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The map label for this gene is purN [H]

Identifier: 193213356

GI number: 193213356

Start: 1879574

End: 1880176

Strand: Direct

Name: purN [H]

Synonym: Cpar_1717

Alternate gene names: 193213356

Gene position: 1879574-1880176 (Clockwise)

Preceding gene: 193213354

Following gene: 193213357

Centisome position: 82.1

GC content: 58.37

Gene sequence:

>603_bases
ATGAGTGACAACAAAAAACGGCTGGCAGTCTTCTGCTCGGGAACGGGCTCCAATTTCAAAGCGCTGTTCCATGCGATCAT
CGAACGCGAGCTGCCCGCCGAGATCGTGCTATGCCTATCGAACCGCGCGGAATGCGGCGCGATGGATTTTGCGAAAGAGT
ATGGTATCGAGGCAATTCACTTGTCGGAATCGCAGTTCGATTCGCATGACGAGTTTGCCAGCGCTATGCTGGAGGCGCTC
CGGAATCGGCAGATCGACATGATCCTGCTTGCCGGGTATCTGCGCAAGATCCCGGACGCGGTGATCGCCGCTTATCCGGA
AAAGATCGTAAACATCCATCCGTCGCTTTTGCCGGAGTTCGGCGGCCACGGCATGTACGGAATTCGTGTGCACGAAGCGG
TCATCGCATCGGGCGAAACCCGGAGCGGCGCGACGGTGCATTTCGTGAACGAGGAGTACGACAAGGGGCGCATCATCAAG
CAGAACCATGTGCCGGTGCTGCCGGAGGACACGCCCGAATCGCTTGCCGAACGGGTGCTCCGCTGCGAACACCGCCTTTA
CCCCGATGCGCTCGAACAACTGCTTGACGAGCAGATGCCATGA

Upstream 100 bases:

>100_bases
TTCCCGCCGGAGCCCGGCGCAGGAAACCTTTCAGCTTGAAAAAAGCAACGTTAGGGTGCATATTAGAAGAACTTCACAAA
ATCCTTTGCTCTCGATCTGA

Downstream 100 bases:

>100_bases
CAACGGCGACCATCAGCATCAGCGAAATCTTCCACTCCATTCAGGGCGAATCATCGTTCGCGGGATGGCCGTGCGCCTTC
GTGCGCCTCGCCGGATGCGG

Product: phosphoribosylglycinamide formyltransferase

Products: NA

Alternate protein names: 5'-phosphoribosylglycinamide transformylase; GAR transformylase; GART [H]

Number of amino acids: Translated: 200; Mature: 199

Protein sequence:

>200_residues
MSDNKKRLAVFCSGTGSNFKALFHAIIERELPAEIVLCLSNRAECGAMDFAKEYGIEAIHLSESQFDSHDEFASAMLEAL
RNRQIDMILLAGYLRKIPDAVIAAYPEKIVNIHPSLLPEFGGHGMYGIRVHEAVIASGETRSGATVHFVNEEYDKGRIIK
QNHVPVLPEDTPESLAERVLRCEHRLYPDALEQLLDEQMP

Sequences:

>Translated_200_residues
MSDNKKRLAVFCSGTGSNFKALFHAIIERELPAEIVLCLSNRAECGAMDFAKEYGIEAIHLSESQFDSHDEFASAMLEAL
RNRQIDMILLAGYLRKIPDAVIAAYPEKIVNIHPSLLPEFGGHGMYGIRVHEAVIASGETRSGATVHFVNEEYDKGRIIK
QNHVPVLPEDTPESLAERVLRCEHRLYPDALEQLLDEQMP
>Mature_199_residues
SDNKKRLAVFCSGTGSNFKALFHAIIERELPAEIVLCLSNRAECGAMDFAKEYGIEAIHLSESQFDSHDEFASAMLEALR
NRQIDMILLAGYLRKIPDAVIAAYPEKIVNIHPSLLPEFGGHGMYGIRVHEAVIASGETRSGATVHFVNEEYDKGRIIKQ
NHVPVLPEDTPESLAERVLRCEHRLYPDALEQLLDEQMP

Specific function: De novo purine biosynthesis; third step. [C]

COG id: COG0299

COG function: function code F; Folate-dependent phosphoribosylglycinamide formyltransferase PurN

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GART family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=189, Percent_Identity=39.1534391534392, Blast_Score=133, Evalue=1e-31,
Organism=Homo sapiens, GI209869995, Length=189, Percent_Identity=39.1534391534392, Blast_Score=133, Evalue=1e-31,
Organism=Homo sapiens, GI209869993, Length=189, Percent_Identity=39.1534391534392, Blast_Score=133, Evalue=1e-31,
Organism=Escherichia coli, GI1788846, Length=192, Percent_Identity=30.2083333333333, Blast_Score=113, Evalue=9e-27,
Organism=Escherichia coli, GI1787483, Length=132, Percent_Identity=31.0606060606061, Blast_Score=63, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17567511, Length=193, Percent_Identity=31.0880829015544, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24582400, Length=198, Percent_Identity=36.3636363636364, Blast_Score=138, Evalue=3e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002376
- InterPro:   IPR001555
- InterPro:   IPR004607 [H]

Pfam domain/function: PF00551 Formyl_trans_N [H]

EC number: =2.1.2.2 [H]

Molecular weight: Translated: 22388; Mature: 22257

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS00373 GART

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDNKKRLAVFCSGTGSNFKALFHAIIERELPAEIVLCLSNRAECGAMDFAKEYGIEAIH
CCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHHHHHHHHCCEEEE
LSESQFDSHDEFASAMLEALRNRQIDMILLAGYLRKIPDAVIAAYPEKIVNIHPSLLPEF
ECCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHC
GGHGMYGIRVHEAVIASGETRSGATVHFVNEEYDKGRIIKQNHVPVLPEDTPESLAERVL
CCCCEEEEEHHHHHHHCCCCCCCCEEEEECCCCCCCCEEECCCCCCCCCCCHHHHHHHHH
RCEHRLYPDALEQLLDEQMP
HHHHCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
SDNKKRLAVFCSGTGSNFKALFHAIIERELPAEIVLCLSNRAECGAMDFAKEYGIEAIH
CCCCEEEEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHHHHHHHHCCEEEE
LSESQFDSHDEFASAMLEALRNRQIDMILLAGYLRKIPDAVIAAYPEKIVNIHPSLLPEF
ECCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHC
GGHGMYGIRVHEAVIASGETRSGATVHFVNEEYDKGRIIKQNHVPVLPEDTPESLAERVL
CCCCEEEEEHHHHHHHCCCCCCCCEEEEECCCCCCCCEEECCCCCCCCCCCHHHHHHHHH
RCEHRLYPDALEQLLDEQMP
HHHHCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3036807; 9384377 [H]