BacMap

Definition	Wolbachia endosymbiont of Culex quinquefasciatus Pel, complete genome.
Accession	NC_010981
Length	1,482,455

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The map label for this gene is ccmA [H]

Identifier: 190571605

GI number: 190571605

Start: 1301966

End: 1302589

Strand: Reverse

Name: ccmA [H]

Synonym: WPa_1228

Alternate gene names: 190571605

Gene position: 1302589-1301966 (Counterclockwise)

Preceding gene: 190571606

Following gene: 190571602

Centisome position: 87.87

GC content: 36.06

Gene sequence:

>624_bases
ATGCTTGAATGTAAAAATCTATCCTGTGCTCGTAATAACAAAGTATTATTTAAAAACCTCAATTTTAAAGCTGAGCCAAA
ATCAAAAATCTTAATCACTGGTCCAAATGGTAGCGGCAAAACCAGCTTAATCAGAAGTTTATCTGGACTCTTACCGCCAG
TATCAGGCAATATAAGATACTACGGAAAAGACATATATGATGATCCAAAATCCTTTATATCTTCCATGGTTTACGTAGGA
CATAAAAACGCCTGTAAAGATAGCTTAACAATTGGTGAAAACATAGAATTCTGGGCAAGAATACGGAACACTAGAGAATC
AGTTATGGCAGCTGCTTATTGTTTAGAGTTGCAACCTGTATTTAACATTAGATATGGTGAACTTTCTGCAGGCTGGAAAA
GAAGAGTTGCGCTTGCCCGCCTTTTAATTTCTAATGCAAATATCTGGCTGATAGATGAACCTTTCTGTAATCTTGATAGC
ACAACATGTGAATTAGTATTGAACCTAATCTCAATACGCTCTGAGCAGAACGGTACAGTAATTATTACAGGACATAGCTC
TACAGAACAATTGTGTGACTTCAAGACAATCGACATACGTGATTTTAACAGACCTCTTGTATAA

Upstream 100 bases:

>100_bases
ATTGATACACAGAGAAGGTGATAAGAAAGGATTTTGGGAGCTATTTATAAAAGCTCAGTCTTCAACTAAGGGTAAATATA
AAGGAAAAGGCAGATAATCC

Downstream 100 bases:

>100_bases
TTTTTGGCCTTAAAATTAACACATCTCTTTCAAAGGCTCTATATTAAAAATAGAAAGCCCAGAAGCGATTACGTGCGCTA
AGGCTTGTACGAGAAACATT

Product: cytochrome c biogenesis protein CcmA

Products: NA

Alternate protein names: Heme exporter protein A [H]

Number of amino acids: Translated: 207; Mature: 207

Protein sequence:

>207_residues
MLECKNLSCARNNKVLFKNLNFKAEPKSKILITGPNGSGKTSLIRSLSGLLPPVSGNIRYYGKDIYDDPKSFISSMVYVG
HKNACKDSLTIGENIEFWARIRNTRESVMAAAYCLELQPVFNIRYGELSAGWKRRVALARLLISNANIWLIDEPFCNLDS
TTCELVLNLISIRSEQNGTVIITGHSSTEQLCDFKTIDIRDFNRPLV

Sequences:

>Translated_207_residues
MLECKNLSCARNNKVLFKNLNFKAEPKSKILITGPNGSGKTSLIRSLSGLLPPVSGNIRYYGKDIYDDPKSFISSMVYVG
HKNACKDSLTIGENIEFWARIRNTRESVMAAAYCLELQPVFNIRYGELSAGWKRRVALARLLISNANIWLIDEPFCNLDS
TTCELVLNLISIRSEQNGTVIITGHSSTEQLCDFKTIDIRDFNRPLV
>Mature_207_residues
MLECKNLSCARNNKVLFKNLNFKAEPKSKILITGPNGSGKTSLIRSLSGLLPPVSGNIRYYGKDIYDDPKSFISSMVYVG
HKNACKDSLTIGENIEFWARIRNTRESVMAAAYCLELQPVFNIRYGELSAGWKRRVALARLLISNANIWLIDEPFCNLDS
TTCELVLNLISIRSEQNGTVIITGHSSTEQLCDFKTIDIRDFNRPLV

Specific function: Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system [H]

COG id: COG4133

COG function: function code O; ABC-type transport system involved in cytochrome c biogenesis, ATPase component

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Homo sapiens, GI116734710, Length=190, Percent_Identity=24.7368421052632, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI27436953, Length=192, Percent_Identity=26.0416666666667, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI21536376, Length=162, Percent_Identity=27.1604938271605, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI30795238, Length=164, Percent_Identity=31.0975609756098, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI27881501, Length=164, Percent_Identity=31.0975609756098, Blast_Score=71, Evalue=5e-13,
Organism=Homo sapiens, GI42741659, Length=197, Percent_Identity=26.9035532994924, Blast_Score=71, Evalue=6e-13,
Organism=Homo sapiens, GI9961252, Length=194, Percent_Identity=27.319587628866, Blast_Score=70, Evalue=9e-13,
Organism=Homo sapiens, GI9961250, Length=194, Percent_Identity=27.319587628866, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI4505771, Length=194, Percent_Identity=27.319587628866, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI105990541, Length=161, Percent_Identity=27.3291925465839, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI153792144, Length=202, Percent_Identity=23.2673267326733, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI171184400, Length=200, Percent_Identity=30, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI45446740, Length=183, Percent_Identity=24.5901639344262, Blast_Score=67, Evalue=8e-12,
Organism=Homo sapiens, GI46592915, Length=191, Percent_Identity=26.7015706806283, Blast_Score=67, Evalue=8e-12,
Organism=Homo sapiens, GI47078218, Length=183, Percent_Identity=24.5901639344262, Blast_Score=67, Evalue=9e-12,
Organism=Homo sapiens, GI46592898, Length=195, Percent_Identity=27.1794871794872, Blast_Score=67, Evalue=9e-12,
Organism=Homo sapiens, GI27477115, Length=197, Percent_Identity=24.3654822335025, Blast_Score=67, Evalue=9e-12,
Organism=Homo sapiens, GI46592956, Length=191, Percent_Identity=26.7015706806283, Blast_Score=67, Evalue=9e-12,
Organism=Homo sapiens, GI46592964, Length=191, Percent_Identity=26.7015706806283, Blast_Score=67, Evalue=9e-12,
Organism=Homo sapiens, GI46592978, Length=191, Percent_Identity=26.7015706806283, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI46592971, Length=188, Percent_Identity=27.1276595744681, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI27262624, Length=173, Percent_Identity=28.3236994219653, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI27262626, Length=173, Percent_Identity=28.3236994219653, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI9955968, Length=185, Percent_Identity=25.9459459459459, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI9955966, Length=185, Percent_Identity=25.9459459459459, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI45243524, Length=185, Percent_Identity=25.9459459459459, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI87082064, Length=186, Percent_Identity=36.0215053763441, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1790467, Length=210, Percent_Identity=24.7619047619048, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1788761, Length=198, Percent_Identity=30.3030303030303, Blast_Score=78, Evalue=5e-16,
Organism=Escherichia coli, GI87081782, Length=201, Percent_Identity=27.363184079602, Blast_Score=77, Evalue=6e-16,
Organism=Escherichia coli, GI1786253, Length=173, Percent_Identity=31.2138728323699, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI87082267, Length=184, Percent_Identity=27.7173913043478, Blast_Score=73, Evalue=1e-14,
Organism=Escherichia coli, GI1787041, Length=196, Percent_Identity=28.0612244897959, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI87081834, Length=205, Percent_Identity=28.780487804878, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI87081709, Length=165, Percent_Identity=26.6666666666667, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1786654, Length=207, Percent_Identity=27.0531400966184, Blast_Score=67, Evalue=7e-13,
Organism=Escherichia coli, GI1789672, Length=181, Percent_Identity=28.1767955801105, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1788165, Length=186, Percent_Identity=24.7311827956989, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI48994943, Length=202, Percent_Identity=26.2376237623762, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1786698, Length=200, Percent_Identity=27, Blast_Score=64, Evalue=6e-12,
Organism=Escherichia coli, GI1787113, Length=198, Percent_Identity=28.7878787878788, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI1789586, Length=204, Percent_Identity=26.9607843137255, Blast_Score=63, Evalue=1e-11,
Organism=Escherichia coli, GI1789593, Length=199, Percent_Identity=26.1306532663317, Blast_Score=62, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI115533608, Length=198, Percent_Identity=27.2727272727273, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71992290, Length=192, Percent_Identity=26.0416666666667, Blast_Score=71, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17565586, Length=192, Percent_Identity=27.0833333333333, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17541710, Length=183, Percent_Identity=27.3224043715847, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI193211015, Length=192, Percent_Identity=24.4791666666667, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI193211017, Length=192, Percent_Identity=24.4791666666667, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI193208177, Length=187, Percent_Identity=31.0160427807487, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI212646699, Length=201, Percent_Identity=24.8756218905473, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71996809, Length=183, Percent_Identity=22.9508196721311, Blast_Score=64, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI71983523, Length=174, Percent_Identity=25.8620689655172, Blast_Score=64, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI71983510, Length=174, Percent_Identity=25.8620689655172, Blast_Score=64, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI71983516, Length=174, Percent_Identity=25.8620689655172, Blast_Score=64, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17533971, Length=186, Percent_Identity=25.8064516129032, Blast_Score=64, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6320874, Length=191, Percent_Identity=27.2251308900524, Blast_Score=70, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6323959, Length=181, Percent_Identity=29.8342541436464, Blast_Score=69, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6324985, Length=231, Percent_Identity=27.2727272727273, Blast_Score=66, Evalue=4e-12,
Organism=Drosophila melanogaster, GI19920532, Length=185, Percent_Identity=28.1081081081081, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24580930, Length=185, Percent_Identity=28.1081081081081, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24643674, Length=194, Percent_Identity=26.2886597938144, Blast_Score=74, Evalue=7e-14,
Organism=Drosophila melanogaster, GI28574533, Length=212, Percent_Identity=30.188679245283, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI281363262, Length=190, Percent_Identity=25.7894736842105, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24653245, Length=190, Percent_Identity=25.7894736842105, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI28574744, Length=166, Percent_Identity=28.9156626506024, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR005895
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: =3.6.3.41 [H]

Molecular weight: Translated: 23253; Mature: 23253

Theoretical pI: Translated: 8.86; Mature: 8.86

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
3.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLECKNLSCARNNKVLFKNLNFKAEPKSKILITGPNGSGKTSLIRSLSGLLPPVSGNIRY
CCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCCCEEE
YGKDIYDDPKSFISSMVYVGHKNACKDSLTIGENIEFWARIRNTRESVMAAAYCLELQPV
ECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCE
FNIRYGELSAGWKRRVALARLLISNANIWLIDEPFCNLDSTTCELVLNLISIRSEQNGTV
EEEEECCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCEE
IITGHSSTEQLCDFKTIDIRDFNRPLV
EEECCCCHHHHHCEEEEEEECCCCCCC
>Mature Secondary Structure
MLECKNLSCARNNKVLFKNLNFKAEPKSKILITGPNGSGKTSLIRSLSGLLPPVSGNIRY
CCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCCCEEE
YGKDIYDDPKSFISSMVYVGHKNACKDSLTIGENIEFWARIRNTRESVMAAAYCLELQPV
ECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCE
FNIRYGELSAGWKRRVALARLLISNANIWLIDEPFCNLDSTTCELVLNLISIRSEQNGTV
EEEEECCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCEE
IITGHSSTEQLCDFKTIDIRDFNRPLV
EEECCCCHHHHHCEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA