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The map label for this gene is gcvT

Identifier: 194334616

GI number: 194334616

Start: 1983753

End: 1984844

Strand: Reverse

Name: gcvT

Synonym: Paes_1817

Alternate gene names: 194334616

Gene position: 1984844-1983753 (Counterclockwise)

Preceding gene: 194334618

Following gene: 194334615

Centisome position: 78.99

GC content: 52.38

Gene sequence:

>1092_bases
ATGAAAAAAACTGCACTGTATGCCTGGCATGAAGCTGCCGGGGCTAAAATTATCGATTTCGGCGGTTATCTGATGCCGGT
TCAGTATAGCGGAATCATCGCTGAACATACATGTGTCAGAACGTCTGCCGGTCTGTTTGACGTCTCACATATGGGGAACT
TCATGGTCAAGGGGAGAGGCGCAAAAGCGTTTCTGCAGCATATGACCTCAAATGATGTCGACAAGCTTTCGGACGGCCAG
GCCCAGTATACCCTGCTGCTCTATCCTGAGGGAGGCATCGTTGATGATCTTATTATCTACCGTATAGATGCCGACACCTG
GTTTATGGTGGTCAACGCAAGCAACATGGAAAAAGATTATTCCTGGCTGCAGGAACATCTTGGATCGTTTGAAGGGGTTC
AGCTCGAAAATCACACGGAGGAACTCTCTTTGATAGCCTTGCAGGGTCCTCGATCAATGGAGATTCTCGATCGCGTTTTT
ACAGGAGGTGAATGCAGTGGGATCAAGCCGTTTCACTTCCGAACCGTGCCGTTCAACGGCAGGGAGGTGATCGTCGCTGC
CACGGGATATACCGGAGAGCGTGGTGTTGAGATTTCCGTTCCCAACGACGCGGCAACAGCACTCTGGGTCGCGTTGATGG
AGGCCGGCAGTGCTGACGGTATTCAGCCTATCGGTTTAGGGGCGCGCGATACGCTTCGCCTCGAAATGGGCTATCCTCTC
TACGGCCATGAAATCAATCGGGAGACGAGTCCCATCGAAGCGCGGCTGAAGTGGGTGACCAGGCTCGACAAGGGAAATTT
TGTCGGCAGGGAGTCCTGTGTTGCTGTCGACATCAATCCGCAACGTACGGTTGTCGGTTTCATGATGCATGAACGGGCAA
TTCCCCGTCAGGGCTTTACTGTCTACAATCGCGACCGTAAACCGCTTGGCTCGGTATGCAGTGGAACGATGTCTCCTACG
CTCAAACAGCCGATCGGTACCGCTGATGTGCCGCGCGGCTATATGAAGAGCGGAACACCGCTCTATCTGGAAGTCAGGGG
AAAGTTCTATAAAGGAGAGGTTGTCAAACTTCCATTTGTCAACAGAGCCTGA

Upstream 100 bases:

>100_bases
CAGTACGAAACATCCCAACATCTTTTTTGAACGTGACTTGAACGTGTTCGTCAGAAAAACACGTCGACAGGTCTTTTGCA
ACTGAGCAATACACACATTT

Downstream 100 bases:

>100_bases
CAGCATACGCCTGTCGGGCAAGGCTTAACGATTGATAGGGACCAGATGGATAACGCACACTATGTCAATGAACAAGGAAA
CGATTAAAAAAGAATTTTCA

Product: glycine cleavage system aminomethyltransferase T

Products: NA

Alternate protein names: Glycine cleavage system T protein

Number of amino acids: Translated: 363; Mature: 363

Protein sequence:

>363_residues
MKKTALYAWHEAAGAKIIDFGGYLMPVQYSGIIAEHTCVRTSAGLFDVSHMGNFMVKGRGAKAFLQHMTSNDVDKLSDGQ
AQYTLLLYPEGGIVDDLIIYRIDADTWFMVVNASNMEKDYSWLQEHLGSFEGVQLENHTEELSLIALQGPRSMEILDRVF
TGGECSGIKPFHFRTVPFNGREVIVAATGYTGERGVEISVPNDAATALWVALMEAGSADGIQPIGLGARDTLRLEMGYPL
YGHEINRETSPIEARLKWVTRLDKGNFVGRESCVAVDINPQRTVVGFMMHERAIPRQGFTVYNRDRKPLGSVCSGTMSPT
LKQPIGTADVPRGYMKSGTPLYLEVRGKFYKGEVVKLPFVNRA

Sequences:

>Translated_363_residues
MKKTALYAWHEAAGAKIIDFGGYLMPVQYSGIIAEHTCVRTSAGLFDVSHMGNFMVKGRGAKAFLQHMTSNDVDKLSDGQ
AQYTLLLYPEGGIVDDLIIYRIDADTWFMVVNASNMEKDYSWLQEHLGSFEGVQLENHTEELSLIALQGPRSMEILDRVF
TGGECSGIKPFHFRTVPFNGREVIVAATGYTGERGVEISVPNDAATALWVALMEAGSADGIQPIGLGARDTLRLEMGYPL
YGHEINRETSPIEARLKWVTRLDKGNFVGRESCVAVDINPQRTVVGFMMHERAIPRQGFTVYNRDRKPLGSVCSGTMSPT
LKQPIGTADVPRGYMKSGTPLYLEVRGKFYKGEVVKLPFVNRA
>Mature_363_residues
MKKTALYAWHEAAGAKIIDFGGYLMPVQYSGIIAEHTCVRTSAGLFDVSHMGNFMVKGRGAKAFLQHMTSNDVDKLSDGQ
AQYTLLLYPEGGIVDDLIIYRIDADTWFMVVNASNMEKDYSWLQEHLGSFEGVQLENHTEELSLIALQGPRSMEILDRVF
TGGECSGIKPFHFRTVPFNGREVIVAATGYTGERGVEISVPNDAATALWVALMEAGSADGIQPIGLGARDTLRLEMGYPL
YGHEINRETSPIEARLKWVTRLDKGNFVGRESCVAVDINPQRTVVGFMMHERAIPRQGFTVYNRDRKPLGSVCSGTMSPT
LKQPIGTADVPRGYMKSGTPLYLEVRGKFYKGEVVKLPFVNRA

Specific function: The glycine cleavage system catalyzes the degradation of glycine

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family

Homologues:

Organism=Homo sapiens, GI44662838, Length=371, Percent_Identity=33.6927223719677, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI257796258, Length=361, Percent_Identity=32.6869806094183, Blast_Score=162, Evalue=4e-40,
Organism=Homo sapiens, GI257796256, Length=312, Percent_Identity=33.0128205128205, Blast_Score=135, Evalue=4e-32,
Organism=Homo sapiens, GI257796254, Length=369, Percent_Identity=30.3523035230352, Blast_Score=132, Evalue=5e-31,
Organism=Homo sapiens, GI24797151, Length=332, Percent_Identity=24.3975903614458, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI194306651, Length=266, Percent_Identity=25.5639097744361, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI197927446, Length=362, Percent_Identity=25.6906077348066, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI21361378, Length=362, Percent_Identity=25.6906077348066, Blast_Score=97, Evalue=3e-20,
Organism=Escherichia coli, GI1789272, Length=368, Percent_Identity=37.7717391304348, Blast_Score=236, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI17560118, Length=374, Percent_Identity=36.3636363636364, Blast_Score=182, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI71994045, Length=315, Percent_Identity=27.6190476190476, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71994052, Length=315, Percent_Identity=27.6190476190476, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI32563613, Length=257, Percent_Identity=27.6264591439689, Blast_Score=85, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6320222, Length=381, Percent_Identity=35.6955380577428, Blast_Score=203, Evalue=3e-53,
Organism=Drosophila melanogaster, GI20129441, Length=375, Percent_Identity=34.9333333333333, Blast_Score=195, Evalue=5e-50,
Organism=Drosophila melanogaster, GI28571104, Length=258, Percent_Identity=24.8062015503876, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI20130091, Length=354, Percent_Identity=22.0338983050847, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): GCST_PROA2 (B4S437)

Other databases:

- EMBL:   CP001108
- RefSeq:   YP_002016476.1
- ProteinModelPortal:   B4S437
- SMR:   B4S437
- GeneID:   6460267
- GenomeReviews:   CP001108_GR
- KEGG:   paa:Paes_1817
- HOGENOM:   HBG299834
- OMA:   KALYGGM
- ProtClustDB:   PRK00389
- GO:   GO:0005737
- HAMAP:   MF_00259
- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903
- PIRSF:   PIRSF006487
- TIGRFAMs:   TIGR00528

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C

EC number: =2.1.2.10

Molecular weight: Translated: 40168; Mature: 40168

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKTALYAWHEAAGAKIIDFGGYLMPVQYSGIIAEHTCVRTSAGLFDVSHMGNFMVKGRG
CCCCEEEEEECCCCCEEEECCCEEEEEEECCEEEECEEEECCCCEEEHHHCCCEEEECCC
AKAFLQHMTSNDVDKLSDGQAQYTLLLYPEGGIVDDLIIYRIDADTWFMVVNASNMEKDY
HHHHHHHHCCCCHHHCCCCCEEEEEEEECCCCCCCEEEEEEECCCEEEEEEECCCCHHHH
SWLQEHLGSFEGVQLENHTEELSLIALQGPRSMEILDRVFTGGECSGIKPFHFRTVPFNG
HHHHHHCCCCCCEEECCCCCEEEEEEECCCCHHHHHHHHHCCCCCCCCCCEEEEECCCCC
REVIVAATGYTGERGVEISVPNDAATALWVALMEAGSADGIQPIGLGARDTLRLEMGYPL
CEEEEEEECCCCCCCEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCE
YGHEINRETSPIEARLKWVTRLDKGNFVGRESCVAVDINPQRTVVGFMMHERAIPRQGFT
ECCCCCCCCCCHHHHHHHHHEECCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCE
VYNRDRKPLGSVCSGTMSPTLKQPIGTADVPRGYMKSGTPLYLEVRGKFYKGEVVKLPFV
EEECCCCCHHHHHCCCCCCHHHCCCCCCCCCCCHHCCCCEEEEEECCEEECCCEEEECCC
NRA
CCC
>Mature Secondary Structure
MKKTALYAWHEAAGAKIIDFGGYLMPVQYSGIIAEHTCVRTSAGLFDVSHMGNFMVKGRG
CCCCEEEEEECCCCCEEEECCCEEEEEEECCEEEECEEEECCCCEEEHHHCCCEEEECCC
AKAFLQHMTSNDVDKLSDGQAQYTLLLYPEGGIVDDLIIYRIDADTWFMVVNASNMEKDY
HHHHHHHHCCCCHHHCCCCCEEEEEEEECCCCCCCEEEEEEECCCEEEEEEECCCCHHHH
SWLQEHLGSFEGVQLENHTEELSLIALQGPRSMEILDRVFTGGECSGIKPFHFRTVPFNG
HHHHHHCCCCCCEEECCCCCEEEEEEECCCCHHHHHHHHHCCCCCCCCCCEEEEECCCCC
REVIVAATGYTGERGVEISVPNDAATALWVALMEAGSADGIQPIGLGARDTLRLEMGYPL
CEEEEEEECCCCCCCEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCE
YGHEINRETSPIEARLKWVTRLDKGNFVGRESCVAVDINPQRTVVGFMMHERAIPRQGFT
ECCCCCCCCCCHHHHHHHHHEECCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCE
VYNRDRKPLGSVCSGTMSPTLKQPIGTADVPRGYMKSGTPLYLEVRGKFYKGEVVKLPFV
EEECCCCCHHHHHCCCCCCHHHCCCCCCCCCCCHHCCCCEEEEEECCEEECCCEEEECCC
NRA
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA