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The map label for this gene is rotA [H]

Identifier: 193213295

GI number: 193213295

Start: 1806477

End: 1806965

Strand: Direct

Name: rotA [H]

Synonym: Cpar_1653

Alternate gene names: 193213295

Gene position: 1806477-1806965 (Clockwise)

Preceding gene: 193213294

Following gene: 193213296

Centisome position: 78.91

GC content: 57.87

Gene sequence:

>489_bases
ATGCCAGCACAATTCATTATCAAGACCAGCATGGGAGACATTGCGATCTCCCTGTACGACGACACCCCGCAGCACCGCGA
CAACTTCATCAAACTCGTTGACGAAAAATACTACGACGGCATCCGGTTCCACCGGGTCATCGAGGGCTTCATGATCCAGT
CGGGCGATCCGCTCTCCCGCCACGACGACAAACGCATGATGCACGGCACCGGCGGCCCCGAGTACCGCGTTCCGGCTGAA
ATCAAGCACTCCAACAAGAAAGGAACGCTTGCCGCCGCGAGGGATAACAACCCGCAGAAAGCCTCGTCGGGCAGCCAGTT
CTACATCAACCAGGCCGACAACAACTTCCTCGATGGCGAGTACACCGTGTTCGGCGTCGTTGAGTCCGGAATCGACGTGG
TCGATGCGATTGCGGCTGTCGATACCGACATGCGCGACAACCCGATCAAACCGGTCACCATCGAAACTATCACCCCGGTA
ACCGCCTGA

Upstream 100 bases:

>100_bases
CAGCTCGGCTGTGGTCGCCAACCGCACTCTCTGGCGTCTTGAAGGCGCAGGCGTCCCGATTCCGCAACTCTGAATTTTTC
CGACACTCAAACAGCAGAAC

Downstream 100 bases:

>100_bases
ACGAACCTGTCATGGAAAGCATCTCCTCGAACCTCGCCGCCGTCAGGGAACAGATCGCCGAGGCCTGCCGCAAAGCGGGC
CGAAGTGTGGATGAGGTCAC

Product: cyclophilin type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 162; Mature: 161

Protein sequence:

>162_residues
MPAQFIIKTSMGDIAISLYDDTPQHRDNFIKLVDEKYYDGIRFHRVIEGFMIQSGDPLSRHDDKRMMHGTGGPEYRVPAE
IKHSNKKGTLAAARDNNPQKASSGSQFYINQADNNFLDGEYTVFGVVESGIDVVDAIAAVDTDMRDNPIKPVTIETITPV
TA

Sequences:

>Translated_162_residues
MPAQFIIKTSMGDIAISLYDDTPQHRDNFIKLVDEKYYDGIRFHRVIEGFMIQSGDPLSRHDDKRMMHGTGGPEYRVPAE
IKHSNKKGTLAAARDNNPQKASSGSQFYINQADNNFLDGEYTVFGVVESGIDVVDAIAAVDTDMRDNPIKPVTIETITPV
TA
>Mature_161_residues
PAQFIIKTSMGDIAISLYDDTPQHRDNFIKLVDEKYYDGIRFHRVIEGFMIQSGDPLSRHDDKRMMHGTGGPEYRVPAEI
KHSNKKGTLAAARDNNPQKASSGSQFYINQADNNFLDGEYTVFGVVESGIDVVDAIAAVDTDMRDNPIKPVTIETITPVT
A

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. This protein is not essential for growth. Presumably plays a role in signal transduction [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI7706339, Length=159, Percent_Identity=35.2201257861635, Blast_Score=92, Evalue=2e-19,
Organism=Homo sapiens, GI24308049, Length=155, Percent_Identity=37.4193548387097, Blast_Score=84, Evalue=5e-17,
Organism=Homo sapiens, GI19557636, Length=154, Percent_Identity=34.4155844155844, Blast_Score=80, Evalue=6e-16,
Organism=Homo sapiens, GI4758950, Length=154, Percent_Identity=37.6623376623377, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI64276486, Length=164, Percent_Identity=33.5365853658537, Blast_Score=73, Evalue=9e-14,
Organism=Homo sapiens, GI20911035, Length=140, Percent_Identity=36.4285714285714, Blast_Score=73, Evalue=1e-13,
Organism=Homo sapiens, GI22547212, Length=154, Percent_Identity=34.4155844155844, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI7657473, Length=154, Percent_Identity=34.4155844155844, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI22547215, Length=155, Percent_Identity=34.8387096774194, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI10863927, Length=137, Percent_Identity=37.2262773722628, Blast_Score=69, Evalue=2e-12,
Organism=Escherichia coli, GI1789763, Length=159, Percent_Identity=38.3647798742138, Blast_Score=84, Evalue=3e-18,
Organism=Escherichia coli, GI1786736, Length=165, Percent_Identity=37.5757575757576, Blast_Score=83, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71980594, Length=154, Percent_Identity=37.6623376623377, Blast_Score=91, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17539496, Length=155, Percent_Identity=36.1290322580645, Blast_Score=90, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI71980590, Length=145, Percent_Identity=38.6206896551724, Blast_Score=88, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17506311, Length=163, Percent_Identity=36.8098159509202, Blast_Score=86, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17552780, Length=154, Percent_Identity=37.6623376623377, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17551284, Length=161, Percent_Identity=32.9192546583851, Blast_Score=69, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17551282, Length=161, Percent_Identity=32.9192546583851, Blast_Score=69, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17532643, Length=153, Percent_Identity=33.3333333333333, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17506307, Length=154, Percent_Identity=35.7142857142857, Blast_Score=67, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI32563659, Length=158, Percent_Identity=27.8481012658228, Blast_Score=66, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI71997782, Length=165, Percent_Identity=31.5151515151515, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320510, Length=152, Percent_Identity=39.4736842105263, Blast_Score=74, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6321848, Length=156, Percent_Identity=37.1794871794872, Blast_Score=71, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6323562, Length=152, Percent_Identity=33.5526315789474, Blast_Score=70, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6320359, Length=141, Percent_Identity=33.3333333333333, Blast_Score=61, Evalue=6e-11,
Organism=Drosophila melanogaster, GI17986117, Length=156, Percent_Identity=35.8974358974359, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI19922376, Length=151, Percent_Identity=31.7880794701987, Blast_Score=84, Evalue=5e-17,
Organism=Drosophila melanogaster, GI20130249, Length=153, Percent_Identity=38.562091503268, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI17136360, Length=154, Percent_Identity=32.4675324675325, Blast_Score=73, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24586038, Length=156, Percent_Identity=34.6153846153846, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24652460, Length=132, Percent_Identity=32.5757575757576, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI19922912, Length=134, Percent_Identity=35.0746268656716, Blast_Score=67, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 18005; Mature: 17874

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAQFIIKTSMGDIAISLYDDTPQHRDNFIKLVDEKYYDGIRFHRVIEGFMIQSGDPLSR
CCCEEEEEECCCEEEEEEECCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHEECCCCCCCC
HDDKRMMHGTGGPEYRVPAEIKHSNKKGTLAAARDNNPQKASSGSQFYINQADNNFLDGE
CCCCEEECCCCCCCEECCHHEECCCCCCEEEEECCCCCCCCCCCCEEEEECCCCCCCCCC
YTVFGVVESGIDVVDAIAAVDTDMRDNPIKPVTIETITPVTA
EEEEEEECCCHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCC
>Mature Secondary Structure 
PAQFIIKTSMGDIAISLYDDTPQHRDNFIKLVDEKYYDGIRFHRVIEGFMIQSGDPLSR
CCEEEEEECCCEEEEEEECCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHEECCCCCCCC
HDDKRMMHGTGGPEYRVPAEIKHSNKKGTLAAARDNNPQKASSGSQFYINQADNNFLDGE
CCCCEEECCCCCCCEECCHHEECCCCCCEEEEECCCCCCCCCCCCEEEEECCCCCCCCCC
YTVFGVVESGIDVVDAIAAVDTDMRDNPIKPVTIETITPVTA
EEEEEEECCCHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7948017 [H]