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The map label for this gene is alsR [H]

Identifier: 192288983

GI number: 192288983

Start: 602619

End: 603500

Strand: Reverse

Name: alsR [H]

Synonym: Rpal_0553

Alternate gene names: 192288983

Gene position: 603500-602619 (Counterclockwise)

Preceding gene: 192288987

Following gene: 192288981

Centisome position: 10.51

GC content: 66.1

Gene sequence:

>882_bases
ATGGAAATCCGCCATCTCCGCTATTTCGCCGCCGTCGCGCGGCACCTGAACTTCACGGCAGCCGCCGAGAGCCTCGGCGT
CGCCCAGCCTCCGCTCAGTCAGCAAATCAGGGACCTGGAAGCCGAGATCGGCACCCCGCTGTTCGAGCGGACGACCCGGC
GTGTGGCGCTGACCCGCGCCGGCGAGGATTTCCTGAAGCAGGCGCTCGCCATTCTGGAGCGGGCCGACAATGCCGTTCAG
CGCGCCCGCTCGATCGGCGCAGGCACCGCCGGCATCCTCAATGTCGGGCTGACCGGATCAGTGCTGACCGGCCCGCTCGG
ACGAGCGATCCAGCAGTTTGCGCTCAACTATCCGAACGTCGATCTCCGCATCCACGAGATGTCGCCCGACCGCCAGGTTG
CGGCGCTGAAATCCGGCCAGACCGATGTGAGCTTCCTGCGCTGTCCGCCGCAGGATGCCGAGATCGCCAGCGAACTGGCG
TGGCGGGAATCGGTCCGGCTGGTCCTGCCGAAAGGCCATGCGCTATCGGCCAGGAAGGTGACCCTGGCGGATCTCCGGGA
CGAGAGCTTCGTGTTTCTGCGGCTGGAGGACTCGCTGTTTGCGAAATACTTATGGCAGTGCTGTTTCGAGGCGGGCTACG
CGCCGCGCGTCACCCATCAGGCGATCGAGTCGACCTCGCTGACGAGTCTGGTCGCAGCAGGTCTCGGCGTCGCCATCATC
CCGGAATTCGTCAGCAAGCTGGCCCACCCCGACGTGGTGTATCGGCCGATCGCCGGACCGCCGATTTCGGCCGACGTTCA
CGCACTGACGACCGCCGCCAACAACCCGCTCGCGAGTCAGTTCATCGCACTGGTGCAGACGCTGTCCGGCAAGGCGAGCT
GA

Upstream 100 bases:

>100_bases
TGTTCCCGGGATCTGGAGCCTGAGAAACAATCACTGCTGAGTTTCTAGACGTCAAATATTTCATATGTCTCGATTGAGAC
GTTTGGCATACGATTTGAGG

Downstream 100 bases:

>100_bases
CGATCCAATTTGTTCGGCGCAGCGGCCGAACCACGCAAAAATCCAACTCACAGTCGAGGGCCCGCCGGCATCGCCGGCAG
GCCCCACGACCATGCTGGAC

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Als operon regulatory protein [H]

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MEIRHLRYFAAVARHLNFTAAAESLGVAQPPLSQQIRDLEAEIGTPLFERTTRRVALTRAGEDFLKQALAILERADNAVQ
RARSIGAGTAGILNVGLTGSVLTGPLGRAIQQFALNYPNVDLRIHEMSPDRQVAALKSGQTDVSFLRCPPQDAEIASELA
WRESVRLVLPKGHALSARKVTLADLRDESFVFLRLEDSLFAKYLWQCCFEAGYAPRVTHQAIESTSLTSLVAAGLGVAII
PEFVSKLAHPDVVYRPIAGPPISADVHALTTAANNPLASQFIALVQTLSGKAS

Sequences:

>Translated_293_residues
MEIRHLRYFAAVARHLNFTAAAESLGVAQPPLSQQIRDLEAEIGTPLFERTTRRVALTRAGEDFLKQALAILERADNAVQ
RARSIGAGTAGILNVGLTGSVLTGPLGRAIQQFALNYPNVDLRIHEMSPDRQVAALKSGQTDVSFLRCPPQDAEIASELA
WRESVRLVLPKGHALSARKVTLADLRDESFVFLRLEDSLFAKYLWQCCFEAGYAPRVTHQAIESTSLTSLVAAGLGVAII
PEFVSKLAHPDVVYRPIAGPPISADVHALTTAANNPLASQFIALVQTLSGKAS
>Mature_293_residues
MEIRHLRYFAAVARHLNFTAAAESLGVAQPPLSQQIRDLEAEIGTPLFERTTRRVALTRAGEDFLKQALAILERADNAVQ
RARSIGAGTAGILNVGLTGSVLTGPLGRAIQQFALNYPNVDLRIHEMSPDRQVAALKSGQTDVSFLRCPPQDAEIASELA
WRESVRLVLPKGHALSARKVTLADLRDESFVFLRLEDSLFAKYLWQCCFEAGYAPRVTHQAIESTSLTSLVAAGLGVAII
PEFVSKLAHPDVVYRPIAGPPISADVHALTTAANNPLASQFIALVQTLSGKAS

Specific function: Regulates the expression of the alsSD operon for acetoin biosynthesis [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1788887, Length=293, Percent_Identity=38.5665529010239, Blast_Score=159, Evalue=3e-40,
Organism=Escherichia coli, GI1787879, Length=265, Percent_Identity=36.9811320754717, Blast_Score=147, Evalue=6e-37,
Organism=Escherichia coli, GI2367136, Length=268, Percent_Identity=33.2089552238806, Blast_Score=145, Evalue=3e-36,
Organism=Escherichia coli, GI1790399, Length=294, Percent_Identity=29.9319727891156, Blast_Score=114, Evalue=6e-27,
Organism=Escherichia coli, GI157672245, Length=248, Percent_Identity=33.4677419354839, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI145693105, Length=303, Percent_Identity=27.0627062706271, Blast_Score=87, Evalue=9e-19,
Organism=Escherichia coli, GI1787530, Length=261, Percent_Identity=27.2030651340996, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI1788297, Length=252, Percent_Identity=27.7777777777778, Blast_Score=84, Evalue=9e-18,
Organism=Escherichia coli, GI87081904, Length=187, Percent_Identity=32.0855614973262, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1787601, Length=245, Percent_Identity=28.1632653061224, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1787806, Length=262, Percent_Identity=25.9541984732824, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1788748, Length=262, Percent_Identity=23.6641221374046, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1789173, Length=128, Percent_Identity=39.0625, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1790262, Length=247, Percent_Identity=25.9109311740891, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1789204, Length=296, Percent_Identity=27.3648648648649, Blast_Score=67, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 31670; Mature: 31670

Theoretical pI: Translated: 8.10; Mature: 8.10

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIRHLRYFAAVARHLNFTAAAESLGVAQPPLSQQIRDLEAEIGTPLFERTTRRVALTRA
CCCHHHHHHHHHHHHCCHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHC
GEDFLKQALAILERADNAVQRARSIGAGTAGILNVGLTGSVLTGPLGRAIQQFALNYPNV
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHEECCCCCHHHHHHHHHHHHHHHCCCCCC
DLRIHEMSPDRQVAALKSGQTDVSFLRCPPQDAEIASELAWRESVRLVLPKGHALSARKV
EEEEEECCCCHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHCCEEEECCCCCCCCCEE
TLADLRDESFVFLRLEDSLFAKYLWQCCFEAGYAPRVTHQAIESTSLTSLVAAGLGVAII
HHHHCCCCCEEEEEECHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHHH
PEFVSKLAHPDVVYRPIAGPPISADVHALTTAANNPLASQFIALVQTLSGKAS
HHHHHHHCCCCEEEECCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MEIRHLRYFAAVARHLNFTAAAESLGVAQPPLSQQIRDLEAEIGTPLFERTTRRVALTRA
CCCHHHHHHHHHHHHCCHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHC
GEDFLKQALAILERADNAVQRARSIGAGTAGILNVGLTGSVLTGPLGRAIQQFALNYPNV
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHEECCCCCHHHHHHHHHHHHHHHCCCCCC
DLRIHEMSPDRQVAALKSGQTDVSFLRCPPQDAEIASELAWRESVRLVLPKGHALSARKV
EEEEEECCCCHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHCCEEEECCCCCCCCCEE
TLADLRDESFVFLRLEDSLFAKYLWQCCFEAGYAPRVTHQAIESTSLTSLVAAGLGVAII
HHHHCCCCCEEEEEECHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHHH
PEFVSKLAHPDVVYRPIAGPPISADVHALTTAANNPLASQFIALVQTLSGKAS
HHHHHHHCCCCEEEECCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7685336; 9353933; 9384377 [H]