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The map label for this gene is macA [H]

Identifier: 194333626

GI number: 194333626

Start: 870441

End: 871613

Strand: Reverse

Name: macA [H]

Synonym: Paes_0793

Alternate gene names: 194333626

Gene position: 871613-870441 (Counterclockwise)

Preceding gene: 194333627

Following gene: 194333625

Centisome position: 34.69

GC content: 52.09

Gene sequence:

>1173_bases
ATGAACAACACCATCACGACACTGCGCCATAGCGCCCCGGCTTGCCTCTTCTGCCTCCTGCTTATGAGCTGCAGCCACAA
CAGCAAGGCTCCGGAACCGGACACACAGGCTCCCCCTCGCGTCTCAATCGTTCAATCCATGCGAACAGCCGTTCAGCCGG
AACTTTCCTACCCTGGAGAAATACGGGCGAGCAGGCAGACCGAACTCTCTTTCAGGGTCAGCGGGCCGCTGACCGCCATT
CTGAAACAACCCGGTGATCACGTTCAGAAAGGAGAGGTGCTGATGCAGATCGACCAACGAGATTACCTCGACAACATAAA
AATACTCGAAGCCGAACTCAGAGGAGCACAAGCCAGATCGAAAAAATCGACCAGTGATTTCGACCGCGCAAAAAAGCTCC
TCCATGAAGATGTGATCGCCCGATCAGACTACGACATGGCCCAGAGCTCGGCAGCATCAGCACAGGCAACGGTACAGAAT
CTCAAAGCTCAGCTCTCACTGGCACGCCATCAGTATGAAGACACCTCGCTCAGAGCTCCATACAACGGGATTGTGACGGC
GCAACTGGCTGAAAATCATGAAATGATCCGCGCCGGACAGATCGTCACGAGGATGCATGACATCTCCACTCTTGAAATCG
ACTGCAATGTCGCTGAAAACGACATGAACAGATTCGATCTCAAAAAAGGACTACAAGGTCTCATAACCCTTCCTGCAGCA
GAAGGCAGATCGTTCTCTGCTGAACTGAAAGAATGGAGTACCGCCGCAGATACCACAACAAGAACATATCGGCTGACATT
TTCCCTCTCCGCTCCTGAAGACAGCTCGATTCTTCCCGGAATGACAGGAGAAATCACCATCAGCAATCTGAAATCCACGA
CACCGGTCGTCACGATTCCCATCGATGCCCTGGCTGCCGGAGAGGAAGGAAAGTCGATGGTGTGGCTCTATGATACCAGA
GACGGAACCCTGCGATCACACATCATCGAAACAGGAGCAATGACTGACGACAACACCATTGTGGTCACTTCCGGCCTTAA
AGGAGATGAAAGCATTGCATTGACTGGTTCACAACTGATCTCAGAAGGGATGCAAGTGACCGTTCAGGCATCTCACGACT
CTCAAAGTCCTCAAAGCGACGCATCCAAAGCCAAAGGAGAAAACCAGCAATGA

Upstream 100 bases:

>100_bases
ACCTCCGTAAAATGGAAGATTTCATCGTCAAGCAGACTGAGCGACTCCTTGGTATAGGAAACAATCCATCTCAATCTCAA
CAGTAGCGCAACCACCCTCA

Downstream 100 bases:

>100_bases
TCAACCCGGCTCAGTTTGCACTGCAGAAACGAACAATCATGGTCATGCTTTGCGTCATCCTCGTCGGCGCCGGCATTCTT
TCCTATGAAAAGCTCGGCAG

Product: RND family efflux transporter MFP subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MNNTITTLRHSAPACLFCLLLMSCSHNSKAPEPDTQAPPRVSIVQSMRTAVQPELSYPGEIRASRQTELSFRVSGPLTAI
LKQPGDHVQKGEVLMQIDQRDYLDNIKILEAELRGAQARSKKSTSDFDRAKKLLHEDVIARSDYDMAQSSAASAQATVQN
LKAQLSLARHQYEDTSLRAPYNGIVTAQLAENHEMIRAGQIVTRMHDISTLEIDCNVAENDMNRFDLKKGLQGLITLPAA
EGRSFSAELKEWSTAADTTTRTYRLTFSLSAPEDSSILPGMTGEITISNLKSTTPVVTIPIDALAAGEEGKSMVWLYDTR
DGTLRSHIIETGAMTDDNTIVVTSGLKGDESIALTGSQLISEGMQVTVQASHDSQSPQSDASKAKGENQQ

Sequences:

>Translated_390_residues
MNNTITTLRHSAPACLFCLLLMSCSHNSKAPEPDTQAPPRVSIVQSMRTAVQPELSYPGEIRASRQTELSFRVSGPLTAI
LKQPGDHVQKGEVLMQIDQRDYLDNIKILEAELRGAQARSKKSTSDFDRAKKLLHEDVIARSDYDMAQSSAASAQATVQN
LKAQLSLARHQYEDTSLRAPYNGIVTAQLAENHEMIRAGQIVTRMHDISTLEIDCNVAENDMNRFDLKKGLQGLITLPAA
EGRSFSAELKEWSTAADTTTRTYRLTFSLSAPEDSSILPGMTGEITISNLKSTTPVVTIPIDALAAGEEGKSMVWLYDTR
DGTLRSHIIETGAMTDDNTIVVTSGLKGDESIALTGSQLISEGMQVTVQASHDSQSPQSDASKAKGENQQ
>Mature_390_residues
MNNTITTLRHSAPACLFCLLLMSCSHNSKAPEPDTQAPPRVSIVQSMRTAVQPELSYPGEIRASRQTELSFRVSGPLTAI
LKQPGDHVQKGEVLMQIDQRDYLDNIKILEAELRGAQARSKKSTSDFDRAKKLLHEDVIARSDYDMAQSSAASAQATVQN
LKAQLSLARHQYEDTSLRAPYNGIVTAQLAENHEMIRAGQIVTRMHDISTLEIDCNVAENDMNRFDLKKGLQGLITLPAA
EGRSFSAELKEWSTAADTTTRTYRLTFSLSAPEDSSILPGMTGEITISNLKSTTPVVTIPIDALAAGEEGKSMVWLYDTR
DGTLRSHIIETGAMTDDNTIVVTSGLKGDESIALTGSQLISEGMQVTVQASHDSQSPQSDASKAKGENQQ

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789929, Length=386, Percent_Identity=24.6113989637306, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI87081796, Length=315, Percent_Identity=25.3968253968254, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 42477; Mature: 42477

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNTITTLRHSAPACLFCLLLMSCSHNSKAPEPDTQAPPRVSIVQSMRTAVQPELSYPGE
CCCCHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCC
IRASRQTELSFRVSGPLTAILKQPGDHVQKGEVLMQIDQRDYLDNIKILEAELRGAQARS
CCCCCCCEEEEEECCCHHHHHCCCCCCCCCCCEEEEECCHHHHCCCEEEEHHHHCCHHHC
KKSTSDFDRAKKLLHEDVIARSDYDMAQSSAASAQATVQNLKAQLSLARHQYEDTSLRAP
CCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
YNGIVTAQLAENHEMIRAGQIVTRMHDISTLEIDCNVAENDMNRFDLKKGLQGLITLPAA
CCCEEEEEECCCCHHHHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHCCCEEEEECCC
EGRSFSAELKEWSTAADTTTRTYRLTFSLSAPEDSSILPGMTGEITISNLKSTTPVVTIP
CCCCCHHHHHHHCCCCCCCEEEEEEEEEECCCCCCCCCCCCCCCEEEECCCCCCCEEEEE
IDALAAGEEGKSMVWLYDTRDGTLRSHIIETGAMTDDNTIVVTSGLKGDESIALTGSQLI
HHHEECCCCCCEEEEEEECCCCHHHHHHHHCCCCCCCCEEEEEECCCCCCEEEEEHHHHH
SEGMQVTVQASHDSQSPQSDASKAKGENQQ
CCCCEEEEEECCCCCCCCHHHHHCCCCCCC
>Mature Secondary Structure
MNNTITTLRHSAPACLFCLLLMSCSHNSKAPEPDTQAPPRVSIVQSMRTAVQPELSYPGE
CCCCHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCC
IRASRQTELSFRVSGPLTAILKQPGDHVQKGEVLMQIDQRDYLDNIKILEAELRGAQARS
CCCCCCCEEEEEECCCHHHHHCCCCCCCCCCCEEEEECCHHHHCCCEEEEHHHHCCHHHC
KKSTSDFDRAKKLLHEDVIARSDYDMAQSSAASAQATVQNLKAQLSLARHQYEDTSLRAP
CCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
YNGIVTAQLAENHEMIRAGQIVTRMHDISTLEIDCNVAENDMNRFDLKKGLQGLITLPAA
CCCEEEEEECCCCHHHHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHCCCEEEEECCC
EGRSFSAELKEWSTAADTTTRTYRLTFSLSAPEDSSILPGMTGEITISNLKSTTPVVTIP
CCCCCHHHHHHHCCCCCCCEEEEEEEEEECCCCCCCCCCCCCCCEEEECCCCCCCEEEEE
IDALAAGEEGKSMVWLYDTRDGTLRSHIIETGAMTDDNTIVVTSGLKGDESIALTGSQLI
HHHEECCCCCCEEEEEEECCCCHHHHHHHHCCCCCCCCEEEEEECCCCCCEEEEEHHHHH
SEGMQVTVQASHDSQSPQSDASKAKGENQQ
CCCCEEEEEECCCCCCCCHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]