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The map label for this gene is sdhB [H]

Identifier: 194333596

GI number: 194333596

Start: 812150

End: 812875

Strand: Reverse

Name: sdhB [H]

Synonym: Paes_0762

Alternate gene names: 194333596

Gene position: 812875-812150 (Counterclockwise)

Preceding gene: 194333597

Following gene: 194333595

Centisome position: 32.35

GC content: 49.45

Gene sequence:

>726_bases
ATGTTTTCTAATAAGTACGATTTAGTTTTCATGACCTATACCATAAGGATTCTGAGATACAATCCGCAATCAGATACTGA
ACCGTATTACAGAGAGTACCAGGTAGAAGCTGCGCCACATGAGAGGATCCTTGATGTCCTGGTAAGGATTCAGTCTGATC
ACGACAGCACTCTGGCTCTCAGAAAGTCCTGTGGCCATGGCGTTTGCGGAAGCGATGCCATGCTGATCAATGGTGAAAAC
AGGCTTGCCTGTTCAACCCTTGTCAGGGATATCAAAGGCACCCTCATCAGAGTGGAGCCTCTCCCTGGAGCCCCGGTCAA
GCGCGACCTTGTGCTCGACACCGATCGCTTCTGGGATAAATACCAGGCGGTCATGCCCTACCTTATACCCTCTGAACCCG
CCCCGGACAAAGAAAGGCTGCAAAGCCCTGCGGAACATAAGAAAATAGAGGAATCAACGAAATGCATCCTCTGTGGCGCA
TGTACTCATGCCTGCCCTACAACGTGGGCAAACGCAACCTACCTCGGTCCAGCAGCCCTCTTGAAAGCATATCGTTTCAT
CTTCGATTCCCGTGACCAGGCAACCGGACAACGAATCGAAAGAATAGCCTCAGATGATGGCATATGGCGATGTTATACCG
CCTATAACTGTGTGGAGGCGTGCCCTAAAGATATCGATATCACCTGGCATATCTCACAGTTGAAAAAAGCGGCAATACGA
ATGTAA

Upstream 100 bases:

>100_bases
GGAACCAGCTGTAAGACCTGTGAAGAGGCTCCGGTTATCGAGAGAGTTCAGATTACCACAGGCAAAACGTCACAATAACT
CCGGAACCACTATCTCCGGA

Downstream 100 bases:

>100_bases
ACACGCATTGTGAGGTAACATCAAACCACATGAACGGTCACCAAACCTCTTTCTACCTCTAAAGCGCGATGGGATACTCT
GGAGACATTACAGGCATTGA

Product: succinate dehydrogenase and fumarate reductase iron-sulfur protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 241; Mature: 241

Protein sequence:

>241_residues
MFSNKYDLVFMTYTIRILRYNPQSDTEPYYREYQVEAAPHERILDVLVRIQSDHDSTLALRKSCGHGVCGSDAMLINGEN
RLACSTLVRDIKGTLIRVEPLPGAPVKRDLVLDTDRFWDKYQAVMPYLIPSEPAPDKERLQSPAEHKKIEESTKCILCGA
CTHACPTTWANATYLGPAALLKAYRFIFDSRDQATGQRIERIASDDGIWRCYTAYNCVEACPKDIDITWHISQLKKAAIR
M

Sequences:

>Translated_241_residues
MFSNKYDLVFMTYTIRILRYNPQSDTEPYYREYQVEAAPHERILDVLVRIQSDHDSTLALRKSCGHGVCGSDAMLINGEN
RLACSTLVRDIKGTLIRVEPLPGAPVKRDLVLDTDRFWDKYQAVMPYLIPSEPAPDKERLQSPAEHKKIEESTKCILCGA
CTHACPTTWANATYLGPAALLKAYRFIFDSRDQATGQRIERIASDDGIWRCYTAYNCVEACPKDIDITWHISQLKKAAIR
M
>Mature_241_residues
MFSNKYDLVFMTYTIRILRYNPQSDTEPYYREYQVEAAPHERILDVLVRIQSDHDSTLALRKSCGHGVCGSDAMLINGEN
RLACSTLVRDIKGTLIRVEPLPGAPVKRDLVLDTDRFWDKYQAVMPYLIPSEPAPDKERLQSPAEHKKIEESTKCILCGA
CTHACPTTWANATYLGPAALLKAYRFIFDSRDQATGQRIERIASDDGIWRCYTAYNCVEACPKDIDITWHISQLKKAAIR
M

Specific function: Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth [H]

COG id: COG0479

COG function: function code C; Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 4Fe-4S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI115387094, Length=225, Percent_Identity=36.8888888888889, Blast_Score=161, Evalue=4e-40,
Organism=Escherichia coli, GI1786943, Length=236, Percent_Identity=38.5593220338983, Blast_Score=182, Evalue=2e-47,
Organism=Escherichia coli, GI1790596, Length=222, Percent_Identity=36.4864864864865, Blast_Score=158, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI17533915, Length=227, Percent_Identity=35.6828193832599, Blast_Score=155, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6322987, Length=228, Percent_Identity=38.5964912280702, Blast_Score=172, Evalue=6e-44,
Organism=Drosophila melanogaster, GI17137106, Length=231, Percent_Identity=38.5281385281385, Blast_Score=168, Evalue=3e-42,
Organism=Drosophila melanogaster, GI24643156, Length=233, Percent_Identity=36.9098712446352, Blast_Score=159, Evalue=2e-39,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR012285
- InterPro:   IPR009051
- InterPro:   IPR004489 [H]

Pfam domain/function: NA

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 27438; Mature: 27438

Theoretical pI: Translated: 7.35; Mature: 7.35

Prosite motif: PS51085 2FE2S_FER_2 ; PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
4.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSNKYDLVFMTYTIRILRYNPQSDTEPYYREYQVEAAPHERILDVLVRIQSDHDSTLAL
CCCCCEEEEEEEEEEEEEEECCCCCCCCHHHHEEECCCCHHHHHHHHHHHCCCCCHHHHH
RKSCGHGVCGSDAMLINGENRLACSTLVRDIKGTLIRVEPLPGAPVKRDLVLDTDRFWDK
HHHCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCEEEEECCCCCCCCCCEEECCHHHHHH
YQAVMPYLIPSEPAPDKERLQSPAEHKKIEESTKCILCGACTHACPTTWANATYLGPAAL
HHHHCCEECCCCCCCCHHHHCCCHHHHHHHHCCCEEEEECCCCCCCCCCCCCEECCHHHH
LKAYRFIFDSRDQATGQRIERIASDDGIWRCYTAYNCVEACPKDIDITWHISQLKKAAIR
HHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEHHHHHHHHHCCCCCEEEEEHHHHHHHHHC
M
C
>Mature Secondary Structure
MFSNKYDLVFMTYTIRILRYNPQSDTEPYYREYQVEAAPHERILDVLVRIQSDHDSTLAL
CCCCCEEEEEEEEEEEEEEECCCCCCCCHHHHEEECCCCHHHHHHHHHHHCCCCCHHHHH
RKSCGHGVCGSDAMLINGENRLACSTLVRDIKGTLIRVEPLPGAPVKRDLVLDTDRFWDK
HHHCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCEEEEECCCCCCCCCCEEECCHHHHHH
YQAVMPYLIPSEPAPDKERLQSPAEHKKIEESTKCILCGACTHACPTTWANATYLGPAAL
HHHHCCEECCCCCCCCHHHHCCCHHHHHHHHCCCEEEEECCCCCCCCCCCCCEECCHHHH
LKAYRFIFDSRDQATGQRIERIASDDGIWRCYTAYNCVEACPKDIDITWHISQLKKAAIR
HHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEHHHHHHHHHCCCCCEEEEEHHHHHHHHHC
M
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 6388571; 8905232; 9278503; 6376123; 9298646 [H]