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The map label for this gene is rmlA1 [H]

Identifier: 194334562

GI number: 194334562

Start: 1921041

End: 1921937

Strand: Reverse

Name: rmlA1 [H]

Synonym: Paes_1760

Alternate gene names: 194334562

Gene position: 1921937-1921041 (Counterclockwise)

Preceding gene: 194334563

Following gene: 194334561

Centisome position: 76.48

GC content: 56.19

Gene sequence:

>897_bases
ATGAAAGGAATTATTCTTGCCGGGGGATCGGGTACGCGGTTGTATCCGGTGACGAAGGCGGTGTCGAAGCAGCTGCTGCC
GATCTATGACAAGCCGATGATCTATTATCCGCTGAGTACGTTGATGCTGGCGGGGATCCGGGAGGTGCTGGTGATTTCGA
CGCCTCAGGATCTGCCGTTGTTTGAGCGGATGCTCGGCGACGGGAGTGACTGGGGGATCAGTTTGTCGTATATGGAGCAG
CCGTCGCCGGATGGGCTGGCGCAGGCTTTTCTGCTGGGCGAGTCGTTTATCGGCGGCGATGATGTGTCGCTGATTCTGGG
GGATAATATCTTTTTCGGGTACGGCTTCAGCGGTATGCTGCGCGATGCGGTGGAGAGCGTTCGTGAGGAGCGTGTGGCAA
ATATTTTCGGGTATTATGTCAATGATCCGGAGCGGTATGGCGTTGCGGAGTTCGATGAGTCGGGCAGGGTGCTGTCGATC
GAGGAGAAGCCGTTGCTGCCGAAGTCGAATTATGCGGTTGTTGGGTTGTATTTCTATACGAACGATGTGGTTGCGGTGGC
TAAAAACGTGAAGCCGTCGGCACGGGGCGAACTGGAGATTACGTCGGTGAACGAGGAGTACCTGCGTCGGGACCGGTTGA
AGATGTCGATCATGGGCCGTGGGTTTGCGTGGCTGGATACGGGGACGCACGAGTCGTTTCAGGAGGCGGGAAATTTTATC
GAGACGGTGGAGAAGCGCCAGGGTCTGAAGATCGCTTGTCCGGAGGAGATTGCGTGGCGCAACAAGTGGATAGATGACGC
CCAGCTTGAGGAACTGGCCCGCCCGCTCCTGAAAAGCCAGTACGGGGAGTACTTGATGAGTTTGTTCGAGCAAAAGCAGG
AGCTTGTTGAAGTATAG

Upstream 100 bases:

>100_bases
AAGGCTTAGAGAGGACGTTAAAATATGAGTTTATAGATAATCACTCTGATCAACCTGTATTTTTTACAGAATAAATAGCT
TATCAGAAGGATTTTAAGAA

Downstream 100 bases:

>100_bases
ATTTGTTCTGCTGTTTTTCCTTTCTTTTCCCTCATTTCATTTTACTCTGTCATTTCTATGAATGTTATTTCAACATTGAT
TCCTGATGTGTTGATATTTG

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: G1P-TT 1; dTDP-glucose pyrophosphorylase 1; dTDP-glucose synthase 1 [H]

Number of amino acids: Translated: 298; Mature: 298

Protein sequence:

>298_residues
MKGIILAGGSGTRLYPVTKAVSKQLLPIYDKPMIYYPLSTLMLAGIREVLVISTPQDLPLFERMLGDGSDWGISLSYMEQ
PSPDGLAQAFLLGESFIGGDDVSLILGDNIFFGYGFSGMLRDAVESVREERVANIFGYYVNDPERYGVAEFDESGRVLSI
EEKPLLPKSNYAVVGLYFYTNDVVAVAKNVKPSARGELEITSVNEEYLRRDRLKMSIMGRGFAWLDTGTHESFQEAGNFI
ETVEKRQGLKIACPEEIAWRNKWIDDAQLEELARPLLKSQYGEYLMSLFEQKQELVEV

Sequences:

>Translated_298_residues
MKGIILAGGSGTRLYPVTKAVSKQLLPIYDKPMIYYPLSTLMLAGIREVLVISTPQDLPLFERMLGDGSDWGISLSYMEQ
PSPDGLAQAFLLGESFIGGDDVSLILGDNIFFGYGFSGMLRDAVESVREERVANIFGYYVNDPERYGVAEFDESGRVLSI
EEKPLLPKSNYAVVGLYFYTNDVVAVAKNVKPSARGELEITSVNEEYLRRDRLKMSIMGRGFAWLDTGTHESFQEAGNFI
ETVEKRQGLKIACPEEIAWRNKWIDDAQLEELARPLLKSQYGEYLMSLFEQKQELVEV
>Mature_298_residues
MKGIILAGGSGTRLYPVTKAVSKQLLPIYDKPMIYYPLSTLMLAGIREVLVISTPQDLPLFERMLGDGSDWGISLSYMEQ
PSPDGLAQAFLLGESFIGGDDVSLILGDNIFFGYGFSGMLRDAVESVREERVANIFGYYVNDPERYGVAEFDESGRVLSI
EEKPLLPKSNYAVVGLYFYTNDVVAVAKNVKPSARGELEITSVNEEYLRRDRLKMSIMGRGFAWLDTGTHESFQEAGNFI
ETVEKRQGLKIACPEEIAWRNKWIDDAQLEELARPLLKSQYGEYLMSLFEQKQELVEV

Specific function: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=253, Percent_Identity=24.901185770751, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI11761619, Length=253, Percent_Identity=24.901185770751, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1788351, Length=287, Percent_Identity=67.595818815331, Blast_Score=415, Evalue=1e-117,
Organism=Escherichia coli, GI1790224, Length=292, Percent_Identity=64.041095890411, Blast_Score=387, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI133931050, Length=240, Percent_Identity=25.8333333333333, Blast_Score=73, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6320148, Length=282, Percent_Identity=25.886524822695, Blast_Score=69, Evalue=7e-13,
Organism=Drosophila melanogaster, GI21355443, Length=238, Percent_Identity=23.9495798319328, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24644084, Length=238, Percent_Identity=23.9495798319328, Blast_Score=75, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005907
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 33488; Mature: 33488

Theoretical pI: Translated: 4.42; Mature: 4.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGIILAGGSGTRLYPVTKAVSKQLLPIYDKPMIYYPLSTLMLAGIREVLVISTPQDLPL
CCCEEEECCCCCEEEEHHHHHHHCCCCCCCCCEEEECHHHHHHHHHHHEEEEECCCCCHH
FERMLGDGSDWGISLSYMEQPSPDGLAQAFLLGESFIGGDDVSLILGDNIFFGYGFSGML
HHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHCCCCCCCCEEEEEECCEEEECCHHHHH
RDAVESVREERVANIFGYYVNDPERYGVAEFDESGRVLSIEEKPLLPKSNYAVVGLYFYT
HHHHHHHHHHHHHHHHHEECCCHHHCCCCEECCCCCEEEECCCCCCCCCCCEEEEEEEEE
NDVVAVAKNVKPSARGELEITSVNEEYLRRDRLKMSIMGRGFAWLDTGTHESFQEAGNFI
CCHHHHHHCCCCCCCCCEEEEECCHHHHHHHHHHEEECCCCEEEEECCCHHHHHHHHHHH
ETVEKRQGLKIACPEEIAWRNKWIDDAQLEELARPLLKSQYGEYLMSLFEQKQELVEV
HHHHHHCCCEEECCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKGIILAGGSGTRLYPVTKAVSKQLLPIYDKPMIYYPLSTLMLAGIREVLVISTPQDLPL
CCCEEEECCCCCEEEEHHHHHHHCCCCCCCCCEEEECHHHHHHHHHHHEEEEECCCCCHH
FERMLGDGSDWGISLSYMEQPSPDGLAQAFLLGESFIGGDDVSLILGDNIFFGYGFSGML
HHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHCCCCCCCCEEEEEECCEEEECCHHHHH
RDAVESVREERVANIFGYYVNDPERYGVAEFDESGRVLSIEEKPLLPKSNYAVVGLYFYT
HHHHHHHHHHHHHHHHHEECCCHHHCCCCEECCCCCEEEECCCCCCCCCCCEEEEEEEEE
NDVVAVAKNVKPSARGELEITSVNEEYLRRDRLKMSIMGRGFAWLDTGTHESFQEAGNFI
CCHHHHHHCCCCCCCCCEEEEECCHHHHHHHHHHEEECCCCEEEEECCCHHHHHHHHHHH
ETVEKRQGLKIACPEEIAWRNKWIDDAQLEELARPLLKSQYGEYLMSLFEQKQELVEV
HHHHHHCCCEEECCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7517391; 9097040; 9278503; 7517390 [H]