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The map label for this gene is aegA [H]

Identifier: 193213391

GI number: 193213391

Start: 1921672

End: 1923660

Strand: Direct

Name: aegA [H]

Synonym: Cpar_1752

Alternate gene names: 193213391

Gene position: 1921672-1923660 (Clockwise)

Preceding gene: 193213390

Following gene: 193213394

Centisome position: 83.94

GC content: 65.26

Gene sequence:

>1989_bases
ATGATACCGACCATGAAACCTGTCAACCTCATTATCGATGGCCGCAGCGTGCAGGCGGCTCCGGGACAGACCATCCTCGA
AGCGGCTCGCGAAAACGGCATCCGCATCCCGACGCTCTGCTTCCACAAAGAGATCGAAGCGACCGGCTCGTGCTGGATCT
GCATCGTGGAACTGAAAGGCAAGAACCGCTTCATCCCGTCGTGCAGCACGAAGGTAAGCGAAGGGATGGTGGTCGAAACG
CGCAACGCCGAGCTTGACGCGATGCGCCGCCAGAGCCTCGAACGGCTGCTGGCCCAGCACTGCGGCGACTGTCTCGCGCC
GTGCGAACTCGCCTGCCCGGCAGGTTGCGACATTCCCGGATTCGTCTCGGCCATCGCCAAAGGCAACGACCGCGAAGCGC
TCGAAATCATTCGCCGCACGATCCCGCTGCCTGGCATTCTCGGGCGCGTCTGCCCCGCCCCGTGCGAAGAGGCGTGCCGC
CGCCACGGCGTTGACGAGCCGGTCTCGATCTGCGCCCTCAAACGCTTCGCCGCCGACCAGGAGATGACGGAAGGCTCGGA
ACTGCCGGAGCGCGAACCGGCCTCCGGCAAGCGCGTGGCCATCGTCGGCGCGGGTCCAGCGGGCCTGACCGCCGCGTGGT
TCCTGCTGCTCGGCGGGCATGAGGTGACGATTTTGGATGCGAACGAAAAAGCGGGTGGCATGATGCGCTACGGCATCCCG
AAATTCCGCCTGCCCGAAGCGGTGATCGACGCCGATGTCGAGCCGCTCGTGAAGATGGGAGCGACCTTCCGCTTCTCGAC
CATGTTCGGCAAGGACGCTGGACTGGCCGGATTGCAGAAAGAGCATGACGCCGTACTGCTCACCATCGGCGCAAGCCAGG
CCTCGAAGCTCGGCATTCCGGGCGAAGAGCTTGACGGCGTGCAGAGCGGCATCGATTTCCTCGCCGACGTTGCGGACGGA
ACCGCCACCGCGCCCGGCAAGTCGGTGATCGTCATCGGCGGCGGCAACACGGCCATCGACGCGGCACGCACCGCCCTGCG
CCTCGGCGCGGAAGCGGTGACGATTCTCTACCGTCGCGGACGCGAGGAGATGCCCGCCAACCGTCTTGAAATCGAGGAAG
CGATTGCCGAAGGAGTCGAGCTTCGCCTGCTCGCCGCGCCGGTCGCGATTGAAAAAGGAGCAGATGGACTCGTCGTCACG
GCGGTCGAAATGCAACTCGGCGAGCCGGACGCAAGTGGCCGCCGCCGTCCGGTTCCGGTCGCGGGGTCGGAGTTCACGCT
CCAGGCCGACACGGTCATCTCAGCCACCGGCCAGCAGGTTGACCTTCCGACAGAAGCCGCATCGGGCATCGGCACCGAGC
GCAACGGCACGATCAAAGTCAATGGTGGATCGATGCTTACCGAAGCAGCGGGTGTCTTCGCGGCGGGCGACTGCGTCAGC
GGCCCCGATCTGGCTATCGAAGCCGTCCGGCAGGGCCGACTGGCCGCAGAGGCGATCGACCGCTTCCTGAACGGCGGCGA
TCCGGCAGCGACAGGAACGGCAATGTTCAACTCAACCTACGGAGCGCGAGACAAGGCCCCGCACCAGTTCTACGACCGGG
CGAGACCTGCGGCGCGTATTGCCGTGCCGGAGCTGGAGGCGGAGTCGAGACGCCGGAGCTTCGAGGAGGCGGTAACAGGA
TACGACCCGGAACAGGCGCGAGAGGAGGCCAAACGCTGCCTGCGCTGTCGCTGTCAGGCGGTTGACGATTGCCGCCTGCG
CAATCTGGCCACGGCATTCGGCGTGACCACTCCGGTAGTCGAAGAGACCCACGAGTACTTCAGCATCGACAGGTCGGGCA
ACATACGGTTCGAGCGGGAAAAGTGCGTTGATTGCGGCGTCTGCATCCGCACGATGGAGTCGATTTCAGGAGACGTGGCA
ACCATTCAGGAAGAGCTGGTCGAGCACTGCCCGACCGGAGCCATCAGCGGGCGCGGACGCTCACGCTGA

Upstream 100 bases:

>100_bases
ACCTCGACCCCCATGTGGCTGCTCGAAAAGGTGGCCAACTACATCGGCAAAACCTTCGGCGATGACTCCGGCAACCCGGA
CGCATGAACGCAACCATGAA

Downstream 100 bases:

>100_bases
CCTCACAGACTTTTGCAGCTTATTCACTCGCCGTTTTGCGGGCTTTCGTCTTGCTTGAACAGCCAGTCGAAAGCCCTCAT
TGCGCCTCCCCTCTGGTCAA

Product: putative NADPH-dependent glutamate synthase small subunit

Products: L-glutamine; 2-oxoglutarate; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 662; Mature: 662

Protein sequence:

>662_residues
MIPTMKPVNLIIDGRSVQAAPGQTILEAARENGIRIPTLCFHKEIEATGSCWICIVELKGKNRFIPSCSTKVSEGMVVET
RNAELDAMRRQSLERLLAQHCGDCLAPCELACPAGCDIPGFVSAIAKGNDREALEIIRRTIPLPGILGRVCPAPCEEACR
RHGVDEPVSICALKRFAADQEMTEGSELPEREPASGKRVAIVGAGPAGLTAAWFLLLGGHEVTILDANEKAGGMMRYGIP
KFRLPEAVIDADVEPLVKMGATFRFSTMFGKDAGLAGLQKEHDAVLLTIGASQASKLGIPGEELDGVQSGIDFLADVADG
TATAPGKSVIVIGGGNTAIDAARTALRLGAEAVTILYRRGREEMPANRLEIEEAIAEGVELRLLAAPVAIEKGADGLVVT
AVEMQLGEPDASGRRRPVPVAGSEFTLQADTVISATGQQVDLPTEAASGIGTERNGTIKVNGGSMLTEAAGVFAAGDCVS
GPDLAIEAVRQGRLAAEAIDRFLNGGDPAATGTAMFNSTYGARDKAPHQFYDRARPAARIAVPELEAESRRRSFEEAVTG
YDPEQAREEAKRCLRCRCQAVDDCRLRNLATAFGVTTPVVEETHEYFSIDRSGNIRFEREKCVDCGVCIRTMESISGDVA
TIQEELVEHCPTGAISGRGRSR

Sequences:

>Translated_662_residues
MIPTMKPVNLIIDGRSVQAAPGQTILEAARENGIRIPTLCFHKEIEATGSCWICIVELKGKNRFIPSCSTKVSEGMVVET
RNAELDAMRRQSLERLLAQHCGDCLAPCELACPAGCDIPGFVSAIAKGNDREALEIIRRTIPLPGILGRVCPAPCEEACR
RHGVDEPVSICALKRFAADQEMTEGSELPEREPASGKRVAIVGAGPAGLTAAWFLLLGGHEVTILDANEKAGGMMRYGIP
KFRLPEAVIDADVEPLVKMGATFRFSTMFGKDAGLAGLQKEHDAVLLTIGASQASKLGIPGEELDGVQSGIDFLADVADG
TATAPGKSVIVIGGGNTAIDAARTALRLGAEAVTILYRRGREEMPANRLEIEEAIAEGVELRLLAAPVAIEKGADGLVVT
AVEMQLGEPDASGRRRPVPVAGSEFTLQADTVISATGQQVDLPTEAASGIGTERNGTIKVNGGSMLTEAAGVFAAGDCVS
GPDLAIEAVRQGRLAAEAIDRFLNGGDPAATGTAMFNSTYGARDKAPHQFYDRARPAARIAVPELEAESRRRSFEEAVTG
YDPEQAREEAKRCLRCRCQAVDDCRLRNLATAFGVTTPVVEETHEYFSIDRSGNIRFEREKCVDCGVCIRTMESISGDVA
TIQEELVEHCPTGAISGRGRSR
>Mature_662_residues
MIPTMKPVNLIIDGRSVQAAPGQTILEAARENGIRIPTLCFHKEIEATGSCWICIVELKGKNRFIPSCSTKVSEGMVVET
RNAELDAMRRQSLERLLAQHCGDCLAPCELACPAGCDIPGFVSAIAKGNDREALEIIRRTIPLPGILGRVCPAPCEEACR
RHGVDEPVSICALKRFAADQEMTEGSELPEREPASGKRVAIVGAGPAGLTAAWFLLLGGHEVTILDANEKAGGMMRYGIP
KFRLPEAVIDADVEPLVKMGATFRFSTMFGKDAGLAGLQKEHDAVLLTIGASQASKLGIPGEELDGVQSGIDFLADVADG
TATAPGKSVIVIGGGNTAIDAARTALRLGAEAVTILYRRGREEMPANRLEIEEAIAEGVELRLLAAPVAIEKGADGLVVT
AVEMQLGEPDASGRRRPVPVAGSEFTLQADTVISATGQQVDLPTEAASGIGTERNGTIKVNGGSMLTEAAGVFAAGDCVS
GPDLAIEAVRQGRLAAEAIDRFLNGGDPAATGTAMFNSTYGARDKAPHQFYDRARPAARIAVPELEAESRRRSFEEAVTG
YDPEQAREEAKRCLRCRCQAVDDCRLRNLATAFGVTTPVVEETHEYFSIDRSGNIRFEREKCVDCGVCIRTMESISGDVA
TIQEELVEHCPTGAISGRGRSR

Specific function: Unknown

COG id: COG0493

COG function: function code ER; NADPH-dependent glutamate synthase beta chain and related oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 4 4Fe-4S ferredoxin-type domains [H]

Homologues:

Organism=Homo sapiens, GI119943098, Length=440, Percent_Identity=32.2727272727273, Blast_Score=158, Evalue=2e-38,
Organism=Homo sapiens, GI33519475, Length=126, Percent_Identity=31.7460317460317, Blast_Score=75, Evalue=3e-13,
Organism=Escherichia coli, GI1788811, Length=417, Percent_Identity=37.410071942446, Blast_Score=244, Evalue=1e-65,
Organism=Escherichia coli, GI1789606, Length=430, Percent_Identity=36.2790697674419, Blast_Score=235, Evalue=7e-63,
Organism=Escherichia coli, GI87082180, Length=412, Percent_Identity=36.6504854368932, Blast_Score=226, Evalue=3e-60,
Organism=Escherichia coli, GI1789243, Length=425, Percent_Identity=37.1764705882353, Blast_Score=225, Evalue=9e-60,
Organism=Escherichia coli, GI1788468, Length=409, Percent_Identity=38.1418092909535, Blast_Score=217, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI17570289, Length=473, Percent_Identity=31.7124735729387, Blast_Score=174, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI71984108, Length=483, Percent_Identity=29.8136645962733, Blast_Score=137, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17565758, Length=132, Percent_Identity=33.3333333333333, Blast_Score=71, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI32566231, Length=132, Percent_Identity=33.3333333333333, Blast_Score=71, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI193209088, Length=132, Percent_Identity=32.5757575757576, Blast_Score=70, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6320030, Length=444, Percent_Identity=30.4054054054054, Blast_Score=161, Evalue=4e-40,
Organism=Drosophila melanogaster, GI28574881, Length=449, Percent_Identity=33.4075723830735, Blast_Score=200, Evalue=3e-51,
Organism=Drosophila melanogaster, GI24665539, Length=449, Percent_Identity=33.4075723830735, Blast_Score=200, Evalue=3e-51,
Organism=Drosophila melanogaster, GI24665547, Length=449, Percent_Identity=32.9621380846325, Blast_Score=199, Evalue=4e-51,
Organism=Drosophila melanogaster, GI24665543, Length=449, Percent_Identity=32.9621380846325, Blast_Score=199, Evalue=4e-51,
Organism=Drosophila melanogaster, GI24640763, Length=435, Percent_Identity=31.0344827586207, Blast_Score=130, Evalue=3e-30,
Organism=Drosophila melanogaster, GI18858217, Length=435, Percent_Identity=31.0344827586207, Blast_Score=130, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24640559, Length=135, Percent_Identity=31.1111111111111, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24640557, Length=135, Percent_Identity=31.1111111111111, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI17137178, Length=160, Percent_Identity=34.375, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001450
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR013027
- InterPro:   IPR012285
- InterPro:   IPR006006 [H]

Pfam domain/function: PF00037 Fer4; PF07992 Pyr_redox_2 [H]

EC number: 1.4.1.13

Molecular weight: Translated: 70376; Mature: 70376

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
3.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPTMKPVNLIIDGRSVQAAPGQTILEAARENGIRIPTLCFHKEIEATGSCWICIVELKG
CCCCCCCCEEEEECCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCEEEEEEEECC
KNRFIPSCSTKVSEGMVVETRNAELDAMRRQSLERLLAQHCGDCLAPCELACPAGCDIPG
CCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHH
FVSAIAKGNDREALEIIRRTIPLPGILGRVCPAPCEEACRRHGVDEPVSICALKRFAADQ
HHHHHHCCCCHHHHHHHHHHCCCCHHHHHCCCCCHHHHHHHCCCCCHHHHHHHHHHHCCH
EMTEGSELPEREPASGKRVAIVGAGPAGLTAAWFLLLGGHEVTILDANEKAGGMMRYGIP
HHCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHCCCCEEEEEECCCCCCCEECCCCC
KFRLPEAVIDADVEPLVKMGATFRFSTMFGKDAGLAGLQKEHDAVLLTIGASQASKLGIP
CCCCCHHHHCCCHHHHHHCCCCEEEEEHHCCCCCCCCCCCCCCEEEEEECCCCCCCCCCC
GEELDGVQSGIDFLADVADGTATAPGKSVIVIGGGNTAIDAARTALRLGAEAVTILYRRG
CHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHCHHHHHHHHHCC
REEMPANRLEIEEAIAEGVELRLLAAPVAIEKGADGLVVTAVEMQLGEPDASGRRRPVPV
CCCCCCHHHHHHHHHHCCCEEEEEECCCCEECCCCCEEEEEEEEECCCCCCCCCCCCCCC
AGSEFTLQADTVISATGQQVDLPTEAASGIGTERNGTIKVNGGSMLTEAAGVFAAGDCVS
CCCCEEEEECEEEECCCCEECCCHHHHHCCCCCCCCEEEECCCCHHHHHCCCEEECCCCC
GPDLAIEAVRQGRLAAEAIDRFLNGGDPAATGTAMFNSTYGARDKAPHQFYDRARPAARI
CCHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCHHHHCCCCCCCCCCCHHHHHHCCCCCEE
AVPELEAESRRRSFEEAVTGYDPEQAREEAKRCLRCRCQAVDDCRLRNLATAFGVTTPVV
ECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHH
EETHEYFSIDRSGNIRFEREKCVDCGVCIRTMESISGDVATIQEELVEHCPTGAISGRGR
HHHHHHEEECCCCCEEECHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCC
SR
CC
>Mature Secondary Structure
MIPTMKPVNLIIDGRSVQAAPGQTILEAARENGIRIPTLCFHKEIEATGSCWICIVELKG
CCCCCCCCEEEEECCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCEEEEEEEECC
KNRFIPSCSTKVSEGMVVETRNAELDAMRRQSLERLLAQHCGDCLAPCELACPAGCDIPG
CCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHH
FVSAIAKGNDREALEIIRRTIPLPGILGRVCPAPCEEACRRHGVDEPVSICALKRFAADQ
HHHHHHCCCCHHHHHHHHHHCCCCHHHHHCCCCCHHHHHHHCCCCCHHHHHHHHHHHCCH
EMTEGSELPEREPASGKRVAIVGAGPAGLTAAWFLLLGGHEVTILDANEKAGGMMRYGIP
HHCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHCCCCEEEEEECCCCCCCEECCCCC
KFRLPEAVIDADVEPLVKMGATFRFSTMFGKDAGLAGLQKEHDAVLLTIGASQASKLGIP
CCCCCHHHHCCCHHHHHHCCCCEEEEEHHCCCCCCCCCCCCCCEEEEEECCCCCCCCCCC
GEELDGVQSGIDFLADVADGTATAPGKSVIVIGGGNTAIDAARTALRLGAEAVTILYRRG
CHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHCHHHHHHHHHCC
REEMPANRLEIEEAIAEGVELRLLAAPVAIEKGADGLVVTAVEMQLGEPDASGRRRPVPV
CCCCCCHHHHHHHHHHCCCEEEEEECCCCEECCCCCEEEEEEEEECCCCCCCCCCCCCCC
AGSEFTLQADTVISATGQQVDLPTEAASGIGTERNGTIKVNGGSMLTEAAGVFAAGDCVS
CCCCEEEEECEEEECCCCEECCCHHHHHCCCCCCCCEEEECCCCHHHHHCCCEEECCCCC
GPDLAIEAVRQGRLAAEAIDRFLNGGDPAATGTAMFNSTYGARDKAPHQFYDRARPAARI
CCHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCHHHHCCCCCCCCCCCHHHHHHCCCCCEE
AVPELEAESRRRSFEEAVTGYDPEQAREEAKRCLRCRCQAVDDCRLRNLATAFGVTTPVV
ECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHH
EETHEYFSIDRSGNIRFEREKCVDCGVCIRTMESISGDVATIQEELVEHCPTGAISGRGR
HHHHHHEEECCCCCEEECHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCC
SR
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-glutamate; NADP+

Specific reaction: 2 L-glutamate + NADP+ = L-glutamine + 2-oxoglutarate + NADPH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8955321; 9205837; 9278503 [H]