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The map label for this gene is wecA [H]

Identifier: 194334569

GI number: 194334569

Start: 1928930

End: 1930114

Strand: Reverse

Name: wecA [H]

Synonym: Paes_1769

Alternate gene names: 194334569

Gene position: 1930114-1928930 (Counterclockwise)

Preceding gene: 194334570

Following gene: 194334568

Centisome position: 76.81

GC content: 57.89

Gene sequence:

>1185_bases
ATGACCCCCTACTACCTAACCCCCATCCCGCTCCTGGCGCTCGCGTCGTGCAGCGCGCTCTTCACCGGCAACGGTGACGA
CGCCCAGCAGGCAGCAATCGTCCCGTTCGGGCAATATCTGGGCATCTATCTCGTCGCCCTGACCGTCGCCTACGGAATGA
TCCTCTTCCTGACGATACACGCCGAAAAGCTCGGCTTCATCGACCACCCTGACGGCATCCGTAAAATTCACACGGTAGCC
AAACCGCTTGTTGGCGGTATCGGCGTGATCACCGCCGTGGTGATCTCGATGTTCGTTTTTGTTCCGGTGGTGCAGTATCT
CGGCCTCATCATCGCCATGCTCATGGTCGGCACCGTCGGTGCGCTCGACGACCGCCACGACCTGCACTTCAAAGTCCGTT
TTATCGTCCAGATCGCCGCAACCGTCGCCATCATGACCCTGGGAGGTACGGTCCTGCACTCCTTCGGCAACCTGGTTGGT
TTGGGTGTCATATCGACAGGCTTTCTCGCCTATGTCATTACCATCTTCTGCGTGCTTGGCGTGATTAACGCGGTCAATAT
GATCGACGGCCTCGACGGCCTTGCCGGCGGCACCTCGCTCGTCGCCTTCAGCGCCTTCGGGATGCTCGCCTGGCTCAACG
GCCAGCTTGAACTGATGCTGATCAGTGTTGCCTTTGTCGGAGCCCTTGCTGCATTCCTGCGCTTCAACTGGTTTCCGTCC
AAACTCTTCATGGGCGACGCCGGCAGTATGACCCTCGGCTTCGTCCTCGCCTTCTTCGCTATCGAAGTGAGTCAGAAAGC
AGGAAGCATCGTCTCCCCGGTCGCCGCGCTGCTCATCCTGGCGCTGCCGATCACCGATACGATCACCGTCATGATCAAAC
GGGTCCTGAAAGGCCAAAGCCCTTTCCACCCCGACAAAACGCACCTGCACCACATCCTCAAAGCCATGGGCGTCAACCAC
CACAAAGTCGTCATCGTCATGATCGCCGCAACCGTTGTCTCGTCCGCCATCGCCGTGATAGGAACCTTGCTGCAGCTGCC
CGACTACGCATTCTTCAGCATCTACCTCGCCTGCTTCACCACATATTTTTTAGCATCATACCGAATCAAAGGAATCTACC
GAAGACTCATCTGGCTCAGGCAGCAGCGGGTGTTTAACGTAGAGTTGGGGGAGGTACTGCGATAG

Upstream 100 bases:

>100_bases
TGCCTCTCGATCACCGGTCTCTCAAGTTAAAGGCATTCTTGTTTCAAGTCTCAAGTCTCGTTCTCCCCCCCTCAACGTTT
ACCACCAAGGAGATCGCAAA

Downstream 100 bases:

>100_bases
CAGGGGAGTGCCGAGTTCTGAGTTCTGAGATAGGGAGGAAGTGCTAAGTCCGTAGTACTAAGAGCTCAGAACTCTTTTCT
CCGAACAGAGAACTAAGCAC

Product: glycosyl transferase family 4

Products: UMP; Undecaprenyl N-Acetyl-Alpha-D-Glucosaminyl Pyrophosphate. [C]

Alternate protein names: UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase; Undecaprenyl-phosphate GlcNAc-1-phosphate transferase [H]

Number of amino acids: Translated: 394; Mature: 393

Protein sequence:

>394_residues
MTPYYLTPIPLLALASCSALFTGNGDDAQQAAIVPFGQYLGIYLVALTVAYGMILFLTIHAEKLGFIDHPDGIRKIHTVA
KPLVGGIGVITAVVISMFVFVPVVQYLGLIIAMLMVGTVGALDDRHDLHFKVRFIVQIAATVAIMTLGGTVLHSFGNLVG
LGVISTGFLAYVITIFCVLGVINAVNMIDGLDGLAGGTSLVAFSAFGMLAWLNGQLELMLISVAFVGALAAFLRFNWFPS
KLFMGDAGSMTLGFVLAFFAIEVSQKAGSIVSPVAALLILALPITDTITVMIKRVLKGQSPFHPDKTHLHHILKAMGVNH
HKVVIVMIAATVVSSAIAVIGTLLQLPDYAFFSIYLACFTTYFLASYRIKGIYRRLIWLRQQRVFNVELGEVLR

Sequences:

>Translated_394_residues
MTPYYLTPIPLLALASCSALFTGNGDDAQQAAIVPFGQYLGIYLVALTVAYGMILFLTIHAEKLGFIDHPDGIRKIHTVA
KPLVGGIGVITAVVISMFVFVPVVQYLGLIIAMLMVGTVGALDDRHDLHFKVRFIVQIAATVAIMTLGGTVLHSFGNLVG
LGVISTGFLAYVITIFCVLGVINAVNMIDGLDGLAGGTSLVAFSAFGMLAWLNGQLELMLISVAFVGALAAFLRFNWFPS
KLFMGDAGSMTLGFVLAFFAIEVSQKAGSIVSPVAALLILALPITDTITVMIKRVLKGQSPFHPDKTHLHHILKAMGVNH
HKVVIVMIAATVVSSAIAVIGTLLQLPDYAFFSIYLACFTTYFLASYRIKGIYRRLIWLRQQRVFNVELGEVLR
>Mature_393_residues
TPYYLTPIPLLALASCSALFTGNGDDAQQAAIVPFGQYLGIYLVALTVAYGMILFLTIHAEKLGFIDHPDGIRKIHTVAK
PLVGGIGVITAVVISMFVFVPVVQYLGLIIAMLMVGTVGALDDRHDLHFKVRFIVQIAATVAIMTLGGTVLHSFGNLVGL
GVISTGFLAYVITIFCVLGVINAVNMIDGLDGLAGGTSLVAFSAFGMLAWLNGQLELMLISVAFVGALAAFLRFNWFPSK
LFMGDAGSMTLGFVLAFFAIEVSQKAGSIVSPVAALLILALPITDTITVMIKRVLKGQSPFHPDKTHLHHILKAMGVNHH
KVVIVMIAATVVSSAIAVIGTLLQLPDYAFFSIYLACFTTYFLASYRIKGIYRRLIWLRQQRVFNVELGEVLR

Specific function: Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP- C55). It is the first lipid-linked intermediate involved in enterobacter

COG id: COG0472

COG function: function code M; UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 4 family. WecA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790218, Length=285, Percent_Identity=35.7894736842105, Blast_Score=181, Evalue=5e-47,
Organism=Escherichia coli, GI1786275, Length=315, Percent_Identity=27.9365079365079, Blast_Score=74, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012750
- InterPro:   IPR000715 [H]

Pfam domain/function: PF00953 Glycos_transf_4 [H]

EC number: 2.7.8.- [C]

Molecular weight: Translated: 42479; Mature: 42347

Theoretical pI: Translated: 9.22; Mature: 9.22

Prosite motif: PS01348 MRAY_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCC
>Mature Secondary Structure 
TPYYLTPIPLLALASCSALFTGNGDDAQQAAIVPFGQYLGIYLVALTVAYGMILFLTIH
CCCCCCHHHHHHHHHHHHHEECCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH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HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-Acetyl-D-Glucosamine; Undecaprenyl Phosphate [C]

Specific reaction: UDP-N-Acetyl-D-Glucosamine + Undecaprenyl Phosphate = UMP + Undecaprenyl N-Acetyl-Alpha-D-Glucosaminyl Pyrophosphate. [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]