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The map label for this gene is sucC

Identifier: 194333450

GI number: 194333450

Start: 647427

End: 648599

Strand: Reverse

Name: sucC

Synonym: Paes_0607

Alternate gene names: 194333450

Gene position: 648599-647427 (Counterclockwise)

Preceding gene: 194333452

Following gene: 194333446

Centisome position: 25.81

GC content: 52.0

Gene sequence:

>1173_bases
ATGAATATCCATGAGTATCAGGGCAAGGATATACTACGCAAATTCGGAGTATCCGTCCCCAAAGGCATTGTGGCATTTAC
CGCCGAAGAGGCTCGCCAGGCTGCAGAACAGCTTTTTGAAGAACAGGAAAATCCTGTTGTCGTCGTCAAGGCACAGATCC
ATGCCGGAGGCAGAGGAAAAGCCGGAGGAGTCAAGCTTGCAAAATCACCTGACGAGGTCTTCGACATTGCACGTCAGATG
ATTGGCTGCACCCTTGTGACCCATCAGACCGGACCGGAAGGCAAAGAGGTTCGTCGCCTGCTCGTCGAAGAGGGCATGAA
TATCGAAAAAGAGTTTTATGTCGGCATTACGCTCGACCGCGCCACATCCCAGAATGTGCTGATGGTCTCGACCGAAGGTG
GCATGGAAATCGAAACAGTCGCAGAAGAAACCCCTGAAAAACTGCTTAAAATCCAGATCCATCCGCTTCAGGGTCTTCAG
GGATTCCAGGCACGACAGGCGGCTTTTTTCCTCGGTCTCGAGGGAGACAAGTTCAAAAACACCGTCAAATTCATCACAGC
GCTCTACAAGGCCTACACCGCAATCGATGCTTCGATTGCTGAAATCAACCCGCTGGTCATCACCAAAGAGGGAAAGGTTA
TGGCTCTTGACGCCAAAATCAATTTCGACTCCAACGCACTCTTCCGCCACAAGGACTTTCTTGAACTGCGTGATATCAGT
GAAGAGGACCCGTTTGAAGTCGAAGCATCGAAATCAAATCTGAACTACGTCCGGCTTGACGGCAATGTCGGCTGCATGGT
CAACGGTGCAGGTCTTGCAATGGCAACGATGGACATGATCCAGCTTGCCGGAGGCAAACCGGCCAACTTCCTTGACGTCG
GAGGCAGCGCGAGCCCCGAAACCGTTGAAGAAGGCTTCAAGATCATCATGAGTGACAAAAACGTCAAAGCCATCCTTATC
AATATCTTCGGAGGCATCGTCCGTTGCGACCGCGTAGCCGGAGGAGTTATCGAAGCCGCCAAAAAGGTTGGGCTCGACAT
GCCGGTCATCGTCCGGCTCGAAGGCACCAATGCCGAAATTGCCCAGAAAATGCTTGATGAATCAGGGCTCAACCTGATCG
CAGCAAACGGTCTGCGCGAAGCCGCACAGAAAGTCAACGAAGCACTTTCCTGA

Upstream 100 bases:

>100_bases
AGATTTTAATGAAAGGGCTTTTTTTGCTATAATAAAGCTTTTGTTTCCCACTTTTGCGAACAGTTATCTGTTCTAGAGTT
TTAACCAATACCAGAGCACC

Downstream 100 bases:

>100_bases
CCAGTTCATGCTCACCAGAAAAAAAGCCCTCAAAACGAGGGCTTTTTTCGTAACACTCCAGCACTCAACACTCACGTCTC
AGCACTCGCTTCTCTGAACA

Product: succinyl-CoA synthetase subunit beta

Products: NA

Alternate protein names: Succinyl-CoA synthetase subunit beta; SCS-beta

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MNIHEYQGKDILRKFGVSVPKGIVAFTAEEARQAAEQLFEEQENPVVVVKAQIHAGGRGKAGGVKLAKSPDEVFDIARQM
IGCTLVTHQTGPEGKEVRRLLVEEGMNIEKEFYVGITLDRATSQNVLMVSTEGGMEIETVAEETPEKLLKIQIHPLQGLQ
GFQARQAAFFLGLEGDKFKNTVKFITALYKAYTAIDASIAEINPLVITKEGKVMALDAKINFDSNALFRHKDFLELRDIS
EEDPFEVEASKSNLNYVRLDGNVGCMVNGAGLAMATMDMIQLAGGKPANFLDVGGSASPETVEEGFKIIMSDKNVKAILI
NIFGGIVRCDRVAGGVIEAAKKVGLDMPVIVRLEGTNAEIAQKMLDESGLNLIAANGLREAAQKVNEALS

Sequences:

>Translated_390_residues
MNIHEYQGKDILRKFGVSVPKGIVAFTAEEARQAAEQLFEEQENPVVVVKAQIHAGGRGKAGGVKLAKSPDEVFDIARQM
IGCTLVTHQTGPEGKEVRRLLVEEGMNIEKEFYVGITLDRATSQNVLMVSTEGGMEIETVAEETPEKLLKIQIHPLQGLQ
GFQARQAAFFLGLEGDKFKNTVKFITALYKAYTAIDASIAEINPLVITKEGKVMALDAKINFDSNALFRHKDFLELRDIS
EEDPFEVEASKSNLNYVRLDGNVGCMVNGAGLAMATMDMIQLAGGKPANFLDVGGSASPETVEEGFKIIMSDKNVKAILI
NIFGGIVRCDRVAGGVIEAAKKVGLDMPVIVRLEGTNAEIAQKMLDESGLNLIAANGLREAAQKVNEALS
>Mature_390_residues
MNIHEYQGKDILRKFGVSVPKGIVAFTAEEARQAAEQLFEEQENPVVVVKAQIHAGGRGKAGGVKLAKSPDEVFDIARQM
IGCTLVTHQTGPEGKEVRRLLVEEGMNIEKEFYVGITLDRATSQNVLMVSTEGGMEIETVAEETPEKLLKIQIHPLQGLQ
GFQARQAAFFLGLEGDKFKNTVKFITALYKAYTAIDASIAEINPLVITKEGKVMALDAKINFDSNALFRHKDFLELRDIS
EEDPFEVEASKSNLNYVRLDGNVGCMVNGAGLAMATMDMIQLAGGKPANFLDVGGSASPETVEEGFKIIMSDKNVKAILI
NIFGGIVRCDRVAGGVIEAAKKVGLDMPVIVRLEGTNAEIAQKMLDESGLNLIAANGLREAAQKVNEALS

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0045

COG function: function code C; Succinyl-CoA synthetase, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain

Homologues:

Organism=Homo sapiens, GI11321583, Length=392, Percent_Identity=45.6632653061224, Blast_Score=339, Evalue=2e-93,
Organism=Homo sapiens, GI157779135, Length=387, Percent_Identity=46.2532299741602, Blast_Score=328, Evalue=6e-90,
Organism=Homo sapiens, GI294862256, Length=363, Percent_Identity=46.5564738292011, Blast_Score=312, Evalue=3e-85,
Organism=Escherichia coli, GI1786948, Length=389, Percent_Identity=52.1850899742931, Blast_Score=385, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI17539378, Length=398, Percent_Identity=44.4723618090452, Blast_Score=333, Evalue=1e-91,
Organism=Caenorhabditis elegans, GI17567829, Length=391, Percent_Identity=43.4782608695652, Blast_Score=313, Evalue=8e-86,
Organism=Caenorhabditis elegans, GI17557344, Length=344, Percent_Identity=27.3255813953488, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6321683, Length=397, Percent_Identity=44.080604534005, Blast_Score=341, Evalue=1e-94,
Organism=Drosophila melanogaster, GI21356231, Length=399, Percent_Identity=45.8646616541353, Blast_Score=335, Evalue=2e-92,
Organism=Drosophila melanogaster, GI161078106, Length=389, Percent_Identity=43.9588688946015, Blast_Score=310, Evalue=8e-85,
Organism=Drosophila melanogaster, GI24645208, Length=389, Percent_Identity=43.9588688946015, Blast_Score=310, Evalue=8e-85,
Organism=Drosophila melanogaster, GI281361397, Length=390, Percent_Identity=44.1025641025641, Blast_Score=309, Evalue=2e-84,
Organism=Drosophila melanogaster, GI281361395, Length=390, Percent_Identity=44.1025641025641, Blast_Score=309, Evalue=2e-84,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2361 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SUCC_PROA2 (B4S612)

Other databases:

- EMBL:   CP001108
- RefSeq:   YP_002015310.1
- ProteinModelPortal:   B4S612
- SMR:   B4S612
- GeneID:   6458505
- GenomeReviews:   CP001108_GR
- KEGG:   paa:Paes_0607
- HOGENOM:   HBG315432
- OMA:   NPLIVMK
- ProtClustDB:   PRK00696
- HAMAP:   MF_00558
- InterPro:   IPR011761
- InterPro:   IPR013650
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR005811
- InterPro:   IPR017866
- InterPro:   IPR005809
- InterPro:   IPR016102
- Gene3D:   G3DSA:3.30.1490.20
- Gene3D:   G3DSA:3.30.470.20
- Gene3D:   G3DSA:3.40.50.261
- PANTHER:   PTHR11815
- TIGRFAMs:   TIGR01016

Pfam domain/function: PF08442 ATP-grasp_2; PF00549 Ligase_CoA; SSF52210 CoA_ligase

EC number: =6.2.1.5

Molecular weight: Translated: 42253; Mature: 42253

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS50975 ATP_GRASP; PS01217 SUCCINYL_COA_LIG_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIHEYQGKDILRKFGVSVPKGIVAFTAEEARQAAEQLFEEQENPVVVVKAQIHAGGRGK
CCCCCCCCHHHHHHCCCCCCCCCEEEEHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCC
AGGVKLAKSPDEVFDIARQMIGCTLVTHQTGPEGKEVRRLLVEEGMNIEKEFYVGITLDR
CCCEEECCCHHHHHHHHHHHHCEEEEEECCCCCHHHHHHHHHHCCCCCCEEEEEEEEEEC
ATSQNVLMVSTEGGMEIETVAEETPEKLLKIQIHPLQGLQGFQARQAAFFLGLEGDKFKN
CCCCCEEEEECCCCCEEHHHHHHCHHEEEEEEEECCCCCCCCCCCCEEEEEECCCHHHHH
TVKFITALYKAYTAIDASIAEINPLVITKEGKVMALDAKINFDSNALFRHKDFLELRDIS
HHHHHHHHHHHHHHHCCHHHHCCCEEEECCCCEEEEEEEECCCCCCEECCCCHHHHHCCC
EEDPFEVEASKSNLNYVRLDGNVGCMVNGAGLAMATMDMIQLAGGKPANFLDVGGSASPE
CCCCCEEEECCCCCCEEEECCCEEEEEECCCHHHHHHHHHHHCCCCCCCEEECCCCCCHH
TVEEGFKIIMSDKNVKAILINIFGGIVRCDRVAGGVIEAAKKVGLDMPVIVRLEGTNAEI
HHHCCCEEEECCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHH
AQKMLDESGLNLIAANGLREAAQKVNEALS
HHHHHHHCCCEEEEECHHHHHHHHHHHHCC
>Mature Secondary Structure
MNIHEYQGKDILRKFGVSVPKGIVAFTAEEARQAAEQLFEEQENPVVVVKAQIHAGGRGK
CCCCCCCCHHHHHHCCCCCCCCCEEEEHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCC
AGGVKLAKSPDEVFDIARQMIGCTLVTHQTGPEGKEVRRLLVEEGMNIEKEFYVGITLDR
CCCEEECCCHHHHHHHHHHHHCEEEEEECCCCCHHHHHHHHHHCCCCCCEEEEEEEEEEC
ATSQNVLMVSTEGGMEIETVAEETPEKLLKIQIHPLQGLQGFQARQAAFFLGLEGDKFKN
CCCCCEEEEECCCCCEEHHHHHHCHHEEEEEEEECCCCCCCCCCCCEEEEEECCCHHHHH
TVKFITALYKAYTAIDASIAEINPLVITKEGKVMALDAKINFDSNALFRHKDFLELRDIS
HHHHHHHHHHHHHHHCCHHHHCCCEEEECCCCEEEEEEEECCCCCCEECCCCHHHHHCCC
EEDPFEVEASKSNLNYVRLDGNVGCMVNGAGLAMATMDMIQLAGGKPANFLDVGGSASPE
CCCCCEEEECCCCCCEEEECCCEEEEEECCCHHHHHHHHHHHCCCCCCCEEECCCCCCHH
TVEEGFKIIMSDKNVKAILINIFGGIVRCDRVAGGVIEAAKKVGLDMPVIVRLEGTNAEI
HHHCCCEEEECCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHH
AQKMLDESGLNLIAANGLREAAQKVNEALS
HHHHHHHCCCEEEEECHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA