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The map label for this gene is mscS [H]

Identifier: 194333630

GI number: 194333630

Start: 875278

End: 876084

Strand: Reverse

Name: mscS [H]

Synonym: Paes_0797

Alternate gene names: 194333630

Gene position: 876084-875278 (Counterclockwise)

Preceding gene: 194333631

Following gene: 194333629

Centisome position: 34.86

GC content: 47.96

Gene sequence:

>807_bases
ATGAACATCAACACCCAGCAAATTCTTGACCTTATCGTCACCTATGGCCTGAAAATCGTTACCGGCCTGATTATCCTCTT
CATCGGCATAAAGATTGCCGGTTTTACCGACAGGAAAATCGAAAACCTGCTTCACAAAAAAGCCGATATCGACGAAATGC
TGGTGAAGTTTCTCTCCAACCTTGTACGATACACCATCATCGCCTTCTCTGTCGCCGCATTTCTGAACCAGGTAGGCATT
CAGACCGCCAGTATCATTGCCGTGCTCGGAACCGCCGGACTTGCTGTAGGACTTGCCATACAGGGAACGCTCTCCAATAT
CGCCGCAGGTGTTATGCTGCTCATCTTCCGTCCCTTCAGAACAGGAAACTACGTTGAGGTTGGCGGACACGGGGGCACGG
TCAAAGCCTTAAGTCTCTTCACGACCGAACTTGCTACTCCCGATAACGTTCAGATTATCATTCCAAACAATTCGGTATGG
GGCAACTCCATTGTCAATTATTCTTTCCACGACACACGCAGAGTTGATTTCATCCTCTCAATATCCTATAGCGACAATAT
CAGCACCGGCATCGATACCATTCGACGTGTGATAGACGGGGAGACAAGAATACAAAAAACGCCTGAACCTCAGATTGTCG
TCAGTGAACTTGCAGCCAGTTCTGTAGACATCACGGTAAGAGCCTGGGTAGAAAAGGATAATTACTGGCCCGTTAAATTT
GACCTCACCAGACAGTTCAAGGAAAATCTGGAAGCTGCCGGACTCCATATTCCCTTCCCGCAGCAAGACATTCACCTTAT
CCGCTAA

Upstream 100 bases:

>100_bases
AAGCCTGACAATACCATTACAACCCGTAGCTGTTATCAGACGCTGAAGAGAAGACAGCTACGGGCCAGCTTTTCATGAAC
AAACTGAACCGAATGGTCTG

Downstream 100 bases:

>100_bases
GATGCAGCGTATTGCTATCGTCGGAGCTGGAATAGGAGGGCTCAGCGCTGCCGCAAGGCTTGGAAAAATGGGGTATGCTG
TCGACCTGTATGAAAAAAAC

Product: mechanosensitive ion channel MscS

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 268; Mature: 268

Protein sequence:

>268_residues
MNINTQQILDLIVTYGLKIVTGLIILFIGIKIAGFTDRKIENLLHKKADIDEMLVKFLSNLVRYTIIAFSVAAFLNQVGI
QTASIIAVLGTAGLAVGLAIQGTLSNIAAGVMLLIFRPFRTGNYVEVGGHGGTVKALSLFTTELATPDNVQIIIPNNSVW
GNSIVNYSFHDTRRVDFILSISYSDNISTGIDTIRRVIDGETRIQKTPEPQIVVSELAASSVDITVRAWVEKDNYWPVKF
DLTRQFKENLEAAGLHIPFPQQDIHLIR

Sequences:

>Translated_268_residues
MNINTQQILDLIVTYGLKIVTGLIILFIGIKIAGFTDRKIENLLHKKADIDEMLVKFLSNLVRYTIIAFSVAAFLNQVGI
QTASIIAVLGTAGLAVGLAIQGTLSNIAAGVMLLIFRPFRTGNYVEVGGHGGTVKALSLFTTELATPDNVQIIIPNNSVW
GNSIVNYSFHDTRRVDFILSISYSDNISTGIDTIRRVIDGETRIQKTPEPQIVVSELAASSVDITVRAWVEKDNYWPVKF
DLTRQFKENLEAAGLHIPFPQQDIHLIR
>Mature_268_residues
MNINTQQILDLIVTYGLKIVTGLIILFIGIKIAGFTDRKIENLLHKKADIDEMLVKFLSNLVRYTIIAFSVAAFLNQVGI
QTASIIAVLGTAGLAVGLAIQGTLSNIAAGVMLLIFRPFRTGNYVEVGGHGGTVKALSLFTTELATPDNVQIIIPNNSVW
GNSIVNYSFHDTRRVDFILSISYSDNISTGIDTIRRVIDGETRIQKTPEPQIVVSELAASSVDITVRAWVEKDNYWPVKF
DLTRQFKENLEAAGLHIPFPQQDIHLIR

Specific function: Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions. The channel is sensitive to voltage [H]

COG id: COG0668

COG function: function code M; Small-conductance mechanosensitive channel

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mscS (TC 1.A.23) family [H]

Homologues:

Organism=Escherichia coli, GI1789291, Length=258, Percent_Identity=42.2480620155039, Blast_Score=214, Evalue=6e-57,
Organism=Escherichia coli, GI1787591, Length=256, Percent_Identity=24.21875, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1786670, Length=212, Percent_Identity=23.1132075471698, Blast_Score=77, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010920
- InterPro:   IPR011066
- InterPro:   IPR006685
- InterPro:   IPR006686
- InterPro:   IPR011014
- InterPro:   IPR008910 [H]

Pfam domain/function: PF00924 MS_channel; PF05552 TM_helix [H]

EC number: NA

Molecular weight: Translated: 29579; Mature: 29579

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNINTQQILDLIVTYGLKIVTGLIILFIGIKIAGFTDRKIENLLHKKADIDEMLVKFLSN
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHH
LVRYTIIAFSVAAFLNQVGIQTASIIAVLGTAGLAVGLAIQGTLSNIAAGVMLLIFRPFR
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHEEHHHHHHHHHHHHHHHHCCCC
TGNYVEVGGHGGTVKALSLFTTELATPDNVQIIIPNNSVWGNSIVNYSFHDTRRVDFILS
CCCEEEECCCCCCHHHHHHHHHHCCCCCCCEEEECCCCCCCCCEEECCCCCCCEEEEEEE
ISYSDNISTGIDTIRRVIDGETRIQKTPEPQIVVSELAASSVDITVRAWVEKDNYWPVKF
EECCCCCHHHHHHHHHHHCCCHHCCCCCCCHHHHHHHHCCCCEEEEEEEEECCCEEEEEE
DLTRQFKENLEAAGLHIPFPQQDIHLIR
HHHHHHHHCHHHCCCCCCCCCCCCEECC
>Mature Secondary Structure
MNINTQQILDLIVTYGLKIVTGLIILFIGIKIAGFTDRKIENLLHKKADIDEMLVKFLSN
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHH
LVRYTIIAFSVAAFLNQVGIQTASIIAVLGTAGLAVGLAIQGTLSNIAAGVMLLIFRPFR
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHEEHHHHHHHHHHHHHHHHCCCC
TGNYVEVGGHGGTVKALSLFTTELATPDNVQIIIPNNSVWGNSIVNYSFHDTRRVDFILS
CCCEEEECCCCCCHHHHHHHHHHCCCCCCCEEEECCCCCCCCCEEECCCCCCCEEEEEEE
ISYSDNISTGIDTIRRVIDGETRIQKTPEPQIVVSELAASSVDITVRAWVEKDNYWPVKF
EECCCCCHHHHHHHHHHHCCCHHCCCCCCCHHHHHHHHCCCCEEEEEEEEECCCEEEEEE
DLTRQFKENLEAAGLHIPFPQQDIHLIR
HHHHHHHHCHHHCCCCCCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12542086 [H]