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The map label for this gene is ywlC [H]

Identifier: 194333295

GI number: 194333295

Start: 484572

End: 485522

Strand: Reverse

Name: ywlC [H]

Synonym: Paes_0452

Alternate gene names: 194333295

Gene position: 485522-484572 (Counterclockwise)

Preceding gene: 194333296

Following gene: 194333290

Centisome position: 19.32

GC content: 62.57

Gene sequence:

>951_bases
ATGCAGACACTCATTACAGACTCTCCGAGAGAAGCTGCCGACTTCATCAATCGTGGCCAAATCGTAGCATTTCCAACCGA
AACCGTCTATGGCCTCGGGGCCGATATCACCAACGATGATGCCGTGCAACGTATCTTCCTGGCCAAAGGAAGACCGGGCG
ACAACCCTCTCATCGTTCACGTGTATTCACCGAAAGAAGTGGAAAAAGTCGCCGCTTCCATACCCGAAACAGCGAGAAAG
CTCATGGACCGCTTTTTTCCCGGTCCGCTGACGCTTGTGCTCTGCAAACAGTCCCGGATTTCGCCGCTCGTCACCGCAGG
GCTCCCCACGGTGGGAGTCCGCTGCCCGCGGCATCCCGTCACAAGAGCGTTCCTCAGAGAGTGCCGCCACCCTGTGGCCG
CACCCTCGGCGAACCTGTCGGGCAAACCGAGTTCGACTGACTGGAAATCGGTCCATGAGGACCTGAACGGAAAAATCAAT
TGCATTCTCAGGGGAGAACAAAGCGCCATCGGCCTCGAATCGACGATCGTGGACTGCGCGACCGAACCGCCCCGGCTGCT
CAGGGCGGGCGCCATCAGCCTCGACGAGCTGCGCGCGATCGTCCCCGGCCTGCTCGGCCCGGCCGCGATCGAGGAGCACG
CTCAGCCGAAAAGCCCCGGCCTGAAATACCCGCACTACGCCCCCTCGGCTGAGATCAGGCTGTGCGGAGAGGAGTACGGA
GTATGCGAGGGAGGGAAAGAAACCGCCTGGATCGGGCTATCGCCTCCTCCGGAAGGCGCGGCCGTTACCTGCCGCTGCGA
CGACGCCGGGGAATACGCCCACCGGCTGTTCCGCTTTTTCCGCGAGTGCGACCGTGAGCACATCAGGACCATCTTCTGCG
AGATGCCCCCGCCCGAAGGCATCGGCCAGGCCCTCCGCGACCGCCTGCGGCGGGCGGCGGAGGGAAAGTAA

Upstream 100 bases:

>100_bases
GTTAACGAGCGCGCTGGCAGGCTATCTCTTTTATCTCATCCTGCAACCGGGCGACATCCCCGCACTCTCATTCTGCCCAT
AGACGCACAGCAGATCGATC

Downstream 100 bases:

>100_bases
GCGGTTCACACCGGGCAACCACAGTTATACCCTTGCGGGGTATATTTTGCAAATATACCCCGCAAGGGTTCGACCAACAG
ACAAACGCACCGCAACTATG

Product: Sua5/YciO/YrdC/YwlC family protein

Products: NA

Alternate protein names: t(6)A37 threonylcarbamoyladenosine biosynthesis protein YwlC [H]

Number of amino acids: Translated: 316; Mature: 316

Protein sequence:

>316_residues
MQTLITDSPREAADFINRGQIVAFPTETVYGLGADITNDDAVQRIFLAKGRPGDNPLIVHVYSPKEVEKVAASIPETARK
LMDRFFPGPLTLVLCKQSRISPLVTAGLPTVGVRCPRHPVTRAFLRECRHPVAAPSANLSGKPSSTDWKSVHEDLNGKIN
CILRGEQSAIGLESTIVDCATEPPRLLRAGAISLDELRAIVPGLLGPAAIEEHAQPKSPGLKYPHYAPSAEIRLCGEEYG
VCEGGKETAWIGLSPPPEGAAVTCRCDDAGEYAHRLFRFFRECDREHIRTIFCEMPPPEGIGQALRDRLRRAAEGK

Sequences:

