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The map label for this gene is nhaB [H]

Identifier: 194733981

GI number: 194733981

Start: 1884835

End: 1886379

Strand: Direct

Name: nhaB [H]

Synonym: SeSA_A1948

Alternate gene names: 194733981

Gene position: 1884835-1886379 (Clockwise)

Preceding gene: 194735382

Following gene: 194734519

Centisome position: 40.03

GC content: 52.82

Gene sequence:

>1545_bases
ATGGAGATCTCATGGGGTCGCGCCATGTGGCGCAACTTTTTAGGCCAGTCGCCCGACTGGTACAAACTGGCACTACTTGT
CTTTTTAATTATTAACCCATTCATTTTCTTAGCTAATCCCTTTATTGCCGGTTGGCTGCTGGTGGCAGAGTTTATCTTCA
CCCTGGCGATGGCGTTAAAGTGTTACCCCCTGCTGCCCGGCGGGTTACTGGCCATTGAAGCCGTCATCATCGGCATGACC
AGCGCCGCCCATGTACGTGAAGAGGTTGCCGCCAACCTGGAAGTCTTGCTGCTGCTGATGTTTATGGTGGCAGGCATCTA
CTTTATGAAGCAGTTATTGCTGTTTATTTTTACCCGTCTGTTACTCAGTATCCGCTCGAAGATGGTTCTGTCGCTGGCCT
TTTGCGTCGCCGCCGCGTTCTTGTCGGCTTTTCTTGACGCGCTTACCGTCGTTGCGGTGGTGATCAGCGTCGCCGTCGGT
TTTTACGGGATTTACCATCGTGTGGCCTCATCGCGCGGCGAAGAGAACGATATGCTGGACGATAGCCATATCGATCCGCA
TTACAAAACGGTGCTGGAGCAATTCCGCGGATTCTTGCGTAGTCTGATGATGCATGCAGGCGTGGGGACGGCGCTGGGCG
GCGTCATGACCATGGTCGGGGAGCCGCAAAACCTGATCATCGCTAAAGCGGCTGGCTGGCATTTCGGCGACTTCTTTTTA
CGGATGTCGCCTGTCACCGTCCCGGTACTGATATGTGGACTGTTAACCTGTATGCTGGTCGAGAAAATGCGCTGGTTTGG
CTATGGCGAAACGTTGCCCGAAAAAGTCCGCGACGTCTTGCAGCAATTCGACGATCAAAGCCGTAAGAAGCGCACCCGCC
AGGATAAACTTAAACTAATAGTCCAGGCAATTATTGGCGTCTGGCTGGTTACCGCCCTCGCCCTCCATCTCGCGGAGGTG
GGGCTGATTGGTCTGTCGGTTATTATTCTGGCCACCGCGTTAACGGGTGTAACCGATGAACACGCCATCGGCAAAGCGTT
TACCGAGTCGCTGCCGTTTACTGCGCTGTTAACCGTTTTCTTCTCCATTGTGGCGGTTATTATCGATCAACATCTTTTCG
CGCCGATTATTCAGTTTGTCTTGCAAGCCTCTGAACACGCGCAGCTAACGCTGTTCTATCTCTTTAACGGCCTGTTGTCT
TCCATCTCGGATAACGTCTTTGTCGGCACCATTTATATCAACGAAGCGAAGGCGGCAATGGAAAACGGCGCTATCAGCTT
AAAACAGTTTGAGCTGTTAGCCGTGGCCATCAATACCGGTACTAACCTGCCATCGGTAGCGACGCCAAATGGTCAGGCGG
CATTCTTATTCCTGCTGACCTCCGCGCTGGCGCCGTTAATCCGTCTCTCTTATGGCCGTATGGTCTGGATGGCGTTACCG
TACACTATCGTACTGACCCTGATAGGGCTACTGTGCGTCGAATTCACTCTTGCGCCGGTCACCGAATGGATGACTCAGGC
AGGATGGTTAGCAACGCTTTCGTAA

Upstream 100 bases:

>100_bases
GCCAATATCGTTAAGGACTTGCTTGCATTCGTCGCGCTCGCTACTCTCTGTGTTTAAACATAAAAACGCTATTTCATTTT
TCTAGGTAAGGAAAAATTTC

Downstream 100 bases:

>100_bases
CGTTTGGCCGGGCAATACACCGCCCGGCTCCGATTTTTGCCTGATAATTATCCAATTACACATTATTTCATTTCCCGCTA
GTGGCGCACGAATTGAATTG

Product: sodium/proton antiporter

Products: Na (I) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Sodium/proton antiporter nhaB [H]

Number of amino acids: Translated: 514; Mature: 514

Protein sequence:

>514_residues
MEISWGRAMWRNFLGQSPDWYKLALLVFLIINPFIFLANPFIAGWLLVAEFIFTLAMALKCYPLLPGGLLAIEAVIIGMT
SAAHVREEVAANLEVLLLLMFMVAGIYFMKQLLLFIFTRLLLSIRSKMVLSLAFCVAAAFLSAFLDALTVVAVVISVAVG
FYGIYHRVASSRGEENDMLDDSHIDPHYKTVLEQFRGFLRSLMMHAGVGTALGGVMTMVGEPQNLIIAKAAGWHFGDFFL
RMSPVTVPVLICGLLTCMLVEKMRWFGYGETLPEKVRDVLQQFDDQSRKKRTRQDKLKLIVQAIIGVWLVTALALHLAEV
GLIGLSVIILATALTGVTDEHAIGKAFTESLPFTALLTVFFSIVAVIIDQHLFAPIIQFVLQASEHAQLTLFYLFNGLLS
SISDNVFVGTIYINEAKAAMENGAISLKQFELLAVAINTGTNLPSVATPNGQAAFLFLLTSALAPLIRLSYGRMVWMALP
YTIVLTLIGLLCVEFTLAPVTEWMTQAGWLATLS

Sequences:

>Translated_514_residues
MEISWGRAMWRNFLGQSPDWYKLALLVFLIINPFIFLANPFIAGWLLVAEFIFTLAMALKCYPLLPGGLLAIEAVIIGMT
SAAHVREEVAANLEVLLLLMFMVAGIYFMKQLLLFIFTRLLLSIRSKMVLSLAFCVAAAFLSAFLDALTVVAVVISVAVG
FYGIYHRVASSRGEENDMLDDSHIDPHYKTVLEQFRGFLRSLMMHAGVGTALGGVMTMVGEPQNLIIAKAAGWHFGDFFL
RMSPVTVPVLICGLLTCMLVEKMRWFGYGETLPEKVRDVLQQFDDQSRKKRTRQDKLKLIVQAIIGVWLVTALALHLAEV
GLIGLSVIILATALTGVTDEHAIGKAFTESLPFTALLTVFFSIVAVIIDQHLFAPIIQFVLQASEHAQLTLFYLFNGLLS
SISDNVFVGTIYINEAKAAMENGAISLKQFELLAVAINTGTNLPSVATPNGQAAFLFLLTSALAPLIRLSYGRMVWMALP
YTIVLTLIGLLCVEFTLAPVTEWMTQAGWLATLS
>Mature_514_residues
MEISWGRAMWRNFLGQSPDWYKLALLVFLIINPFIFLANPFIAGWLLVAEFIFTLAMALKCYPLLPGGLLAIEAVIIGMT
SAAHVREEVAANLEVLLLLMFMVAGIYFMKQLLLFIFTRLLLSIRSKMVLSLAFCVAAAFLSAFLDALTVVAVVISVAVG
FYGIYHRVASSRGEENDMLDDSHIDPHYKTVLEQFRGFLRSLMMHAGVGTALGGVMTMVGEPQNLIIAKAAGWHFGDFFL
RMSPVTVPVLICGLLTCMLVEKMRWFGYGETLPEKVRDVLQQFDDQSRKKRTRQDKLKLIVQAIIGVWLVTALALHLAEV
GLIGLSVIILATALTGVTDEHAIGKAFTESLPFTALLTVFFSIVAVIIDQHLFAPIIQFVLQASEHAQLTLFYLFNGLLS
SISDNVFVGTIYINEAKAAMENGAISLKQFELLAVAINTGTNLPSVATPNGQAAFLFLLTSALAPLIRLSYGRMVWMALP
YTIVLTLIGLLCVEFTLAPVTEWMTQAGWLATLS

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons [H]

COG id: COG3067

COG function: function code P; Na+/H+ antiporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaB Na(+)/H(+) (TC 2.A.34) antiporter family [H]

Homologues:

Organism=Escherichia coli, GI1787435, Length=513, Percent_Identity=92.0077972709552, Blast_Score=932, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004671 [H]

Pfam domain/function: PF06450 NhaB [H]

EC number: NA

Molecular weight: Translated: 56597; Mature: 56597

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECC
>Mature Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 3 Proton [Periplasm]; Na (I) [Cytoplasm] [C]

Specific reaction: 3 Proton [Periplasm] + 2 Na (I) [Cytoplasm] = 2 Na (I) [Periplasm] + 3 Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA