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The map label for this gene is uppS [H]

Identifier: 194333245

GI number: 194333245

Start: 436711

End: 437529

Strand: Reverse

Name: uppS [H]

Synonym: Paes_0401

Alternate gene names: 194333245

Gene position: 437529-436711 (Counterclockwise)

Preceding gene: 194333248

Following gene: 194333244

Centisome position: 17.41

GC content: 49.08

Gene sequence:

>819_bases
ATGGATTTTTCTACCTCATTGACCCCCCACTGGTTTAAAACAACATCGAATTCCGAGGACAGCGTTGCGCAACAGGACCT
GAAACTGCACTGTCAGCTCCCCCGCCATATCGCCGTCATCATGGACGGGAATGGACGATGGGCCAAAGAAAACGGAAAAT
CACGCATTGAAGGCCATATCGCAGGCGTCGAATCGGTTCGCGACATTGTCGAAGCCTGCGCACAGCTTCAGATCGCCTAT
CTGACTCTTTTCACCTTTTCAACTGAAAACTGGAAAAGACCGGAAAAAGAGATTTCCGCTCTCATGCAGCTTCTGATCAA
GGTGCTCCGCAAAGAAGCCATAAAACTGCATGAAAACAATATCCGGCTTCACGTCATCGGCAATATCGAAAGGCTTCCCG
AAAAAGTTCAGCAGACGCTCAACGAAACGATCGCGCTTACCGCAAAGAATACGGGGCTCACACTCAGTATTGCGTTGAGT
TATAGTGGAAAATGGGATATCTTACAGGCGTGCAGAAAAATAGCTGAAGAGGCGGCGGCGGGTGCGCTCGATCCGAAAAA
AATCAACGAACAACTGATCGAGTCTTATCTTTCAACCCGTGCAATCCCGGACCCTGAGCTCCTGATCCGGACGAGCGGAG
AGCTGCGGATAAGCAACTTTCTCCTTTGGCAAAGTGCCTATTCAGAAATATTTTTCACGAGAACATACTGGCCGGAATTC
CGTCGCAAGCAACTCTATGAAGCGATACGGGATTTCAGTGCGAGGGAAAGACGTTTTGGCCTCACCAGTGAACAACTCAA
AGACAATAAAGCCCGGTAA

Upstream 100 bases:

>100_bases
ATCTCATGTGTTTTGATTGCAAATGAATGCCCTACAGGATATCGGCATAGCAGCATGAAGTTACTGCTGAAAGCGACGTA
TAATGTCTTGAACGACAAAA

Downstream 100 bases:

>100_bases
CAGTAACAACGATGTGTAATTCAATGAAACAACAGCGATCATTTCAGTCATTTCAGACCCTTCTGCTCCTGCTTTTCTTC
ACCATAACCATGGTACCGGG

Product: undecaprenyl diphosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 272; Mature: 272

Protein sequence:

>272_residues
MDFSTSLTPHWFKTTSNSEDSVAQQDLKLHCQLPRHIAVIMDGNGRWAKENGKSRIEGHIAGVESVRDIVEACAQLQIAY
LTLFTFSTENWKRPEKEISALMQLLIKVLRKEAIKLHENNIRLHVIGNIERLPEKVQQTLNETIALTAKNTGLTLSIALS
YSGKWDILQACRKIAEEAAAGALDPKKINEQLIESYLSTRAIPDPELLIRTSGELRISNFLLWQSAYSEIFFTRTYWPEF
RRKQLYEAIRDFSARERRFGLTSEQLKDNKAR

Sequences:

>Translated_272_residues
MDFSTSLTPHWFKTTSNSEDSVAQQDLKLHCQLPRHIAVIMDGNGRWAKENGKSRIEGHIAGVESVRDIVEACAQLQIAY
LTLFTFSTENWKRPEKEISALMQLLIKVLRKEAIKLHENNIRLHVIGNIERLPEKVQQTLNETIALTAKNTGLTLSIALS
YSGKWDILQACRKIAEEAAAGALDPKKINEQLIESYLSTRAIPDPELLIRTSGELRISNFLLWQSAYSEIFFTRTYWPEF
RRKQLYEAIRDFSARERRFGLTSEQLKDNKAR
>Mature_272_residues
MDFSTSLTPHWFKTTSNSEDSVAQQDLKLHCQLPRHIAVIMDGNGRWAKENGKSRIEGHIAGVESVRDIVEACAQLQIAY
LTLFTFSTENWKRPEKEISALMQLLIKVLRKEAIKLHENNIRLHVIGNIERLPEKVQQTLNETIALTAKNTGLTLSIALS
YSGKWDILQACRKIAEEAAAGALDPKKINEQLIESYLSTRAIPDPELLIRTSGELRISNFLLWQSAYSEIFFTRTYWPEF
RRKQLYEAIRDFSARERRFGLTSEQLKDNKAR

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=223, Percent_Identity=36.7713004484305, Blast_Score=159, Evalue=2e-39,
Organism=Homo sapiens, GI45580742, Length=223, Percent_Identity=36.7713004484305, Blast_Score=159, Evalue=2e-39,
Organism=Escherichia coli, GI1786371, Length=235, Percent_Identity=48.0851063829787, Blast_Score=239, Evalue=1e-64,
Organism=Caenorhabditis elegans, GI71993029, Length=245, Percent_Identity=32.6530612244898, Blast_Score=136, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6319474, Length=247, Percent_Identity=32.3886639676113, Blast_Score=122, Evalue=5e-29,
Organism=Saccharomyces cerevisiae, GI6323748, Length=228, Percent_Identity=28.9473684210526, Blast_Score=98, Evalue=1e-21,
Organism=Drosophila melanogaster, GI18857969, Length=221, Percent_Identity=36.1990950226244, Blast_Score=154, Evalue=5e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 31231; Mature: 31231

Theoretical pI: Translated: 9.09; Mature: 9.09

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFSTSLTPHWFKTTSNSEDSVAQQDLKLHCQLPRHIAVIMDGNGRWAKENGKSRIEGHI
CCCCCCCCCCEEECCCCCCHHHHHHHHHHEEECCCEEEEEECCCCCCCCCCCCHHHHHHH
AGVESVRDIVEACAQLQIAYLTLFTFSTENWKRPEKEISALMQLLIKVLRKEAIKLHENN
HHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
IRLHVIGNIERLPEKVQQTLNETIALTAKNTGLTLSIALSYSGKWDILQACRKIAEEAAA
EEEEEECCHHHHHHHHHHHHHHHEEEEEECCCEEEEEEEECCCCCHHHHHHHHHHHHHHC
GALDPKKINEQLIESYLSTRAIPDPELLIRTSGELRISNFLLWQSAYSEIFFTRTYWPEF
CCCCHHHHHHHHHHHHHHHCCCCCCCEEEECCCCEEEHHHHHHHHHHHHHHEECCCCHHH
RRKQLYEAIRDFSARERRFGLTSEQLKDNKAR
HHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCC
>Mature Secondary Structure
MDFSTSLTPHWFKTTSNSEDSVAQQDLKLHCQLPRHIAVIMDGNGRWAKENGKSRIEGHI
CCCCCCCCCCEEECCCCCCHHHHHHHHHHEEECCCEEEEEECCCCCCCCCCCCHHHHHHH
AGVESVRDIVEACAQLQIAYLTLFTFSTENWKRPEKEISALMQLLIKVLRKEAIKLHENN
HHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
IRLHVIGNIERLPEKVQQTLNETIALTAKNTGLTLSIALSYSGKWDILQACRKIAEEAAA
EEEEEECCHHHHHHHHHHHHHHHEEEEEECCCEEEEEEEECCCCCHHHHHHHHHHHHHHC
GALDPKKINEQLIESYLSTRAIPDPELLIRTSGELRISNFLLWQSAYSEIFFTRTYWPEF
CCCCHHHHHHHHHHHHHHHCCCCCCCEEEECCCCEEEHHHHHHHHHHHHHHEECCCCHHH
RRKQLYEAIRDFSARERRFGLTSEQLKDNKAR
HHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12093901 [H]