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The map label for this gene is moaA [H]

Identifier: 193212999

GI number: 193212999

Start: 1465369

End: 1466370

Strand: Direct

Name: moaA [H]

Synonym: Cpar_1349

Alternate gene names: 193212999

Gene position: 1465369-1466370 (Clockwise)

Preceding gene: 193212998

Following gene: 193213002

Centisome position: 64.01

GC content: 58.08

Gene sequence:

>1002_bases
ATGACGCCGGATTCCGAACAGAACCGCGCCGCGTTAACCGACCGGTTCGGGCGCACGATCGACTACGTGCGCATCGCCGT
CACCAGCGCCTGCAACCTGCGCTGCACCTACTGCCTTAAAAACGAGGAAGATGCTGACCGGAAAATCGACCAGCTCGACG
CGGACCAAACAGTAGCGGTCATCGAAGTTCTCGCACAGATGGGCATCCGGAAAGTACGCTTCACGGGCGGCGAGCCGCTG
CTTCACCCGGACATCGTCGAACTGGTTCGGCGCGCCAAAGCGACTCCCGGCATCGACACGGTCAAGTTCACCACCAACGG
CATTCTGCTCGACCGGTATCTGGACGAGCTGATTGCGGCAGGGCTCGACGGTATCAACCTCAGCCTCGACACACTCGACG
CACAAAAGTACCGCGACATCACCCGCCGCGACCGCTTCGCCAGCGTCCGCGCAGCGCTCGACCGGCTGCTCGACATTCCC
GATATGAGCGTCAAAATCAACACGCTCATGCTCCGTGGCATCAACAACGACGAAATTCCGGACTTTGTCGAACTCACCCG
CAGCCACAAGCTCAACGTCAGGTTCATGGAGCTGCAACCGTTTGATGACCAGCAGATATGGCGCACCGGCAAGTTCATGG
GAGCCGAGATGATCCGGGAACAGCTTTTCCAGCACTACCCACAGCTTGAGGCGGTCACCGGGCGCGACACCGAACACTAC
AGCTTCAGATTATCCAACTATCAGGGCTCGATCGCCATCATCCCGGCCTTCTCCCGCAATTTCTGCGGCAGCTGCTCACG
CCTCAGAATCACCGCGGACGGCCGAATCATCAGTTGCCTCTATCATCAGGAAAGCATCGATCTGAAACCCGCCATGAACG
ACGGATTCAATCGCGAACAGATCAGAAAACAGATACTCGAAGCGGTAGGGAAAAAACCGAAGGATGGATTGCACAGCGGC
CGAAACAACGCCGCATCAAGTATGTCCCGAATTGGGGGGTAA

Upstream 100 bases:

>100_bases
TGGAACTCGTCGAACCGCGCGACCCATCGGCACTCTTCAACGCCAACGATCCCGATGCTTTCGACAAAGCCCGGCGAATG
ATGGAAAACGGAGGCCTGCG

Downstream 100 bases:

>100_bases
ATGAAAAAAAGTGTAGGGGCCGGCCTCGCTCCTACCCTTGCGGGAAACGCTATAAAACACTCACTGAATTTCCAGGCACG
ACCTCTCCGCCAGCCAGCAC

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 333; Mature: 332

Protein sequence:

>333_residues
MTPDSEQNRAALTDRFGRTIDYVRIAVTSACNLRCTYCLKNEEDADRKIDQLDADQTVAVIEVLAQMGIRKVRFTGGEPL
LHPDIVELVRRAKATPGIDTVKFTTNGILLDRYLDELIAAGLDGINLSLDTLDAQKYRDITRRDRFASVRAALDRLLDIP
DMSVKINTLMLRGINNDEIPDFVELTRSHKLNVRFMELQPFDDQQIWRTGKFMGAEMIREQLFQHYPQLEAVTGRDTEHY
SFRLSNYQGSIAIIPAFSRNFCGSCSRLRITADGRIISCLYHQESIDLKPAMNDGFNREQIRKQILEAVGKKPKDGLHSG
RNNAASSMSRIGG

Sequences:

>Translated_333_residues
MTPDSEQNRAALTDRFGRTIDYVRIAVTSACNLRCTYCLKNEEDADRKIDQLDADQTVAVIEVLAQMGIRKVRFTGGEPL
LHPDIVELVRRAKATPGIDTVKFTTNGILLDRYLDELIAAGLDGINLSLDTLDAQKYRDITRRDRFASVRAALDRLLDIP
DMSVKINTLMLRGINNDEIPDFVELTRSHKLNVRFMELQPFDDQQIWRTGKFMGAEMIREQLFQHYPQLEAVTGRDTEHY
SFRLSNYQGSIAIIPAFSRNFCGSCSRLRITADGRIISCLYHQESIDLKPAMNDGFNREQIRKQILEAVGKKPKDGLHSG
RNNAASSMSRIGG
>Mature_332_residues
TPDSEQNRAALTDRFGRTIDYVRIAVTSACNLRCTYCLKNEEDADRKIDQLDADQTVAVIEVLAQMGIRKVRFTGGEPLL
HPDIVELVRRAKATPGIDTVKFTTNGILLDRYLDELIAAGLDGINLSLDTLDAQKYRDITRRDRFASVRAALDRLLDIPD
MSVKINTLMLRGINNDEIPDFVELTRSHKLNVRFMELQPFDDQQIWRTGKFMGAEMIREQLFQHYPQLEAVTGRDTEHYS
FRLSNYQGSIAIIPAFSRNFCGSCSRLRITADGRIISCLYHQESIDLKPAMNDGFNREQIRKQILEAVGKKPKDGLHSGR
NNAASSMSRIGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=328, Percent_Identity=37.1951219512195, Blast_Score=228, Evalue=5e-60,
Organism=Homo sapiens, GI22027536, Length=328, Percent_Identity=37.1951219512195, Blast_Score=228, Evalue=5e-60,
Organism=Escherichia coli, GI1786999, Length=328, Percent_Identity=29.8780487804878, Blast_Score=174, Evalue=6e-45,
Organism=Caenorhabditis elegans, GI32566329, Length=325, Percent_Identity=34.7692307692308, Blast_Score=192, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI32566331, Length=302, Percent_Identity=35.4304635761589, Blast_Score=191, Evalue=6e-49,
Organism=Caenorhabditis elegans, GI17561210, Length=327, Percent_Identity=34.5565749235474, Blast_Score=186, Evalue=1e-47,
Organism=Drosophila melanogaster, GI28574488, Length=331, Percent_Identity=36.5558912386707, Blast_Score=203, Evalue=2e-52,
Organism=Drosophila melanogaster, GI28574490, Length=308, Percent_Identity=37.012987012987, Blast_Score=200, Evalue=1e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 37700; Mature: 37568

Theoretical pI: Translated: 7.47; Mature: 7.47

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPDSEQNRAALTDRFGRTIDYVRIAVTSACNLRCTYCLKNEEDADRKIDQLDADQTVAV
CCCCCCCCHHHHHHHHCCHHHHHHHEECCCCCCEEEEEECCCCHHHHHHHHCCCCHHHHH
IEVLAQMGIRKVRFTGGEPLLHPDIVELVRRAKATPGIDTVKFTTNGILLDRYLDELIAA
HHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCCCEEEEECCCEEHHHHHHHHHHC
GLDGINLSLDTLDAQKYRDITRRDRFASVRAALDRLLDIPDMSVKINTLMLRGINNDEIP
CCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCCCH
DFVELTRSHKLNVRFMELQPFDDQQIWRTGKFMGAEMIREQLFQHYPQLEAVTGRDTEHY
HHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCE
SFRLSNYQGSIAIIPAFSRNFCGSCSRLRITADGRIISCLYHQESIDLKPAMNDGFNREQ
EEEEECCCCCEEEEECCCCCCCCCCCEEEEEECCCEEEEEEECCCCCCCCCCCCCCCHHH
IRKQILEAVGKKPKDGLHSGRNNAASSMSRIGG
HHHHHHHHHCCCCCCHHHCCCCHHHHHHHHHCC
>Mature Secondary Structure 
TPDSEQNRAALTDRFGRTIDYVRIAVTSACNLRCTYCLKNEEDADRKIDQLDADQTVAV
CCCCCCCHHHHHHHHCCHHHHHHHEECCCCCCEEEEEECCCCHHHHHHHHCCCCHHHHH
IEVLAQMGIRKVRFTGGEPLLHPDIVELVRRAKATPGIDTVKFTTNGILLDRYLDELIAA
HHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCCCEEEEECCCEEHHHHHHHHHHC
GLDGINLSLDTLDAQKYRDITRRDRFASVRAALDRLLDIPDMSVKINTLMLRGINNDEIP
CCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCCCH
DFVELTRSHKLNVRFMELQPFDDQQIWRTGKFMGAEMIREQLFQHYPQLEAVTGRDTEHY
HHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCE
SFRLSNYQGSIAIIPAFSRNFCGSCSRLRITADGRIISCLYHQESIDLKPAMNDGFNREQ
EEEEECCCCCEEEEECCCCCCCCCCCEEEEEECCCEEEEEEECCCCCCCCCCCCCCCHHH
IRKQILEAVGKKPKDGLHSGRNNAASSMSRIGG
HHHHHHHHHCCCCCCHHHCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12093901 [H]