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The map label for this gene is accC [H]

Identifier: 193213520

GI number: 193213520

Start: 2069425

End: 2070768

Strand: Direct

Name: accC [H]

Synonym: Cpar_1881

Alternate gene names: 193213520

Gene position: 2069425-2070768 (Clockwise)

Preceding gene: 193213519

Following gene: 193213533

Centisome position: 90.4

GC content: 58.85

Gene sequence:

>1344_bases
TTGTTCAAAAAAATACTCATAGCTAACCGTGGAGAGATCGCCTTAAGGGTCATGCACACCTGCCGGGAGATGGGCATTTG
CACCGTCGCCGTCTATTCGACCGCCGATGTCGATTCTCTTCATGTCAAGTATGCAGACGAAGCGGTCTGCATCGGCCCGC
CCCTTTCGCGTGAAAGCTACCTCAACATCCCGCGCATTATCGCGGCTGCCGAAGTCACCAACGCTGACGCCATTCATCCC
GGTTACGGCTTCCTTGCCGAGAACGCCGATTTTTCAGAAGTCTGCCACTCCTCGAATATCAAGTTCATCGGCCCATCGGC
TGACATGATCAACCGGATGGGCGACAAGAACACCGCCAAATCGACCATGATCGCCGCCGGCGTGCCGGTGGTGCCCGGTA
GCGAAGGCTTGGTCGAGGATGTCGGTCACGCAATCGAAACCGCCAAAAGAATTGGCTACCCGGTCATCATCAAGCCGACT
GCCGGTGGCGGCGGCAAGGGTATGAGAGTGGTGCATGAAGAGAGCCAGCTCGAAAAAAACCTCAAGACCGCGCAGAGCGA
AGCCGGCATGGCGTTCGGCAACAGCGGCGTCTATATCGAAAAGTTCCTTGAAAATCCTCGTCACATCGAAATTCAGATTC
TGGCCGACCAGCACGGCAACGTGCTGCACCTCGGCGAGCGCGACTGCACCGTGCAGCGCCGCCACCAGAAGCTGATCGAG
GAGACCCCCTCACCGGTGGTCGATGAAGCCCTGCGCACGAAGATGGGCGAAGCAGCCGTGGCCGCCGCCAAGGCGATCAA
CTACGAAGGCGCCGGCACCATCGAGTTCCTGCTCGACAAGCACAAGAACTTCTACTTCATGGAGATGAACACCCGCATCC
AGGTGGAGCATCCCGTGACCGAGCAGCGCTACGATGTCGATCTGGTCAAGGAGCAGATTCGCATCGCCGCTGGTGGAAGT
CTCGAAGGCAAAGTGTTTGAGCCACGCGGCCACTCCATCGAGTGCCGCATCAACGCCGAAGATCCCGAGCACATGTTCAG
GCCGTCGCCGGGCGAGGTGCAGGTGTTCCACACTCCGGGCGGGCCGGGCGTCAGAATCGACTCCCACTGCTACGCAAGCT
ACGTGGTGCCGTCGAACTACGACTCCATGATCGGCAAACTCATCGTCACCGCGCACACCCGCGACGAAGCGATCGCCCGC
ATGTCGAGAGCGCTCGACGAGTTCATCGTGATGGGCATCAAGACTACCATTCCGTTCCACAAGCAGGTCATGCACGACCC
GGTCTTCAGGAGTGGCGAGTTCGACACCAGCTTCCTCGACAGCTTCCGCTACGAAAAGCACTAA

Upstream 100 bases:

>100_bases
CCGGAACCATCGCCGAAATTCTCGTTGAAAACGGTCAGCCTGTCGAATACAATCAGGTCCTGTTCCGAATCAAGCCATAA
CTTTCAACCAGTACTGCACC

Downstream 100 bases:

>100_bases
GCGCTCTCGACAGAGCGCTCTGGCTCGTAACAGTAAAGCCCTGCGACCTCGATGGTTTGCAGGGCTTTCGTTTTTCCGCC
GTTTCAAATCAACAACAAAC

Product: acetyl-CoA carboxylase, biotin carboxylase

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MFKKILIANRGEIALRVMHTCREMGICTVAVYSTADVDSLHVKYADEAVCIGPPLSRESYLNIPRIIAAAEVTNADAIHP
GYGFLAENADFSEVCHSSNIKFIGPSADMINRMGDKNTAKSTMIAAGVPVVPGSEGLVEDVGHAIETAKRIGYPVIIKPT
AGGGGKGMRVVHEESQLEKNLKTAQSEAGMAFGNSGVYIEKFLENPRHIEIQILADQHGNVLHLGERDCTVQRRHQKLIE
ETPSPVVDEALRTKMGEAAVAAAKAINYEGAGTIEFLLDKHKNFYFMEMNTRIQVEHPVTEQRYDVDLVKEQIRIAAGGS
LEGKVFEPRGHSIECRINAEDPEHMFRPSPGEVQVFHTPGGPGVRIDSHCYASYVVPSNYDSMIGKLIVTAHTRDEAIAR
MSRALDEFIVMGIKTTIPFHKQVMHDPVFRSGEFDTSFLDSFRYEKH

Sequences:

>Translated_447_residues
MFKKILIANRGEIALRVMHTCREMGICTVAVYSTADVDSLHVKYADEAVCIGPPLSRESYLNIPRIIAAAEVTNADAIHP
GYGFLAENADFSEVCHSSNIKFIGPSADMINRMGDKNTAKSTMIAAGVPVVPGSEGLVEDVGHAIETAKRIGYPVIIKPT
AGGGGKGMRVVHEESQLEKNLKTAQSEAGMAFGNSGVYIEKFLENPRHIEIQILADQHGNVLHLGERDCTVQRRHQKLIE
ETPSPVVDEALRTKMGEAAVAAAKAINYEGAGTIEFLLDKHKNFYFMEMNTRIQVEHPVTEQRYDVDLVKEQIRIAAGGS
LEGKVFEPRGHSIECRINAEDPEHMFRPSPGEVQVFHTPGGPGVRIDSHCYASYVVPSNYDSMIGKLIVTAHTRDEAIAR
MSRALDEFIVMGIKTTIPFHKQVMHDPVFRSGEFDTSFLDSFRYEKH
>Mature_447_residues
MFKKILIANRGEIALRVMHTCREMGICTVAVYSTADVDSLHVKYADEAVCIGPPLSRESYLNIPRIIAAAEVTNADAIHP
GYGFLAENADFSEVCHSSNIKFIGPSADMINRMGDKNTAKSTMIAAGVPVVPGSEGLVEDVGHAIETAKRIGYPVIIKPT
AGGGGKGMRVVHEESQLEKNLKTAQSEAGMAFGNSGVYIEKFLENPRHIEIQILADQHGNVLHLGERDCTVQRRHQKLIE
ETPSPVVDEALRTKMGEAAVAAAKAINYEGAGTIEFLLDKHKNFYFMEMNTRIQVEHPVTEQRYDVDLVKEQIRIAAGGS
LEGKVFEPRGHSIECRINAEDPEHMFRPSPGEVQVFHTPGGPGVRIDSHCYASYVVPSNYDSMIGKLIVTAHTRDEAIAR
MSRALDEFIVMGIKTTIPFHKQVMHDPVFRSGEFDTSFLDSFRYEKH

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=439, Percent_Identity=49.2027334851936, Blast_Score=424, Evalue=1e-119,
Organism=Homo sapiens, GI106049528, Length=445, Percent_Identity=47.6404494382022, Blast_Score=417, Evalue=1e-116,
Organism=Homo sapiens, GI106049295, Length=445, Percent_Identity=47.6404494382022, Blast_Score=417, Evalue=1e-116,
Organism=Homo sapiens, GI106049292, Length=445, Percent_Identity=47.6404494382022, Blast_Score=417, Evalue=1e-116,
Organism=Homo sapiens, GI189095269, Length=442, Percent_Identity=48.1900452488688, Blast_Score=413, Evalue=1e-115,
Organism=Homo sapiens, GI65506442, Length=442, Percent_Identity=48.1900452488688, Blast_Score=413, Evalue=1e-115,
Organism=Homo sapiens, GI295821183, Length=442, Percent_Identity=48.1900452488688, Blast_Score=412, Evalue=1e-115,
Organism=Homo sapiens, GI38679971, Length=508, Percent_Identity=31.2992125984252, Blast_Score=246, Evalue=2e-65,
Organism=Homo sapiens, GI38679977, Length=508, Percent_Identity=31.2992125984252, Blast_Score=246, Evalue=2e-65,
Organism=Homo sapiens, GI38679967, Length=508, Percent_Identity=31.2992125984252, Blast_Score=246, Evalue=2e-65,
Organism=Homo sapiens, GI38679974, Length=508, Percent_Identity=31.2992125984252, Blast_Score=246, Evalue=3e-65,
Organism=Homo sapiens, GI38679960, Length=508, Percent_Identity=31.2992125984252, Blast_Score=246, Evalue=3e-65,
Organism=Homo sapiens, GI134142062, Length=509, Percent_Identity=30.4518664047151, Blast_Score=236, Evalue=4e-62,
Organism=Escherichia coli, GI1789654, Length=443, Percent_Identity=56.8848758465011, Blast_Score=468, Evalue=1e-133,
Organism=Escherichia coli, GI1786216, Length=243, Percent_Identity=21.8106995884774, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17562816, Length=448, Percent_Identity=45.5357142857143, Blast_Score=395, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI71987519, Length=440, Percent_Identity=47.9545454545455, Blast_Score=392, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI17567343, Length=442, Percent_Identity=46.1538461538462, Blast_Score=389, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI133931226, Length=488, Percent_Identity=31.1475409836066, Blast_Score=218, Evalue=4e-57,
Organism=Caenorhabditis elegans, GI71997163, Length=513, Percent_Identity=29.4346978557505, Blast_Score=202, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI71997168, Length=513, Percent_Identity=29.4346978557505, Blast_Score=202, Evalue=3e-52,
Organism=Saccharomyces cerevisiae, GI6319685, Length=448, Percent_Identity=43.3035714285714, Blast_Score=374, Evalue=1e-104,
Organism=Saccharomyces cerevisiae, GI6319695, Length=449, Percent_Identity=44.543429844098, Blast_Score=355, Evalue=6e-99,
Organism=Saccharomyces cerevisiae, GI6321376, Length=448, Percent_Identity=45.0892857142857, Blast_Score=347, Evalue=1e-96,
Organism=Saccharomyces cerevisiae, GI6323863, Length=483, Percent_Identity=31.4699792960663, Blast_Score=222, Evalue=1e-58,
Organism=Saccharomyces cerevisiae, GI6324343, Length=518, Percent_Identity=30.3088803088803, Blast_Score=211, Evalue=2e-55,
Organism=Saccharomyces cerevisiae, GI6322331, Length=315, Percent_Identity=22.8571428571429, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI281363050, Length=448, Percent_Identity=47.0982142857143, Blast_Score=400, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652224, Length=448, Percent_Identity=47.0982142857143, Blast_Score=400, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652222, Length=448, Percent_Identity=47.0982142857143, Blast_Score=400, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652220, Length=448, Percent_Identity=47.0982142857143, Blast_Score=400, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652218, Length=448, Percent_Identity=47.0982142857143, Blast_Score=400, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652212, Length=448, Percent_Identity=47.0982142857143, Blast_Score=400, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652210, Length=448, Percent_Identity=47.0982142857143, Blast_Score=400, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652214, Length=448, Percent_Identity=47.0982142857143, Blast_Score=400, Evalue=1e-112,
Organism=Drosophila melanogaster, GI19921944, Length=448, Percent_Identity=47.0982142857143, Blast_Score=400, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652216, Length=448, Percent_Identity=47.0982142857143, Blast_Score=400, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24651757, Length=441, Percent_Identity=45.578231292517, Blast_Score=386, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24651759, Length=405, Percent_Identity=44.1975308641975, Blast_Score=343, Evalue=1e-94,
Organism=Drosophila melanogaster, GI161076407, Length=503, Percent_Identity=30.6163021868787, Blast_Score=227, Evalue=1e-59,
Organism=Drosophila melanogaster, GI24586460, Length=503, Percent_Identity=30.6163021868787, Blast_Score=227, Evalue=1e-59,
Organism=Drosophila melanogaster, GI161076409, Length=503, Percent_Identity=30.6163021868787, Blast_Score=226, Evalue=2e-59,
Organism=Drosophila melanogaster, GI24586458, Length=503, Percent_Identity=30.6163021868787, Blast_Score=226, Evalue=2e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 49345; Mature: 49345

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKKILIANRGEIALRVMHTCREMGICTVAVYSTADVDSLHVKYADEAVCIGPPLSRESY
CCCEEEEECCCCHHHHHHHHHHHCCEEEEEEEECCCCCEEEEEECCCEEEECCCCCCCCC
LNIPRIIAAAEVTNADAIHPGYGFLAENADFSEVCHSSNIKFIGPSADMINRMGDKNTAK
CCCCHHEEEHCCCCCCCCCCCCCEEECCCCHHHHHHCCCCEEECCCHHHHHHCCCCCCHH
STMIAAGVPVVPGSEGLVEDVGHAIETAKRIGYPVIIKPTAGGGGKGMRVVHEESQLEKN
HEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEHHHHHHHH
LKTAQSEAGMAFGNSGVYIEKFLENPRHIEIQILADQHGNVLHLGERDCTVQRRHQKLIE
HHHHHHHCCCEECCCCCCHHHHHCCCCEEEEEEEECCCCCEEEECCCCCHHHHHHHHHHH
ETPSPVVDEALRTKMGEAAVAAAKAINYEGAGTIEFLLDKHKNFYFMEMNTRIQVEHPVT
HCCCHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHEECCCCCEEEEEECCEEEEECCCC
EQRYDVDLVKEQIRIAAGGSLEGKVFEPRGHSIECRINAEDPEHMFRPSPGEVQVFHTPG
CCCCCHHHHHHHHHEEECCCCCCEEECCCCCEEEEEECCCCHHHHCCCCCCCEEEEECCC
GPGVRIDSHCYASYVVPSNYDSMIGKLIVTAHTRDEAIARMSRALDEFIVMGIKTTIPFH
CCCEEECCCEEEEEEECCCHHHHHHEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCHH
KQVMHDPVFRSGEFDTSFLDSFRYEKH
HHHHHCCCCCCCCCCHHHHHHHCCCCC
>Mature Secondary Structure
MFKKILIANRGEIALRVMHTCREMGICTVAVYSTADVDSLHVKYADEAVCIGPPLSRESY
CCCEEEEECCCCHHHHHHHHHHHCCEEEEEEEECCCCCEEEEEECCCEEEECCCCCCCCC
LNIPRIIAAAEVTNADAIHPGYGFLAENADFSEVCHSSNIKFIGPSADMINRMGDKNTAK
CCCCHHEEEHCCCCCCCCCCCCCEEECCCCHHHHHHCCCCEEECCCHHHHHHCCCCCCHH
STMIAAGVPVVPGSEGLVEDVGHAIETAKRIGYPVIIKPTAGGGGKGMRVVHEESQLEKN
HEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEHHHHHHHH
LKTAQSEAGMAFGNSGVYIEKFLENPRHIEIQILADQHGNVLHLGERDCTVQRRHQKLIE
HHHHHHHCCCEECCCCCCHHHHHCCCCEEEEEEEECCCCCEEEECCCCCHHHHHHHHHHH
ETPSPVVDEALRTKMGEAAVAAAKAINYEGAGTIEFLLDKHKNFYFMEMNTRIQVEHPVT
HCCCHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHEECCCCCEEEEEECCEEEEECCCC
EQRYDVDLVKEQIRIAAGGSLEGKVFEPRGHSIECRINAEDPEHMFRPSPGEVQVFHTPG
CCCCCHHHHHHHHHEEECCCCCCEEECCCCCEEEEEECCCCHHHHCCCCCCCEEEEECCC
GPGVRIDSHCYASYVVPSNYDSMIGKLIVTAHTRDEAIARMSRALDEFIVMGIKTTIPFH
CCCEEECCCEEEEEEECCCHHHHHHEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCHH
KQVMHDPVFRSGEFDTSFLDSFRYEKH
HHHHHCCCCCCCCCCHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8102363; 11759840 [H]