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The map label for this gene is acoC [H]

Identifier: 194333509

GI number: 194333509

Start: 719079

End: 719951

Strand: Reverse

Name: acoC [H]

Synonym: Paes_0675

Alternate gene names: 194333509

Gene position: 719951-719079 (Counterclockwise)

Preceding gene: 194333512

Following gene: 194333507

Centisome position: 28.65

GC content: 48.57

Gene sequence:

>873_bases
ATGAAAAGCACAACGAAAGACATATTCTATCTCTGGGAATACGAACCGGGAAAAACTGCAAGGATTCGCTACAGGCGGTA
CGGGCCCGATAAGACCCGGAAACCGGTGCTGCTTTTTGTTCATGGCTATGGAGGAATGCTGGAGCACTGGAACCTTAACA
TCCCTGAATTCCAGAATGAATACACGATCTTCGCGCTTGACCTGATCGGTTTCGGCAAATCGGAAAAACCAAATACCCGT
TACCGTCTCGAACTCTTCGCAGACCAGATCAATGCGTTCATACGGTTTCTCGAACTCGAAGATGTCATCATCATCGGACA
CTCAATGGGTGGAGCTTCAGGACTTTACTATGCTCATCAGAATCCGGATGTTCTTCGCGGACTGATACTGGCAAATCCTT
CCGGTCTGTTTGGTGATACCATGGATCCTATGGCCAAAGCCTTTTTCGGACTTATTGCATCGCCGCTGATAGGAGAGTTC
ATGTTTGCAGCCTTTGCCAATCCGATCGGAGTCAGTCAAAGCCTTATGCCGACCTACTACAACCAGAAAAAAGTAGACCT
GAAACTGATCAACCAGTTTACCAGACCCCTCCAGGACAAAGGCGCTGTATGGTCATTTCTATCGCCATCACGAAGGCCGA
ACGATTTCACACTCGAGCATCTTCCAAAACCATGCAACTATCGCAACAAGGCGTTTCTGATATGGGGTGCTGAAGACTCC
GCACTGCCTCCGCATAAAATCATCCCCGAATTCCAGGAGATTCTACCACAGGCCGGAGCCTACATTATACCCAAAGCGTC
GCACTGCATCCATCACGACGCCCACGAAGATTTCAACAATCGTTTACGCCACATTCTCAACCATGAACTCTGA

Upstream 100 bases:

>100_bases
TAACCAATTTAACAAATTCAGCCATAGACTCTGCATTTCATTCATCTTGGGCTATATTATCCATTGAAATTGACAACTCT
GTATTATGAAGACCTGAGCC

Downstream 100 bases:

>100_bases
GCGTTAGCGAGGAGACTCAGGAGGAGGTGTCGATCCTGCCGCGCTGACGGAAACGAAGATCTTTCAGCTGAGGAGATTTG
ATGCCGATCTGAAAAAAGTA

Product: alpha/beta hydrolase fold protein

Products: NA

Alternate protein names: Acetoin dehydrogenase E2 component; Dihydrolipoamide acetyltransferase component of acetoin cleaving system [H]

Number of amino acids: Translated: 290; Mature: 290

Protein sequence:

>290_residues
MKSTTKDIFYLWEYEPGKTARIRYRRYGPDKTRKPVLLFVHGYGGMLEHWNLNIPEFQNEYTIFALDLIGFGKSEKPNTR
YRLELFADQINAFIRFLELEDVIIIGHSMGGASGLYYAHQNPDVLRGLILANPSGLFGDTMDPMAKAFFGLIASPLIGEF
MFAAFANPIGVSQSLMPTYYNQKKVDLKLINQFTRPLQDKGAVWSFLSPSRRPNDFTLEHLPKPCNYRNKAFLIWGAEDS
ALPPHKIIPEFQEILPQAGAYIIPKASHCIHHDAHEDFNNRLRHILNHEL

Sequences:

>Translated_290_residues
MKSTTKDIFYLWEYEPGKTARIRYRRYGPDKTRKPVLLFVHGYGGMLEHWNLNIPEFQNEYTIFALDLIGFGKSEKPNTR
YRLELFADQINAFIRFLELEDVIIIGHSMGGASGLYYAHQNPDVLRGLILANPSGLFGDTMDPMAKAFFGLIASPLIGEF
MFAAFANPIGVSQSLMPTYYNQKKVDLKLINQFTRPLQDKGAVWSFLSPSRRPNDFTLEHLPKPCNYRNKAFLIWGAEDS
ALPPHKIIPEFQEILPQAGAYIIPKASHCIHHDAHEDFNNRLRHILNHEL
>Mature_290_residues
MKSTTKDIFYLWEYEPGKTARIRYRRYGPDKTRKPVLLFVHGYGGMLEHWNLNIPEFQNEYTIFALDLIGFGKSEKPNTR
YRLELFADQINAFIRFLELEDVIIIGHSMGGASGLYYAHQNPDVLRGLILANPSGLFGDTMDPMAKAFFGLIASPLIGEF
MFAAFANPIGVSQSLMPTYYNQKKVDLKLINQFTRPLQDKGAVWSFLSPSRRPNDFTLEHLPKPCNYRNKAFLIWGAEDS
ALPPHKIIPEFQEILPQAGAYIIPKASHCIHHDAHEDFNNRLRHILNHEL

Specific function: 3-hydroxyphenylpropionate degradation. [C]

COG id: COG0596

COG function: function code R; Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 lipoyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI50658087, Length=113, Percent_Identity=30.0884955752212, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17554012, Length=301, Percent_Identity=22.5913621262458, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24586385, Length=103, Percent_Identity=32.0388349514563, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24586387, Length=103, Percent_Identity=32.0388349514563, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24586391, Length=103, Percent_Identity=32.0388349514563, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24586389, Length=103, Percent_Identity=32.0388349514563, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003016
- InterPro:   IPR000073
- InterPro:   IPR000089
- InterPro:   IPR011053 [H]

Pfam domain/function: PF00561 Abhydrolase_1; PF00364 Biotin_lipoyl [H]

EC number: =2.3.1.12 [H]

Molecular weight: Translated: 33269; Mature: 33269

Theoretical pI: Translated: 8.23; Mature: 8.23

Prosite motif: PS00120 LIPASE_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSTTKDIFYLWEYEPGKTARIRYRRYGPDKTRKPVLLFVHGYGGMLEHWNLNIPEFQNE
CCCCCCEEEEEEEECCCCEEEEEEEECCCCCCCCCEEEEEECCCCCEEECCCCCCCCCCC
YTIFALDLIGFGKSEKPNTRYRLELFADQINAFIRFLELEDVIIIGHSMGGASGLYYAHQ
EEEEEEEEECCCCCCCCCCEEEHHHHHHHHHHHHHHHEECCEEEEEECCCCCCCEEEECC
NPDVLRGLILANPSGLFGDTMDPMAKAFFGLIASPLIGEFMFAAFANPIGVSQSLMPTYY
CHHHHHEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCHHC
NQKKVDLKLINQFTRPLQDKGAVWSFLSPSRRPNDFTLEHLPKPCNYRNKAFLIWGAEDS
CCCCHHHHHHHHHHHCHHHCCCEEECCCCCCCCCCCCHHHCCCCCCCCCCEEEEECCCCC
ALPPHKIIPEFQEILPQAGAYIIPKASHCIHHDAHEDFNNRLRHILNHEL
CCCCHHHHHHHHHHHHHCCCEEEECCHHHHCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKSTTKDIFYLWEYEPGKTARIRYRRYGPDKTRKPVLLFVHGYGGMLEHWNLNIPEFQNE
CCCCCCEEEEEEEECCCCEEEEEEEECCCCCCCCCEEEEEECCCCCEEECCCCCCCCCCC
YTIFALDLIGFGKSEKPNTRYRLELFADQINAFIRFLELEDVIIIGHSMGGASGLYYAHQ
EEEEEEEEECCCCCCCCCCEEEHHHHHHHHHHHHHHHEECCEEEEEECCCCCCCEEEECC
NPDVLRGLILANPSGLFGDTMDPMAKAFFGLIASPLIGEFMFAAFANPIGVSQSLMPTYY
CHHHHHEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCHHC
NQKKVDLKLINQFTRPLQDKGAVWSFLSPSRRPNDFTLEHLPKPCNYRNKAFLIWGAEDS
CCCCHHHHHHHHHHHCHHHCCCEEECCCCCCCCCCCCHHHCCCCCCCCCCEEEEECCCCC
ALPPHKIIPEFQEILPQAGAYIIPKASHCIHHDAHEDFNNRLRHILNHEL
CCCCHHHHHHHHHHHHHCCCEEEECCHHHHCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7813883 [H]