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The map label for this gene is purE [H]

Identifier: 193213151

GI number: 193213151

Start: 1650561

End: 1651055

Strand: Direct

Name: purE [H]

Synonym: Cpar_1506

Alternate gene names: 193213151

Gene position: 1650561-1651055 (Clockwise)

Preceding gene: 193213147

Following gene: 193213152

Centisome position: 72.1

GC content: 63.64

Gene sequence:

>495_bases
ATGGTCGGCATCCTGATGGGATCCGATTCCGATTTCGACATCATGAAAGAGGCGGCCAGCGTCCTCGACGAGTTCGGCAT
TCCGTTTGAAATGTCGGTCATCTCGGCACACCGCACGCCGGGCGACCTCGAGGCCTACGCGTCTTCGGCGCAGGAGCGCG
GCCTGAAGGCGATCATCGCCGGTGCGGGTGGCGCGGCGCACCTGCCGGGCGTCACGGCGGCTATGACTCCCCTGCCGGTC
ATCGGCGTACCGATCTTCAACAAGAAACTCAGCGGCCAGGACTCGCTCTACGCCATCGTGCAGATGCCCGCCGGCATTCC
GATAGCCACAGTCGGTATCGACAACGCCCGCAACGCGGCGCTGCTCGCCGTGCAGATGCTCGCACTGTGCGACGAAGCGC
TGATGCAGAAGCTCAAGGAGTTCCGCCAAAAGCTTGCCGACGCCTCGCGCCAGAAAACCGCCAAAGTCAGGGAAAAGCTC
CGTGCGAACGGCTGA

Upstream 100 bases:

>100_bases
GCAAATTTATAGCCCTCAAACTGCAACGGCCTTAATCATTAGTAAGGCCGCATAATTTCTTTTTTCCATGACACCATCAT
CCACAGACGCACAGGCGCCA

Downstream 100 bases:

>100_bases
GTTCTGGATCGACCGGCTCCGGCTCGAACGCCACCCCGAAGGGGGCTGGTACCGCGAAACCTACCGCAGCGAGGGCGAGT
ACGACTTCAGCGGAGCCGCG

Product: phosphoribosylaminoimidazole carboxylase, catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 164; Mature: 164

Protein sequence:

>164_residues
MVGILMGSDSDFDIMKEAASVLDEFGIPFEMSVISAHRTPGDLEAYASSAQERGLKAIIAGAGGAAHLPGVTAAMTPLPV
IGVPIFNKKLSGQDSLYAIVQMPAGIPIATVGIDNARNAALLAVQMLALCDEALMQKLKEFRQKLADASRQKTAKVREKL
RANG

Sequences:

>Translated_164_residues
MVGILMGSDSDFDIMKEAASVLDEFGIPFEMSVISAHRTPGDLEAYASSAQERGLKAIIAGAGGAAHLPGVTAAMTPLPV
IGVPIFNKKLSGQDSLYAIVQMPAGIPIATVGIDNARNAALLAVQMLALCDEALMQKLKEFRQKLADASRQKTAKVREKL
RANG
>Mature_164_residues
MVGILMGSDSDFDIMKEAASVLDEFGIPFEMSVISAHRTPGDLEAYASSAQERGLKAIIAGAGGAAHLPGVTAAMTPLPV
IGVPIFNKKLSGQDSLYAIVQMPAGIPIATVGIDNARNAALLAVQMLALCDEALMQKLKEFRQKLADASRQKTAKVREKL
RANG

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=148, Percent_Identity=47.972972972973, Blast_Score=129, Evalue=9e-32,
Organism=Saccharomyces cerevisiae, GI6324702, Length=144, Percent_Identity=59.7222222222222, Blast_Score=184, Evalue=8e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 17264; Mature: 17264

Theoretical pI: Translated: 7.52; Mature: 7.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVGILMGSDSDFDIMKEAASVLDEFGIPFEMSVISAHRTPGDLEAYASSAQERGLKAIIA
CEEEEECCCCCHHHHHHHHHHHHHHCCCEEEHHHHCCCCCCHHHHHHHHHHHCCCEEEEE
GAGGAAHLPGVTAAMTPLPVIGVPIFNKKLSGQDSLYAIVQMPAGIPIATVGIDNARNAA
CCCCCCCCCCCHHHHCCCCEECCCCCCCCCCCCCCEEEEEECCCCCEEEEECCCCCCHHH
LLAVQMLALCDEALMQKLKEFRQKLADASRQKTAKVREKLRANG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MVGILMGSDSDFDIMKEAASVLDEFGIPFEMSVISAHRTPGDLEAYASSAQERGLKAIIA
CEEEEECCCCCHHHHHHHHHHHHHHCCCEEEHHHHCCCCCCHHHHHHHHHHHCCCEEEEE
GAGGAAHLPGVTAAMTPLPVIGVPIFNKKLSGQDSLYAIVQMPAGIPIATVGIDNARNAA
CCCCCCCCCCCHHHHCCCCEECCCCCCCCCCCCCCEEEEEECCCCCEEEEECCCCCCHHH
LLAVQMLALCDEALMQKLKEFRQKLADASRQKTAKVREKLRANG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]