Click here to switch to the map view.

The map label for this gene is rfbB [H]

Identifier: 194334560

GI number: 194334560

Start: 1919329

End: 1920396

Strand: Reverse

Name: rfbB [H]

Synonym: Paes_1758

Alternate gene names: 194334560

Gene position: 1920396-1919329 (Counterclockwise)

Preceding gene: 194334561

Following gene: 194334559

Centisome position: 76.42

GC content: 51.03

Gene sequence:

>1068_bases
ATGGATGATTTATTTATGAAAAATATTCTTGTTACAGGCGGAGCCGGGTTTATCGGGTCACATGTGGTGCGGCGGTTTGT
CAATGCGTATCCGGAGTACCGGATAACGAATCTTGATGCGTTGACGTATGCGGGGAATCTGGAGAACCTTCGCGATGTGG
AGGATCGTGAGAACTACCGGTTCGTGAAGGGGGATATCACGGACGGTGAGGCGATGATGGCGCTGTTCCGCGAGGAGGCG
TTTGACGGGGTAGTCCATCTGGCTGCGGAGTCGCATGTGGACCGCTCGATTGCCAATCCTTCAGCATTTGTGATGACGAA
CGTGATTGGGACTGTGAATCTGCTGAATGCGGCTCGTACAGCATGGGCCGATGGGTTTGAGGGGAAGTTGTTTTACCATA
TTTCGACGGATGAGGTGTATGGGACGCTGGGGTCTGACGGGATGTTTACGGAGGAGACGGCGTATGATCCGCACAGTCCG
TATTCGGCGTCGAAGGCGTCGTCGGATCATTTTGTTCGAGCCTATCACGATACCTACGGGCTGCCGGCAGTCATCAGTAA
CTGCTCGAATAACTATGGATCATTCCAGTTTCCCGAGAAACTCATTCCGCTTTTTATCAATAATATCTGCAACAACAAGC
CGTTACCGGTCTATGGAAAGGGCGAAAATATACGCGACTGGCTCTGGGTGGTTGATCACGCGAGCGCGATTGACGTGATC
TATCATAACGGGAAACAGGGAGAGACCTACAATATCGGTGGAAATAATGAGTGGACGAACATCGCGCTTATCAGATTGCT
CTGCGGCATTATGGACAGGAAGCTCGGGCGTTCTGAGGGAGAGTCGGAGAAACTGATCAGCTATGTGACCGACAGGGCTG
GTCATGATTTCCGGTACGCGATCGATTCTTCGAAGCTCCAGCAGGAACTGGGATGGACTCCATCAAGTCGATTCGAGGAG
GGGCTGGAGAAAACGGTTGATTGGTATCTCGCTAATAGCGAGTGGCTTGAACGTGTCACTTCGAAAGCTTATCGGAGGTA
TTACAAGGAAACGTATGGTATTCATTAA

Upstream 100 bases:

>100_bases
TACAGGTATCACAGAAGGATGCTACTCAACCGCTGTTGGACGAGTCTTATCTGTTTTCCTATGAGAGCTTTAAGAAAGAA
GCTGTTTACCCCCAACGTTG

Downstream 100 bases:

>100_bases
ACTGGGTATTTTTAATAAATCAAATAAGTTCTATGATTTCATATAAAATATCGCATCTCAAACAACTTGAGGCTGAGTCC
ATCCATATCATCCGAGAAGT

Product: dTDP-glucose 4,6-dehydratase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 355; Mature: 355

Protein sequence:

>355_residues
MDDLFMKNILVTGGAGFIGSHVVRRFVNAYPEYRITNLDALTYAGNLENLRDVEDRENYRFVKGDITDGEAMMALFREEA
FDGVVHLAAESHVDRSIANPSAFVMTNVIGTVNLLNAARTAWADGFEGKLFYHISTDEVYGTLGSDGMFTEETAYDPHSP
YSASKASSDHFVRAYHDTYGLPAVISNCSNNYGSFQFPEKLIPLFINNICNNKPLPVYGKGENIRDWLWVVDHASAIDVI
YHNGKQGETYNIGGNNEWTNIALIRLLCGIMDRKLGRSEGESEKLISYVTDRAGHDFRYAIDSSKLQQELGWTPSSRFEE
GLEKTVDWYLANSEWLERVTSKAYRRYYKETYGIH

Sequences:

>Translated_355_residues
MDDLFMKNILVTGGAGFIGSHVVRRFVNAYPEYRITNLDALTYAGNLENLRDVEDRENYRFVKGDITDGEAMMALFREEA
FDGVVHLAAESHVDRSIANPSAFVMTNVIGTVNLLNAARTAWADGFEGKLFYHISTDEVYGTLGSDGMFTEETAYDPHSP
YSASKASSDHFVRAYHDTYGLPAVISNCSNNYGSFQFPEKLIPLFINNICNNKPLPVYGKGENIRDWLWVVDHASAIDVI
YHNGKQGETYNIGGNNEWTNIALIRLLCGIMDRKLGRSEGESEKLISYVTDRAGHDFRYAIDSSKLQQELGWTPSSRFEE
GLEKTVDWYLANSEWLERVTSKAYRRYYKETYGIH
>Mature_355_residues
MDDLFMKNILVTGGAGFIGSHVVRRFVNAYPEYRITNLDALTYAGNLENLRDVEDRENYRFVKGDITDGEAMMALFREEA
FDGVVHLAAESHVDRSIANPSAFVMTNVIGTVNLLNAARTAWADGFEGKLFYHISTDEVYGTLGSDGMFTEETAYDPHSP
YSASKASSDHFVRAYHDTYGLPAVISNCSNNYGSFQFPEKLIPLFINNICNNKPLPVYGKGENIRDWLWVVDHASAIDVI
YHNGKQGETYNIGGNNEWTNIALIRLLCGIMDRKLGRSEGESEKLISYVTDRAGHDFRYAIDSSKLQQELGWTPSSRFEE
GLEKTVDWYLANSEWLERVTSKAYRRYYKETYGIH

Specific function: Catalyzes the dehydration of dTDP-D-glucose to form dTDP-6-deoxy-D-xylo-4-hexulose via a three-step process involving oxidation, dehydration and reduction [H]

COG id: COG1088

COG function: function code M; dTDP-D-glucose 4,6-dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family. dTDP-glucose dehydratase subfamily [H]

Homologues:

Organism=Homo sapiens, GI7657641, Length=329, Percent_Identity=41.3373860182371, Blast_Score=254, Evalue=8e-68,
Organism=Homo sapiens, GI42516563, Length=344, Percent_Identity=24.7093023255814, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI56237023, Length=360, Percent_Identity=26.3888888888889, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI56118217, Length=360, Percent_Identity=26.3888888888889, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI189083684, Length=360, Percent_Identity=26.3888888888889, Blast_Score=76, Evalue=5e-14,
Organism=Escherichia coli, GI1788353, Length=357, Percent_Identity=52.9411764705882, Blast_Score=374, Evalue=1e-105,
Organism=Escherichia coli, GI48994969, Length=348, Percent_Identity=53.1609195402299, Blast_Score=356, Evalue=1e-99,
Organism=Escherichia coli, GI1788366, Length=291, Percent_Identity=26.4604810996564, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI1786974, Length=352, Percent_Identity=25.8522727272727, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17568069, Length=325, Percent_Identity=35.3846153846154, Blast_Score=201, Evalue=4e-52,
Organism=Caenorhabditis elegans, GI115532424, Length=326, Percent_Identity=32.8220858895706, Blast_Score=170, Evalue=8e-43,
Organism=Caenorhabditis elegans, GI71982035, Length=361, Percent_Identity=26.8698060941828, Blast_Score=85, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI71982038, Length=361, Percent_Identity=26.3157894736842, Blast_Score=84, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17539532, Length=331, Percent_Identity=23.5649546827795, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21356223, Length=352, Percent_Identity=25.8522727272727, Blast_Score=81, Evalue=9e-16,
Organism=Drosophila melanogaster, GI19923002, Length=357, Percent_Identity=26.3305322128852, Blast_Score=79, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005888
- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =4.2.1.46 [H]

Molecular weight: Translated: 40181; Mature: 40181

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDDLFMKNILVTGGAGFIGSHVVRRFVNAYPEYRITNLDALTYAGNLENLRDVEDRENYR
CCCHHHHHHHEECCCHHHHHHHHHHHHHCCCCCEEECCHHEEECCCCHHHHCCCCCCCEE
FVKGDITDGEAMMALFREEAFDGVVHLAAESHVDRSIANPSAFVMTNVIGTVNLLNAART
EEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
AWADGFEGKLFYHISTDEVYGTLGSDGMFTEETAYDPHSPYSASKASSDHFVRAYHDTYG
HHCCCCCCEEEEEEECHHHEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEHHHCCC
LPAVISNCSNNYGSFQFPEKLIPLFINNICNNKPLPVYGKGENIRDWLWVVDHASAIDVI
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHCCCEEEEE
YHNGKQGETYNIGGNNEWTNIALIRLLCGIMDRKLGRSEGESEKLISYVTDRAGHDFRYA
EECCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCEEEE
IDSSKLQQELGWTPSSRFEEGLEKTVDWYLANSEWLERVTSKAYRRYYKETYGIH
CCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MDDLFMKNILVTGGAGFIGSHVVRRFVNAYPEYRITNLDALTYAGNLENLRDVEDRENYR
CCCHHHHHHHEECCCHHHHHHHHHHHHHCCCCCEEECCHHEEECCCCHHHHCCCCCCCEE
FVKGDITDGEAMMALFREEAFDGVVHLAAESHVDRSIANPSAFVMTNVIGTVNLLNAART
EEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
AWADGFEGKLFYHISTDEVYGTLGSDGMFTEETAYDPHSPYSASKASSDHFVRAYHDTYG
HHCCCCCCEEEEEEECHHHEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEHHHCCC
LPAVISNCSNNYGSFQFPEKLIPLFINNICNNKPLPVYGKGENIRDWLWVVDHASAIDVI
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHCCCEEEEE
YHNGKQGETYNIGGNNEWTNIALIRLLCGIMDRKLGRSEGESEKLISYVTDRAGHDFRYA
EECCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCEEEE
IDSSKLQQELGWTPSSRFEEGLEKTVDWYLANSEWLERVTSKAYRRYYKETYGIH
CCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8253667 [H]