>Translated_316_residues
MQTLITDSPREAADFINRGQIVAFPTETVYGLGADITNDDAVQRIFLAKGRPGDNPLIVHVYSPKEVEKVAASIPETARK
LMDRFFPGPLTLVLCKQSRISPLVTAGLPTVGVRCPRHPVTRAFLRECRHPVAAPSANLSGKPSSTDWKSVHEDLNGKIN
CILRGEQSAIGLESTIVDCATEPPRLLRAGAISLDELRAIVPGLLGPAAIEEHAQPKSPGLKYPHYAPSAEIRLCGEEYG
VCEGGKETAWIGLSPPPEGAAVTCRCDDAGEYAHRLFRFFRECDREHIRTIFCEMPPPEGIGQALRDRLRRAAEGK
>Mature_316_residues
MQTLITDSPREAADFINRGQIVAFPTETVYGLGADITNDDAVQRIFLAKGRPGDNPLIVHVYSPKEVEKVAASIPETARK
LMDRFFPGPLTLVLCKQSRISPLVTAGLPTVGVRCPRHPVTRAFLRECRHPVAAPSANLSGKPSSTDWKSVHEDLNGKIN
CILRGEQSAIGLESTIVDCATEPPRLLRAGAISLDELRAIVPGLLGPAAIEEHAQPKSPGLKYPHYAPSAEIRLCGEEYG
VCEGGKETAWIGLSPPPEGAAVTCRCDDAGEYAHRLFRFFRECDREHIRTIFCEMPPPEGIGQALRDRLRRAAEGK

Specific function: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (Probable) [H]

COG id: COG0009

COG function: function code J; Putative translation factor (SUA5)

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 YrdC-like domain [H]

Homologues:

Organism=Homo sapiens, GI58761510, Length=183, Percent_Identity=29.5081967213115, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI2367210, Length=144, Percent_Identity=29.1666666666667, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI87081864, Length=185, Percent_Identity=23.7837837837838, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17537239, Length=200, Percent_Identity=32, Blast_Score=72, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6321269, Length=366, Percent_Identity=33.6065573770492, Blast_Score=168, Evalue=1e-42,
Organism=Drosophila melanogaster, GI78707274, Length=170, Percent_Identity=31.1764705882353, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR005145
- InterPro:   IPR004388
- InterPro:   IPR006070
- InterPro:   IPR010923 [H]

Pfam domain/function: PF03481 SUA5; PF01300 Sua5_yciO_yrdC [H]

EC number: NA

Molecular weight: Translated: 34446; Mature: 34446

Theoretical pI: Translated: 7.14; Mature: 7.14

Prosite motif: PS51163 YRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.5 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
3.5 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTLITDSPREAADFINRGQIVAFPTETVYGLGADITNDDAVQRIFLAKGRPGDNPLIVH
CCCCCCCCCHHHHHHHCCCCEEEECCHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCEEEE
VYSPKEVEKVAASIPETARKLMDRFFPGPLTLVLCKQSRISPLVTAGLPTVGVRCPRHPV
EECCHHHHHHHHHCHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHCCCCCCCCCCCCCHH
TRAFLRECRHPVAAPSANLSGKPSSTDWKSVHEDLNGKINCILRGEQSAIGLESTIVDCA
HHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHCC
TEPPRLLRAGAISLDELRAIVPGLLGPAAIEEHAQPKSPGLKYPHYAPSAEIRLCGEEYG
CCCHHHHHHCCCCHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCCCC
VCEGGKETAWIGLSPPPEGAAVTCRCDDAGEYAHRLFRFFRECDREHIRTIFCEMPPPEG
CCCCCCCEEEEECCCCCCCCEEEEEECCHHHHHHHHHHHHHHHCHHHHHEEEECCCCCHH
IGQALRDRLRRAAEGK
HHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQTLITDSPREAADFINRGQIVAFPTETVYGLGADITNDDAVQRIFLAKGRPGDNPLIVH
CCCCCCCCCHHHHHHHCCCCEEEECCHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCEEEE
VYSPKEVEKVAASIPETARKLMDRFFPGPLTLVLCKQSRISPLVTAGLPTVGVRCPRHPV
EECCHHHHHHHHHCHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHCCCCCCCCCCCCCHH
TRAFLRECRHPVAAPSANLSGKPSSTDWKSVHEDLNGKINCILRGEQSAIGLESTIVDCA
HHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHCC
TEPPRLLRAGAISLDELRAIVPGLLGPAAIEEHAQPKSPGLKYPHYAPSAEIRLCGEEYG
CCCHHHHHHCCCCHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCCCC
VCEGGKETAWIGLSPPPEGAAVTCRCDDAGEYAHRLFRFFRECDREHIRTIFCEMPPPEG
CCCCCCCEEEEECCCCCCCCEEEEEECCHHHHHHHHHHHHHHHCHHHHHEEEECCCCCHH
IGQALRDRLRRAAEGK
HHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]