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The map label for this gene is pepA [H]

Identifier: 190571477

GI number: 190571477

Start: 1165387

End: 1166925

Strand: Direct

Name: pepA [H]

Synonym: WPa_1092

Alternate gene names: 190571477

Gene position: 1165387-1166925 (Clockwise)

Preceding gene: 190571476

Following gene: 190571478

Centisome position: 78.61

GC content: 38.34

Gene sequence:

>1539_bases
ATGTATATGAAAAATATCTTACTAATGTTTTTACTATGCTTTATGTGCAGCTTACAATTATTTGCAACGGAGATGTCAAC
GATGAAGATAACAATTTCTAAAGCTTTACCCGATTTTGAGACGCTAGTGGTAGGTTTTTTTGAGGGTGATAAGCTCATAA
CTAATGTTCTACAAGATAAGCAAGCTATAGATAACATCAAGAAATTTAGTGATTTTAATGGAGGTTTTGGTGAATTTTTC
TCCGTTACTTCATCAGAGGGAAAAAATATTATAGTTGCTGGTCTTGGAATGAGAGATGAATGGGATGAAAGCAAAGGATT
AAATATTGGTGGTAAAATATATTGTGAGCTAAGCAGATTAAGAATCAAGCGAGCGGCAATCTCAATCGAAGGCAATGCAG
CAAATGTTGCATACGGTGCATTTTTGCGCAGTTTTAAATTTGATAAGTATAAAACCAAAAAGGATGAAAAAGTTACAGAA
GTAGAGGAGATCACAGTGCTAACGAAAGATGAGCAATTCAGTAGTGCTGAAAAATCATTTGAGCGTTTAAGACAAGAAGG
TGAAGGCATATTTCTTGCACGTACTCTTACCATTGAACCACCTAATGTTTTATATCCAGAATCCTATGCTGATTATATAA
AAACCGAGCTTACTAAGCTTGGCCTTGAAATCGAAGTGCTTGGTAAGAAGCAGATGGAAGAGAAAAAAATGGGAGCATTG
CTTGGGGTAGCACAGGGAAGTAGTAAAGAGCCAAAATTAGTAGTGATCAAATGGAATGGAGCTTTCAAGGAACAAAAGCC
TGTAGCTTTTGTGGGTAAAGGCATAACGTTTGATACTGGTGGAGTGTCACTCAAGCCTTCGCGTGGCATGGAGTCAATGA
AATATGACATGGCGGGTTCTGCTACTGTGGTTGGGGTGATGCGTACTCTAGCTGGACGAAAAGCAAAGGTAAATGCAGTT
GGTGTAGTTGCACTTGCAGAAAATGCAGTGGACGGTAATGCTCAAAGACCAAGTGATGTAGTAACTTCGATGTCTGGACA
GACGATAGAAGTGTTGAACACTGATGCAGAAGGAAGGCTCATACTTGCAGATGCTTTATGGTATACACAAGATAGATTTG
CACCGAAATTTATGATCGACCTTGCAACTTTAACTGGTGCTATAGTGGTTGCACTGGGAAATAATGAATATGCTGGTCTT
TTTTCAAATAACGATGAATTAGCGAATCATCTGATTGATGTAGGAAATGAAGTAAATGAGAAATTATGGCGTTTTCCTAT
GAATGAAACTTATAACAAAATTATTGATTCGCCGATTGCTGATGTGCAAAATATAGCTCCTGCAGGTTCTGGTGGAGATA
GTATAATGGCTGCACAGTTTCTACAGCGTTTTGTAAACGACACTTGTTGGGCACATTTAGACATTGCAGGCACTGCTTGG
CACGAAAAAGGCACTGATATTTCTCCAAGAGGGGCAGTAGGTTTCGGTGTAAGGTTGCTAAATAAGTTGGTTGAGAAGTA
CTATGAGATTAATAATTAA

Upstream 100 bases:

>100_bases
TAATATAACCCTAGGTGGGCATAACAAATTTTCTGATAAAAGATAAAGCCCTTGCATATCAGCGGAGTTCATAGTAGTCT
TAAGCGCTATTGTACTTAAA

Downstream 100 bases:

>100_bases
GGATCTTTGTATTGAGTTTATAGCTTAATTTACGGCTACATGAATGTCTATTTATAAGACGTAGAAAATGATATCATCAA
AGTAACTTACATTTTCTTTT

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 512; Mature: 512

Protein sequence:

>512_residues
MYMKNILLMFLLCFMCSLQLFATEMSTMKITISKALPDFETLVVGFFEGDKLITNVLQDKQAIDNIKKFSDFNGGFGEFF
SVTSSEGKNIIVAGLGMRDEWDESKGLNIGGKIYCELSRLRIKRAAISIEGNAANVAYGAFLRSFKFDKYKTKKDEKVTE
VEEITVLTKDEQFSSAEKSFERLRQEGEGIFLARTLTIEPPNVLYPESYADYIKTELTKLGLEIEVLGKKQMEEKKMGAL
LGVAQGSSKEPKLVVIKWNGAFKEQKPVAFVGKGITFDTGGVSLKPSRGMESMKYDMAGSATVVGVMRTLAGRKAKVNAV
GVVALAENAVDGNAQRPSDVVTSMSGQTIEVLNTDAEGRLILADALWYTQDRFAPKFMIDLATLTGAIVVALGNNEYAGL
FSNNDELANHLIDVGNEVNEKLWRFPMNETYNKIIDSPIADVQNIAPAGSGGDSIMAAQFLQRFVNDTCWAHLDIAGTAW
HEKGTDISPRGAVGFGVRLLNKLVEKYYEINN

Sequences:

>Translated_512_residues
MYMKNILLMFLLCFMCSLQLFATEMSTMKITISKALPDFETLVVGFFEGDKLITNVLQDKQAIDNIKKFSDFNGGFGEFF
SVTSSEGKNIIVAGLGMRDEWDESKGLNIGGKIYCELSRLRIKRAAISIEGNAANVAYGAFLRSFKFDKYKTKKDEKVTE
VEEITVLTKDEQFSSAEKSFERLRQEGEGIFLARTLTIEPPNVLYPESYADYIKTELTKLGLEIEVLGKKQMEEKKMGAL
LGVAQGSSKEPKLVVIKWNGAFKEQKPVAFVGKGITFDTGGVSLKPSRGMESMKYDMAGSATVVGVMRTLAGRKAKVNAV
GVVALAENAVDGNAQRPSDVVTSMSGQTIEVLNTDAEGRLILADALWYTQDRFAPKFMIDLATLTGAIVVALGNNEYAGL
FSNNDELANHLIDVGNEVNEKLWRFPMNETYNKIIDSPIADVQNIAPAGSGGDSIMAAQFLQRFVNDTCWAHLDIAGTAW
HEKGTDISPRGAVGFGVRLLNKLVEKYYEINN
>Mature_512_residues
MYMKNILLMFLLCFMCSLQLFATEMSTMKITISKALPDFETLVVGFFEGDKLITNVLQDKQAIDNIKKFSDFNGGFGEFF
SVTSSEGKNIIVAGLGMRDEWDESKGLNIGGKIYCELSRLRIKRAAISIEGNAANVAYGAFLRSFKFDKYKTKKDEKVTE
VEEITVLTKDEQFSSAEKSFERLRQEGEGIFLARTLTIEPPNVLYPESYADYIKTELTKLGLEIEVLGKKQMEEKKMGAL
LGVAQGSSKEPKLVVIKWNGAFKEQKPVAFVGKGITFDTGGVSLKPSRGMESMKYDMAGSATVVGVMRTLAGRKAKVNAV
GVVALAENAVDGNAQRPSDVVTSMSGQTIEVLNTDAEGRLILADALWYTQDRFAPKFMIDLATLTGAIVVALGNNEYAGL
FSNNDELANHLIDVGNEVNEKLWRFPMNETYNKIIDSPIADVQNIAPAGSGGDSIMAAQFLQRFVNDTCWAHLDIAGTAW
HEKGTDISPRGAVGFGVRLLNKLVEKYYEINN

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=427, Percent_Identity=35.1288056206089, Blast_Score=232, Evalue=5e-61,
Organism=Homo sapiens, GI47155554, Length=379, Percent_Identity=29.023746701847, Blast_Score=144, Evalue=2e-34,
Organism=Escherichia coli, GI1790710, Length=506, Percent_Identity=36.9565217391304, Blast_Score=267, Evalue=1e-72,
Organism=Escherichia coli, GI87082123, Length=281, Percent_Identity=38.0782918149466, Blast_Score=169, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI17556903, Length=318, Percent_Identity=29.559748427673, Blast_Score=125, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI17565172, Length=289, Percent_Identity=25.9515570934256, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI21355725, Length=362, Percent_Identity=34.2541436464088, Blast_Score=194, Evalue=2e-49,
Organism=Drosophila melanogaster, GI24661038, Length=359, Percent_Identity=33.7047353760446, Blast_Score=193, Evalue=2e-49,
Organism=Drosophila melanogaster, GI20129969, Length=356, Percent_Identity=30.3370786516854, Blast_Score=181, Evalue=1e-45,
Organism=Drosophila melanogaster, GI24662227, Length=419, Percent_Identity=29.1169451073986, Blast_Score=179, Evalue=5e-45,
Organism=Drosophila melanogaster, GI161077148, Length=355, Percent_Identity=30.7042253521127, Blast_Score=172, Evalue=4e-43,
Organism=Drosophila melanogaster, GI20130057, Length=355, Percent_Identity=30.7042253521127, Blast_Score=172, Evalue=4e-43,
Organism=Drosophila melanogaster, GI21355645, Length=419, Percent_Identity=27.9236276849642, Blast_Score=164, Evalue=9e-41,
Organism=Drosophila melanogaster, GI24662223, Length=419, Percent_Identity=27.9236276849642, Blast_Score=164, Evalue=9e-41,
Organism=Drosophila melanogaster, GI19922386, Length=434, Percent_Identity=28.5714285714286, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI20129963, Length=342, Percent_Identity=29.8245614035088, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI21357381, Length=304, Percent_Identity=33.2236842105263, Blast_Score=135, Evalue=5e-32,
Organism=Drosophila melanogaster, GI221379063, Length=304, Percent_Identity=33.2236842105263, Blast_Score=135, Evalue=5e-32,
Organism=Drosophila melanogaster, GI221379062, Length=304, Percent_Identity=33.2236842105263, Blast_Score=135, Evalue=5e-32,
Organism=Drosophila melanogaster, GI24646701, Length=358, Percent_Identity=25.1396648044693, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24646703, Length=358, Percent_Identity=25.1396648044693, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI21358201, Length=358, Percent_Identity=25.1396648044693, Blast_Score=90, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 56404; Mature: 56404

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYMKNILLMFLLCFMCSLQLFATEMSTMKITISKALPDFETLVVGFFEGDKLITNVLQDK
CCHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEHHCCCCCHHEEEEEECCHHHHHHHHHHH
QAIDNIKKFSDFNGGFGEFFSVTSSEGKNIIVAGLGMRDEWDESKGLNIGGKIYCELSRL
HHHHHHHHHHCCCCCHHHHHEEECCCCCEEEEEECCCCCCCCCCCCCCCCCEEEEEHHHH
RIKRAAISIEGNAANVAYGAFLRSFKFDKYKTKKDEKVTEVEEITVLTKDEQFSSAEKSF
EEEEHEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHEEEEECCCHHHHHHHHH
ERLRQEGEGIFLARTLTIEPPNVLYPESYADYIKTELTKLGLEIEVLGKKQMEEKKMGAL
HHHHHCCCCEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHH
LGVAQGSSKEPKLVVIKWNGAFKEQKPVAFVGKGITFDTGGVSLKPSRGMESMKYDMAGS
EEECCCCCCCCEEEEEEECCCCCCCCCEEEEECCEEECCCCEEECCCCCCHHHHHCCCCC
ATVVGVMRTLAGRKAKVNAVGVVALAENAVDGNAQRPSDVVTSMSGQTIEVLNTDAEGRL
HHHHHHHHHHCCCCEEECEEEEEEEECCCCCCCCCCCHHHHHHCCCCEEEEEECCCCCCE
ILADALWYTQDRFAPKFMIDLATLTGAIVVALGNNEYAGLFSNNDELANHLIDVGNEVNE
EEEEHHHHHHHCCCHHHHHHHHHHCCEEEEEECCCCEEEEECCCHHHHHHHHHCCCHHHH
KLWRFPMNETYNKIIDSPIADVQNIAPAGSGGDSIMAAQFLQRFVNDTCWAHLDIAGTAW
HHHCCCCCHHHHHHHCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECEEEE
HEKGTDISPRGAVGFGVRLLNKLVEKYYEINN
CCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MYMKNILLMFLLCFMCSLQLFATEMSTMKITISKALPDFETLVVGFFEGDKLITNVLQDK
CCHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEHHCCCCCHHEEEEEECCHHHHHHHHHHH
QAIDNIKKFSDFNGGFGEFFSVTSSEGKNIIVAGLGMRDEWDESKGLNIGGKIYCELSRL
HHHHHHHHHHCCCCCHHHHHEEECCCCCEEEEEECCCCCCCCCCCCCCCCCEEEEEHHHH
RIKRAAISIEGNAANVAYGAFLRSFKFDKYKTKKDEKVTEVEEITVLTKDEQFSSAEKSF
EEEEHEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHEEEEECCCHHHHHHHHH
ERLRQEGEGIFLARTLTIEPPNVLYPESYADYIKTELTKLGLEIEVLGKKQMEEKKMGAL
HHHHHCCCCEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHH
LGVAQGSSKEPKLVVIKWNGAFKEQKPVAFVGKGITFDTGGVSLKPSRGMESMKYDMAGS
EEECCCCCCCCEEEEEEECCCCCCCCCEEEEECCEEECCCCEEECCCCCCHHHHHCCCCC
ATVVGVMRTLAGRKAKVNAVGVVALAENAVDGNAQRPSDVVTSMSGQTIEVLNTDAEGRL
HHHHHHHHHHCCCCEEECEEEEEEEECCCCCCCCCCCHHHHHHCCCCEEEEEECCCCCCE
ILADALWYTQDRFAPKFMIDLATLTGAIVVALGNNEYAGLFSNNDELANHLIDVGNEVNE
EEEEHHHHHHHCCCHHHHHHHHHHCCEEEEEECCCCEEEEECCCHHHHHHHHHCCCHHHH
KLWRFPMNETYNKIIDSPIADVQNIAPAGSGGDSIMAAQFLQRFVNDTCWAHLDIAGTAW
HHHCCCCCHHHHHHHCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECEEEE
HEKGTDISPRGAVGFGVRLLNKLVEKYYEINN
CCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA