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The map label for this gene is serS

Identifier: 194333565

GI number: 194333565

Start: 781235

End: 782530

Strand: Reverse

Name: serS

Synonym: Paes_0731

Alternate gene names: 194333565

Gene position: 782530-781235 (Counterclockwise)

Preceding gene: 194333566

Following gene: 194333562

Centisome position: 31.14

GC content: 50.0

Gene sequence:

>1296_bases
ATGCTTGACATCAATTTCATCCGTCAAAACCCCGAAAAGGTAAGCCGCATGCTGGAACAGCGCCAGCAGCGGGAAGATAT
TGCCAAACTCAATCAGCTTCTCGACTTCGATGTCCGCAGAAGAACAATGGTTCAGAGAACCGATGAACTCAAAGCCCTCC
GCAATAAAGTCTCTAAAGATATTGCCGTCATTAAGCGCTCCGGACAGGGTTCGGCCGACGATCTTATCGTGCAGATGAAA
GCTGTCGCTGATGAAATTTCAGGCATGGACGACACCCTTAAATCACTCGAAGCCCAAATAGAGGAGCTTCTTCTTTCACT
GCCTAACAAGCTGCATGAGGATGTTCCTGAAGGCCGTTGTGCTGATGACAACCACATTTATCGCGAAAAGCTCTCTTTCG
ACCATAAGCTCGACTTCCCTCTTGACAATCATCTTGACCTCGGCAAACGCCTTGGGATACTCGATTTTGAACGAGGAGCA
AAAATTACCGGCGCGGGCTTTCCGGTCTATACCGCAAAAGGGGCTCGACTGGAAAGAGCACTGATTAACTTCATGCTTGA
TCAGCATACCTCCGTAAACGGATACACCGAAGTCCTCCCGCCTCTGTTCGTTAACCGTGAATCGCTTCGTGGAACCGGAC
AGTGGCCGAAATTTGCCGACCAGGTCTATTACATGAATGAGGACAATCTGTATGCTATTCCTACAGCCGAGGTACCGCTC
ACCAACATGCACCGCGATGAGATCCTTGACGCATCAGATATCCCGCTTGCCTATGCGGCCTATACCCCCTGTTTCCGAAG
AGAAGCAGGAAGTTATGGAAAAGACACAAGAGGATTTCTCAGAGTGCATCAGTTCAACAAAGTAGAACTGGTTCGATACG
CCACCCCGACAACATCATATGACGCCCTTCAGGAAATTCTCTCCCATGCAGAAGGAATCCTTCAGGCGCTGAAAATCCCC
TATCGGGTTCTTCTTCTCTGCAGCGGCGATATCAGTGCCAATGCAACCAAATGCTATGACATTGAAGTGTGGGCGCCGGG
TGAAGGAAAATTTCTCGAAGCATCGAGCTGCTCTAACTTTGAAGACTATCAGGCAAGAAGGGCAAATATCCGCTACAGGC
CGGAAGATGGGGGCAAACCGACCTATGTTCACACGCTCAACGGATCAGGGCTTGCAACATCGAGACTCATGGTTGCGCTG
CTGGAAAACTACCAGACGCCTGAAGGCAGTATCAGAATCCCGGATGTGCTCCAGCCATACACCGGTTTCAGCAGCATCGA
TCAGGCAGCTGAATGA

Upstream 100 bases:

>100_bases
TATGGGGGCGGCCATGAAAGAGCTCAAAGGCAAGGCCGACGGCGGCACAGTACAGGAAATCGTCAAATCAGCACTCTCCG
CTTAATTTAACCGGCACCTT

Downstream 100 bases:

>100_bases
TTCCCTGAAGCAATACGCTCCTTGAACTGCCTGACCATAGCGCTGACCTCGTCGGTCAGGATCAGAAACGCGTCATGTCC
GTACGGCTCGCGAAGGTAAC

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MLDINFIRQNPEKVSRMLEQRQQREDIAKLNQLLDFDVRRRTMVQRTDELKALRNKVSKDIAVIKRSGQGSADDLIVQMK
AVADEISGMDDTLKSLEAQIEELLLSLPNKLHEDVPEGRCADDNHIYREKLSFDHKLDFPLDNHLDLGKRLGILDFERGA
KITGAGFPVYTAKGARLERALINFMLDQHTSVNGYTEVLPPLFVNRESLRGTGQWPKFADQVYYMNEDNLYAIPTAEVPL
TNMHRDEILDASDIPLAYAAYTPCFRREAGSYGKDTRGFLRVHQFNKVELVRYATPTTSYDALQEILSHAEGILQALKIP
YRVLLLCSGDISANATKCYDIEVWAPGEGKFLEASSCSNFEDYQARRANIRYRPEDGGKPTYVHTLNGSGLATSRLMVAL
LENYQTPEGSIRIPDVLQPYTGFSSIDQAAE

Sequences:

>Translated_431_residues
MLDINFIRQNPEKVSRMLEQRQQREDIAKLNQLLDFDVRRRTMVQRTDELKALRNKVSKDIAVIKRSGQGSADDLIVQMK
AVADEISGMDDTLKSLEAQIEELLLSLPNKLHEDVPEGRCADDNHIYREKLSFDHKLDFPLDNHLDLGKRLGILDFERGA
KITGAGFPVYTAKGARLERALINFMLDQHTSVNGYTEVLPPLFVNRESLRGTGQWPKFADQVYYMNEDNLYAIPTAEVPL
TNMHRDEILDASDIPLAYAAYTPCFRREAGSYGKDTRGFLRVHQFNKVELVRYATPTTSYDALQEILSHAEGILQALKIP
YRVLLLCSGDISANATKCYDIEVWAPGEGKFLEASSCSNFEDYQARRANIRYRPEDGGKPTYVHTLNGSGLATSRLMVAL
LENYQTPEGSIRIPDVLQPYTGFSSIDQAAE
>Mature_431_residues
MLDINFIRQNPEKVSRMLEQRQQREDIAKLNQLLDFDVRRRTMVQRTDELKALRNKVSKDIAVIKRSGQGSADDLIVQMK
AVADEISGMDDTLKSLEAQIEELLLSLPNKLHEDVPEGRCADDNHIYREKLSFDHKLDFPLDNHLDLGKRLGILDFERGA
KITGAGFPVYTAKGARLERALINFMLDQHTSVNGYTEVLPPLFVNRESLRGTGQWPKFADQVYYMNEDNLYAIPTAEVPL
TNMHRDEILDASDIPLAYAAYTPCFRREAGSYGKDTRGFLRVHQFNKVELVRYATPTTSYDALQEILSHAEGILQALKIP
YRVLLLCSGDISANATKCYDIEVWAPGEGKFLEASSCSNFEDYQARRANIRYRPEDGGKPTYVHTLNGSGLATSRLMVAL
LENYQTPEGSIRIPDVLQPYTGFSSIDQAAE

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=465, Percent_Identity=33.7634408602151, Blast_Score=212, Evalue=4e-55,
Organism=Homo sapiens, GI8923421, Length=440, Percent_Identity=30.2272727272727, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI225579074, Length=443, Percent_Identity=30.0225733634311, Blast_Score=166, Evalue=3e-41,
Organism=Escherichia coli, GI1787120, Length=427, Percent_Identity=42.8571428571429, Blast_Score=352, Evalue=2e-98,
Organism=Caenorhabditis elegans, GI17539260, Length=467, Percent_Identity=31.6916488222698, Blast_Score=215, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI17542084, Length=240, Percent_Identity=30, Blast_Score=122, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6321799, Length=431, Percent_Identity=32.2505800464037, Blast_Score=216, Evalue=7e-57,
Organism=Saccharomyces cerevisiae, GI6320226, Length=440, Percent_Identity=30.9090909090909, Blast_Score=204, Evalue=2e-53,
Organism=Drosophila melanogaster, GI24581334, Length=468, Percent_Identity=30.5555555555556, Blast_Score=203, Evalue=1e-52,
Organism=Drosophila melanogaster, GI17737985, Length=338, Percent_Identity=31.9526627218935, Blast_Score=147, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_PROA2 (B4S6M3)

Other databases:

- EMBL:   CP001108
- RefSeq:   YP_002015425.1
- ProteinModelPortal:   B4S6M3
- SMR:   B4S6M3
- GeneID:   6459622
- GenomeReviews:   CP001108_GR
- KEGG:   paa:Paes_0731
- HOGENOM:   HBG629391
- OMA:   FQARRIR
- ProtClustDB:   PRK05431
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 48729; Mature: 48729

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 282-282 BINDING 289-289 BINDING 389-389

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDINFIRQNPEKVSRMLEQRQQREDIAKLNQLLDFDVRRRTMVQRTDELKALRNKVSKD
CCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAVIKRSGQGSADDLIVQMKAVADEISGMDDTLKSLEAQIEELLLSLPNKLHEDVPEGRC
HHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCC
ADDNHIYREKLSFDHKLDFPLDNHLDLGKRLGILDFERGAKITGAGFPVYTAKGARLERA
CCCCHHHHHHHCCCCCCCCCCCCCCCHHHHCCCEECCCCCEEECCCCCEEECCCHHHHHH
LINFMLDQHTSVNGYTEVLPPLFVNRESLRGTGQWPKFADQVYYMNEDNLYAIPTAEVPL
HHHHHHHCCCCCCCHHHHCCHHHCCHHHCCCCCCCCCHHCEEEEECCCCEEEECCCCCCC
TNMHRDEILDASDIPLAYAAYTPCFRREAGSYGKDTRGFLRVHQFNKVELVRYATPTTSY
CCCCHHHCCCCCCCCEEHHHHCHHHHHHCCCCCCCCHHHHEEECCCCEEEEEEECCCCCH
DALQEILSHAEGILQALKIPYRVLLLCSGDISANATKCYDIEVWAPGEGKFLEASSCSNF
HHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCEEEEEEEEEECCCCCEEECCCCCCC
EDYQARRANIRYRPEDGGKPTYVHTLNGSGLATSRLMVALLENYQTPEGSIRIPDVLQPY
HHHHHHHCCCEECCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCEECCHHHCCC
TGFSSIDQAAE
CCHHHHHHHCC
>Mature Secondary Structure
MLDINFIRQNPEKVSRMLEQRQQREDIAKLNQLLDFDVRRRTMVQRTDELKALRNKVSKD
CCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAVIKRSGQGSADDLIVQMKAVADEISGMDDTLKSLEAQIEELLLSLPNKLHEDVPEGRC
HHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCC
ADDNHIYREKLSFDHKLDFPLDNHLDLGKRLGILDFERGAKITGAGFPVYTAKGARLERA
CCCCHHHHHHHCCCCCCCCCCCCCCCHHHHCCCEECCCCCEEECCCCCEEECCCHHHHHH
LINFMLDQHTSVNGYTEVLPPLFVNRESLRGTGQWPKFADQVYYMNEDNLYAIPTAEVPL
HHHHHHHCCCCCCCHHHHCCHHHCCHHHCCCCCCCCCHHCEEEEECCCCEEEECCCCCCC
TNMHRDEILDASDIPLAYAAYTPCFRREAGSYGKDTRGFLRVHQFNKVELVRYATPTTSY
CCCCHHHCCCCCCCCEEHHHHCHHHHHHCCCCCCCCHHHHEEECCCCEEEEEEECCCCCH
DALQEILSHAEGILQALKIPYRVLLLCSGDISANATKCYDIEVWAPGEGKFLEASSCSNF
HHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCEEEEEEEEEECCCCCEEECCCCCCC
EDYQARRANIRYRPEDGGKPTYVHTLNGSGLATSRLMVALLENYQTPEGSIRIPDVLQPY
HHHHHHHCCCEECCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCEECCHHHCCC
TGFSSIDQAAE
CCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA