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The map label for this gene is ybdR [H]

Identifier: 194734069

GI number: 194734069

Start: 751348

End: 752586

Strand: Direct

Name: ybdR [H]

Synonym: SeSA_A0774

Alternate gene names: 194734069

Gene position: 751348-752586 (Clockwise)

Preceding gene: 194738178

Following gene: 194737782

Centisome position: 15.96

GC content: 54.24

Gene sequence:

>1239_bases
ATGAAAGCATTGACGTATCACGGTCCACATCACGTAAAGGTTGAAAACGTACCCGATCCCGGCATTGAGCAGCCTGACGA
TATCATTTTGCGTGTTACCGCCACCGCGATTTGCGGATCTGATTTGCATCTCTATCGCGGCAAGATCCCACAGGTAAAAC
ATGGCGATATTTTCGGCCATGAGTTTATGGGCGAGGTGGTGGAAACCGGACATGATGTAAAGAATATTCGGAAAGGGGAT
CGGGTCGTTATCCCGTTTGTCATTGCCTGTGGTGACTGCTTTTTCTGTCGGCTACAGCAATATTCAGCGTGTGAAAACAC
TAACGACGGACACGGCGCGGCGATGAATAAAAAACAGATCCCGCCACCGGCGGCGCTGTTTGGGTATAGCCATCTGTATG
GCGGCGTTCCCGGCGGACAGGCCGAATATGTTCGCGTGCCAAAAGGTAATGTCGGTCCATTTAAGGTGCCGCCGCTGTTA
TCTGACGATAAGGCGCTGTTTCTTTCTGATATTTTGCCTACCGCCTGGCAGGCGGCAAAAAATGCCCAGATTCAGCAAGG
TTCCAGCGTGGCGGTTTTTGGCGCAGGGCCGGTAGGATTACTGACTATCGCCTGTGCGCGACTGCTGGGCGCGGAGCAGA
TCTTCGTCGTTGATCACCACGCCTGGCGCTTGCGTTTCGCCGAAGAACGTTATGGCGCGATACCGATCAACTTCGATGAT
GAGAACGATCCGGCGGAAAAAATCATCGAGCAGACGGCAGGCCACCGCGGCGTGGACGCGGTAATTGATGCCGTAGGCTT
TGAAGCGAAAGGCAGTTTGACGGAGACGGTGCTGACGAACCTTAAACTGGAAGGCAGTAGCGGCAAAGCGCTGCGACAAT
GTATCGCGGCGGTCAGACGCGGCGGCGTGGTCAGCGTACCCGGCGTGTATGCCGGTTTTATTCACGGCTTTTTATTCGGC
GACGCCTTTGATAAGGGGCTAACTTTTAAAATGGGTCAAACCCATGTTCACGCGTGGCTGGGGGAATTATTACCGCTTAT
TGAAAAAGGGTTGCTGAAGCCGGAGGAGATTGTCACGCACTATATGCCGTTTGAAGAGGCGGCGCGCGGCTACGAAATTT
TCGAAAAACGCGAAGAAGAGTGCCGGAAGGTTATCCTGGTGCCGGGAGCGACGTCGGCACAAGCGGCGCAGAAACAGGCG
ACGGGAGTAATCAACCCGATGCCAGGCGGCGTTGTCTGA

Upstream 100 bases:

>100_bases
CCAGGAAAAATCCTAAAGCCGCCTGTTTTGCCGGCAGTCTCTCCGGGATAGCTACCCTTTTATAGTCGAACGCAACATTC
ACCGTTACCCCGGAGGCTGC

Downstream 100 bases:

>100_bases
AACAGGCAGAAATGAAAGGGCTAACGGAAAGAGGATGCACAGGCATCCTCTGTGTAAACGCATTAACGCTTATGCAGATG
GTTTAACGCAGGAAGTCGCC

Product: S-(hydroxymethyl)glutathione dehydrogenase (glutathione-dependent formaldehyde dehydrogenase) (fdh) (faldh)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 412; Mature: 412

Protein sequence:

>412_residues
MKALTYHGPHHVKVENVPDPGIEQPDDIILRVTATAICGSDLHLYRGKIPQVKHGDIFGHEFMGEVVETGHDVKNIRKGD
RVVIPFVIACGDCFFCRLQQYSACENTNDGHGAAMNKKQIPPPAALFGYSHLYGGVPGGQAEYVRVPKGNVGPFKVPPLL
SDDKALFLSDILPTAWQAAKNAQIQQGSSVAVFGAGPVGLLTIACARLLGAEQIFVVDHHAWRLRFAEERYGAIPINFDD
ENDPAEKIIEQTAGHRGVDAVIDAVGFEAKGSLTETVLTNLKLEGSSGKALRQCIAAVRRGGVVSVPGVYAGFIHGFLFG
DAFDKGLTFKMGQTHVHAWLGELLPLIEKGLLKPEEIVTHYMPFEEAARGYEIFEKREEECRKVILVPGATSAQAAQKQA
TGVINPMPGGVV

Sequences:

>Translated_412_residues
MKALTYHGPHHVKVENVPDPGIEQPDDIILRVTATAICGSDLHLYRGKIPQVKHGDIFGHEFMGEVVETGHDVKNIRKGD
RVVIPFVIACGDCFFCRLQQYSACENTNDGHGAAMNKKQIPPPAALFGYSHLYGGVPGGQAEYVRVPKGNVGPFKVPPLL
SDDKALFLSDILPTAWQAAKNAQIQQGSSVAVFGAGPVGLLTIACARLLGAEQIFVVDHHAWRLRFAEERYGAIPINFDD
ENDPAEKIIEQTAGHRGVDAVIDAVGFEAKGSLTETVLTNLKLEGSSGKALRQCIAAVRRGGVVSVPGVYAGFIHGFLFG
DAFDKGLTFKMGQTHVHAWLGELLPLIEKGLLKPEEIVTHYMPFEEAARGYEIFEKREEECRKVILVPGATSAQAAQKQA
TGVINPMPGGVV
>Mature_412_residues
MKALTYHGPHHVKVENVPDPGIEQPDDIILRVTATAICGSDLHLYRGKIPQVKHGDIFGHEFMGEVVETGHDVKNIRKGD
RVVIPFVIACGDCFFCRLQQYSACENTNDGHGAAMNKKQIPPPAALFGYSHLYGGVPGGQAEYVRVPKGNVGPFKVPPLL
SDDKALFLSDILPTAWQAAKNAQIQQGSSVAVFGAGPVGLLTIACARLLGAEQIFVVDHHAWRLRFAEERYGAIPINFDD
ENDPAEKIIEQTAGHRGVDAVIDAVGFEAKGSLTETVLTNLKLEGSSGKALRQCIAAVRRGGVVSVPGVYAGFIHGFLFG
DAFDKGLTFKMGQTHVHAWLGELLPLIEKGLLKPEEIVTHYMPFEEAARGYEIFEKREEECRKVILVPGATSAQAAQKQA
TGVINPMPGGVV

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=383, Percent_Identity=25.5874673629243, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI71565154, Length=245, Percent_Identity=29.7959183673469, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI156523966, Length=373, Percent_Identity=23.8605898123324, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI4501939, Length=245, Percent_Identity=26.1224489795918, Blast_Score=79, Evalue=9e-15,
Organism=Homo sapiens, GI71565152, Length=362, Percent_Identity=24.585635359116, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI4501929, Length=362, Percent_Identity=24.0331491712707, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI4501933, Length=242, Percent_Identity=26.8595041322314, Blast_Score=69, Evalue=9e-12,
Organism=Escherichia coli, GI1786825, Length=412, Percent_Identity=91.2621359223301, Blast_Score=785, Evalue=0.0,
Organism=Escherichia coli, GI1790045, Length=400, Percent_Identity=27.75, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1787863, Length=395, Percent_Identity=24.8101265822785, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI226510992, Length=385, Percent_Identity=24.9350649350649, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI87082125, Length=261, Percent_Identity=27.5862068965517, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1788075, Length=387, Percent_Identity=25.3229974160207, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1790718, Length=225, Percent_Identity=28, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788407, Length=316, Percent_Identity=25.3164556962025, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1786552, Length=246, Percent_Identity=28.4552845528455, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI87081918, Length=255, Percent_Identity=27.4509803921569, Blast_Score=68, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17562876, Length=287, Percent_Identity=27.8745644599303, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI25146526, Length=222, Percent_Identity=26.1261261261261, Blast_Score=66, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6320033, Length=411, Percent_Identity=25.7907542579075, Blast_Score=100, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6319258, Length=301, Percent_Identity=29.9003322259136, Blast_Score=94, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6319257, Length=298, Percent_Identity=28.1879194630872, Blast_Score=88, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6319621, Length=277, Percent_Identity=29.2418772563177, Blast_Score=71, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6323729, Length=384, Percent_Identity=26.3020833333333, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17137530, Length=381, Percent_Identity=25.9842519685039, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI17737895, Length=249, Percent_Identity=25.7028112449799, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: NA

Molecular weight: Translated: 44531; Mature: 44531

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALTYHGPHHVKVENVPDPGIEQPDDIILRVTATAICGSDLHLYRGKIPQVKHGDIFGH
CCCEECCCCCEEEECCCCCCCCCCCCCEEEEEEEHHHCCCCCHHHCCCCCCCCCCCCCCH
EFMGEVVETGHDVKNIRKGDRVVIPFVIACGDCFFCRLQQYSACENTNDGHGAAMNKKQI
HHHHHHHHCCCHHHHHCCCCEEEEEHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCC
PPPAALFGYSHLYGGVPGGQAEYVRVPKGNVGPFKVPPLLSDDKALFLSDILPTAWQAAK
CCCHHHHHHHHHHCCCCCCCCCEEECCCCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHC
NAQIQQGSSVAVFGAGPVGLLTIACARLLGAEQIFVVDHHAWRLRFAEERYGAIPINFDD
CCCCCCCCEEEEEECCHHHHHHHHHHHHHCCCEEEEEECCCEEEEEHHHCCCEEEECCCC
ENDPAEKIIEQTAGHRGVDAVIDAVGFEAKGSLTETVLTNLKLEGSSGKALRQCIAAVRR
CCCHHHHHHHHHCCCCCHHHHHHHHCCCCCCCHHHHHHHHEEEECCCCHHHHHHHHHHHC
GGVVSVPGVYAGFIHGFLFGDAFDKGLTFKMGQTHVHAWLGELLPLIEKGLLKPEEIVTH
CCEEECCHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHHCCCHHHHHHH
YMPFEEAARGYEIFEKREEECRKVILVPGATSAQAAQKQATGVINPMPGGVV
HCCHHHHHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MKALTYHGPHHVKVENVPDPGIEQPDDIILRVTATAICGSDLHLYRGKIPQVKHGDIFGH
CCCEECCCCCEEEECCCCCCCCCCCCCEEEEEEEHHHCCCCCHHHCCCCCCCCCCCCCCH
EFMGEVVETGHDVKNIRKGDRVVIPFVIACGDCFFCRLQQYSACENTNDGHGAAMNKKQI
HHHHHHHHCCCHHHHHCCCCEEEEEHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCC
PPPAALFGYSHLYGGVPGGQAEYVRVPKGNVGPFKVPPLLSDDKALFLSDILPTAWQAAK
CCCHHHHHHHHHHCCCCCCCCCEEECCCCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHC
NAQIQQGSSVAVFGAGPVGLLTIACARLLGAEQIFVVDHHAWRLRFAEERYGAIPINFDD
CCCCCCCCEEEEEECCHHHHHHHHHHHHHCCCEEEEEECCCEEEEEHHHCCCEEEECCCC
ENDPAEKIIEQTAGHRGVDAVIDAVGFEAKGSLTETVLTNLKLEGSSGKALRQCIAAVRR
CCCHHHHHHHHHCCCCCHHHHHHHHCCCCCCCHHHHHHHHEEEECCCCHHHHHHHHHHHC
GGVVSVPGVYAGFIHGFLFGDAFDKGLTFKMGQTHVHAWLGELLPLIEKGLLKPEEIVTH
CCEEECCHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHHCCCHHHHHHH
YMPFEEAARGYEIFEKREEECRKVILVPGATSAQAAQKQATGVINPMPGGVV
HCCHHHHHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503 [H]