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The map label for this gene is dxr

Identifier: 194332968

GI number: 194332968

Start: 125650

End: 126798

Strand: Reverse

Name: dxr

Synonym: Paes_0121

Alternate gene names: 194332968

Gene position: 126798-125650 (Counterclockwise)

Preceding gene: 194332969

Following gene: 194332967

Centisome position: 5.05

GC content: 54.31

Gene sequence:

>1149_bases
ATGAAATCACTCTCTATCCTCGGCAGCACCGGATCTATCGGCTTAAGCACCCTTGATGTTGTCCGTCAGCACCCCGACCG
TTTCACCATCACCGGTCTTGCTGAAGGTCATGACGTTACCCTTCTTGCAGAACAGATCAGGGAATTCAAGCCATCGATTG
TCTCAGTCCGGGATGAAGCATCTGCGAATCAGTTGCGAGAACTGATCGGCGAGTCCGGTCCGGAAATCCGCTGGGGTATT
GAGGGTGCTGCAGTCGTTGGCGAAGCTGATGGCTCTGATATGGTGGTATCGGCAATTGTCGGCGCTGCAGGTCTCGTCCC
GACAGTACGAGCGATCAAAGCCGGTAAGGATATCGCTCTGGCCAACAAGGAAACTCTCGTTGTTGCAGGACAGCTTGTCT
CAGAACTCGTCAGAGAACACAAGGTGCAGCTACTTCCCGTCGACAGTGAACATTCTGCGATATTCCAGTCCCTGTCAGGT
CACCGCACAGAAGATATTGAAAGGATCATCCTCACCGCATCGGGAGGCCCTTTCCGTAAAACCCCGGCGGAAGAGCTGAA
GCTGGTCAAGCCGGAACAGGCCCTGAAACATCCGCAGTGGTCAATGGGCGCAAAGATCACCATCGACTCGGCAACCCTTA
TGAACAAAGGTCTCGAAGTCATCGAGGCACACTGGCTCTTCAACATGCCAGCTGAAAAGATCGGCGTAGTTGTCCACCCT
CAGAGCATCATTCACTCGATGGTTGAATATATTGACGGCTGTGTTATGGCTCAGCTCGGCGCTCCCGATATGCGCGCACC
GATCGCCTATGCGCTCTCCTGGCCGGAACGGTGCGAAAGCGGCATCAAAAAGCTCGACCTGACGCAGATAGGAACCCTGA
CCTTCGAAGAGCCTGACATGAAACGCTTCCCCGCCCTCCGGCTCGCGTTCGACGCACTCAGGGAAGGAAGAACCTATCCT
GCCGTACTGAACGCCGCGAATGAAATTGCCGTTGCTGCATTTTTAAACAACAACATCGGCTTTACCGATATCCCGGCCAT
TGTCGACAAAACCATGCAGGCCCATGAGGCATTGACGCCTGTCGATCTCGACGAATATCTGGCAGTTGACCGCTGGGCCA
GAGAAACTGCAGCGGCATTAACCCTGTAA

Upstream 100 bases:

>100_bases
CACGACAACATTCTCCGGATTTGTAACCATTCGTGAAAAAAACTAAATTCAGGCCGATAACCAGGGATCATTCACCGCAA
TTATCAGCAGACACACCATT

Downstream 100 bases:

>100_bases
GTGAACGGCTAAAGCCTTTCGACAGTTATATGAGAGAAATATCCCGAACGCTGCATAAAAAGCGGCATTCGGGATAGTTT
ATGTTAGCGAAAACCGAACC

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase

Number of amino acids: Translated: 382; Mature: 382

Protein sequence:

>382_residues
MKSLSILGSTGSIGLSTLDVVRQHPDRFTITGLAEGHDVTLLAEQIREFKPSIVSVRDEASANQLRELIGESGPEIRWGI
EGAAVVGEADGSDMVVSAIVGAAGLVPTVRAIKAGKDIALANKETLVVAGQLVSELVREHKVQLLPVDSEHSAIFQSLSG
HRTEDIERIILTASGGPFRKTPAEELKLVKPEQALKHPQWSMGAKITIDSATLMNKGLEVIEAHWLFNMPAEKIGVVVHP
QSIIHSMVEYIDGCVMAQLGAPDMRAPIAYALSWPERCESGIKKLDLTQIGTLTFEEPDMKRFPALRLAFDALREGRTYP
AVLNAANEIAVAAFLNNNIGFTDIPAIVDKTMQAHEALTPVDLDEYLAVDRWARETAAALTL

Sequences:

