILEAKKRLAGKIYKTGMPRSNYFSERCKGEIFLKFENMQRTGSFKIRGAFNKLSSLTEAEKRKGVVA
CSAGNHAQGVSLSCAMLGIDGKVVMPKGAPKSKVAATCDYSAEVVLHGDNFNDTIAKVSEIVETEGRIFIPPYDDPKVIA
GQGTIGLEIMEDLYDVDNVIVPIGGGGLIAGIAIAIKSINPTIKVIGVQAENVHGMAASYYAGEITTHRTTGTLADGCDV
SRPGNLTYEIVRELVDDIVLVSEDEIRNSMIALIQRNKVITEGAGALACAALLSGKLDSHIQNRKTVSIISGGNIDLSRV
SQITGLVDA

Specific function: Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=329, Percent_Identity=36.7781155015198, Blast_Score=182, Evalue=3e-46,
Organism=Escherichia coli, GI1789505, Length=329, Percent_Identity=95.1367781155015, Blast_Score=593, Evalue=1e-171,
Organism=Escherichia coli, GI1790207, Length=297, Percent_Identity=38.3838383838384, Blast_Score=192, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI71991565, Length=308, Percent_Identity=39.6103896103896, Blast_Score=181, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI17537387, Length=304, Percent_Identity=39.8026315789474, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17508781, Length=316, Percent_Identity=29.746835443038, Blast_Score=136, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6322631, Length=311, Percent_Identity=38.5852090032154, Blast_Score=202, Evalue=6e-53,
Organism=Saccharomyces cerevisiae, GI6320930, Length=298, Percent_Identity=35.9060402684564, Blast_Score=175, Evalue=8e-45,
Organism=Saccharomyces cerevisiae, GI6319788, Length=284, Percent_Identity=25.7042253521127, Blast_Score=86, Evalue=9e-18,
Organism=Drosophila melanogaster, GI21355833, Length=311, Percent_Identity=39.5498392282958, Blast_Score=159, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24645328, Length=215, Percent_Identity=39.5348837209302, Blast_Score=101, Evalue=8e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 35112; Mature: 35112

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHITYDLPVAIEDILEAKKRLAGKIYKTGMPRSNYFSERCKGEIFLKFENMQRTGSFKIR
CEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCEEEEEEECCCCCCCEEEE
GAFNKLSSLTEAEKRKGVVACSAGNHAQGVSLSCAMLGIDGKVVMPKGAPKSKVAATCDY
EHHHHHHHHHHHHHHCCEEEEECCCCCCCCEEEEEEEECCCEEEECCCCCCCCEEEEECC
SAEVVLHGDNFNDTIAKVSEIVETEGRIFIPPYDDPKVIAGQGTIGLEIMEDLYDVDNVI
CEEEEEECCCCCHHHHHHHHHHHCCCEEEECCCCCCCEEECCCCCHHHHHHHHHCCCCEE
VPIGGGGLIAGIAIAIKSINPTIKVIGVQAENVHGMAASYYAGEITTHRTTGTLADGCDV
EEECCCHHHHHHHHHHCCCCCEEEEEEEEECCCCCCEEEEEECCEEEECCCCCCCCCCCC
SRPGNLTYEIVRELVDDIVLVSEDEIRNSMIALIQRNKVITEGAGALACAALLSGKLDSH
CCCCCHHHHHHHHHHHHEEEECHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHCHHHHH
IQNRKTVSIISGGNIDLSRVSQITGLVDA
HCCCCEEEEEECCCCCHHHHHHHHHCCCC
>Mature Secondary Structure
MHITYDLPVAIEDILEAKKRLAGKIYKTGMPRSNYFSERCKGEIFLKFENMQRTGSFKIR
CEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCEEEEEEECCCCCCCEEEE
GAFNKLSSLTEAEKRKGVVACSAGNHAQGVSLSCAMLGIDGKVVMPKGAPKSKVAATCDY
EHHHHHHHHHHHHHHCCEEEEECCCCCCCCEEEEEEEECCCEEEECCCCCCCCEEEEECC
SAEVVLHGDNFNDTIAKVSEIVETEGRIFIPPYDDPKVIAGQGTIGLEIMEDLYDVDNVI
CEEEEEECCCCCHHHHHHHHHHHCCCEEEECCCCCCCEEECCCCCHHHHHHHHHCCCCEE
VPIGGGGLIAGIAIAIKSINPTIKVIGVQAENVHGMAASYYAGEITTHRTTGTLADGCDV
EEECCCHHHHHHHHHHCCCCCEEEEEEEEECCCCCCEEEEEECCEEEECCCCCCCCCCCC
SRPGNLTYEIVRELVDDIVLVSEDEIRNSMIALIQRNKVITEGAGALACAALLSGKLDSH
CCCCCHHHHHHHHHHHHEEEECHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHCHHHHH
IQNRKTVSIISGGNIDLSRVSQITGLVDA
HCCCCEEEEEECCCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]