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The map label for this gene is folP [H]

Identifier: 194333305

GI number: 194333305

Start: 496786

End: 497661

Strand: Reverse

Name: folP [H]

Synonym: Paes_0462

Alternate gene names: 194333305

Gene position: 497661-496786 (Counterclockwise)

Preceding gene: 194333306

Following gene: 194333304

Centisome position: 19.8

GC content: 52.4

Gene sequence:

>876_bases
ATGCAGCAGGAACCAAGAATTCAACGCCTTCTTTCATGCAGGGGGCATGTACTCGATTTCCGTAAAAAACCCTGCGTCAT
GGGTATTCTGAATACGACCCCTGACTCATTTTATGACGGCGGTCGCCACCGGGACAAAGCGCTGCATCATGCGCTCTCGA
TGATCAGCTATGGCGCAGATATTATCGATATTGGCGGGGAATCAACCCGGCCGGGCGCTGAGGCGGTTTCTGCAGAAGAA
GAAATCCGCCGGACAGCACCCCTGATCAGGGAGTTGAAAAAACACACCTCCATTCCAATCTCCATCGACACATGGAAGGC
TGAGGTTGCCGAAGAAGCGCTTCAATGCGGTGCATCTATCGTCAATGATATTTCAGGGTTCACCTTTGATGAAGCGCTGC
CCGATGTCTGCAAAAAATACCAGGCGGCAGTCATTCTCATGCACACCACCGATAGACCGGACCAGATGCAGTGGAGCACC
GAAACAGGCGGGGCTGAGCGCGATATCGTCGCTCTCGTCAAAACAGCGCTTGAAGCATCTGTAGCCAATGCAAAAGCACA
CGGCATAGACCAGGTCGTCATTGACCCCGGTTTCGGCTTTGGCAAAAGCGTCAGGGAAAACTTTATCCTGCTCAAACGCC
TGCATGAATTTCACTCCCTCGGATTGCCCGTGCTGGCTGGTTTATCAAGAAAGTCCTTTCTCGGTCATGCCGTTCAAACA
CACAACGCTCCATTACCTTCCGCTGATGATCGCCTTGCGGCGACAGTGAGCGCCAATACCATCGCCCTCTTCAATGGTGC
TGATATTCTGAGAGTTCATGATGTCAGCGAAGCTGTTGCAACAGCAGCCATCATCAAAGCGGTCGGAAACGCATGA

Upstream 100 bases:

>100_bases
CCAAAAGAACTCTCCTCGGCTGGATCGCCATCGCCATATTCATACTCTGTTTTACTCCCGTTCCATTCGGGGTAATCTGA
AAACGAAATCCGAACGACAG

Downstream 100 bases:

>100_bases
AAATCGAGGCAAGATCGCGCCATGAGGTCTGCGGATGAAGAGCAAACAGGTAATTTTTATTAAATTTTCCCGGACGCACT
CACGATCCTAACCCGGGGCA

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 291; Mature: 291

Protein sequence:

>291_residues
MQQEPRIQRLLSCRGHVLDFRKKPCVMGILNTTPDSFYDGGRHRDKALHHALSMISYGADIIDIGGESTRPGAEAVSAEE
EIRRTAPLIRELKKHTSIPISIDTWKAEVAEEALQCGASIVNDISGFTFDEALPDVCKKYQAAVILMHTTDRPDQMQWST
ETGGAERDIVALVKTALEASVANAKAHGIDQVVIDPGFGFGKSVRENFILLKRLHEFHSLGLPVLAGLSRKSFLGHAVQT
HNAPLPSADDRLAATVSANTIALFNGADILRVHDVSEAVATAAIIKAVGNA

Sequences:

>Translated_291_residues
MQQEPRIQRLLSCRGHVLDFRKKPCVMGILNTTPDSFYDGGRHRDKALHHALSMISYGADIIDIGGESTRPGAEAVSAEE
EIRRTAPLIRELKKHTSIPISIDTWKAEVAEEALQCGASIVNDISGFTFDEALPDVCKKYQAAVILMHTTDRPDQMQWST
ETGGAERDIVALVKTALEASVANAKAHGIDQVVIDPGFGFGKSVRENFILLKRLHEFHSLGLPVLAGLSRKSFLGHAVQT
HNAPLPSADDRLAATVSANTIALFNGADILRVHDVSEAVATAAIIKAVGNA
>Mature_291_residues
MQQEPRIQRLLSCRGHVLDFRKKPCVMGILNTTPDSFYDGGRHRDKALHHALSMISYGADIIDIGGESTRPGAEAVSAEE
EIRRTAPLIRELKKHTSIPISIDTWKAEVAEEALQCGASIVNDISGFTFDEALPDVCKKYQAAVILMHTTDRPDQMQWST
ETGGAERDIVALVKTALEASVANAKAHGIDQVVIDPGFGFGKSVRENFILLKRLHEFHSLGLPVLAGLSRKSFLGHAVQT
HNAPLPSADDRLAATVSANTIALFNGADILRVHDVSEAVATAAIIKAVGNA

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=285, Percent_Identity=41.4035087719298, Blast_Score=195, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6324073, Length=330, Percent_Identity=30.3030303030303, Blast_Score=127, Evalue=3e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 31459; Mature: 31459

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQEPRIQRLLSCRGHVLDFRKKPCVMGILNTTPDSFYDGGRHRDKALHHALSMISYGAD
CCCCHHHHHHHHHCCHHHHHCCCCCEEEEECCCCHHHHCCCCHHHHHHHHHHHHHHHCCC
IIDIGGESTRPGAEAVSAEEEIRRTAPLIRELKKHTSIPISIDTWKAEVAEEALQCGASI
EEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHH
VNDISGFTFDEALPDVCKKYQAAVILMHTTDRPDQMQWSTETGGAERDIVALVKTALEAS
HHHHCCCCHHHHHHHHHHHHHHEEEEEEECCCCCCCEECCCCCCCHHHHHHHHHHHHHHH
VANAKAHGIDQVVIDPGFGFGKSVRENFILLKRLHEFHSLGLPVLAGLSRKSFLGHAVQT
HHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHCCCHHHHHHHHHHH
HNAPLPSADDRLAATVSANTIALFNGADILRVHDVSEAVATAAIIKAVGNA
CCCCCCCCCCCEEEEECCCEEEEECCCCEEEEHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQQEPRIQRLLSCRGHVLDFRKKPCVMGILNTTPDSFYDGGRHRDKALHHALSMISYGAD
CCCCHHHHHHHHHCCHHHHHCCCCCEEEEECCCCHHHHCCCCHHHHHHHHHHHHHHHCCC
IIDIGGESTRPGAEAVSAEEEIRRTAPLIRELKKHTSIPISIDTWKAEVAEEALQCGASI
EEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHH
VNDISGFTFDEALPDVCKKYQAAVILMHTTDRPDQMQWSTETGGAERDIVALVKTALEAS
HHHHCCCCHHHHHHHHHHHHHHEEEEEEECCCCCCCEECCCCCCCHHHHHHHHHHHHHHH
VANAKAHGIDQVVIDPGFGFGKSVRENFILLKRLHEFHSLGLPVLAGLSRKSFLGHAVQT
HHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHCCCHHHHHHHHHHH
HNAPLPSADDRLAATVSANTIALFNGADILRVHDVSEAVATAAIIKAVGNA
CCCCCCCCCCCEEEEECCCEEEEECCCCEEEEHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]