>Translated_382_residues
MKSLSILGSTGSIGLSTLDVVRQHPDRFTITGLAEGHDVTLLAEQIREFKPSIVSVRDEASANQLRELIGESGPEIRWGI
EGAAVVGEADGSDMVVSAIVGAAGLVPTVRAIKAGKDIALANKETLVVAGQLVSELVREHKVQLLPVDSEHSAIFQSLSG
HRTEDIERIILTASGGPFRKTPAEELKLVKPEQALKHPQWSMGAKITIDSATLMNKGLEVIEAHWLFNMPAEKIGVVVHP
QSIIHSMVEYIDGCVMAQLGAPDMRAPIAYALSWPERCESGIKKLDLTQIGTLTFEEPDMKRFPALRLAFDALREGRTYP
AVLNAANEIAVAAFLNNNIGFTDIPAIVDKTMQAHEALTPVDLDEYLAVDRWARETAAALTL
>Mature_382_residues
MKSLSILGSTGSIGLSTLDVVRQHPDRFTITGLAEGHDVTLLAEQIREFKPSIVSVRDEASANQLRELIGESGPEIRWGI
EGAAVVGEADGSDMVVSAIVGAAGLVPTVRAIKAGKDIALANKETLVVAGQLVSELVREHKVQLLPVDSEHSAIFQSLSG
HRTEDIERIILTASGGPFRKTPAEELKLVKPEQALKHPQWSMGAKITIDSATLMNKGLEVIEAHWLFNMPAEKIGVVVHP
QSIIHSMVEYIDGCVMAQLGAPDMRAPIAYALSWPERCESGIKKLDLTQIGTLTFEEPDMKRFPALRLAFDALREGRTYP
AVLNAANEIAVAAFLNNNIGFTDIPAIVDKTMQAHEALTPVDLDEYLAVDRWARETAAALTL

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family

Homologues:

Organism=Escherichia coli, GI1786369, Length=389, Percent_Identity=51.413881748072, Blast_Score=382, Evalue=1e-107,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXR_PROA2 (B4S387)

Other databases:

- EMBL:   CP001108
- RefSeq:   YP_002014828.1
- ProteinModelPortal:   B4S387
- SMR:   B4S387
- GeneID:   6458466
- GenomeReviews:   CP001108_GR
- KEGG:   paa:Paes_0121
- HOGENOM:   HBG430762
- OMA:   IHSMVEY
- ProtClustDB:   PRK05447
- HAMAP:   MF_00183
- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF006205
- TIGRFAMs:   TIGR00243

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom

EC number: =1.1.1.267

Molecular weight: Translated: 41358; Mature: 41358

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: NA

Important sites: BINDING 123-123 BINDING 150-150 BINDING 174-174 BINDING 197-197 BINDING 219-219

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSLSILGSTGSIGLSTLDVVRQHPDRFTITGLAEGHDVTLLAEQIREFKPSIVSVRDEA
CCCCEEECCCCCCCHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHCCCCEEECCCC
SANQLRELIGESGPEIRWGIEGAAVVGEADGSDMVVSAIVGAAGLVPTVRAIKAGKDIAL
CHHHHHHHHCCCCCCEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEE
ANKETLVVAGQLVSELVREHKVQLLPVDSEHSAIFQSLSGHRTEDIERIILTASGGPFRK
CCCCEEEEHHHHHHHHHHHCCEEEEECCCHHHHHHHHHCCCCCCCEEEEEEEECCCCCCC
TPAEELKLVKPEQALKHPQWSMGAKITIDSATLMNKGLEVIEAHWLFNMPAEKIGVVVHP
CCHHHHEECCCHHHHCCCCCCCCCEEEECHHHHHHCCHHHHHHHHHCCCCHHHCEEEECC
QSIIHSMVEYIDGCVMAQLGAPDMRAPIAYALSWPERCESGIKKLDLTQIGTLTFEEPDM
HHHHHHHHHHHCCHHEECCCCCCCCCCHHHCCCCHHHHHHHHHHCCHHHHCEEEECCCCH
KRFPALRLAFDALREGRTYPAVLNAANEIAVAAFLNNNIGFTDIPAIVDKTMQAHEALTP
HHHHHHHHHHHHHHCCCCCHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCC
VDLDEYLAVDRWARETAAALTL
CCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKSLSILGSTGSIGLSTLDVVRQHPDRFTITGLAEGHDVTLLAEQIREFKPSIVSVRDEA
CCCCEEECCCCCCCHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHCCCCEEECCCC
SANQLRELIGESGPEIRWGIEGAAVVGEADGSDMVVSAIVGAAGLVPTVRAIKAGKDIAL
CHHHHHHHHCCCCCCEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEE
ANKETLVVAGQLVSELVREHKVQLLPVDSEHSAIFQSLSGHRTEDIERIILTASGGPFRK
CCCCEEEEHHHHHHHHHHHCCEEEEECCCHHHHHHHHHCCCCCCCEEEEEEEECCCCCCC
TPAEELKLVKPEQALKHPQWSMGAKITIDSATLMNKGLEVIEAHWLFNMPAEKIGVVVHP
CCHHHHEECCCHHHHCCCCCCCCCEEEECHHHHHHCCHHHHHHHHHCCCCHHHCEEEECC
QSIIHSMVEYIDGCVMAQLGAPDMRAPIAYALSWPERCESGIKKLDLTQIGTLTFEEPDM
HHHHHHHHHHHCCHHEECCCCCCCCCCHHHCCCCHHHHHHHHHHCCHHHHCEEEECCCCH
KRFPALRLAFDALREGRTYPAVLNAANEIAVAAFLNNNIGFTDIPAIVDKTMQAHEALTP
HHHHHHHHHHHHHHCCCCCHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCC
VDLDEYLAVDRWARETAAALTL
CCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA