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The map label for this gene is gdhA [H]

Identifier: 193213540

GI number: 193213540

Start: 2097944

End: 2099272

Strand: Direct

Name: gdhA [H]

Synonym: Cpar_1901

Alternate gene names: 193213540

Gene position: 2097944-2099272 (Clockwise)

Preceding gene: 193213539

Following gene: 193213541

Centisome position: 91.64

GC content: 61.25

Gene sequence:

>1329_bases
ATGCAGACAATCGACGACCACCCGCCAGAAGGCACGCCAGCTCCCGAACCCTTCGTGCTCGACACCTGCACATCCGCCGG
AGCAGCAAAAGACAATCCGTTCGAAATCGCCCGCAGGCAGCTCGACGAAGCGGCAACGGTCATCGGCCTCGATCCGGAAG
TGCTGGAACTGCTCCGATGGCCGATGCGCGAAATGCATATCACCATTCCGGTCAAAATGGACGACGGCTCGGTGCGCGCG
TTTCACGGCTTCAGGGTGCAGTACAACGACGCGCGCGGCCCCAACAAAGGCGGCATCCGGTTCCATCCCGACGAAACCAT
CGACACGGTCAGGGCGCTGGCTGCATGGATGACCTGGAAAACCGCCGTCATGAATATTCCGCTCGGCGGCGCCAAGGGCG
GAGTGATCTGCAATCCGAAAGCCATGTCTGAAGGCGAGCTCGAACGGCTCTCGCGAAGCTACATCCGGCAGGTCGGTCGA
CTGCTTGGACTGACAAAGGACGTGCCCGCGCCTGACGTCTATACCACCCCGCAGATCATGGCCTGGATGGCCGACGAATA
CTCCTTCATGCAGGGACACAACGACTTCGGCGTCATTACCGGCAAGCCGATCGCCCTCGGAGGATCGCTGGGGCGCGGAG
ACGCAACGGCACGGGGCGGCATCATCTGCATCCGCGAAGCCGCCAAAGCGCTCGGCATCGACCTTCACGGCAAAATCGTC
GCCATCAACGGCTACGGCAACGCAGGCTCGTTCGCGCACAAACTCGTTGTCGAACAGCTCGGCATGAAGGTGGTCGCCGT
CTCCGACTCGAAAGGCGCAATCTATCAGCCGGACGGTATCGACTACGACGCCATCATGGAGCACAAAAGACGCAACGGAA
CCGTGGGCGGATTTCCGGGCTCGACACCGCTAAGTAACGGCGAACTGCTCAAGCTCAACGTCGCCGTGCTCATTCCGGCC
GCCCTCGAAGACGAGATCACCGGCGCCAACGCTCGCGACATCAACGCCGCCATCGTGGCGGAACTGGCCAACGGCCCAAC
TACCCCCAAAGCCGACAAGATCCTCCACGAACGAGGCGTCTACCTCATTCCCGATCTTCTCTGCAACGCAGGTGGCGTAA
CGGTCTCCTACTTTGAAATGGTGCAGAACACCAGCGGCTGGTACTGGGAGGAAGAGGAGGTTCACCGACAACTCGAAAAA
AAGATGACCGCCGCCTTCAGCGCGGTGCACGAAGCCGCCCTCGCCTGGAAGGTCGATAACCGCACGGCCGCAATGATCGT
AGCCATACGCCGCATCGAGGAGGCCATGACACTGCGTGGCTGGGTGTAA

Upstream 100 bases:

>100_bases
GCGGCGATGCCGATCAAGCCTCCCGGGATGCCGTGGTCGGTTATGGCGCAGTCATGTTCACCACCCACTGATTTACACAC
AACCCCTAACTCCATTTGTC

Downstream 100 bases:

>100_bases
GCCACTTGATGCCGGTCAAACCCTAACGATGCACTGGCAAAAAAGGAAATAACTGATTAAGGTAGAGCGCGGAGAACTTT
TTATAACGATCGTGACCTTA

Product: Glu/Leu/Phe/Val dehydrogenase

Products: NA

Alternate protein names: GDH [H]

Number of amino acids: Translated: 442; Mature: 442

Protein sequence:

>442_residues
MQTIDDHPPEGTPAPEPFVLDTCTSAGAAKDNPFEIARRQLDEAATVIGLDPEVLELLRWPMREMHITIPVKMDDGSVRA
FHGFRVQYNDARGPNKGGIRFHPDETIDTVRALAAWMTWKTAVMNIPLGGAKGGVICNPKAMSEGELERLSRSYIRQVGR
LLGLTKDVPAPDVYTTPQIMAWMADEYSFMQGHNDFGVITGKPIALGGSLGRGDATARGGIICIREAAKALGIDLHGKIV
AINGYGNAGSFAHKLVVEQLGMKVVAVSDSKGAIYQPDGIDYDAIMEHKRRNGTVGGFPGSTPLSNGELLKLNVAVLIPA
ALEDEITGANARDINAAIVAELANGPTTPKADKILHERGVYLIPDLLCNAGGVTVSYFEMVQNTSGWYWEEEEVHRQLEK
KMTAAFSAVHEAALAWKVDNRTAAMIVAIRRIEEAMTLRGWV

Sequences:

>Translated_442_residues
MQTIDDHPPEGTPAPEPFVLDTCTSAGAAKDNPFEIARRQLDEAATVIGLDPEVLELLRWPMREMHITIPVKMDDGSVRA
FHGFRVQYNDARGPNKGGIRFHPDETIDTVRALAAWMTWKTAVMNIPLGGAKGGVICNPKAMSEGELERLSRSYIRQVGR
LLGLTKDVPAPDVYTTPQIMAWMADEYSFMQGHNDFGVITGKPIALGGSLGRGDATARGGIICIREAAKALGIDLHGKIV
AINGYGNAGSFAHKLVVEQLGMKVVAVSDSKGAIYQPDGIDYDAIMEHKRRNGTVGGFPGSTPLSNGELLKLNVAVLIPA
ALEDEITGANARDINAAIVAELANGPTTPKADKILHERGVYLIPDLLCNAGGVTVSYFEMVQNTSGWYWEEEEVHRQLEK
KMTAAFSAVHEAALAWKVDNRTAAMIVAIRRIEEAMTLRGWV
>Mature_442_residues
MQTIDDHPPEGTPAPEPFVLDTCTSAGAAKDNPFEIARRQLDEAATVIGLDPEVLELLRWPMREMHITIPVKMDDGSVRA
FHGFRVQYNDARGPNKGGIRFHPDETIDTVRALAAWMTWKTAVMNIPLGGAKGGVICNPKAMSEGELERLSRSYIRQVGR
LLGLTKDVPAPDVYTTPQIMAWMADEYSFMQGHNDFGVITGKPIALGGSLGRGDATARGGIICIREAAKALGIDLHGKIV
AINGYGNAGSFAHKLVVEQLGMKVVAVSDSKGAIYQPDGIDYDAIMEHKRRNGTVGGFPGSTPLSNGELLKLNVAVLIPA
ALEDEITGANARDINAAIVAELANGPTTPKADKILHERGVYLIPDLLCNAGGVTVSYFEMVQNTSGWYWEEEEVHRQLEK
KMTAAFSAVHEAALAWKVDNRTAAMIVAIRRIEEAMTLRGWV

Specific function: Unknown

COG id: COG0334

COG function: function code E; Glutamate dehydrogenase/leucine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Glu/Leu/Phe/Val dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI31377775, Length=343, Percent_Identity=41.399416909621, Blast_Score=265, Evalue=9e-71,
Organism=Homo sapiens, GI4885281, Length=343, Percent_Identity=41.1078717201166, Blast_Score=261, Evalue=1e-69,
Organism=Escherichia coli, GI1788059, Length=400, Percent_Identity=30.25, Blast_Score=166, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI17544676, Length=336, Percent_Identity=41.9642857142857, Blast_Score=238, Evalue=4e-63,
Organism=Saccharomyces cerevisiae, GI6319256, Length=402, Percent_Identity=29.8507462686567, Blast_Score=152, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6324951, Length=445, Percent_Identity=28.5393258426966, Blast_Score=148, Evalue=1e-36,
Organism=Drosophila melanogaster, GI45553475, Length=366, Percent_Identity=38.2513661202186, Blast_Score=235, Evalue=4e-62,
Organism=Drosophila melanogaster, GI45549226, Length=343, Percent_Identity=39.6501457725948, Blast_Score=235, Evalue=5e-62,
Organism=Drosophila melanogaster, GI24649283, Length=346, Percent_Identity=38.728323699422, Blast_Score=232, Evalue=3e-61,
Organism=Drosophila melanogaster, GI24649460, Length=280, Percent_Identity=40.7142857142857, Blast_Score=194, Evalue=1e-49,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 9362 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006095
- InterPro:   IPR006096
- InterPro:   IPR006097
- InterPro:   IPR014362
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00208 ELFV_dehydrog; PF02812 ELFV_dehydrog_N [H]

EC number: =1.4.1.3 [H]

Molecular weight: Translated: 47919; Mature: 47919

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: PS00074 GLFV_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTIDDHPPEGTPAPEPFVLDTCTSAGAAKDNPFEIARRQLDEAATVIGLDPEVLELLRW
CCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHEEECCCHHHHHHHHC
PMREMHITIPVKMDDGSVRAFHGFRVQYNDARGPNKGGIRFHPDETIDTVRALAAWMTWK
CHHHEEEEEEEEECCCCEEEEEEEEEEECCCCCCCCCCCEECCCHHHHHHHHHHHHHHHH
TAVMNIPLGGAKGGVICNPKAMSEGELERLSRSYIRQVGRLLGLTKDVPAPDVYTTPQIM
HHEEECCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHH
AWMADEYSFMQGHNDFGVITGKPIALGGSLGRGDATARGGIICIREAAKALGIDLHGKIV
HHHHHHHHHHCCCCCCEEEECCCEEECCCCCCCCCCCCCCEEEEEHHHHHHCCEECCEEE
AINGYGNAGSFAHKLVVEQLGMKVVAVSDSKGAIYQPDGIDYDAIMEHKRRNGTVGGFPG
EEECCCCCCHHHHHHHHHHHCCEEEEEECCCCCEECCCCCCHHHHHHHHHCCCCCCCCCC
STPLSNGELLKLNVAVLIPAALEDEITGANARDINAAIVAELANGPTTPKADKILHERGV
CCCCCCCCEEEEEEEEEEEHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHCCC
YLIPDLLCNAGGVTVSYFEMVQNTSGWYWEEEEVHRQLEKKMTAAFSAVHEAALAWKVDN
EEEHHHHHCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEECC
RTAAMIVAIRRIEEAMTLRGWV
CHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MQTIDDHPPEGTPAPEPFVLDTCTSAGAAKDNPFEIARRQLDEAATVIGLDPEVLELLRW
CCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHEEECCCHHHHHHHHC
PMREMHITIPVKMDDGSVRAFHGFRVQYNDARGPNKGGIRFHPDETIDTVRALAAWMTWK
CHHHEEEEEEEEECCCCEEEEEEEEEEECCCCCCCCCCCEECCCHHHHHHHHHHHHHHHH
TAVMNIPLGGAKGGVICNPKAMSEGELERLSRSYIRQVGRLLGLTKDVPAPDVYTTPQIM
HHEEECCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHH
AWMADEYSFMQGHNDFGVITGKPIALGGSLGRGDATARGGIICIREAAKALGIDLHGKIV
HHHHHHHHHHCCCCCCEEEECCCEEECCCCCCCCCCCCCCEEEEEHHHHHHCCEECCEEE
AINGYGNAGSFAHKLVVEQLGMKVVAVSDSKGAIYQPDGIDYDAIMEHKRRNGTVGGFPG
EEECCCCCCHHHHHHHHHHHCCEEEEEECCCCCEECCCCCCHHHHHHHHHCCCCCCCCCC
STPLSNGELLKLNVAVLIPAALEDEITGANARDINAAIVAELANGPTTPKADKILHERGV
CCCCCCCCEEEEEEEEEEEHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHCCC
YLIPDLLCNAGGVTVSYFEMVQNTSGWYWEEEEVHRQLEKKMTAAFSAVHEAALAWKVDN
EEEHHHHHCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEECC
RTAAMIVAIRRIEEAMTLRGWV
CHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8135516 [H]