BacMap

Definition	Wolbachia endosymbiont of Culex quinquefasciatus Pel, complete genome.
Accession	NC_010981
Length	1,482,455

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The map label for this gene is fabG [H]

Identifier: 190571578

GI number: 190571578

Start: 1271936

End: 1272670

Strand: Reverse

Name: fabG [H]

Synonym: WPa_1198

Alternate gene names: 190571578

Gene position: 1272670-1271936 (Counterclockwise)

Preceding gene: 190571579

Following gene: 190571577

Centisome position: 85.85

GC content: 34.01

Gene sequence:

>735_bases
ATGTTTGGATTAGAGAATAAGAAATTTCTGATTACTGGTGCATCAGGCGGAATAGGCCAGGCAATTGTAGAAATTATGCA
TAAGGCCAGAGCAACTTTATGTATTTCTAGTACAAAAAAAGAAATACTCGAAGAAGTTGCTAAAAAATATGAAAAAAACA
TTCACGTACTTCCTTGCAACTTATCAAATCCTGAAGAGGTAAATCAACTAATAAATAAAGCAAGTGAGTTGATGAAAGGC
TTTGATGGACTCATATGCAATGCAGGAATTACACAAGACAGCTTATTGTTGAGAATGACAGATGAAGCATGGCAAAAGGT
GATTGATATTAATTTGACCTCCACATTTAAGCTAAATAGAGAAGCATGCAAGAAATTAATTAAAAATAATTGGGGAAGAA
TCATAAATATTTCTTCAATAGTAGGATTGACAGGAAATGCCGGGCAAGTAAATTATGCAGCATCAAAAGCTGGAATAATA
GCTATGAGCAAATCTATAGCAAAAGAAGTTGCAAGTCGCGGTGTAACAGTAAATTGCATTGCTCCTGGATTTATAGATAC
TAAAATGACTGAAGTTTTAAATGAAGGACAAAAGGAAAAAATATTAGATAACATCCCAATGAAAAGAATGGGAACAGGAA
AAGAAATAGCAGCAGGAGTATTGTTTTTAGCAAGCGATGAGGCAAAATATATAACGGGACATGTGCTTAACATCAATGGT
GGGCTATTTATGTAG

Upstream 100 bases:

>100_bases
CAAGATTTATCAAGAAGCTTCTATTAAATGAAAGTTATGCAAAAAATCTATTGCAAGTCTTTTAATATTCTGTTAAGAGC
TGGAACAAATAAAAATTATT

Downstream 100 bases:

>100_bases
CAACACTTATTTATGGACAAATTATAAGTTTTACTTTACAATAAGTATATATATAAATTTATTTTCGCGTTAGTTTATTA
CTTGGAGGCAAAAGAATGAG

Product: 3-oxoacyl-(acyl-carrier-protein) reductase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 244; Mature: 244

Protein sequence:

>244_residues
MFGLENKKFLITGASGGIGQAIVEIMHKARATLCISSTKKEILEEVAKKYEKNIHVLPCNLSNPEEVNQLINKASELMKG
FDGLICNAGITQDSLLLRMTDEAWQKVIDINLTSTFKLNREACKKLIKNNWGRIINISSIVGLTGNAGQVNYAASKAGII
AMSKSIAKEVASRGVTVNCIAPGFIDTKMTEVLNEGQKEKILDNIPMKRMGTGKEIAAGVLFLASDEAKYITGHVLNING
GLFM

Sequences:

>Translated_244_residues
MFGLENKKFLITGASGGIGQAIVEIMHKARATLCISSTKKEILEEVAKKYEKNIHVLPCNLSNPEEVNQLINKASELMKG
FDGLICNAGITQDSLLLRMTDEAWQKVIDINLTSTFKLNREACKKLIKNNWGRIINISSIVGLTGNAGQVNYAASKAGII
AMSKSIAKEVASRGVTVNCIAPGFIDTKMTEVLNEGQKEKILDNIPMKRMGTGKEIAAGVLFLASDEAKYITGHVLNING
GLFM
>Mature_244_residues
MFGLENKKFLITGASGGIGQAIVEIMHKARATLCISSTKKEILEEVAKKYEKNIHVLPCNLSNPEEVNQLINKASELMKG
FDGLICNAGITQDSLLLRMTDEAWQKVIDINLTSTFKLNREACKKLIKNNWGRIINISSIVGLTGNAGQVNYAASKAGII
AMSKSIAKEVASRGVTVNCIAPGFIDTKMTEVLNEGQKEKILDNIPMKRMGTGKEIAAGVLFLASDEAKYITGHVLNING
GLFM

Specific function: Proposed to modify Nod factor fatty acyl chain [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI15277342, Length=253, Percent_Identity=35.5731225296443, Blast_Score=156, Evalue=2e-38,
Organism=Homo sapiens, GI40254992, Length=232, Percent_Identity=34.9137931034483, Blast_Score=142, Evalue=4e-34,
Organism=Homo sapiens, GI19923817, Length=251, Percent_Identity=31.8725099601594, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI32483357, Length=244, Percent_Identity=28.2786885245902, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI5031737, Length=245, Percent_Identity=27.7551020408163, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI4503301, Length=222, Percent_Identity=34.2342342342342, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI10190704, Length=254, Percent_Identity=30.7086614173228, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI59889578, Length=190, Percent_Identity=33.1578947368421, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI4504505, Length=204, Percent_Identity=27.9411764705882, Blast_Score=91, Evalue=8e-19,
Organism=Homo sapiens, GI4758504, Length=248, Percent_Identity=28.6290322580645, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI66933014, Length=207, Percent_Identity=28.0193236714976, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI126723750, Length=247, Percent_Identity=24.2914979757085, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI33667109, Length=199, Percent_Identity=28.1407035175879, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI126723191, Length=181, Percent_Identity=27.0718232044199, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI7705925, Length=243, Percent_Identity=23.8683127572016, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI109715829, Length=243, Percent_Identity=25.1028806584362, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI31542939, Length=237, Percent_Identity=28.6919831223629, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI7706318, Length=211, Percent_Identity=25.5924170616114, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI40807363, Length=189, Percent_Identity=28.042328042328, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI142976729, Length=184, Percent_Identity=27.1739130434783, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI210032110, Length=188, Percent_Identity=25, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI20149619, Length=213, Percent_Identity=25.3521126760563, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI83715985, Length=248, Percent_Identity=26.6129032258064, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI32455239, Length=192, Percent_Identity=30.2083333333333, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI5031765, Length=192, Percent_Identity=30.2083333333333, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI50726952, Length=195, Percent_Identity=27.6923076923077, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI4504503, Length=215, Percent_Identity=24.1860465116279, Blast_Score=64, Evalue=9e-11,
Organism=Escherichia coli, GI1787335, Length=241, Percent_Identity=45.643153526971, Blast_Score=222, Evalue=1e-59,
Organism=Escherichia coli, GI87082160, Length=248, Percent_Identity=30.6451612903226, Blast_Score=127, Evalue=9e-31,
Organism=Escherichia coli, GI87082100, Length=253, Percent_Identity=32.4110671936759, Blast_Score=120, Evalue=6e-29,
Organism=Escherichia coli, GI2367175, Length=244, Percent_Identity=32.7868852459016, Blast_Score=120, Evalue=7e-29,
Organism=Escherichia coli, GI1789208, Length=247, Percent_Identity=29.5546558704453, Blast_Score=117, Evalue=6e-28,
Organism=Escherichia coli, GI1790717, Length=249, Percent_Identity=27.710843373494, Blast_Score=117, Evalue=7e-28,
Organism=Escherichia coli, GI1789378, Length=251, Percent_Identity=33.0677290836653, Blast_Score=109, Evalue=1e-25,
Organism=Escherichia coli, GI1788459, Length=243, Percent_Identity=27.1604938271605, Blast_Score=94, Evalue=8e-21,
Organism=Escherichia coli, GI1786812, Length=248, Percent_Identity=26.2096774193548, Blast_Score=91, Evalue=8e-20,
Organism=Escherichia coli, GI2367365, Length=247, Percent_Identity=28.3400809716599, Blast_Score=88, Evalue=5e-19,
Organism=Escherichia coli, GI1787905, Length=243, Percent_Identity=27.5720164609054, Blast_Score=87, Evalue=8e-19,
Organism=Escherichia coli, GI1787526, Length=245, Percent_Identity=26.9387755102041, Blast_Score=81, Evalue=7e-17,
Organism=Escherichia coli, GI1789057, Length=223, Percent_Identity=25.1121076233184, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1786701, Length=201, Percent_Identity=26.3681592039801, Blast_Score=70, Evalue=9e-14,
Organism=Escherichia coli, GI1787820, Length=200, Percent_Identity=24.5, Blast_Score=64, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI25147288, Length=240, Percent_Identity=41.25, Blast_Score=166, Evalue=8e-42,
Organism=Caenorhabditis elegans, GI17555706, Length=243, Percent_Identity=38.2716049382716, Blast_Score=166, Evalue=9e-42,
Organism=Caenorhabditis elegans, GI17560676, Length=245, Percent_Identity=34.6938775510204, Blast_Score=137, Evalue=7e-33,
Organism=Caenorhabditis elegans, GI71994600, Length=245, Percent_Identity=28.9795918367347, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17561402, Length=250, Percent_Identity=28.4, Blast_Score=99, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17536651, Length=254, Percent_Identity=31.1023622047244, Blast_Score=94, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17538182, Length=248, Percent_Identity=29.0322580645161, Blast_Score=94, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI115534694, Length=247, Percent_Identity=27.5303643724696, Blast_Score=91, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI71994604, Length=246, Percent_Identity=27.2357723577236, Blast_Score=90, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI17508651, Length=249, Percent_Identity=28.9156626506024, Blast_Score=87, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17536025, Length=251, Percent_Identity=29.0836653386454, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17564282, Length=192, Percent_Identity=30.7291666666667, Blast_Score=84, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17562904, Length=262, Percent_Identity=27.0992366412214, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI72000259, Length=257, Percent_Identity=26.8482490272374, Blast_Score=81, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17544670, Length=269, Percent_Identity=28.6245353159851, Blast_Score=80, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17559104, Length=262, Percent_Identity=26.3358778625954, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI193204405, Length=264, Percent_Identity=30.3030303030303, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17561272, Length=241, Percent_Identity=25.7261410788382, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17568967, Length=188, Percent_Identity=25.531914893617, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17562910, Length=259, Percent_Identity=27.7992277992278, Blast_Score=77, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17563726, Length=261, Percent_Identity=28.3524904214559, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17560150, Length=260, Percent_Identity=26.9230769230769, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17562906, Length=266, Percent_Identity=27.4436090225564, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17538480, Length=254, Percent_Identity=25.9842519685039, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17531453, Length=266, Percent_Identity=28.1954887218045, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17562908, Length=259, Percent_Identity=27.4131274131274, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17508895, Length=194, Percent_Identity=24.7422680412371, Blast_Score=74, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17560332, Length=263, Percent_Identity=26.2357414448669, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17562990, Length=260, Percent_Identity=26.9230769230769, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17551412, Length=254, Percent_Identity=25.9842519685039, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI193203117, Length=187, Percent_Identity=27.807486631016, Blast_Score=71, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI193203115, Length=187, Percent_Identity=27.807486631016, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17560220, Length=266, Percent_Identity=27.8195488721804, Blast_Score=68, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17538486, Length=263, Percent_Identity=25.4752851711027, Blast_Score=67, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI32563809, Length=196, Percent_Identity=26.530612244898, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17507613, Length=196, Percent_Identity=26.530612244898, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6324126, Length=203, Percent_Identity=30.5418719211823, Blast_Score=102, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6322861, Length=251, Percent_Identity=29.8804780876494, Blast_Score=99, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6323882, Length=206, Percent_Identity=29.126213592233, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6322226, Length=186, Percent_Identity=29.0322580645161, Blast_Score=67, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6322227, Length=199, Percent_Identity=26.1306532663317, Blast_Score=63, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24639444, Length=243, Percent_Identity=33.7448559670782, Blast_Score=144, Evalue=7e-35,
Organism=Drosophila melanogaster, GI21355319, Length=249, Percent_Identity=34.136546184739, Blast_Score=135, Evalue=3e-32,
Organism=Drosophila melanogaster, GI23397609, Length=245, Percent_Identity=30.2040816326531, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI28571526, Length=251, Percent_Identity=30.6772908366534, Blast_Score=104, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24644339, Length=245, Percent_Identity=31.0204081632653, Blast_Score=104, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24643142, Length=240, Percent_Identity=28.3333333333333, Blast_Score=103, Evalue=9e-23,
Organism=Drosophila melanogaster, GI17737361, Length=256, Percent_Identity=27.34375, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI21357041, Length=252, Percent_Identity=29.3650793650794, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI18859837, Length=191, Percent_Identity=31.9371727748691, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24644337, Length=248, Percent_Identity=31.4516129032258, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI21358495, Length=196, Percent_Identity=26.530612244898, Blast_Score=81, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24641232, Length=232, Percent_Identity=26.7241379310345, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI116007236, Length=243, Percent_Identity=23.8683127572016, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24581726, Length=133, Percent_Identity=27.0676691729323, Blast_Score=64, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011284
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 26472; Mature: 26472

Theoretical pI: Translated: 9.23; Mature: 9.23

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFGLENKKFLITGASGGIGQAIVEIMHKARATLCISSTKKEILEEVAKKYEKNIHVLPCN
CCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECC
LSNPEEVNQLINKASELMKGFDGLICNAGITQDSLLLRMTDEAWQKVIDINLTSTFKLNR
CCCHHHHHHHHHHHHHHHHHHCCEEECCCCCCCHHEEEECHHHHHHHHCCCCCCEEEECH
EACKKLIKNNWGRIINISSIVGLTGNAGQVNYAASKAGIIAMSKSIAKEVASRGVTVNCI
HHHHHHHHCCCCCEEEEHHEEECCCCCCCEEEHHCCCCHHHHHHHHHHHHHHCCCEEEEE
APGFIDTKMTEVLNEGQKEKILDNIPMKRMGTGKEIAAGVLFLASDEAKYITGHVLNING
CCCCHHHHHHHHHCCCCHHHHHHCCCHHHCCCCHHHHHEEEEEECCCCEEEEEEEEEECC
GLFM
CCCC
>Mature Secondary Structure
MFGLENKKFLITGASGGIGQAIVEIMHKARATLCISSTKKEILEEVAKKYEKNIHVLPCN
CCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECC
LSNPEEVNQLINKASELMKGFDGLICNAGITQDSLLLRMTDEAWQKVIDINLTSTFKLNR
CCCHHHHHHHHHHHHHHHHHHCCEEECCCCCCCHHEEEECHHHHHHHHCCCCCCEEEECH
EACKKLIKNNWGRIINISSIVGLTGNAGQVNYAASKAGIIAMSKSIAKEVASRGVTVNCI
HHHHHHHHCCCCCEEEEHHEEECCCCCCCEEEHHCCCCHHHHHHHHHHHHHHCCCEEEEE
APGFIDTKMTEVLNEGQKEKILDNIPMKRMGTGKEIAAGVLFLASDEAKYITGHVLNING
CCCCHHHHHHHHHCCCCHHHHHHCCCHHHCCCCHHHHHEEEEEECCCCEEEEEEEEEECC
GLFM
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9100384 [H]