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The map label for this gene is hslU [H]

Identifier: 193213901

GI number: 193213901

Start: 213225

End: 214730

Strand: Direct

Name: hslU [H]

Synonym: Ctha_0182

Alternate gene names: 193213901

Gene position: 213225-214730 (Clockwise)

Preceding gene: 193213900

Following gene: 193213902

Centisome position: 6.47

GC content: 45.68

Gene sequence:

>1506_bases
ATGCCAAAATCAAAATCTTCTAAAGAACTCACCGAAGATGAAGTAAAATCTACATCGGAGCAAAAGAAAAGTGATATGAC
GGAAACGGGTGACGAACGCGACAATAAAATTCCAGAACATTTTCTGACGCCGAGTCAAATTGTTAAGGAGTTAGACAAGT
ACATTATTGGACAACGCGAAGCGAAAAAATCAGTAGCCATTGCGCTCAGAAATCGGCTTCGCCGCCAGCGCGTTGAAGGC
GCGCTTCGCGACGAAATTATGCCAAACAACATCATCATGATTGGCCCCACCGGTGTTGGCAAAACGGAAATTGCACGCCG
CTTGGCAAAGCTTTCTGGCGCTCCGTTCGTCAAAGTTGAGGCATCAAAATTTACCGAAGTGGGATATGTCGGTCGCGATG
TTGAATCCATGATTCGCGACTTGATGGATTTGGCCGTTGGCATGGTCAGAAGCGAGCAATCAGTTGTGGTTCAGGAAAAA
GCAAAACAGCTGGCCGAAGAACGCATTCTGGACATTTTACTGCCGCCCGTGAAAAAAATTCCGGCTGGATTTAAAAAGCA
ACAATCGGCTGAAACAGACGCGGACACAGACGAGGATAAAACGGAAAACGAAATCAACGACAGAAGCCGCGAAAAAATGA
GAGACCGATTGAGAAATGGCAAGCTCGACGATAAAACCATTGAGCTGGAAGTTTCTTCTGATTCGCAAGGCATGATGCAA
ATTCTCGGCCCTTTTGGTCCAATGGAAGACATCGGCGGAATGATGCAGGATATTATCAGCGGTTTGCCGAAAAAACGAAA
AAAACGTCGCGTGACCATTTCCGAAGCCAAAGTTATTCTTGAGCAAGAAGAAACCCAGAAGCTTATCGACATGGATGCGG
TGGTCAAAGAAGCCACGCAGCGCGTTGAAAATTCAGGCATTGTCTTTATCGATGAGATCGACAAAATTGCGTCCAGTTCC
ACCGGAAATGGGCGTAGCCCGGATGTCAGCCGCGAAGGCGTTCAGCGCGATTTGCTTCCCATTGTGGAAGGCTCGAATGT
GGCAACCAAATATGGCCTGGTGAAAACCGACCATGTTTTGTTCATCGCATCTGGCGCGTTTCATGTAGCCAAACCATCGG
ACTTAATTCCTGAACTTCAAGGACGATTTCCAATTCGTGTTGAACTGAAAAGTTTGCAGGAAGATGATTTCGTCAAAATT
CTCACGCAACCAGAAAATGCCTTGATTAAGCAATACACGGCGCTGTTGAAAACAGAAAACGTGGAGCTGGAATTTTTGGA
AGATGGCATTCAGGAAATTGCACGAATCGCAGCCCAAGTCAATGAGTCAGTTGAAAATATTGGCGCTCGGCGCTTGCACA
CCATTATGACAACGTTGCTGGAAGAACTGATGTTTAATATTCCTGAAAACATTCCAGACAACAAAATCGTAGTGGACAAA
GCGATGGTCGAAAGCCGGTTGAGTGATATTGCCAAAGATAGAGACCTAAGCCGATATATTTTATAA

Upstream 100 bases:

>100_bases
ATTCTGGGTTATTTGGGAAGGTATTTCCATTGTTTGACGAATACGATACATTCTGAATTTGACCCGAGGTTTTCTAAAGT
TTTAAAAGCAAAAAAGATAG

Downstream 100 bases:

>100_bases
GCTTATAAACAAATTTATTCATTTAGCGTACAAGCAACCGGTTTTTTGAGACTTTTTTAATCAATAAAACTTGCTTGAAA
AAAAAATATGGAAACAAGAC

Product: ATP-dependent protease ATP-binding subunit HslU

Products: NA

Alternate protein names: Unfoldase HslU [H]

Number of amino acids: Translated: 501; Mature: 500

Protein sequence:

>501_residues
MPKSKSSKELTEDEVKSTSEQKKSDMTETGDERDNKIPEHFLTPSQIVKELDKYIIGQREAKKSVAIALRNRLRRQRVEG
ALRDEIMPNNIIMIGPTGVGKTEIARRLAKLSGAPFVKVEASKFTEVGYVGRDVESMIRDLMDLAVGMVRSEQSVVVQEK
AKQLAEERILDILLPPVKKIPAGFKKQQSAETDADTDEDKTENEINDRSREKMRDRLRNGKLDDKTIELEVSSDSQGMMQ
ILGPFGPMEDIGGMMQDIISGLPKKRKKRRVTISEAKVILEQEETQKLIDMDAVVKEATQRVENSGIVFIDEIDKIASSS
TGNGRSPDVSREGVQRDLLPIVEGSNVATKYGLVKTDHVLFIASGAFHVAKPSDLIPELQGRFPIRVELKSLQEDDFVKI
LTQPENALIKQYTALLKTENVELEFLEDGIQEIARIAAQVNESVENIGARRLHTIMTTLLEELMFNIPENIPDNKIVVDK
AMVESRLSDIAKDRDLSRYIL

Sequences:

>Translated_501_residues
MPKSKSSKELTEDEVKSTSEQKKSDMTETGDERDNKIPEHFLTPSQIVKELDKYIIGQREAKKSVAIALRNRLRRQRVEG
ALRDEIMPNNIIMIGPTGVGKTEIARRLAKLSGAPFVKVEASKFTEVGYVGRDVESMIRDLMDLAVGMVRSEQSVVVQEK
AKQLAEERILDILLPPVKKIPAGFKKQQSAETDADTDEDKTENEINDRSREKMRDRLRNGKLDDKTIELEVSSDSQGMMQ
ILGPFGPMEDIGGMMQDIISGLPKKRKKRRVTISEAKVILEQEETQKLIDMDAVVKEATQRVENSGIVFIDEIDKIASSS
TGNGRSPDVSREGVQRDLLPIVEGSNVATKYGLVKTDHVLFIASGAFHVAKPSDLIPELQGRFPIRVELKSLQEDDFVKI
LTQPENALIKQYTALLKTENVELEFLEDGIQEIARIAAQVNESVENIGARRLHTIMTTLLEELMFNIPENIPDNKIVVDK
AMVESRLSDIAKDRDLSRYIL
>Mature_500_residues
PKSKSSKELTEDEVKSTSEQKKSDMTETGDERDNKIPEHFLTPSQIVKELDKYIIGQREAKKSVAIALRNRLRRQRVEGA
LRDEIMPNNIIMIGPTGVGKTEIARRLAKLSGAPFVKVEASKFTEVGYVGRDVESMIRDLMDLAVGMVRSEQSVVVQEKA
KQLAEERILDILLPPVKKIPAGFKKQQSAETDADTDEDKTENEINDRSREKMRDRLRNGKLDDKTIELEVSSDSQGMMQI
LGPFGPMEDIGGMMQDIISGLPKKRKKRRVTISEAKVILEQEETQKLIDMDAVVKEATQRVENSGIVFIDEIDKIASSST
GNGRSPDVSREGVQRDLLPIVEGSNVATKYGLVKTDHVLFIASGAFHVAKPSDLIPELQGRFPIRVELKSLQEDDFVKIL
TQPENALIKQYTALLKTENVELEFLEDGIQEIARIAAQVNESVENIGARRLHTIMTTLLEELMFNIPENIPDNKIVVDKA
MVESRLSDIAKDRDLSRYIL

Specific function: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N

COG id: COG1220

COG function: function code O; ATP-dependent protease HslVU (ClpYQ), ATPase subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family. HslU subfamily [H]

Homologues:

Organism=Homo sapiens, GI7242140, Length=112, Percent_Identity=43.75, Blast_Score=83, Evalue=6e-16,
Organism=Escherichia coli, GI1790366, Length=461, Percent_Identity=52.060737527115, Blast_Score=454, Evalue=1e-129,
Organism=Escherichia coli, GI1786642, Length=270, Percent_Identity=32.2222222222222, Blast_Score=103, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71982908, Length=238, Percent_Identity=30.672268907563, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71982905, Length=238, Percent_Identity=30.2521008403361, Blast_Score=91, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6319704, Length=128, Percent_Identity=35.9375, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24648291, Length=264, Percent_Identity=30.6818181818182, Blast_Score=99, Evalue=8e-21,
Organism=Drosophila melanogaster, GI24648289, Length=264, Percent_Identity=30.6818181818182, Blast_Score=99, Evalue=8e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR019489
- InterPro:   IPR004491 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 56248; Mature: 56117

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKSKSSKELTEDEVKSTSEQKKSDMTETGDERDNKIPEHFLTPSQIVKELDKYIIGQRE
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHCCCHHHHHHHHHHHHHCCHH
AKKSVAIALRNRLRRQRVEGALRDEIMPNNIIMIGPTGVGKTEIARRLAKLSGAPFVKVE
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHCCCCEEEEE
ASKFTEVGYVGRDVESMIRDLMDLAVGMVRSEQSVVVQEKAKQLAEERILDILLPPVKKI
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHC
PAGFKKQQSAETDADTDEDKTENEINDRSREKMRDRLRNGKLDDKTIELEVSSDSQGMMQ
CCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHH
ILGPFGPMEDIGGMMQDIISGLPKKRKKRRVTISEAKVILEQEETQKLIDMDAVVKEATQ
HHCCCCCHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RVENSGIVFIDEIDKIASSSTGNGRSPDVSREGVQRDLLPIVEGSNVATKYGLVKTDHVL
HHHCCCEEEEECHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHCCCEEECCEE
FIASGAFHVAKPSDLIPELQGRFPIRVELKSLQEDDFVKILTQPENALIKQYTALLKTEN
EEECCCEECCCCHHHHHHHCCCCCEEEEHHHCCCCCHHEECCCCHHHHHHHHHHHHHHCC
VELEFLEDGIQEIARIAAQVNESVENIGARRLHTIMTTLLEELMFNIPENIPDNKIVVDK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEHHH
AMVESRLSDIAKDRDLSRYIL
HHHHHHHHHHHHHCCHHHHCC
>Mature Secondary Structure 
PKSKSSKELTEDEVKSTSEQKKSDMTETGDERDNKIPEHFLTPSQIVKELDKYIIGQRE
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHCCCHHHHHHHHHHHHHCCHH
AKKSVAIALRNRLRRQRVEGALRDEIMPNNIIMIGPTGVGKTEIARRLAKLSGAPFVKVE
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHCCCCEEEEE
ASKFTEVGYVGRDVESMIRDLMDLAVGMVRSEQSVVVQEKAKQLAEERILDILLPPVKKI
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHC
PAGFKKQQSAETDADTDEDKTENEINDRSREKMRDRLRNGKLDDKTIELEVSSDSQGMMQ
CCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHH
ILGPFGPMEDIGGMMQDIISGLPKKRKKRRVTISEAKVILEQEETQKLIDMDAVVKEATQ
HHCCCCCHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RVENSGIVFIDEIDKIASSSTGNGRSPDVSREGVQRDLLPIVEGSNVATKYGLVKTDHVL
HHHCCCEEEEECHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHCCCEEECCEE
FIASGAFHVAKPSDLIPELQGRFPIRVELKSLQEDDFVKILTQPENALIKQYTALLKTEN
EEECCCEECCCCHHHHHHHCCCCCEEEEHHHCCCCCHHEECCCCHHHHHHHHHHHHHHCC
VELEFLEDGIQEIARIAAQVNESVENIGARRLHTIMTTLLEELMFNIPENIPDNKIVVDK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEHHH
AMVESRLSDIAKDRDLSRYIL
HHHHHHHHHHHHHCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12093901 [H]