Click here to switch to the map view.

The map label for this gene is uvrC [H]

Identifier: 193213289

GI number: 193213289

Start: 1800004

End: 1801893

Strand: Direct

Name: uvrC [H]

Synonym: Cpar_1647

Alternate gene names: 193213289

Gene position: 1800004-1801893 (Clockwise)

Preceding gene: 193213288

Following gene: 193213290

Centisome position: 78.63

GC content: 59.15

Gene sequence:

>1890_bases
ATGGCCGACACCTCCGCAACAATACCGGAAAAGCCCGCACGCGAAACACTTGCTGAAAAGCTCGCCTCGCTGCCAACTTC
GCCCGGCGTGTACCGGTTCAGCAATGCGGCAGGCACGGTGATCTATGTCGGCAAAGCACGAAACCTGCGCAACCGGGTTC
GCTCCTACTTCAACAGTCAGGGGCGCCAGCCGGGCAAAACCGCCGTGCTGGTGAGCCACATCGCCGATCTGAACGTCATC
ATCACCTCATCGGAGGTCGAGGCGCTGATTCTCGAAAACAACCTCATCAAGGAGCTGAAGCCGCGCTACAACGTCAACCT
CAAGGATGACAAAAGCTACCCCTACGTGGTCATCACCAACGAGCGGTTCCCGCGCATTTTTCTGACGCGGCAGGTTCGGC
GTGACGGCTCGCAGTACTTCGGCCCCTACACCGAAGCTTCCCAGCTCCGGCTGATTCTCGACCTAATCGGCTCGATCTTT
CCGGTGAGAAGCTGCAAATACAAGCTCACCGAAGAGGCGGTCGCAGCAGGCAAGTACCGGGTCTGCCTCGACTACCACAT
CCACAAATGCAAAGGGCCGTGCGAAGGGCTGCAATCGGAGGAGGAGTACCAGGCGATGATCCGCGAGATCGTCACCCTTC
TCAAAGGAAAAACCTCGGCGCTTGTGCGCGACCTGACTGCCGAAATGCAGCAGAAAGCCGCGGAATTGAAGTTCGAGGAA
GCGGCCACGCTGAAAGCACAGATCGAAGGACTGAAGCGTTACGCCGAACGGCAGAAGGTGGTAAGCAACGAACCGGTTGA
CCGCGACGTATTCGCCATAGCGACCGGCGAGGAGGACGCCTGCGGGGTGATCTTCCGCATCCGCGAGGGCAAGCTCATCG
GCTCGCGCCACACCTATCTGACCAACACCGGCAACACGCCGCTGCCGAACCTGCTCGCCTCGTTCCTCGAACACTACTAC
CTGGAAACGCCCGACCTTATCCCGCAGGAGATATTCCTGCAAGCCGAGCTGCCGGAGGAGGAGCTTGAAGCGCTGCGCCA
GCTCCTCGCATCACGCCAGACCGGGCAGCGGCAGGTGCGCTTCACGGTACCGCGCATCGGTGAAAAGGCGCAGCTCATCG
CCATGTGCCTCGACAACGCCGAGCACCACCTGCACGAATTCATGGTGCAGAAGCGGCTCCGCGGCGAGATGTCGCGCAAG
TCACCAGCTCTTGAATCACTCAAGCAGGTGCTGCATCTCGACAAGCTTCCCGAACGGATCGAGTGCTTCGACAACTCGCA
TTTTCAGGGCACCGATTACGTCAGCTCGATGGTCACCTTCGTCTTAGGCAAACCGAAAAAATCGGATTACCGAAAGTTCA
AACTGAAAAGCTTCGAGGGCTCGGACGACTACGCCGCCATGCAAGAAGCGGTCACCCGGCGCTACAGCGGAACACTTGCC
GAGGAGCTGCCGATGCCCGATCTGGTGCTCATCGACGGCGGCAAGGGGCAGGTCAACGTAGCCTGGAAAGCCTTGCAGGA
ACTCGGCATCGACGTCCCGGTGGCAGGCCTGGCCAAACGGCTCGAAGAGATTTTCGTACCGAACGAGCGCGACCCGTACA
ACCTGCCGAAAACCTCCCCGGCGCTCAAGCTTTTGCAACAATTGCGTGACGAAGCGCACCGCTTCGCCATCACCTACCAC
CGCAAGCTCCGGAGCGACCGGACCATCCGCACCGAGCTGACCGGCATCAAGGGTGTGGGCGAAAAAAGCGCCGAAAAGCT
GCTGAGCCGCTTCGGATCTGTCGAAACCGTCGCAAAAGCCTCGATCGAAGAACTTTCTGAAGTAACCGGAAGAAAAACTG
CCGAAAGCATTTACCGCTATTTCCGGCAGCAGGATGCCGATCAACCATAA

Upstream 100 bases:

>100_bases
ACACAACCATCGACAAACAAAAAAAGGCGTGGAACCATCCGCGCCTTTTTTTGTTATCATAAATCCGGAAACCCAGTAAC
GCAGACTGCACGATTTCGTC

Downstream 100 bases:

>100_bases
ACGCACCTTCCGGAAAGGGCTCTTTTTTTGAAAAAAAATCTGCTATATTTTCTCGTGTGATTTTTTATGATCGTGAAAGC
TTGAAAAAGCGTGTATGAGT

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 629; Mature: 628

Protein sequence:

>629_residues
MADTSATIPEKPARETLAEKLASLPTSPGVYRFSNAAGTVIYVGKARNLRNRVRSYFNSQGRQPGKTAVLVSHIADLNVI
ITSSEVEALILENNLIKELKPRYNVNLKDDKSYPYVVITNERFPRIFLTRQVRRDGSQYFGPYTEASQLRLILDLIGSIF
PVRSCKYKLTEEAVAAGKYRVCLDYHIHKCKGPCEGLQSEEEYQAMIREIVTLLKGKTSALVRDLTAEMQQKAAELKFEE
AATLKAQIEGLKRYAERQKVVSNEPVDRDVFAIATGEEDACGVIFRIREGKLIGSRHTYLTNTGNTPLPNLLASFLEHYY
LETPDLIPQEIFLQAELPEEELEALRQLLASRQTGQRQVRFTVPRIGEKAQLIAMCLDNAEHHLHEFMVQKRLRGEMSRK
SPALESLKQVLHLDKLPERIECFDNSHFQGTDYVSSMVTFVLGKPKKSDYRKFKLKSFEGSDDYAAMQEAVTRRYSGTLA
EELPMPDLVLIDGGKGQVNVAWKALQELGIDVPVAGLAKRLEEIFVPNERDPYNLPKTSPALKLLQQLRDEAHRFAITYH
RKLRSDRTIRTELTGIKGVGEKSAEKLLSRFGSVETVAKASIEELSEVTGRKTAESIYRYFRQQDADQP

Sequences:

>Translated_629_residues
MADTSATIPEKPARETLAEKLASLPTSPGVYRFSNAAGTVIYVGKARNLRNRVRSYFNSQGRQPGKTAVLVSHIADLNVI
ITSSEVEALILENNLIKELKPRYNVNLKDDKSYPYVVITNERFPRIFLTRQVRRDGSQYFGPYTEASQLRLILDLIGSIF
PVRSCKYKLTEEAVAAGKYRVCLDYHIHKCKGPCEGLQSEEEYQAMIREIVTLLKGKTSALVRDLTAEMQQKAAELKFEE
AATLKAQIEGLKRYAERQKVVSNEPVDRDVFAIATGEEDACGVIFRIREGKLIGSRHTYLTNTGNTPLPNLLASFLEHYY
LETPDLIPQEIFLQAELPEEELEALRQLLASRQTGQRQVRFTVPRIGEKAQLIAMCLDNAEHHLHEFMVQKRLRGEMSRK
SPALESLKQVLHLDKLPERIECFDNSHFQGTDYVSSMVTFVLGKPKKSDYRKFKLKSFEGSDDYAAMQEAVTRRYSGTLA
EELPMPDLVLIDGGKGQVNVAWKALQELGIDVPVAGLAKRLEEIFVPNERDPYNLPKTSPALKLLQQLRDEAHRFAITYH
RKLRSDRTIRTELTGIKGVGEKSAEKLLSRFGSVETVAKASIEELSEVTGRKTAESIYRYFRQQDADQP
>Mature_628_residues
ADTSATIPEKPARETLAEKLASLPTSPGVYRFSNAAGTVIYVGKARNLRNRVRSYFNSQGRQPGKTAVLVSHIADLNVII
TSSEVEALILENNLIKELKPRYNVNLKDDKSYPYVVITNERFPRIFLTRQVRRDGSQYFGPYTEASQLRLILDLIGSIFP
VRSCKYKLTEEAVAAGKYRVCLDYHIHKCKGPCEGLQSEEEYQAMIREIVTLLKGKTSALVRDLTAEMQQKAAELKFEEA
ATLKAQIEGLKRYAERQKVVSNEPVDRDVFAIATGEEDACGVIFRIREGKLIGSRHTYLTNTGNTPLPNLLASFLEHYYL
ETPDLIPQEIFLQAELPEEELEALRQLLASRQTGQRQVRFTVPRIGEKAQLIAMCLDNAEHHLHEFMVQKRLRGEMSRKS
PALESLKQVLHLDKLPERIECFDNSHFQGTDYVSSMVTFVLGKPKKSDYRKFKLKSFEGSDDYAAMQEAVTRRYSGTLAE
ELPMPDLVLIDGGKGQVNVAWKALQELGIDVPVAGLAKRLEEIFVPNERDPYNLPKTSPALKLLQQLRDEAHRFAITYHR
KLRSDRTIRTELTGIKGVGEKSAEKLLSRFGSVETVAKASIEELSEVTGRKTAESIYRYFRQQDADQP

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=618, Percent_Identity=36.7313915857605, Blast_Score=369, Evalue=1e-103,
Organism=Escherichia coli, GI1788037, Length=213, Percent_Identity=29.5774647887324, Blast_Score=75, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 71189; Mature: 71058

Theoretical pI: Translated: 8.69; Mature: 8.69

Prosite motif: PS50151 UVR ; PS50164 UVRC_1 ; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADTSATIPEKPARETLAEKLASLPTSPGVYRFSNAAGTVIYVGKARNLRNRVRSYFNSQ
CCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEECCCCCEEEEECCCHHHHHHHHHHHHHC
GRQPGKTAVLVSHIADLNVIITSSEVEALILENNLIKELKPRYNVNLKDDKSYPYVVITN
CCCCCCHHHHHHHHCCCEEEEECCCCEEEEHHHHHHHHCCCCCCCCCCCCCCCCEEEEEC
ERFPRIFLTRQVRRDGSQYFGPYTEASQLRLILDLIGSIFPVRSCKYKLTEEAVAAGKYR
CCCCHHHHHHHHHHCCHHHCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCEE
VCLDYHIHKCKGPCEGLQSEEEYQAMIREIVTLLKGKTSALVRDLTAEMQQKAAELKFEE
EEEEHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
AATLKAQIEGLKRYAERQKVVSNEPVDRDVFAIATGEEDACGVIFRIREGKLIGSRHTYL
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCEEEEEEECCCEECCCCEEE
TNTGNTPLPNLLASFLEHYYLETPDLIPQEIFLQAELPEEELEALRQLLASRQTGQRQVR
ECCCCCCHHHHHHHHHHHHHCCCCCCCCHHHEEECCCCHHHHHHHHHHHHHCCCCCCEEE
FTVPRIGEKAQLIAMCLDNAEHHLHEFMVQKRLRGEMSRKSPALESLKQVLHLDKLPERI
EECCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCHHHH
ECFDNSHFQGTDYVSSMVTFVLGKPKKSDYRKFKLKSFEGSDDYAAMQEAVTRRYSGTLA
HHHCCCCCCCHHHHHHHHHHHHCCCCCCCHHHEEECCCCCCCHHHHHHHHHHHHHCCCHH
EELPMPDLVLIDGGKGQVNVAWKALQELGIDVPVAGLAKRLEEIFVPNERDPYNLPKTSP
HHCCCCCEEEEECCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCH
ALKLLQQLRDEAHRFAITYHRKLRSDRTIRTELTGIKGVGEKSAEKLLSRFGSVETVAKA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHH
SIEELSEVTGRKTAESIYRYFRQQDADQP
HHHHHHHHHCCHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
ADTSATIPEKPARETLAEKLASLPTSPGVYRFSNAAGTVIYVGKARNLRNRVRSYFNSQ
CCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEECCCCCEEEEECCCHHHHHHHHHHHHHC
GRQPGKTAVLVSHIADLNVIITSSEVEALILENNLIKELKPRYNVNLKDDKSYPYVVITN
CCCCCCHHHHHHHHCCCEEEEECCCCEEEEHHHHHHHHCCCCCCCCCCCCCCCCEEEEEC
ERFPRIFLTRQVRRDGSQYFGPYTEASQLRLILDLIGSIFPVRSCKYKLTEEAVAAGKYR
CCCCHHHHHHHHHHCCHHHCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCEE
VCLDYHIHKCKGPCEGLQSEEEYQAMIREIVTLLKGKTSALVRDLTAEMQQKAAELKFEE
EEEEHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
AATLKAQIEGLKRYAERQKVVSNEPVDRDVFAIATGEEDACGVIFRIREGKLIGSRHTYL
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCEEEEEEECCCEECCCCEEE
TNTGNTPLPNLLASFLEHYYLETPDLIPQEIFLQAELPEEELEALRQLLASRQTGQRQVR
ECCCCCCHHHHHHHHHHHHHCCCCCCCCHHHEEECCCCHHHHHHHHHHHHHCCCCCCEEE
FTVPRIGEKAQLIAMCLDNAEHHLHEFMVQKRLRGEMSRKSPALESLKQVLHLDKLPERI
EECCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCHHHH
ECFDNSHFQGTDYVSSMVTFVLGKPKKSDYRKFKLKSFEGSDDYAAMQEAVTRRYSGTLA
HHHCCCCCCCHHHHHHHHHHHHCCCCCCCHHHEEECCCCCCCHHHHHHHHHHHHHCCCHH
EELPMPDLVLIDGGKGQVNVAWKALQELGIDVPVAGLAKRLEEIFVPNERDPYNLPKTSP
HHCCCCCEEEEECCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCH
ALKLLQQLRDEAHRFAITYHRKLRSDRTIRTELTGIKGVGEKSAEKLLSRFGSVETVAKA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHH
SIEELSEVTGRKTAESIYRYFRQQDADQP
HHHHHHHHHCCHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12093901 [H]