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The map label for this gene is moeZ [H]

Identifier: 194334646

GI number: 194334646

Start: 2020333

End: 2021058

Strand: Reverse

Name: moeZ [H]

Synonym: Paes_1847

Alternate gene names: 194334646

Gene position: 2021058-2020333 (Counterclockwise)

Preceding gene: 194334648

Following gene: 194334645

Centisome position: 80.43

GC content: 52.07

Gene sequence:

>726_bases
ATGAATCGCTACTCTCGTCAGCAGCTTGTTCCAGTGATTGGGGTGGAGGGTCAGGAGAAACTTCGGGACGCAAAAGTTCT
TGTCATCGGTGCCGGCGGTCTTGGTGCTCCGGTTCTTCTTTATCTTGCCGCAGCGGGTGTGGGGACGATCGGAGTTGCTG
ATGGCGACAGGATCGAGGTCAGTAATTTGCAGAGACAGGTGCTTTATCGGACCTGTGATGCAGGAAGAAAAAAAGTGGAT
GTTGCCATTGAGGCCTTGAAAGCTCTCAATCCTGACGTTGATCTGCGTTGTTACCCTCAATACGTCACGCCTCGCGATGC
CGGCGTTCTTGTTCATGATTATGATATCGTTGTCAGCGCATCAGATTCCTTCGCTGCAAAGCTGATGATTAACGATGCGT
GTGTCTGTGAAGCAGTTCCTTGTGTTCATGGTGGTGTCAGCGGGATCGACGGGCAAATTATGACGACGCTTCCGGGAACC
GCCTGTTACCGTTGTGCGTTTAATTTTACCTCCCGTGATGCTTCAGCGGTTGAAAATTTCGCTCAGACCGGGACGCTTGG
GCCGGCGGCGGGAGTGGCAGGAACCCTTCAGGCTGCCGAGGTTATGAAATATGTGTGCGGCTATGGGACTCTCCTGACGG
ATCGGATTCTTCTTTTTGATCTTTCAGAGAGCGGTTTTCACACATTGCCTGTCATGAAAAGGGAAGACTGCTCTTGTTGC
CGGTAG

Upstream 100 bases:

>100_bases
CATAAAGGGTAAGGGGAAGATTTTTTTTCTCTAATATAGGATAAGAGTAAGCTATTCATTTGTTGTTTTCCTTTTTTAAT
TTAGATCTTTTAAAGATATT

Downstream 100 bases:

>100_bases
ACTATTGTTATGCTCCGGGTGGTTTCGGCGTGTTGTTATTTTTAAGAATAAATTCAATTTCAGGGATATCGTGATTTTTC
CATGTGAAAAAGCTGTTTGG

Product: UBA/THIF-type NAD/FAD binding protein

Products: NA

Alternate protein names: Sulfur carrier protein CysO adenylyltransferase; Sulfur carrier protein CysO sulfurtransferase [H]

Number of amino acids: Translated: 241; Mature: 241

Protein sequence:

>241_residues
MNRYSRQQLVPVIGVEGQEKLRDAKVLVIGAGGLGAPVLLYLAAAGVGTIGVADGDRIEVSNLQRQVLYRTCDAGRKKVD
VAIEALKALNPDVDLRCYPQYVTPRDAGVLVHDYDIVVSASDSFAAKLMINDACVCEAVPCVHGGVSGIDGQIMTTLPGT
ACYRCAFNFTSRDASAVENFAQTGTLGPAAGVAGTLQAAEVMKYVCGYGTLLTDRILLFDLSESGFHTLPVMKREDCSCC
R

Sequences:

>Translated_241_residues
MNRYSRQQLVPVIGVEGQEKLRDAKVLVIGAGGLGAPVLLYLAAAGVGTIGVADGDRIEVSNLQRQVLYRTCDAGRKKVD
VAIEALKALNPDVDLRCYPQYVTPRDAGVLVHDYDIVVSASDSFAAKLMINDACVCEAVPCVHGGVSGIDGQIMTTLPGT
ACYRCAFNFTSRDASAVENFAQTGTLGPAAGVAGTLQAAEVMKYVCGYGTLLTDRILLFDLSESGFHTLPVMKREDCSCC
R
>Mature_241_residues
MNRYSRQQLVPVIGVEGQEKLRDAKVLVIGAGGLGAPVLLYLAAAGVGTIGVADGDRIEVSNLQRQVLYRTCDAGRKKVD
VAIEALKALNPDVDLRCYPQYVTPRDAGVLVHDYDIVVSASDSFAAKLMINDACVCEAVPCVHGGVSGIDGQIMTTLPGT
ACYRCAFNFTSRDASAVENFAQTGTLGPAAGVAGTLQAAEVMKYVCGYGTLLTDRILLFDLSESGFHTLPVMKREDCSCC
R

Specific function: Catalyzes the conversion of the sulfur carrier protein CysO to CysO-thiocarboxylate. The reaction is thought to proceed in two steps:first, ATP-dependent activation of CysO as acyl- adenylate (CysO-COOAMP), followed by sulfur transfer to give CysO- thioca

