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The map label for this gene is fabZ

Identifier: 190571422

GI number: 190571422

Start: 1102708

End: 1103139

Strand: Reverse

Name: fabZ

Synonym: WPa_1035

Alternate gene names: 190571422

Gene position: 1103139-1102708 (Counterclockwise)

Preceding gene: 190571423

Following gene: 190571421

Centisome position: 74.41

GC content: 33.8

Gene sequence:

>432_bases
ATGCAATGTAATATCAATGATATTATAAAAATACTACCACATTCTTATCCTTTTCTCTTAGTAGATAGGGTCATAGAATG
CGATCCTGGTATGAGTATAAAAGCAATTAAAAACGTGACTTTCAACGAGCAATTTTTTATTGGTCATTTTCCTGGCCATC
CGATAATGCCAGGAGTTTTGATAATTGAGTCTTTAGCTCAAGCATCTGCTATATGTGTTCTCGGTAAAAAAACAGTAGAA
AATAAAGTTGTATACTTTATGTCCATTGAAAACGCAAAATTCAGAAAGCCAGTCACTCCAGGAGATACCTTAATTCTTCA
ATCTAACTTTGAAGGTTTGCGTTTAGGTGTATACAAATTTAAGTGTGTTGCATCTGTTGGAAAAGAAGAGGTTGCAGGAG
CAACAATCTTAGCAAAACTGCAAGATAAATAA

Upstream 100 bases:

>100_bases
GTTTTATACTCTATGGATGAAGTAGATTTATCGGATGTAGTATTAAAAAATGTAAACAAGGAAATACCCGAATTTGCTTT
GCAAAACATTGAATAGACTT

Downstream 100 bases:

>100_bases
AATCTTCATCTATAAGAAACAGTATGTACACTGTATAGTATAAAGATGCAACTGAATTTCAAAGTCTCATTTTCAAACTT
ATACACTCGTAATGAATTAA

Product: (3R)-hydroxymyristoyl-ACP dehydratase

Products: trans-Delta2-enoyl-acyl-ACP; H2O [C]

Alternate protein names: (3R)-hydroxymyristoyl ACP dehydrase

Number of amino acids: Translated: 143; Mature: 143

Protein sequence:

>143_residues
MQCNINDIIKILPHSYPFLLVDRVIECDPGMSIKAIKNVTFNEQFFIGHFPGHPIMPGVLIIESLAQASAICVLGKKTVE
NKVVYFMSIENAKFRKPVTPGDTLILQSNFEGLRLGVYKFKCVASVGKEEVAGATILAKLQDK

Sequences:

>Translated_143_residues
MQCNINDIIKILPHSYPFLLVDRVIECDPGMSIKAIKNVTFNEQFFIGHFPGHPIMPGVLIIESLAQASAICVLGKKTVE
NKVVYFMSIENAKFRKPVTPGDTLILQSNFEGLRLGVYKFKCVASVGKEEVAGATILAKLQDK
>Mature_143_residues
MQCNINDIIKILPHSYPFLLVDRVIECDPGMSIKAIKNVTFNEQFFIGHFPGHPIMPGVLIIESLAQASAICVLGKKTVE
NKVVYFMSIENAKFRKPVTPGDTLILQSNFEGLRLGVYKFKCVASVGKEEVAGATILAKLQDK

Specific function: Involved in saturated fatty acids biosynthesis

COG id: COG0764

COG function: function code I; 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thioester dehydratase family. FabZ subfamily

Homologues:

Organism=Escherichia coli, GI1786377, Length=136, Percent_Identity=46.3235294117647, Blast_Score=133, Evalue=4e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FABZ_WOLPP (B3CMM1)

Other databases:

- EMBL:   AM999887
- RefSeq:   YP_001975780.1
- ProteinModelPortal:   B3CMM1
- EnsemblBacteria:   EBWOLT00000000855
- GeneID:   6384504
- GenomeReviews:   AM999887_GR
- KEGG:   wpi:WPa_1035
- GeneTree:   EBGT00050000031002
- HOGENOM:   HBG433282
- OMA:   CNINDII
- ProtClustDB:   PRK00006
- GO:   GO:0005737
- HAMAP:   MF_00406
- InterPro:   IPR013114
- InterPro:   IPR010084
- TIGRFAMs:   TIGR01750

Pfam domain/function: PF07977 FabA

EC number: 4.2.1.- [C]

Molecular weight: Translated: 15810; Mature: 15810

Theoretical pI: Translated: 8.64; Mature: 8.64

Prosite motif: NA

Important sites: ACT_SITE 49-49

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQCNINDIIKILPHSYPFLLVDRVIECDPGMSIKAIKNVTFNEQFFIGHFPGHPIMPGVL
CCCCHHHHHHHCCCCCCHHEEHHHHCCCCCCEEEEEECCCCCCEEEEEECCCCCCCCHHH
IIESLAQASAICVLGKKTVENKVVYFMSIENAKFRKPVTPGDTLILQSNFEGLRLGVYKF
HHHHHHHHHEEEEECCCCCCCEEEEEEEECCCCCCCCCCCCCEEEEECCCCCEEEEHHHE
KCVASVGKEEVAGATILAKLQDK
EEHHHCCHHHHCCEEEEEEECCC
>Mature Secondary Structure
MQCNINDIIKILPHSYPFLLVDRVIECDPGMSIKAIKNVTFNEQFFIGHFPGHPIMPGVL
CCCCHHHHHHHCCCCCCHHEEHHHHCCCCCCEEEEEECCCCCCEEEEEECCCCCCCCHHH
IIESLAQASAICVLGKKTVENKVVYFMSIENAKFRKPVTPGDTLILQSNFEGLRLGVYKF
HHHHHHHHHEEEEECCCCCCCEEEEEEEECCCCCCCCCCCCCEEEEECCCCCEEEEHHHE
KCVASVGKEEVAGATILAKLQDK
EEHHHCCHHHHCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-3-hydroxy-acyl-ACP [C]

Specific reaction: D-3-hydroxy-acyl-ACP = trans-Delta2-enoyl-acyl-ACP + H2O [C]

General reaction: Carbon-Oxygen Lyases; Hydro-Lyases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA