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The map label for this gene is opuE [H]

Identifier: 194333634

GI number: 194333634

Start: 878014

End: 879477

Strand: Reverse

Name: opuE [H]

Synonym: Paes_0801

Alternate gene names: 194333634

Gene position: 879477-878014 (Counterclockwise)

Preceding gene: 194333635

Following gene: 194333633

Centisome position: 35.0

GC content: 49.93

Gene sequence:

>1464_bases
ATGAGTAGTGTTGACTATGTGATTTTCGGTATCTACCTGGCTGTAACGCTCTCCATAGGCTTCTATCATTTTCGTCATAA
TAAGGGTGAAGAGGATTATTTTGTCGGCAACCGAAACATGAAACCCTCCCATGTCGGACTCTCGATTGTAGCCACCGACG
TAGGAGGAGGGTTTTCAATCGGACTCGGAGGAGCAGGCTTTCTAATGGGGCTGTCAGGAGCATGGCTGCTTTTCACCGGG
CTTGTCGGAGCATGGCTGTCGGCAATTCTGGTTATTCCGAAAATAAAAAAAATCGATCGCGCCCACGGATTGATGACCTA
TCCGGATTTTCTCAGGCTTCGCTATGACAAGAGAGTTGCATTGACGGCAGCACTCATTTCAGGTATCGGCTACCTCGGCT
TTACCGGAGCCCAGATGCTGGCAGGAGCCAAACTGGCATCGGCGACCTTTCTCCAGCACAATCCTTTCAATATGGAACCG
ATCCTGTTTTCCCTGCTGATCATTGCCGTTGTGACAATCGTCTATACCGTTGCAGGAGGACTCAAGGCAGTCATTTACAC
TGACACCATTCAATGGATTATTCTTCTTGTCGGCCTCATCGTGGTAACTATTCCCGTAACGCTGCAGGCAATAGGCGGCT
TTGAGGTCATGAAAGCAACGCTTCCACAATCCCATTTCTCATTAACGGCACTCTCACTGGCGACCTTCATCAACTGGATG
ATCACGATCATCCCGATCTGGTTCATCGCCATGACCCTCTACCAGAGAATGTATGCGTGCCGATCAGCCGAAGACGCAAA
AAAAGCATGGTACATCGCCGGACTTTTCGAATACCCGATTATGGCATTTGCCGGTGTTTTTCTCGGCATGTGCGCAAGAG
TCGTTTTCCCGGAAGCCGACCCTGAAATGGCAATGCCAATGCTTATACGCGATATATTGCCTGCTGGCGTAACAGGCATC
ATCATAGCAGCATATTTTTCAGCCATCATGTCTACAGCCGACAGCTGTATGATGGCCTCATCAGGAAACTTCACCAGTGA
TCTGCTCAAGCCGTTTCTTCAAAAGCGGCTGAAAGCCAACCCCGATAGCCTCAGACTTTCGATGGTAGTCACCCTGTTTG
TCGGGGTAGCTGCAGCAGTTCTGGCAGCACGCTTTACAACGGTGCTCAATGCGATCCTGTATACCTACTCGTTTATGGTC
TCCGGTCTTTTCATCCCGACCGCAGGAGCGCTGTTCTGGAAAAAAAGCTCATCCAACGGAGCTCTTGCCGCTATGGCGGG
AGGCGGAACCCTCACCCTGCTCTTGATGACAAAAATCATTACCCTGCCCGCACCACTTGACAAACTCGGCCTTGATTCGA
CCATCTACGGCATCGGTTTGTCAGCCCTGCTCTTTCTGATCATTTCACCACTTTTTCCCGACCATATCAAAGAACAACAT
GCTCATGCACACCGACAGAATTGA

Upstream 100 bases:

>100_bases
CGGTATCGAGCAGCTCCTCTCCGACCATGACCAGACCATTTCACTTGTTCCTGCCTCAAACGCAAGGCATTCACGCCGAA
AAGCTGAACAGTAAGCCATT

Downstream 100 bases:

>100_bases
CAACCTGCTTGGAGCGGTTATCCAGCATGGACCGTCAAGCAATAGAATATACATCATGCATACCGGCGCAGCTTCACCGG
CGCAACTGGTGAAAGAAATC

Product: SSS sodium solute transporter superfamily protein

Products: Na (I) [Cytoplasm]; pantothenate [Cytoplasm] [C]

Alternate protein names: Sodium/proline symporter [H]

Number of amino acids: Translated: 487; Mature: 486

Protein sequence:

>487_residues
MSSVDYVIFGIYLAVTLSIGFYHFRHNKGEEDYFVGNRNMKPSHVGLSIVATDVGGGFSIGLGGAGFLMGLSGAWLLFTG
LVGAWLSAILVIPKIKKIDRAHGLMTYPDFLRLRYDKRVALTAALISGIGYLGFTGAQMLAGAKLASATFLQHNPFNMEP
ILFSLLIIAVVTIVYTVAGGLKAVIYTDTIQWIILLVGLIVVTIPVTLQAIGGFEVMKATLPQSHFSLTALSLATFINWM
ITIIPIWFIAMTLYQRMYACRSAEDAKKAWYIAGLFEYPIMAFAGVFLGMCARVVFPEADPEMAMPMLIRDILPAGVTGI
IIAAYFSAIMSTADSCMMASSGNFTSDLLKPFLQKRLKANPDSLRLSMVVTLFVGVAAAVLAARFTTVLNAILYTYSFMV
SGLFIPTAGALFWKKSSSNGALAAMAGGGTLTLLLMTKIITLPAPLDKLGLDSTIYGIGLSALLFLIISPLFPDHIKEQH
AHAHRQN

Sequences:

>Translated_487_residues
MSSVDYVIFGIYLAVTLSIGFYHFRHNKGEEDYFVGNRNMKPSHVGLSIVATDVGGGFSIGLGGAGFLMGLSGAWLLFTG
LVGAWLSAILVIPKIKKIDRAHGLMTYPDFLRLRYDKRVALTAALISGIGYLGFTGAQMLAGAKLASATFLQHNPFNMEP
ILFSLLIIAVVTIVYTVAGGLKAVIYTDTIQWIILLVGLIVVTIPVTLQAIGGFEVMKATLPQSHFSLTALSLATFINWM
ITIIPIWFIAMTLYQRMYACRSAEDAKKAWYIAGLFEYPIMAFAGVFLGMCARVVFPEADPEMAMPMLIRDILPAGVTGI
IIAAYFSAIMSTADSCMMASSGNFTSDLLKPFLQKRLKANPDSLRLSMVVTLFVGVAAAVLAARFTTVLNAILYTYSFMV
SGLFIPTAGALFWKKSSSNGALAAMAGGGTLTLLLMTKIITLPAPLDKLGLDSTIYGIGLSALLFLIISPLFPDHIKEQH
AHAHRQN
>Mature_486_residues
SSVDYVIFGIYLAVTLSIGFYHFRHNKGEEDYFVGNRNMKPSHVGLSIVATDVGGGFSIGLGGAGFLMGLSGAWLLFTGL
VGAWLSAILVIPKIKKIDRAHGLMTYPDFLRLRYDKRVALTAALISGIGYLGFTGAQMLAGAKLASATFLQHNPFNMEPI
LFSLLIIAVVTIVYTVAGGLKAVIYTDTIQWIILLVGLIVVTIPVTLQAIGGFEVMKATLPQSHFSLTALSLATFINWMI
TIIPIWFIAMTLYQRMYACRSAEDAKKAWYIAGLFEYPIMAFAGVFLGMCARVVFPEADPEMAMPMLIRDILPAGVTGII
IAAYFSAIMSTADSCMMASSGNFTSDLLKPFLQKRLKANPDSLRLSMVVTLFVGVAAAVLAARFTTVLNAILYTYSFMVS
GLFIPTAGALFWKKSSSNGALAAMAGGGTLTLLLMTKIITLPAPLDKLGLDSTIYGIGLSALLFLIISPLFPDHIKEQHA
HAHRQN

Specific function: Catalyzes the sodium-dependent uptake of extracellular proline [H]

COG id: COG0591

COG function: function code ER; Na+/proline symporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI4507035, Length=427, Percent_Identity=28.1030444964871, Blast_Score=110, Evalue=4e-24,
Organism=Homo sapiens, GI17941285, Length=473, Percent_Identity=26.6384778012685, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI110835708, Length=555, Percent_Identity=25.5855855855856, Blast_Score=102, Evalue=8e-22,
Organism=Homo sapiens, GI310128183, Length=486, Percent_Identity=24.6913580246914, Blast_Score=102, Evalue=8e-22,
Organism=Homo sapiens, GI157671931, Length=482, Percent_Identity=26.3485477178423, Blast_Score=93, Evalue=6e-19,
Organism=Homo sapiens, GI4507031, Length=482, Percent_Identity=24.4813278008299, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI167466278, Length=486, Percent_Identity=25.7201646090535, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI4507033, Length=471, Percent_Identity=26.3269639065817, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI14140236, Length=495, Percent_Identity=23.030303030303, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI206597483, Length=469, Percent_Identity=26.865671641791, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI109659836, Length=483, Percent_Identity=23.6024844720497, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI206597487, Length=394, Percent_Identity=26.3959390862944, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI11141885, Length=424, Percent_Identity=25.7075471698113, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI109659839, Length=499, Percent_Identity=23.0460921843687, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI87082237, Length=443, Percent_Identity=26.6365688487585, Blast_Score=108, Evalue=8e-25,
Organism=Escherichia coli, GI1787251, Length=441, Percent_Identity=27.437641723356, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1790113, Length=356, Percent_Identity=23.314606741573, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI115533094, Length=419, Percent_Identity=22.9116945107399, Blast_Score=76, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17539284, Length=439, Percent_Identity=23.6902050113895, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI221459588, Length=431, Percent_Identity=24.3619489559165, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24645928, Length=379, Percent_Identity=25.3298153034301, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI221459584, Length=435, Percent_Identity=24.5977011494253, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24651739, Length=413, Percent_Identity=22.7602905569007, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI221459586, Length=424, Percent_Identity=24.7641509433962, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24651741, Length=502, Percent_Identity=22.3107569721116, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24641117, Length=401, Percent_Identity=23.1920199501247, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24640370, Length=392, Percent_Identity=24.234693877551, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI221459582, Length=422, Percent_Identity=25.1184834123223, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI281362918, Length=417, Percent_Identity=22.3021582733813, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24650192, Length=414, Percent_Identity=22.9468599033816, Blast_Score=70, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011851
- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 52616; Mature: 52485

Theoretical pI: Translated: 9.51; Mature: 9.51

Prosite motif: PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSVDYVIFGIYLAVTLSIGFYHFRHNKGEEDYFVGNRNMKPSHVGLSIVATDVGGGFSI
CCCCHHHHHHHHHHHHHHHHHHHEECCCCCCCEEECCCCCCCCCCCEEEEEEECCCCEEE
GLGGAGFLMGLSGAWLLFTGLVGAWLSAILVIPKIKKIDRAHGLMTYPDFLRLRYDKRVA
CCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCHHH
LTAALISGIGYLGFTGAQMLAGAKLASATFLQHNPFNMEPILFSLLIIAVVTIVYTVAGG
HHHHHHHHCCHHHCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
LKAVIYTDTIQWIILLVGLIVVTIPVTLQAIGGFEVMKATLPQSHFSLTALSLATFINWM
CEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHHHHH
ITIIPIWFIAMTLYQRMYACRSAEDAKKAWYIAGLFEYPIMAFAGVFLGMCARVVFPEAD
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PEMAMPMLIRDILPAGVTGIIIAAYFSAIMSTADSCMMASSGNFTSDLLKPFLQKRLKAN
CHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCC
PDSLRLSMVVTLFVGVAAAVLAARFTTVLNAILYTYSFMVSGLFIPTAGALFWKKSSSNG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCC
ALAAMAGGGTLTLLLMTKIITLPAPLDKLGLDSTIYGIGLSALLFLIISPLFPDHIKEQH
CEEEEECCCHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHH
AHAHRQN
HHHCCCC
>Mature Secondary Structure 
SSVDYVIFGIYLAVTLSIGFYHFRHNKGEEDYFVGNRNMKPSHVGLSIVATDVGGGFSI
CCCHHHHHHHHHHHHHHHHHHHEECCCCCCCEEECCCCCCCCCCCEEEEEEECCCCEEE
GLGGAGFLMGLSGAWLLFTGLVGAWLSAILVIPKIKKIDRAHGLMTYPDFLRLRYDKRVA
CCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCHHH
LTAALISGIGYLGFTGAQMLAGAKLASATFLQHNPFNMEPILFSLLIIAVVTIVYTVAGG
HHHHHHHHCCHHHCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
LKAVIYTDTIQWIILLVGLIVVTIPVTLQAIGGFEVMKATLPQSHFSLTALSLATFINWM
CEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHHHHH
ITIIPIWFIAMTLYQRMYACRSAEDAKKAWYIAGLFEYPIMAFAGVFLGMCARVVFPEAD
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PEMAMPMLIRDILPAGVTGIIIAAYFSAIMSTADSCMMASSGNFTSDLLKPFLQKRLKAN
CHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCC
PDSLRLSMVVTLFVGVAAAVLAARFTTVLNAILYTYSFMVSGLFIPTAGALFWKKSSSNG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCC
ALAAMAGGGTLTLLLMTKIITLPAPLDKLGLDSTIYGIGLSALLFLIISPLFPDHIKEQH
CEEEEECCCHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHH
AHAHRQN
HHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Periplasm]; pantothenate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + pantothenate [Periplasm] = Na (I) [Cytoplasm] + pantothenate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969499; 9384377 [H]