COG id: COG0476

COG function: function code H; Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 rhodanese domain [H]

Homologues:

Organism=Homo sapiens, GI7657339, Length=240, Percent_Identity=42.5, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI4885649, Length=150, Percent_Identity=35.3333333333333, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI38045942, Length=159, Percent_Identity=37.1069182389937, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI38045944, Length=159, Percent_Identity=37.1069182389937, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI23510338, Length=166, Percent_Identity=33.1325301204819, Blast_Score=84, Evalue=9e-17,
Organism=Homo sapiens, GI23510340, Length=166, Percent_Identity=33.1325301204819, Blast_Score=84, Evalue=9e-17,
Organism=Homo sapiens, GI38045948, Length=166, Percent_Identity=34.3373493975904, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI13376212, Length=230, Percent_Identity=27.3913043478261, Blast_Score=68, Evalue=9e-12,
Organism=Homo sapiens, GI150417996, Length=150, Percent_Identity=26.6666666666667, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI38327032, Length=216, Percent_Identity=26.8518518518519, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI1787048, Length=242, Percent_Identity=33.4710743801653, Blast_Score=147, Evalue=5e-37,
Organism=Escherichia coli, GI87082356, Length=240, Percent_Identity=39.5833333333333, Blast_Score=144, Evalue=6e-36,
Organism=Caenorhabditis elegans, GI17540406, Length=241, Percent_Identity=40.2489626556017, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI193203301, Length=152, Percent_Identity=34.2105263157895, Blast_Score=87, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI71984476, Length=187, Percent_Identity=32.620320855615, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI86565433, Length=166, Percent_Identity=31.3253012048193, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI86565431, Length=166, Percent_Identity=31.3253012048193, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17508819, Length=179, Percent_Identity=32.4022346368715, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6321903, Length=247, Percent_Identity=36.4372469635627, Blast_Score=137, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6320598, Length=168, Percent_Identity=29.7619047619048, Blast_Score=93, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6322639, Length=168, Percent_Identity=32.1428571428571, Blast_Score=85, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6325323, Length=156, Percent_Identity=31.4102564102564, Blast_Score=80, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24582879, Length=240, Percent_Identity=37.5, Blast_Score=165, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24660640, Length=150, Percent_Identity=39.3333333333333, Blast_Score=103, Evalue=9e-23,
Organism=Drosophila melanogaster, GI28573937, Length=174, Percent_Identity=32.7586206896552, Blast_Score=91, Evalue=5e-19,
Organism=Drosophila melanogaster, GI20129973, Length=160, Percent_Identity=34.375, Blast_Score=79, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007901
- InterPro:   IPR009036
- InterPro:   IPR016040
- InterPro:   IPR001763
- InterPro:   IPR000594 [H]

Pfam domain/function: PF05237 MoeZ_MoeB; PF00581 Rhodanese; PF00899 ThiF [H]

EC number: NA

Molecular weight: Translated: 25586; Mature: 25586

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
4.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRYSRQQLVPVIGVEGQEKLRDAKVLVIGAGGLGAPVLLYLAAAGVGTIGVADGDRIEV
CCCCCCCCCCEEECCCCHHHHCCCEEEEEECCCCHHHHHHHHHHCCCCEEECCCCCEEEH
SNLQRQVLYRTCDAGRKKVDVAIEALKALNPDVDLRCYPQYVTPRDAGVLVHDYDIVVSA
HHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCEEEEEEEEEEEEC
SDSFAAKLMINDACVCEAVPCVHGGVSGIDGQIMTTLPGTACYRCAFNFTSRDASAVENF
CCCEEEEEEECCHHHHHCCCHHCCCCCCCCCEEEECCCCCEEEEEEECCCCCCHHHHHHH
AQTGTLGPAAGVAGTLQAAEVMKYVCGYGTLLTDRILLFDLSESGFHTLPVMKREDCSCC
HHCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHCEEEEEEECCCCCEECCCCCCCCCCCC
R
C
>Mature Secondary Structure
MNRYSRQQLVPVIGVEGQEKLRDAKVLVIGAGGLGAPVLLYLAAAGVGTIGVADGDRIEV
CCCCCCCCCCEEECCCCHHHHCCCEEEEEECCCCHHHHHHHHHHCCCCEEECCCCCEEEH
SNLQRQVLYRTCDAGRKKVDVAIEALKALNPDVDLRCYPQYVTPRDAGVLVHDYDIVVSA
HHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCEEEEEEEEEEEEC
SDSFAAKLMINDACVCEAVPCVHGGVSGIDGQIMTTLPGTACYRCAFNFTSRDASAVENF
CCCEEEEEEECCHHHHHCCCHHCCCCCCCCCEEEECCCCCEEEEEEECCCCCCHHHHHHH
AQTGTLGPAAGVAGTLQAAEVMKYVCGYGTLLTDRILLFDLSESGFHTLPVMKREDCSCC
HHCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHCEEEEEEECCCCCEECCCCCCCCCCCC
R
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]