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The map label for this gene is fnr [H]

Identifier: 194734021

GI number: 194734021

Start: 1727554

End: 1728306

Strand: Direct

Name: fnr [H]

Synonym: SeSA_A1785

Alternate gene names: 194734021

Gene position: 1727554-1728306 (Clockwise)

Preceding gene: 194734500

Following gene: 194736524

Centisome position: 36.69

GC content: 50.07

Gene sequence:

>753_bases
ATGATCCCGGAAAAGCGAATTATACGGCGCATTCAGTCTGGCGGTTGTGCTATCCATTGCCAGGATTGCAGTATCAGCCA
GCTTTGCATCCCGTTCACACTTAACGAGCATGAGCTTGATCAGCTTGATAATATCATCGAGCGCAAAAAGCCCATTCAGA
AAGGGCAAACTCTGTTTAAAGCAGGTGATGAATTGAAATCGCTCTATGCTATCCGCTCCGGAACGATTAAGAGCTACACC
ATTACCGAGCAAGGCGATGAGCAGATTACTGGATTCCATTTAGCAGGCGACCTGGTGGGTTTTGACGCCATTGGCAGCGG
TCATCATCCGAGCTTTGCACAGGCGCTGGAAACCTCAATGGTATGTGAAATACCCTTTGAGACACTGGATGACCTGTCCG
GCAAAATGCCTAACCTGCGTCAGCAAATGATGCGTCTGATGAGCGGTGAAATTAAAGGCGATCAGGATATGATCCTGTTA
TTGTCGAAGAAAAACGCCGAAGAACGTCTGGCTGCGTTTATTTACAACCTGTCCCGCCGCTTTGCGCAGCGTGGTTTTTC
ACCGCGTGAATTCCGCCTGACGATGACCCGTGGCGATATCGGCAACTATCTGGGCTTAACAGTCGAAACCATTAGCCGTC
TGCTGGGGCGTTTCCAGAAAAGCGGTATGCTGGCGGTGAAAGGTAAGTATATTACTATTGAAAACAGCGATGCGCTGGCG
GCCCTCGCCGGTCATACCCGCAACGTCGCTTAA

Upstream 100 bases:

>100_bases
CTTATACTTGAATTATTCCTTCTCCGGGATAGCTCAGACTTACGCGCTCACCAAAAAGATGTTAAAATTGACAAATATCA
ATTACGGCTTGAGCAGACCT

Downstream 100 bases:

>100_bases
ACGTCAGCTAAACCATTGATGTTATCTTCTGCCATATCGTTAAATTTTTCTCATTTATTGATCTGGCAGAAGCGCTTCCT
CTGTTTCATTCACCATATTT

Product: fumarate/nitrate reduction transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 250; Mature: 250

Protein sequence:

>250_residues
MIPEKRIIRRIQSGGCAIHCQDCSISQLCIPFTLNEHELDQLDNIIERKKPIQKGQTLFKAGDELKSLYAIRSGTIKSYT
ITEQGDEQITGFHLAGDLVGFDAIGSGHHPSFAQALETSMVCEIPFETLDDLSGKMPNLRQQMMRLMSGEIKGDQDMILL
LSKKNAEERLAAFIYNLSRRFAQRGFSPREFRLTMTRGDIGNYLGLTVETISRLLGRFQKSGMLAVKGKYITIENSDALA
ALAGHTRNVA

Sequences:

>Translated_250_residues
MIPEKRIIRRIQSGGCAIHCQDCSISQLCIPFTLNEHELDQLDNIIERKKPIQKGQTLFKAGDELKSLYAIRSGTIKSYT
ITEQGDEQITGFHLAGDLVGFDAIGSGHHPSFAQALETSMVCEIPFETLDDLSGKMPNLRQQMMRLMSGEIKGDQDMILL
LSKKNAEERLAAFIYNLSRRFAQRGFSPREFRLTMTRGDIGNYLGLTVETISRLLGRFQKSGMLAVKGKYITIENSDALA
ALAGHTRNVA
>Mature_250_residues
MIPEKRIIRRIQSGGCAIHCQDCSISQLCIPFTLNEHELDQLDNIIERKKPIQKGQTLFKAGDELKSLYAIRSGTIKSYT
ITEQGDEQITGFHLAGDLVGFDAIGSGHHPSFAQALETSMVCEIPFETLDDLSGKMPNLRQQMMRLMSGEIKGDQDMILL
LSKKNAEERLAAFIYNLSRRFAQRGFSPREFRLTMTRGDIGNYLGLTVETISRLLGRFQKSGMLAVKGKYITIENSDALA
ALAGHTRNVA

Specific function: Global transcription factor that controls the expression of over 100 target genes in response to anoxia. It facilitates the adaptation to anaerobic growth conditions by regulating the expression of gene products that are involved in anaerobic energy metab

COG id: COG0664

COG function: function code T; cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH crp-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787595, Length=250, Percent_Identity=99.2, Blast_Score=511, Evalue=1e-146,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018490
- InterPro:   IPR000595
- InterPro:   IPR001808
- InterPro:   IPR012318
- InterPro:   IPR014710
- InterPro:   IPR018335
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00027 cNMP_binding; PF00325 Crp [H]

EC number: NA

Molecular weight: Translated: 27884; Mature: 27884

Theoretical pI: Translated: 8.22; Mature: 8.22

Prosite motif: PS50042 CNMP_BINDING_3 ; PS00042 HTH_CRP_1 ; PS51063 HTH_CRP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPEKRIIRRIQSGGCAIHCQDCSISQLCIPFTLNEHELDQLDNIIERKKPIQKGQTLFK
CCCHHHHHHHHHCCCCEEEECCCCCCEEEEEEECCHHHHHHHHHHHHHHCCHHHHHHHHH
AGDELKSLYAIRSGTIKSYTITEQGDEQITGFHLAGDLVGFDAIGSGHHPSFAQALETSM
HHHHHHHHHHHHCCCEEEEEECCCCCCCEEEEEEECCHHCHHCCCCCCCCHHHHHHHHHH
VCEIPFETLDDLSGKMPNLRQQMMRLMSGEIKGDQDMILLLSKKNAEERLAAFIYNLSRR
EEECCHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHH
FAQRGFSPREFRLTMTRGDIGNYLGLTVETISRLLGRFQKSGMLAVKGKYITIENSDALA
HHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECEEEEEECCCCHH
ALAGHTRNVA
HHHCCCCCCC
>Mature Secondary Structure
MIPEKRIIRRIQSGGCAIHCQDCSISQLCIPFTLNEHELDQLDNIIERKKPIQKGQTLFK
CCCHHHHHHHHHCCCCEEEECCCCCCEEEEEEECCHHHHHHHHHHHHHHCCHHHHHHHHH
AGDELKSLYAIRSGTIKSYTITEQGDEQITGFHLAGDLVGFDAIGSGHHPSFAQALETSM
HHHHHHHHHHHHCCCEEEEEECCCCCCCEEEEEEECCHHCHHCCCCCCCCHHHHHHHHHH
VCEIPFETLDDLSGKMPNLRQQMMRLMSGEIKGDQDMILLLSKKNAEERLAAFIYNLSRR
EEECCHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHH
FAQRGFSPREFRLTMTRGDIGNYLGLTVETISRLLGRFQKSGMLAVKGKYITIENSDALA
HHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECEEEEEECCCCHH
ALAGHTRNVA
HHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]