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The map label for this gene is uvrB [H]

Identifier: 194334626

GI number: 194334626

Start: 1992448

End: 1994499

Strand: Reverse

Name: uvrB [H]

Synonym: Paes_1827

Alternate gene names: 194334626

Gene position: 1994499-1992448 (Counterclockwise)

Preceding gene: 194334627

Following gene: 194334625

Centisome position: 79.37

GC content: 52.68

Gene sequence:

>2052_bases
ATGCCAGACAGCAGTGACCGATACAGACTTGAGAGCAGTTACGAACCGATGGGGGACCAGCCGGGGGCTATTGATGCGCT
TTCGGCAGGCGTGCGTGACGGGGAGCCTTGTCAGACCCTTCTCGGGGTTACCGGTTCCGGAAAAACGTTCACCATGTCGA
ATGTGATTGCCAGAGCGGGCAAACCAGTGCTGGTGATCAGTCATAACAAAACGCTCGCCGCGCAGCTTTATGGAGAGTTG
AAGCAGTTTTTTCCTCATAACGCGGTGGAGTACTTCATCAGTTATTACGATTTTTATCAGCCCGAAGCATATATCCCTTC
AATGGACAAGTATATTGCCAAGGACCTGCGTATCAATGAGGAAATTGAGCGGCTGAGGCTCCGGGCGACCAGTGCACTCC
TGTCAGGCCGACGGGATGTTATTGTGGTGAGTTCTGTGAGCTGTATTTACGGCCTGGGCTCGCCCGAAGACTGGATGGCG
CAGATTCTCGAGCTGCGGACAGGTATGGATATGGATCGGGAGGCTTTTCTTCAGCGTTTGGTGGATCTGCATTTTGTCCG
CGATGACATGGAGCTTTCGTCAGGAAAGTTTCGTGTACGCGGCGACGTCATCGATCTGGTCCCTGCCCATGAGGAGGATG
CCCTGCGTGTGGAATTTTACGGCAGTGAAATCGACCGCTTGCAGCTCTTCAATCCCCGGACAGGAGAGATCATAGAGGAG
CAGGAGTATGCCTGTATCTATCCCGCTCGTCAGTTTGTTGCCGATAAAGCACGGCTTGAGGCTGCAATGCTTTCCATTGA
GAATGAACTTGCCGGTCGGCTCAACACCTTTCGTGCAGAAGACCGTCTTGTTGAAGCTCGCAGGCTCGAGGAGCGGACCC
GTTACGATCTTGAAATGATAAAAGAGCTTGGTTACTGTTCCGGGATCGAAAACTACTCGAGCCACCTGTCGGGGCGTAAG
GCGGGCGAGAGACCATACTGCCTGCTTGATTATTTTCAGGATGATTATATGGTCGTTATCGATGAGTCGCATGTAAGTCT
CCCCCAGATACGGGGAATGTATGCCGGGGACCGCTCGCGAAAAACAATTCTGGTTGAGCACGGTTTTCGCCTTCCTTCAG
CTCTCGATAACCGTCCTTTGCGATTCGAGGAGTTTGAAGAGGTCGTTCCCCAGATGATCTGTGTGAGTGCAACGCCCGGC
GATTACGAACTCACTCGTTCACAAGGGGTGGTTGTAGAGCAGCTGGTCAGACCTACCGGACTGCTCGATCCCGAGATAAC
CGTTCGTCCGGTCAGCGGTCAGATCGATAATCTTCTTGAGGAGATCCGTCAGAACACCGCTAAAGGGTTTAAAACTCTTG
TTATGACGATTACCAAGCGGATGAGCGAGGATCTGCATGACTTTCTTCGTAAGGCCGGCGTTCGTTCACGCTACCTGCAT
TCGGAGATCAAGAGTCTTGAACGCATTCAGATTCTGCGGGAACTTCGCGCCGGCGATGTTGATGTTCTGGTCGGGGTTAA
CCTGCTCAGGGAGGGGCTTGATCTTCCCGAGGTAGCCCTTGTAGCGATTCTTGATGCCGATAAACAGGGCTTTCTGCGTG
ATGCCCGTTCTCTTATGCAGATTGCCGGAAGAGCGGCAAGGAATGTTGAGGGACGAGTTGTATTTTACGCAGACAGGATC
ACTCCGTCAATGCGTGAGGTGATCGATGAAACCGACCGGCGCAGAAAAGTGCAGCAGCAGTTCAATGAAGAGCATGGCAT
CGTTCCCCGTTCGATCATCAAGTCTGTTGATCAGGTACTCAATACAACCAGCGTTGCCGATGCCGAAGAGCGTTTCCGGC
GCAAGAGGCTTGGCCTTCAACAGAAAAACGAGCGTCTGCTCGAGGGCGTTATCGATACCTTGAGCCCTGAAGAGCTCTCT
TCCATGGCAGAAGATCTGAAATGTGAAATGCAGGAGGCAGCAGAGAGCATGGAGTATGAAAAAGCAGCGTGGTTGCGTGA
CGAGATTTCCAAAATCGAGCATGCTGCCGGCGGTAGCGCAAAACAACCCTGA

Upstream 100 bases:

>100_bases
AGTGAGGGGAAATGGGATATTTGTTGTTTTCTCCATTACTTTCTTTCGAAACACTAACGGATAACGAATAACGAATAACG
GATAACAAATAACGATACCA

Downstream 100 bases:

>100_bases
TAACCATTACTGAAAACGTTTCCTGAGGTAGTAGCCGATATGTTAGCACAGATCGAAAAAGATCAATATGAAAAACTTCA
CGAGGTTTTAAGGCTTGCTC

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 683; Mature: 682

Protein sequence:

>683_residues
MPDSSDRYRLESSYEPMGDQPGAIDALSAGVRDGEPCQTLLGVTGSGKTFTMSNVIARAGKPVLVISHNKTLAAQLYGEL
KQFFPHNAVEYFISYYDFYQPEAYIPSMDKYIAKDLRINEEIERLRLRATSALLSGRRDVIVVSSVSCIYGLGSPEDWMA
QILELRTGMDMDREAFLQRLVDLHFVRDDMELSSGKFRVRGDVIDLVPAHEEDALRVEFYGSEIDRLQLFNPRTGEIIEE
QEYACIYPARQFVADKARLEAAMLSIENELAGRLNTFRAEDRLVEARRLEERTRYDLEMIKELGYCSGIENYSSHLSGRK
AGERPYCLLDYFQDDYMVVIDESHVSLPQIRGMYAGDRSRKTILVEHGFRLPSALDNRPLRFEEFEEVVPQMICVSATPG
DYELTRSQGVVVEQLVRPTGLLDPEITVRPVSGQIDNLLEEIRQNTAKGFKTLVMTITKRMSEDLHDFLRKAGVRSRYLH
SEIKSLERIQILRELRAGDVDVLVGVNLLREGLDLPEVALVAILDADKQGFLRDARSLMQIAGRAARNVEGRVVFYADRI
TPSMREVIDETDRRRKVQQQFNEEHGIVPRSIIKSVDQVLNTTSVADAEERFRRKRLGLQQKNERLLEGVIDTLSPEELS
SMAEDLKCEMQEAAESMEYEKAAWLRDEISKIEHAAGGSAKQP

Sequences:

>Translated_683_residues
MPDSSDRYRLESSYEPMGDQPGAIDALSAGVRDGEPCQTLLGVTGSGKTFTMSNVIARAGKPVLVISHNKTLAAQLYGEL
KQFFPHNAVEYFISYYDFYQPEAYIPSMDKYIAKDLRINEEIERLRLRATSALLSGRRDVIVVSSVSCIYGLGSPEDWMA
QILELRTGMDMDREAFLQRLVDLHFVRDDMELSSGKFRVRGDVIDLVPAHEEDALRVEFYGSEIDRLQLFNPRTGEIIEE
QEYACIYPARQFVADKARLEAAMLSIENELAGRLNTFRAEDRLVEARRLEERTRYDLEMIKELGYCSGIENYSSHLSGRK
AGERPYCLLDYFQDDYMVVIDESHVSLPQIRGMYAGDRSRKTILVEHGFRLPSALDNRPLRFEEFEEVVPQMICVSATPG
DYELTRSQGVVVEQLVRPTGLLDPEITVRPVSGQIDNLLEEIRQNTAKGFKTLVMTITKRMSEDLHDFLRKAGVRSRYLH
SEIKSLERIQILRELRAGDVDVLVGVNLLREGLDLPEVALVAILDADKQGFLRDARSLMQIAGRAARNVEGRVVFYADRI
TPSMREVIDETDRRRKVQQQFNEEHGIVPRSIIKSVDQVLNTTSVADAEERFRRKRLGLQQKNERLLEGVIDTLSPEELS
SMAEDLKCEMQEAAESMEYEKAAWLRDEISKIEHAAGGSAKQP
>Mature_682_residues
PDSSDRYRLESSYEPMGDQPGAIDALSAGVRDGEPCQTLLGVTGSGKTFTMSNVIARAGKPVLVISHNKTLAAQLYGELK
QFFPHNAVEYFISYYDFYQPEAYIPSMDKYIAKDLRINEEIERLRLRATSALLSGRRDVIVVSSVSCIYGLGSPEDWMAQ
ILELRTGMDMDREAFLQRLVDLHFVRDDMELSSGKFRVRGDVIDLVPAHEEDALRVEFYGSEIDRLQLFNPRTGEIIEEQ
EYACIYPARQFVADKARLEAAMLSIENELAGRLNTFRAEDRLVEARRLEERTRYDLEMIKELGYCSGIENYSSHLSGRKA
GERPYCLLDYFQDDYMVVIDESHVSLPQIRGMYAGDRSRKTILVEHGFRLPSALDNRPLRFEEFEEVVPQMICVSATPGD
YELTRSQGVVVEQLVRPTGLLDPEITVRPVSGQIDNLLEEIRQNTAKGFKTLVMTITKRMSEDLHDFLRKAGVRSRYLHS
EIKSLERIQILRELRAGDVDVLVGVNLLREGLDLPEVALVAILDADKQGFLRDARSLMQIAGRAARNVEGRVVFYADRIT
PSMREVIDETDRRRKVQQQFNEEHGIVPRSIIKSVDQVLNTTSVADAEERFRRKRLGLQQKNERLLEGVIDTLSPEELSS
MAEDLKCEMQEAAESMEYEKAAWLRDEISKIEHAAGGSAKQP

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=670, Percent_Identity=54.4776119402985, Blast_Score=718, Evalue=0.0,
Organism=Escherichia coli, GI1787357, Length=235, Percent_Identity=25.9574468085106, Blast_Score=72, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 77684; Mature: 77553

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDSSDRYRLESSYEPMGDQPGAIDALSAGVRDGEPCQTLLGVTGSGKTFTMSNVIARAG
CCCCCCCEEECCCCCCCCCCCCCHHHHHCCCCCCCHHHHHHCCCCCCCEEEHHHHHHHCC
KPVLVISHNKTLAAQLYGELKQFFPHNAVEYFISYYDFYQPEAYIPSMDKYIAKDLRINE
CCEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCHH
EIERLRLRATSALLSGRRDVIVVSSVSCIYGLGSPEDWMAQILELRTGMDMDREAFLQRL
HHHHHHHHHHHHHHCCCCCEEEEECHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHH
VDLHFVRDDMELSSGKFRVRGDVIDLVPAHEEDALRVEFYGSEIDRLQLFNPRTGEIIEE
HHHHHHHCCHHCCCCCEEEECCEEEECCCCCCCCEEEEEECCCCCEEEECCCCCCCHHCC
QEYACIYPARQFVADKARLEAAMLSIENELAGRLNTFRAEDRLVEARRLEERTRYDLEMI
CCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KELGYCSGIENYSSHLSGRKAGERPYCLLDYFQDDYMVVIDESHVSLPQIRGMYAGDRSR
HHHHHHCCCHHHHHHCCCCCCCCCCEEEEEECCCCEEEEEECCCCCCHHHHCCCCCCCCC
KTILVEHGFRLPSALDNRPLRFEEFEEVVPQMICVSATPGDYELTRSQGVVVEQLVRPTG
CEEEEECCCCCCHHHCCCCCCHHHHHHHHHHHEEEECCCCCCEECCCCCHHHHHHHCCCC
LLDPEITVRPVSGQIDNLLEEIRQNTAKGFKTLVMTITKRMSEDLHDFLRKAGVRSRYLH
CCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
SEIKSLERIQILRELRAGDVDVLVGVNLLREGLDLPEVALVAILDADKQGFLRDARSLMQ
HHHHHHHHHHHHHHHCCCCEEHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHH
IAGRAARNVEGRVVFYADRITPSMREVIDETDRRRKVQQQFNEEHGIVPRSIIKSVDQVL
HHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
NTTSVADAEERFRRKRLGLQQKNERLLEGVIDTLSPEELSSMAEDLKCEMQEAAESMEYE
HHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
KAAWLRDEISKIEHAAGGSAKQP
HHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
PDSSDRYRLESSYEPMGDQPGAIDALSAGVRDGEPCQTLLGVTGSGKTFTMSNVIARAG
CCCCCCEEECCCCCCCCCCCCCHHHHHCCCCCCCHHHHHHCCCCCCCEEEHHHHHHHCC
KPVLVISHNKTLAAQLYGELKQFFPHNAVEYFISYYDFYQPEAYIPSMDKYIAKDLRINE
CCEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCHH
EIERLRLRATSALLSGRRDVIVVSSVSCIYGLGSPEDWMAQILELRTGMDMDREAFLQRL
HHHHHHHHHHHHHHCCCCCEEEEECHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHH
VDLHFVRDDMELSSGKFRVRGDVIDLVPAHEEDALRVEFYGSEIDRLQLFNPRTGEIIEE
HHHHHHHCCHHCCCCCEEEECCEEEECCCCCCCCEEEEEECCCCCEEEECCCCCCCHHCC
QEYACIYPARQFVADKARLEAAMLSIENELAGRLNTFRAEDRLVEARRLEERTRYDLEMI
CCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KELGYCSGIENYSSHLSGRKAGERPYCLLDYFQDDYMVVIDESHVSLPQIRGMYAGDRSR
HHHHHHCCCHHHHHHCCCCCCCCCCEEEEEECCCCEEEEEECCCCCCHHHHCCCCCCCCC
KTILVEHGFRLPSALDNRPLRFEEFEEVVPQMICVSATPGDYELTRSQGVVVEQLVRPTG
CEEEEECCCCCCHHHCCCCCCHHHHHHHHHHHEEEECCCCCCEECCCCCHHHHHHHCCCC
LLDPEITVRPVSGQIDNLLEEIRQNTAKGFKTLVMTITKRMSEDLHDFLRKAGVRSRYLH
CCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
SEIKSLERIQILRELRAGDVDVLVGVNLLREGLDLPEVALVAILDADKQGFLRDARSLMQ
HHHHHHHHHHHHHHHCCCCEEHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHH
IAGRAARNVEGRVVFYADRITPSMREVIDETDRRRKVQQQFNEEHGIVPRSIIKSVDQVL
HHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
NTTSVADAEERFRRKRLGLQQKNERLLEGVIDTLSPEELSSMAEDLKCEMQEAAESMEYE
HHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
KAAWLRDEISKIEHAAGGSAKQP
HHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA