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The map label for this gene is glmS [H]

Identifier: 190571617

GI number: 190571617

Start: 1312771

End: 1314582

Strand: Reverse

Name: glmS [H]

Synonym: WPa_1241

Alternate gene names: 190571617

Gene position: 1314582-1312771 (Counterclockwise)

Preceding gene: 190571618

Following gene: 190571616

Centisome position: 88.68

GC content: 33.39

Gene sequence:

>1812_bases
GTGTGTGGAATATTAGGTATAGTAAGTAGCGGTGATTCAGTAATACCAACTTTACTAACCGCGTTGCAAAAATTGGAATA
CAGAGGTTATGACTCTTCAGGTATAGCAATTATAAATAATAGAGGTAAGATAGAAGTAAAAAAATCAGAAGGTAAAGTTG
AAAGATTGTGTGAAGTTGTTCATGAGAGCAAGATATCTAGTAGCAAAGTTGGTATAGCACATACTCGTTGGGCTACACAT
GGAGCTCCAAATCTTAAAAATGCTCATCCCATTTATATAAATAATGTTGTTGTTGCTCATAATGGCATAATTGAAAATTA
CAATATATTAAAAAAGGATCTGGAGGAAAAGGGAGTATCTTTCCACACCGATACTGATACAGAAGTGATACCAAACATAT
TAACTTCATATCTTGATGAAGGGTTATCACCAATTGATTCTATATTACAGTGTCTAAACAATTTACAAGGTTCACTTGCT
TTGGCTTTATTATTTGCAGAATATCCAGATACTTTATTTGTTGCAAAAAGAAATTTGCCTTTAGCAATAGGATATAACTG
TAATAAAGTGTTTGCTGCTTCTGATACTAATACTTTGAATTCATTTGTAGAAAAAATATTGCATTTAGAAGATAATGATA
TTGCAGTAATAAAATCTAACGAATTCAGTATATATAATAATGGTATACAAGTTAAACGCAGAACAGAAAATAGCAGTCCA
AGAAATTTTCTAATTAGTAAAAATGGTTACCCTAGCTTTATGCTAAAAGAAATTTTTGAGCAACCGTATGCATTAAACAA
AACAATAAATCAATTTTATAAACAATATAAAGAAATCAACAAAGAATTATTTTCTGAACTAGGTTACATTACTATAGTTG
GATGCGGTTCATCCTATTTTGCTGGACTAATAGCAAAGTGTTGGCTGGAAAGTATTGCTCAAATTCGGGTATATCTAGAA
ATCTCGTCAGAATTTAGGTATAGCAGCGTCAAGCTCGAAGAAGGTAGTATTGGCTTATTCATTTCTCAATCTGGTGAAAC
TGCAGATACTATGGAAGCACTACGTTATGCGAGATTGCAGAAACAAATGATCATTAGCATAATTAATACATTTAATAGCA
GCATAGAAAAAGCCTCAGATATTGTATTGCATACTCTTGCTGGACCTGAGATTGGTGTTGCTTCGACAAAAACCTTTTCT
ACGCAGCTTGCAATTTTAGCATGCTTTGCTGTAGAGCTTGGAAAAATAAAAGGTATACTGGGTAGAGAGAGGATAAAGGA
ACTAAGCGGTGCTATTAATTCCATTCCCGAACATGTAGAGCATGTTTTGAATGTGATGGAAATACAACATATATCAGGCA
GTATATTAGAGCACAATAATATAATTATAATTGGGAGAGGAAGCTCATATGGAGTTGCAATGGAAGGTGCATTGAAGATA
AAAGAGCTTTCATATATCAACACAATTGGTATTGCAGCGGGAGAAATGAAGCACGGTTCTATCGCCTTGATAGACTCTAC
TGTACTTGTTATCGCAATTATTCCTTACGATAATTTATTCTTTAAAACGCTATCCAATATACAAGAGATTATTGCAAGAA
AAGGTAAAGTAATTGCCTTTAGTGATAAGCAAGGAGCACCGCTCTTAAAGGGAATTTGCATAGATGTGGTGCAACTTCCA
GAAGTTGACAATTTTGTTTCTCCAATTATCTACAGTGTTGCTATGCAATTTCTTGCTTATTCTATTGCAGAAAAAAAAGG
GTTAGATGTAGATTGTCCGAGAAATTTAGCTAAATCTGTCACAGTTGAGTAA

Upstream 100 bases:

>100_bases
CAGTAGCTAAATCTATTGAAAAAAGCAAAGTTGAAAAGAATGGCAAGAAAAATAAACTAGAGGAAAGTAAAAAAGACAAA
AATGCTTCATAATTTAAGAA

Downstream 100 bases:

>100_bases
CTTATTTAAAGTGAGTTGCTAATTAACAGCTCTAATTGTCAGTTATAAATTACTGAATTTTACTAATAAATTCATTGCTA
TCATTAGCCCTCTGCGAAAG

Product: glucosamine--fructose-6-phosphate aminotransferase (isomerizing)

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 603; Mature: 603

Protein sequence:

>603_residues
MCGILGIVSSGDSVIPTLLTALQKLEYRGYDSSGIAIINNRGKIEVKKSEGKVERLCEVVHESKISSSKVGIAHTRWATH
GAPNLKNAHPIYINNVVVAHNGIIENYNILKKDLEEKGVSFHTDTDTEVIPNILTSYLDEGLSPIDSILQCLNNLQGSLA
LALLFAEYPDTLFVAKRNLPLAIGYNCNKVFAASDTNTLNSFVEKILHLEDNDIAVIKSNEFSIYNNGIQVKRRTENSSP
RNFLISKNGYPSFMLKEIFEQPYALNKTINQFYKQYKEINKELFSELGYITIVGCGSSYFAGLIAKCWLESIAQIRVYLE
ISSEFRYSSVKLEEGSIGLFISQSGETADTMEALRYARLQKQMIISIINTFNSSIEKASDIVLHTLAGPEIGVASTKTFS
TQLAILACFAVELGKIKGILGRERIKELSGAINSIPEHVEHVLNVMEIQHISGSILEHNNIIIIGRGSSYGVAMEGALKI
KELSYINTIGIAAGEMKHGSIALIDSTVLVIAIIPYDNLFFKTLSNIQEIIARKGKVIAFSDKQGAPLLKGICIDVVQLP
EVDNFVSPIIYSVAMQFLAYSIAEKKGLDVDCPRNLAKSVTVE

Sequences:

>Translated_603_residues
MCGILGIVSSGDSVIPTLLTALQKLEYRGYDSSGIAIINNRGKIEVKKSEGKVERLCEVVHESKISSSKVGIAHTRWATH
GAPNLKNAHPIYINNVVVAHNGIIENYNILKKDLEEKGVSFHTDTDTEVIPNILTSYLDEGLSPIDSILQCLNNLQGSLA
LALLFAEYPDTLFVAKRNLPLAIGYNCNKVFAASDTNTLNSFVEKILHLEDNDIAVIKSNEFSIYNNGIQVKRRTENSSP
RNFLISKNGYPSFMLKEIFEQPYALNKTINQFYKQYKEINKELFSELGYITIVGCGSSYFAGLIAKCWLESIAQIRVYLE
ISSEFRYSSVKLEEGSIGLFISQSGETADTMEALRYARLQKQMIISIINTFNSSIEKASDIVLHTLAGPEIGVASTKTFS
TQLAILACFAVELGKIKGILGRERIKELSGAINSIPEHVEHVLNVMEIQHISGSILEHNNIIIIGRGSSYGVAMEGALKI
KELSYINTIGIAAGEMKHGSIALIDSTVLVIAIIPYDNLFFKTLSNIQEIIARKGKVIAFSDKQGAPLLKGICIDVVQLP
EVDNFVSPIIYSVAMQFLAYSIAEKKGLDVDCPRNLAKSVTVE
>Mature_603_residues
MCGILGIVSSGDSVIPTLLTALQKLEYRGYDSSGIAIINNRGKIEVKKSEGKVERLCEVVHESKISSSKVGIAHTRWATH
GAPNLKNAHPIYINNVVVAHNGIIENYNILKKDLEEKGVSFHTDTDTEVIPNILTSYLDEGLSPIDSILQCLNNLQGSLA
LALLFAEYPDTLFVAKRNLPLAIGYNCNKVFAASDTNTLNSFVEKILHLEDNDIAVIKSNEFSIYNNGIQVKRRTENSSP
RNFLISKNGYPSFMLKEIFEQPYALNKTINQFYKQYKEINKELFSELGYITIVGCGSSYFAGLIAKCWLESIAQIRVYLE
ISSEFRYSSVKLEEGSIGLFISQSGETADTMEALRYARLQKQMIISIINTFNSSIEKASDIVLHTLAGPEIGVASTKTFS
TQLAILACFAVELGKIKGILGRERIKELSGAINSIPEHVEHVLNVMEIQHISGSILEHNNIIIIGRGSSYGVAMEGALKI
KELSYINTIGIAAGEMKHGSIALIDSTVLVIAIIPYDNLFFKTLSNIQEIIARKGKVIAFSDKQGAPLLKGICIDVVQLP
EVDNFVSPIIYSVAMQFLAYSIAEKKGLDVDCPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI205277386, Length=688, Percent_Identity=33.1395348837209, Blast_Score=354, Evalue=1e-97,
Organism=Homo sapiens, GI4826742, Length=693, Percent_Identity=32.7561327561328, Blast_Score=351, Evalue=1e-96,
Organism=Homo sapiens, GI29570798, Length=213, Percent_Identity=28.169014084507, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1790167, Length=613, Percent_Identity=39.1517128874388, Blast_Score=430, Evalue=1e-121,
Organism=Escherichia coli, GI1788651, Length=146, Percent_Identity=34.9315068493151, Blast_Score=84, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17532899, Length=433, Percent_Identity=34.1801385681293, Blast_Score=246, Evalue=3e-65,
Organism=Caenorhabditis elegans, GI17532897, Length=433, Percent_Identity=34.1801385681293, Blast_Score=246, Evalue=3e-65,
Organism=Caenorhabditis elegans, GI17539970, Length=430, Percent_Identity=33.7209302325581, Blast_Score=241, Evalue=6e-64,
Organism=Saccharomyces cerevisiae, GI6322745, Length=430, Percent_Identity=34.8837209302326, Blast_Score=236, Evalue=6e-63,
Organism=Saccharomyces cerevisiae, GI6323731, Length=433, Percent_Identity=28.6374133949192, Blast_Score=164, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6323730, Length=204, Percent_Identity=37.2549019607843, Blast_Score=106, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6323958, Length=149, Percent_Identity=35.5704697986577, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21357745, Length=689, Percent_Identity=33.3817126269956, Blast_Score=359, Evalue=3e-99,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 66383; Mature: 66383

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGILGIVSSGDSVIPTLLTALQKLEYRGYDSSGIAIINNRGKIEVKKSEGKVERLCEVV
CCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCEEEEECCCCHHHHHHHHH
HESKISSSKVGIAHTRWATHGAPNLKNAHPIYINNVVVAHNGIIENYNILKKDLEEKGVS
HHHCCCCCCCCEEEECCCCCCCCCCCCCCCEEEEEEEEEECCCCCCHHHHHHHHHHCCCE
FHTDTDTEVIPNILTSYLDEGLSPIDSILQCLNNLQGSLALALLFAEYPDTLFVAKRNLP
EECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEEECCCC
LAIGYNCNKVFAASDTNTLNSFVEKILHLEDNDIAVIKSNEFSIYNNGIQVKRRTENSSP
EEECCCCCEEEECCCCHHHHHHHHHHHCCCCCCEEEEECCCEEEEECCEEEEEECCCCCC
RNFLISKNGYPSFMLKEIFEQPYALNKTINQFYKQYKEINKELFSELGYITIVGCGSSYF
CEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCHHHH
AGLIAKCWLESIAQIRVYLEISSEFRYSSVKLEEGSIGLFISQSGETADTMEALRYARLQ
HHHHHHHHHHHHHHEEEEEEECCCCCEEEEEEECCCEEEEEECCCCCHHHHHHHHHHHHH
KQMIISIINTFNSSIEKASDIVLHTLAGPEIGVASTKTFSTQLAILACFAVELGKIKGIL
HHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
GRERIKELSGAINSIPEHVEHVLNVMEIQHISGSILEHNNIIIIGRGSSYGVAMEGALKI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCEEEEECCCCCCEEECCCEEE
KELSYINTIGIAAGEMKHGSIALIDSTVLVIAIIPYDNLFFKTLSNIQEIIARKGKVIAF
HHHHHHHHHCCCCCCCCCCCEEEEECCEEEEEEECCCHHHHHHHHHHHHHHHCCCCEEEE
SDKQGAPLLKGICIDVVQLPEVDNFVSPIIYSVAMQFLAYSIAEKKGLDVDCPRNLAKSV
CCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCC
TVE
CCC
>Mature Secondary Structure
MCGILGIVSSGDSVIPTLLTALQKLEYRGYDSSGIAIINNRGKIEVKKSEGKVERLCEVV
CCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCEEEEECCCCHHHHHHHHH
HESKISSSKVGIAHTRWATHGAPNLKNAHPIYINNVVVAHNGIIENYNILKKDLEEKGVS
HHHCCCCCCCCEEEECCCCCCCCCCCCCCCEEEEEEEEEECCCCCCHHHHHHHHHHCCCE
FHTDTDTEVIPNILTSYLDEGLSPIDSILQCLNNLQGSLALALLFAEYPDTLFVAKRNLP
EECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEEECCCC
LAIGYNCNKVFAASDTNTLNSFVEKILHLEDNDIAVIKSNEFSIYNNGIQVKRRTENSSP
EEECCCCCEEEECCCCHHHHHHHHHHHCCCCCCEEEEECCCEEEEECCEEEEEECCCCCC
RNFLISKNGYPSFMLKEIFEQPYALNKTINQFYKQYKEINKELFSELGYITIVGCGSSYF
CEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCHHHH
AGLIAKCWLESIAQIRVYLEISSEFRYSSVKLEEGSIGLFISQSGETADTMEALRYARLQ
HHHHHHHHHHHHHHEEEEEEECCCCCEEEEEEECCCEEEEEECCCCCHHHHHHHHHHHHH
KQMIISIINTFNSSIEKASDIVLHTLAGPEIGVASTKTFSTQLAILACFAVELGKIKGIL
HHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
GRERIKELSGAINSIPEHVEHVLNVMEIQHISGSILEHNNIIIIGRGSSYGVAMEGALKI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCEEEEECCCCCCEEECCCEEE
KELSYINTIGIAAGEMKHGSIALIDSTVLVIAIIPYDNLFFKTLSNIQEIIARKGKVIAF
HHHHHHHHHCCCCCCCCCCCEEEEECCEEEEEEECCCHHHHHHHHHHHHHHHCCCCEEEE
SDKQGAPLLKGICIDVVQLPEVDNFVSPIIYSVAMQFLAYSIAEKKGLDVDCPRNLAKSV
CCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCC
TVE
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]